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Compile Data Set for Download or QSAR

Found 1241 hits with Last Name = 'bankston' and Initial = 'd'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182699
PNG
(US9145392, 400)
Show SMILES CCc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CN(C)C1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H34FN7/c1-4-21-24(28)29-16-30-26(21)33-9-7-19(8-10-33)25-31-23(20-5-6-22(27)17(2)11-20)15-34(25)14-18-12-32(3)13-18/h5-6,11,15-16,18-19H,4,7-10,12-14H2,1-3H3,(H2,28,29,30)
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n/an/a 0.0600n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182489
PNG
(US9145392, 190)
Show SMILES Cc1cc(ccc1F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1Br
Show InChI InChI=1S/C24H29BrFN7/c1-16-13-18(3-4-19(16)26)20-14-33(12-11-31-7-2-8-31)23(30-20)17-5-9-32(10-6-17)24-21(25)22(27)28-15-29-24/h3-4,13-15,17H,2,5-12H2,1H3,(H2,27,28,29)
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US Patent
n/an/a 0.100n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182489
PNG
(US9145392, 190)
Show SMILES Cc1cc(ccc1F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1Br
Show InChI InChI=1S/C24H29BrFN7/c1-16-13-18(3-4-19(16)26)20-14-33(12-11-31-7-2-8-31)23(30-20)17-5-9-32(10-6-17)24-21(25)22(27)28-15-29-24/h3-4,13-15,17H,2,5-12H2,1H3,(H2,27,28,29)
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n/an/a 0.100n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182480
PNG
(US9145392, 181)
Show SMILES CC(C)c1cc(ccn1)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1Br
Show InChI InChI=1S/C25H33BrN8/c1-17(2)20-14-19(4-7-28-20)21-15-34(13-12-32-8-3-9-32)24(31-21)18-5-10-33(11-6-18)25-22(26)23(27)29-16-30-25/h4,7,14-18H,3,5-6,8-13H2,1-2H3,(H2,27,29,30)
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n/an/a 0.110n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182480
PNG
(US9145392, 181)
Show SMILES CC(C)c1cc(ccn1)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1Br
Show InChI InChI=1S/C25H33BrN8/c1-17(2)20-14-19(4-7-28-20)21-15-34(13-12-32-8-3-9-32)24(31-21)18-5-10-33(11-6-18)25-22(26)23(27)29-16-30-25/h4,7,14-18H,3,5-6,8-13H2,1-2H3,(H2,27,29,30)
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n/an/a 0.150n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182671
PNG
(US9145392, 372)
Show SMILES CC(C)CNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F4N8/c1-16(2)13-33-7-10-38-14-22(18-3-4-21(27)20(11-18)26(28,29)30)36-24(38)17-5-8-37(9-6-17)25-19(12-31)23(32)34-15-35-25/h3-4,11,14-17,33H,5-10,13H2,1-2H3,(H2,32,34,35)
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n/an/a 0.200n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182551
PNG
(US9145392, 252)
Show SMILES CCc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H33ClFN7/c1-2-20-24(29)30-17-31-26(20)34-11-7-18(8-12-34)25-32-23(19-5-6-22(28)21(27)15-19)16-35(25)14-13-33-9-3-4-10-33/h5-6,15-18H,2-4,7-14H2,1H3,(H2,29,30,31)
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n/an/a 0.200n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182483
PNG
(US9145392, 184)
Show SMILES COc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CNC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H30FN7O/c1-15-9-18(3-4-19(15)25)20-13-32(12-16-10-27-11-16)23(30-20)17-5-7-31(8-6-17)24-21(33-2)22(26)28-14-29-24/h3-4,9,13-14,16-17,27H,5-8,10-12H2,1-2H3,(H2,26,28,29)
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n/an/a 0.260n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182699
PNG
(US9145392, 400)
Show SMILES CCc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CN(C)C1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H34FN7/c1-4-21-24(28)29-16-30-26(21)33-9-7-19(8-10-33)25-31-23(20-5-6-22(27)17(2)11-20)15-34(25)14-18-12-32(3)13-18/h5-6,11,15-16,18-19H,4,7-10,12-14H2,1-3H3,(H2,28,29,30)
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US Patent
n/an/a 0.300n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182673
PNG
(US9145392, 374)
Show SMILES CNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H24F4N8/c1-30-6-9-35-12-19(15-2-3-18(24)17(10-15)23(25,26)27)33-21(35)14-4-7-34(8-5-14)22-16(11-28)20(29)31-13-32-22/h2-3,10,12-14,30H,4-9H2,1H3,(H2,29,31,32)
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n/an/a 0.400n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182551
PNG
(US9145392, 252)
Show SMILES CCc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H33ClFN7/c1-2-20-24(29)30-17-31-26(20)34-11-7-18(8-12-34)25-32-23(19-5-6-22(28)21(27)15-19)16-35(25)14-13-33-9-3-4-10-33/h5-6,15-18H,2-4,7-14H2,1H3,(H2,29,30,31)
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n/an/a 0.400n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182473
