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Compile Data Set for Download or QSAR

Found 267 hits with Last Name = 'bahnck' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095296
PNG
(CHEMBL3589082 | US9278953, 1)
Show SMILES CCn1ncc2c(F)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C20H21FN4O2/c1-3-25-17-10-12(9-15(21)13(17)11-23-25)16-6-5-14(18(26)24-16)20(2)7-4-8-22-19(20)27/h5-6,9-11H,3-4,7-8H2,1-2H3,(H,22,27)(H,24,26)/t20-/s2
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US Patent
2 -49.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335698
PNG
((R)-3-(3-Methyl-2-oxopiperidin-3-yl)-6-(5-methylqu...)
Show SMILES Cc1cccc2ncc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1S/C21H21N3O2/c1-13-5-3-6-18-15(13)11-14(12-23-18)17-8-7-16(19(25)24-17)21(2)9-4-10-22-20(21)26/h3,5-8,11-12H,4,9-10H2,1-2H3,(H,22,26)(H,24,25)/t21-/m1/s1
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3.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095295
PNG
(CHEMBL3589083 | US9278953, 2)
Show SMILES Cn1ncc2c(Cl)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C19H19ClN4O2/c1-19(6-3-7-21-18(19)26)13-4-5-15(23-17(13)25)11-8-14(20)12-10-22-24(2)16(12)9-11/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,26)(H,23,25)/t19-/s2
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3.60 -48.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50414549
PNG
(CHEMBL563480)
Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26)
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4.40n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335700
PNG
((R)-6-(5-Ethylquinolin-7-yl)-3-(3-methyl-2-oxopipe...)
Show SMILES CCc1cc(cc2ncccc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1S/C22H23N3O2/c1-3-14-12-15(13-19-16(14)6-4-10-23-19)18-8-7-17(20(26)25-18)22(2)9-5-11-24-21(22)27/h4,6-8,10,12-13H,3,5,9,11H2,1-2H3,(H,24,27)(H,25,26)/t22-/m1/s1
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4.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424575
PNG
(CHEMBL2312159)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H29FN8O3/c1-14-22(27-12-28-23(14)36-21-6-5-15(11-20(21)26)32-13-29-30-31-32)33-16-7-18-9-17(33)10-19(8-16)34(18)24(35)37-25(2,3)4/h5-6,11-13,16-19H,7-10H2,1-4H3
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335699
PNG
((R)-3-(3-Methyl-2-oxopiperidin-3-yl)-6-(5-methylqu...)
Show SMILES Cc1cc(cc2ncccc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1S/C21H21N3O2/c1-13-11-14(12-18-15(13)5-3-9-22-18)17-7-6-16(19(25)24-17)21(2)8-4-10-23-20(21)26/h3,5-7,9,11-12H,4,8,10H2,1-2H3,(H,23,26)(H,24,25)/t21-/m1/s1
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7.20n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335702
PNG
((R)-6-(5-Cyclopropylquinolin-7-yl)-3-(3-methyl-2-o...)
Show SMILES C[C@@]1(CCCNC1=O)c1ccc([nH]c1=O)-c1cc(C2CC2)c2cccnc2c1
Show InChI InChI=1S/C23H23N3O2/c1-23(9-3-11-25-22(23)28)18-7-8-19(26-21(18)27)15-12-17(14-5-6-14)16-4-2-10-24-20(16)13-15/h2,4,7-8,10,12-14H,3,5-6,9,11H2,1H3,(H,25,28)(H,26,27)/t23-/m1/s1
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7.30n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095294
PNG
(CHEMBL3589084 | US9278953, 7)
Show SMILES Cn1cnc2cc(cc(Cl)c12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C19H19ClN4O2/c1-19(6-3-7-21-18(19)26)12-4-5-14(23-17(12)25)11-8-13(20)16-15(9-11)22-10-24(16)2/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,26)(H,23,25)/t19-/s2
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US Patent
7.80 -46.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335701
PNG
((R)-6-(5-Chloroquinolin-7-yl)-3-(3-methyl-2-oxopip...)
Show SMILES C[C@@]1(CCCNC1=O)c1ccc([nH]c1=O)-c1cc(Cl)c2cccnc2c1
Show InChI InChI=1S/C20H18ClN3O2/c1-20(7-3-9-23-19(20)26)14-5-6-16(24-18(14)25)12-10-15(21)13-4-2-8-22-17(13)11-12/h2,4-6,8,10-11H,3,7,9H2,1H3,(H,23,26)(H,24,25)/t20-/m1/s1
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8.90n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212596
PNG
(US9278953, 3)
Show SMILES CCn1ncc2c(C)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C21H24N4O2/c1-4-25-18-11-14(10-13(2)15(18)12-23-25)17-7-6-16(19(26)24-17)21(3)8-5-9-22-20(21)27/h6-7,10-12H,4-5,8-9H2,1-3H3,(H,22,27)(H,24,26)/t21-/s2
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9.5 -45.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166587
PNG
(CHEMBL3799530)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)C(C)(C)O
Show InChI InChI=1S/C22H27FN6O3S/c1-5-29-16-11-13(10-15(23)14(16)12-24-29)17(30)25-20-27-26-18(33-20)22(4)6-8-28(9-7-22)19(31)21(2,3)32/h10-12,32H,5-9H2,1-4H3,(H,25,27,30)
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10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212598
PNG
(US9278953, 4)
Show SMILES Cn1ccc2ccc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C20H21N3O2/c1-20(9-3-10-21-19(20)25)15-6-7-16(22-18(15)24)14-5-4-13-8-11-23(2)17(13)12-14/h4-8,11-12H,3,9-10H2,1-2H3,(H,21,25)(H,22,24)/t20-/s2
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11.2 -45.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212605
PNG
(US9278953, 9)
Show SMILES Cn1ccc2cc(cc(F)c12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C19H18FN3O2/c1-19(6-7-21-18(19)25)13-3-4-15(22-17(13)24)12-9-11-5-8-23(2)16(11)14(20)10-12/h3-5,8-10H,6-7H2,1-2H3,(H,21,25)(H,22,24)/t19-/s2
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11.9 -45.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166584
PNG
(CHEMBL3797819)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(C)=O
Show InChI InChI=1S/C20H23FN6O2S/c1-4-27-16-10-13(9-15(21)14(16)11-22-27)17(29)23-19-25-24-18(30-19)20(3)5-7-26(8-6-20)12(2)28/h9-11H,4-8H2,1-3H3,(H,23,25,29)
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12n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212600
PNG
(US9278953, 5)
Show SMILES Cn1ccc2cc(ccc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C20H21N3O2/c1-20(9-3-10-21-19(20)25)15-5-6-16(22-18(15)24)13-4-7-17-14(12-13)8-11-23(17)2/h4-8,11-12H,3,9-10H2,1-2H3,(H,21,25)(H,22,24)/t20-/s2
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12.2 -45.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212607
PNG
(US9278953, 11)
Show SMILES Cn1ncc2c(F)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C19H19FN4O2/c1-19(6-3-7-21-18(19)26)13-4-5-15(23-17(13)25)11-8-14(20)12-10-22-24(2)16(12)9-11/h4-5,8-10H,3,6-7H2,1-2H3,(H,21,26)(H,23,25)/t19-/s2
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13.9 -44.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166580
PNG
(CHEMBL3797824)
Show SMILES CCn1ncc2c(Cl)cc(cc12)C(=O)Nc1nnc(s1)C1CC1
Show InChI InChI=1S/C15H14ClN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22)
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14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212604
PNG
(US9278953, 8)
Show SMILES Cn1ncc2c(Cl)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C18H17ClN4O2/c1-18(5-6-20-17(18)25)12-3-4-14(22-16(12)24)10-7-13(19)11-9-21-23(2)15(11)8-10/h3-4,7-9H,5-6H2,1-2H3,(H,20,25)(H,22,24)/t18-/s2
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14.2 -44.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166585
PNG
(CHEMBL3798872)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)CO
Show InChI InChI=1S/C20H23FN6O3S/c1-3-27-15-9-12(8-14(21)13(15)10-22-27)17(30)23-19-25-24-18(31-19)20(2)4-6-26(7-5-20)16(29)11-28/h8-10,28H,3-7,11H2,1-2H3,(H,23,25,30)
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424576
PNG
(CHEMBL2312158)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1
Show InChI InChI=1S/C25H27FN8O3/c1-14-22(27-12-28-23(14)36-21-4-3-15(11-20(21)26)32-13-29-30-31-32)33-16-7-18-9-17(33)10-19(8-16)34(18)24(35)37-25(2)5-6-25/h3-4,11-13,16-19H,5-10H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166586
PNG
(CHEMBL3799118)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)C(C)O
Show InChI InChI=1/C21H25FN6O3S/c1-4-28-16-10-13(9-15(22)14(16)11-23-28)17(30)24-20-26-25-19(32-20)21(3)5-7-27(8-6-21)18(31)12(2)29/h9-12,29H,4-8H2,1-3H3,(H,24,26,30)
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17n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424564
PNG
(CHEMBL2312506)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H33N5O3/c1-6-20-22(27-14-28-23(20)32-21-8-7-9-26-15(21)2)29-16-10-18-12-17(29)13-19(11-16)30(18)24(31)33-25(3,4)5/h7-9,14,16-19H,6,10-13H2,1-5H3
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18n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424577
PNG
(CHEMBL2312157)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)-n2cnnn2)c1C
Show InChI InChI=1S/C24H27FN8O3/c1-13(2)35-24(34)33-18-6-16-7-19(33)9-17(8-18)32(16)22-14(3)23(27-11-26-22)36-21-5-4-15(10-20(21)25)31-12-28-29-30-31/h4-5,10-13,16-19H,6-9H2,1-3H3
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18n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335704
PNG
((R)-3-(3-Methyl-2-oxopyrrolidin-3-yl)-6-(5-methylq...)
Show SMILES Cc1cccc2ncc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1S/C20H19N3O2/c1-12-4-3-5-17-14(12)10-13(11-22-17)16-7-6-15(18(24)23-16)20(2)8-9-21-19(20)25/h3-7,10-11H,8-9H2,1-2H3,(H,21,25)(H,23,24)/t20-/m1/s1
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18.6n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212606
PNG
(US9278953, 10)
Show SMILES CCn1ccc2ccc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C20H21N3O2/c1-3-23-11-8-13-4-5-14(12-17(13)23)16-7-6-15(18(24)22-16)20(2)9-10-21-19(20)25/h4-8,11-12H,3,9-10H2,1-2H3,(H,21,25)(H,22,24)/t20-/s2
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19.9 -44.0n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424579
PNG
(CHEMBL2312156)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H30N8O3/c1-15-22(26-13-27-23(15)35-21-7-5-16(6-8-21)31-14-28-29-30-31)32-17-9-19-11-18(32)12-20(10-17)33(19)24(34)36-25(2,3)4/h5-8,13-14,17-20H,9-12H2,1-4H3
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21n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212608
PNG
(US9278953, 12)
Show SMILES Cc1cc(cc2n(C)ncc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCCNC1=O
Show InChI InChI=1/C20H22N4O2/c1-12-9-13(10-17-14(12)11-22-24(17)3)16-6-5-15(18(25)23-16)20(2)7-4-8-21-19(20)26/h5-6,9-11H,4,7-8H2,1-3H3,(H,21,26)(H,23,25)/t20-/s2
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25 -43.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212609
PNG
(US9278953, 14)
Show SMILES C[C@@]1(CCCNC1=O)c1ccc([nH]c1=O)-c1cc(F)c2[nH]nc(C3CC3)c2c1
Show InChI InChI=1/C21H21FN4O2/c1-21(7-2-8-23-20(21)28)14-5-6-16(24-19(14)27)12-9-13-17(11-3-4-11)25-26-18(13)15(22)10-12/h5-6,9-11H,2-4,7-8H2,1H3,(H,23,28)(H,24,27)(H,25,26)/t21-/s2
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29.2 -43.0n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50095293
PNG
(CHEMBL3589085 | US9278953, 13)
Show SMILES CCn1ncc2c(C)cc(cc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C20H22N4O2/c1-4-24-17-10-13(9-12(2)14(17)11-22-24)16-6-5-15(18(25)23-16)20(3)7-8-21-19(20)26/h5-6,9-11H,4,7-8H2,1-3H3,(H,21,26)(H,23,25)/t20-/s2
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31.6 -42.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424573
PNG
(CHEMBL2312161)
Show SMILES Cc1c(Oc2ccc(cc2F)-n2cncn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H30FN7O3/c1-15-23(29-13-30-24(15)36-22-6-5-16(11-21(22)27)32-14-28-12-31-32)33-17-7-19-9-18(33)10-20(8-17)34(19)25(35)37-26(2,3)4/h5-6,11-14,17-20H,7-10H2,1-4H3
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33n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166581
PNG
(CHEMBL3797387)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1CC1
Show InChI InChI=1S/C15H14FN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22)
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38n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424548
PNG
(CHEMBL2312517)
Show SMILES Cc1c(Oc2ccc(cc2F)S(C)(=O)=O)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H31FN4O5S/c1-14-22(27-13-28-23(14)34-21-7-6-19(12-20(21)26)36(5,32)33)29-15-8-17-10-16(29)11-18(9-15)30(17)24(31)35-25(2,3)4/h6-7,12-13,15-18H,8-11H2,1-5H3
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41n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM212602
PNG
(US9278953, 6)
Show SMILES Cn1ccc2cc(ccc12)-c1ccc(c(=O)[nH]1)[C@@]1(C)CCNC1=O
Show InChI InChI=1/C19H19N3O2/c1-19(8-9-20-18(19)24)14-4-5-15(21-17(14)23)12-3-6-16-13(11-12)7-10-22(16)2/h3-7,10-11H,8-9H2,1-2H3,(H,20,24)(H,21,23)/t19-/s2
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46 -41.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Test compounds were half log serially diluted in 100% DMSO (J. T. Baker #922401). 1 uL of each compound was added to appropriate wells of a 384-well ...


US Patent US9278953 (2016)


BindingDB Entry DOI: 10.7270/Q2W37V5Z
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424580
PNG
(CHEMBL2312516)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cnnn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1
Show InChI InChI=1S/C25H28N8O3/c1-15-22(26-13-27-23(15)35-21-5-3-16(4-6-21)31-14-28-29-30-31)32-17-9-19-11-18(32)12-20(10-17)33(19)24(34)36-25(2)7-8-25/h3-6,13-14,17-20H,7-12H2,1-2H3
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48n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor EP3 subtype


(Homo sapiens (Human))
BDBM335703
PNG
((R)-3-(6-(5-fluoroquinolin-7-yl)-2-hydroxypyridin-...)
Show SMILES C[C@@]1(CCCNC1=O)c1ccc(nc1O)-c1cc(F)c2cccnc2c1
Show InChI InChI=1S/C20H18FN3O2/c1-20(7-3-9-23-19(20)26)14-5-6-16(24-18(14)25)12-10-15(21)13-4-2-8-22-17(13)11-12/h2,4-6,8,10-11H,3,7,9H2,1H3,(H,23,26)(H,24,25)/t20-/m1/s1
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48.6n/an/an/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
To measure the ability of test compounds in the present invention to bind to the human EP3 receptor, and therefore have the potential to antagonize P...


US Patent US9738626 (2017)


Article DOI: 10.1021/jm030434f
BindingDB Entry DOI: 10.7270/Q2CF9S7K
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166583
PNG
(CHEMBL3797483)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(C1)C(C)=O
Show InChI InChI=1/C19H21FN6O2S/c1-4-26-15-8-12(7-14(20)13(15)9-21-26)16(28)22-18-24-23-17(29-18)19(3)5-6-25(10-19)11(2)27/h7-9H,4-6,10H2,1-3H3,(H,22,24,28)
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53n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50364541
PNG
(CHEMBL1951011)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C21H26FN3O6S/c1-13(2)29-21(26)25-9-7-15(8-10-25)30-19-14(3)20(24-12-23-19)31-18-6-5-16(11-17(18)22)32(4,27)28/h5-6,11-13,15H,7-10H2,1-4H3
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53n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166582
PNG
(CHEMBL3798781)
Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CN(C1)C(C)=O
Show InChI InChI=1S/C18H19FN6O2S/c1-4-25-14-6-11(5-13(19)12(14)7-20-25)15(27)21-17-23-22-16(28-17)18(3)8-24(9-18)10(2)26/h5-7H,4,8-9H2,1-3H3,(H,21,23,27)
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65n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
Prostaglandin E2 receptor


(Homo sapiens (Human))
BDBM50166574
PNG
(CHEMBL3798598)
Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)C1CC1
Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21)
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77n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay


Bioorg Med Chem Lett 26: 2670-5 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424581
PNG
(CHEMBL2312515)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2)-n2cnnn2)c1C
Show InChI InChI=1S/C24H28N8O3/c1-14(2)34-24(33)32-19-8-17-9-20(32)11-18(10-19)31(17)22-15(3)23(26-12-25-22)35-21-6-4-16(5-7-21)30-13-27-28-29-30/h4-7,12-14,17-20H,8-11H2,1-3H3
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94n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424563
PNG
(CHEMBL2312505)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1
Show InChI InChI=1S/C25H31N5O3/c1-4-20-22(27-14-28-23(20)32-21-6-5-9-26-15(21)2)29-16-10-18-12-17(29)13-19(11-16)30(18)24(31)33-25(3)7-8-25/h5-6,9,14,16-19H,4,7-8,10-13H2,1-3H3
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123n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424578
PNG
(CHEMBL2311545)
Show SMILES Cc1c(Oc2ccc(cc2)-n2cncn2)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H31N7O3/c1-16-23(28-14-29-24(16)35-22-7-5-17(6-8-22)31-15-27-13-30-31)32-18-9-20-11-19(32)12-21(10-18)33(20)25(34)36-26(2,3)4/h5-8,13-15,18-21H,9-12H2,1-4H3
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125n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424550
PNG
(CHEMBL2312519)
Show SMILES Cc1c(Oc2ccc(cc2F)S(C)(=O)=O)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1
Show InChI InChI=1S/C25H29FN4O5S/c1-14-22(27-13-28-23(14)34-21-5-4-19(12-20(21)26)36(3,32)33)29-15-8-17-10-16(29)11-18(9-15)30(17)24(31)35-25(2)6-7-25/h4-5,12-13,15-18H,6-11H2,1-3H3
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131n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424583
PNG
(CHEMBL2312513)
Show SMILES Cc1c(Oc2ccc(cc2F)C#N)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C25H28FN5O3/c1-14-22(28-13-29-23(14)33-21-6-5-15(12-27)7-20(21)26)30-16-8-18-10-17(30)11-19(9-16)31(18)24(32)34-25(2,3)4/h5-7,13,16-19H,8-11H2,1-4H3
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133n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424559
PNG
(CHEMBL2312528)
Show SMILES Cc1ncccc1Oc1ncnc(N2C3CC4CC2CC(C3)N4C(=O)OC2(C)CCC2)c1C
Show InChI InChI=1S/C25H31N5O3/c1-15-22(27-14-28-23(15)32-21-6-4-9-26-16(21)2)29-17-10-19-12-18(29)13-20(11-17)30(19)24(31)33-25(3)7-5-8-25/h4,6,9,14,17-20H,5,7-8,10-13H2,1-3H3
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136n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424549
PNG
(CHEMBL2312518)
Show SMILES CC(C)OC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2ccc(cc2F)S(C)(=O)=O)c1C
Show InChI InChI=1S/C24H29FN4O5S/c1-13(2)33-24(30)29-17-7-15-8-18(29)10-16(9-17)28(15)22-14(3)23(27-12-26-22)34-21-6-5-19(11-20(21)25)35(4,31)32/h5-6,11-13,15-18H,7-10H2,1-4H3
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141n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424569
PNG
(CHEMBL2312511)
Show SMILES COc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
Show InChI InChI=1S/C24H31N5O4/c1-14-19(7-6-8-25-14)32-22-20(31-5)21(26-13-27-22)28-15-9-17-11-16(28)12-18(10-15)29(17)23(30)33-24(2,3)4/h6-8,13,15-18H,9-12H2,1-5H3
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163n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424562
PNG
(CHEMBL2312504)
Show SMILES CCc1c(Oc2cccnc2C)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C
Show InChI InChI=1S/C24H31N5O3/c1-5-20-22(26-13-27-23(20)32-21-7-6-8-25-15(21)4)28-16-9-18-11-17(28)12-19(10-16)29(18)24(30)31-14(2)3/h6-8,13-14,16-19H,5,9-12H2,1-4H3
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197n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50424555
PNG
(CHEMBL2312525)
Show SMILES CC(C)COC(=O)N1C2CC3CC1CC(C2)N3c1ncnc(Oc2cccnc2C)c1C
Show InChI InChI=1S/C24H31N5O3/c1-14(2)12-31-24(30)29-19-8-17-9-20(29)11-18(10-19)28(17)22-15(3)23(27-13-26-22)32-21-6-5-7-25-16(21)4/h5-7,13-14,17-20H,8-12H2,1-4H3
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231n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human GPR119 in HEK293FT cell membrane by radioligand binding assay


J Med Chem 56: 301-19 (2013)


Article DOI: 10.1021/jm301626p
BindingDB Entry DOI: 10.7270/Q2BG2Q91
More data for this
Ligand-Target Pair
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