PNG
(US9145392, 174)
Show SMILES CCNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1OC(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-4-32-9-12-37-14-21(18-5-6-20(27)19(13-18)26(28,29)30)35-24(37)17-7-10-36(11-8-17)25-22(38-16(2)3)23(31)33-15-34-25/h5-6,13-17,32H,4,7-12H2,1-3H3,(H2,31,33,34)
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n/an/a 0.440n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182425
PNG
(US9145392, 126)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccnc(c2)C(F)(F)F)c1Br
Show InChI InChI=1S/C23H26BrF3N8/c24-19-20(28)30-14-31-22(19)34-8-3-15(4-9-34)21-32-17(13-35(21)11-10-33-6-1-7-33)16-2-5-29-18(12-16)23(25,26)27/h2,5,12-15H,1,3-4,6-11H2,(H2,28,30,31)
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n/an/a 0.5n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182535
PNG
(US9145392, 236)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2cccc(F)c2)c1Cl
Show InChI InChI=1S/C24H29ClFN7/c25-21-22(27)28-16-29-24(21)32-10-6-17(7-11-32)23-30-20(18-4-3-5-19(26)14-18)15-33(23)13-12-31-8-1-2-9-31/h3-5,14-17H,1-2,6-13H2,(H2,27,28,29)
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n/an/a 0.5n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182624
PNG
(US9145392, 325)
Show SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H29FN8/c1-16-12-18(4-5-20(16)25)21-14-33(11-10-31(2)3)23(30-21)17-6-8-32(9-7-17)24-19(13-26)22(27)28-15-29-24/h4-5,12,14-15,17H,6-11H2,1-3H3,(H2,27,28,29)
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n/an/a 0.5n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182473
PNG
(US9145392, 174)
Show SMILES CCNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1OC(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-4-32-9-12-37-14-21(18-5-6-20(27)19(13-18)26(28,29)30)35-24(37)17-7-10-36(11-8-17)25-22(38-16(2)3)23(31)33-15-34-25/h5-6,13-17,32H,4,7-12H2,1-3H3,(H2,31,33,34)
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n/an/a 0.520n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182517
PNG
(US9145392, 218)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1Cl
Show InChI InChI=1S/C24H26ClF4N7/c25-20-21(30)31-14-32-23(20)35-8-4-15(5-9-35)22-33-19(13-36(22)11-10-34-6-1-7-34)16-2-3-18(26)17(12-16)24(27,28)29/h2-3,12-15H,1,4-11H2,(H2,30,31,32)
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n/an/a 0.600n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182586
PNG
(US9145392, 287)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2ccc(F)c(c2)C(F)(F)F)c1C=O
Show InChI InChI=1S/C26H29F4N7O/c27-21-4-3-18(13-20(21)26(28,29)30)22-14-37(12-11-35-7-1-2-8-35)24(34-22)17-5-9-36(10-6-17)25-19(15-38)23(31)32-16-33-25/h3-4,13-17H,1-2,5-12H2,(H2,31,32,33)
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n/an/a 0.600n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182470
PNG
(US9145392, 171)
Show SMILES CCc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCNC)-c1ccnc(c1)C(F)(F)F
Show InChI InChI=1S/C23H29F3N8/c1-3-17-20(27)30-14-31-22(17)33-9-5-15(6-10-33)21-32-18(13-34(21)11-8-28-2)16-4-7-29-19(12-16)23(24,25)26/h4,7,12-15,28H,3,5-6,8-11H2,1-2H3,(H2,27,30,31)
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n/an/a 0.600n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182305
PNG
(US9145392, 6)
Show SMILES Cn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C=O)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H20F4N6O/c1-30-9-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(30)12-4-6-31(7-5-12)20-14(10-32)18(26)27-11-28-20/h2-3,8-12H,4-7H2,1H3,(H2,26,27,28)
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n/an/a 0.600n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182409
PNG
(US9145392, 110)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1cc[nH]c1
Show InChI InChI=1S/C28H30F4N8/c29-22-3-2-19(14-21(22)28(30,31)32)23-16-40(13-12-38-8-1-9-38)26(37-23)18-5-10-39(11-6-18)27-24(20-4-7-34-15-20)25(33)35-17-36-27/h2-4,7,14-18,34H,1,5-6,8-13H2,(H2,33,35,36)
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n/an/a 0.700n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182481
PNG
(US9145392, 182)
Show SMILES CC(C)c1cc(ccn1)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C=C
Show InChI InChI=1S/C27H36N8/c1-4-22-25(28)30-18-31-27(22)34-12-7-20(8-13-34)26-32-24(17-35(26)15-14-33-10-5-11-33)21-6-9-29-23(16-21)19(2)3/h4,6,9,16-20H,1,5,7-8,10-15H2,2-3H3,(H2,28,30,31)
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n/an/a 0.700n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182421
PNG
(US9145392, 122)
Show SMILES Cc1cc(ccc1F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
Show InChI InChI=1S/C25H29FN8/c1-17-13-19(3-4-21(17)26)22-15-34(12-11-32-7-2-8-32)24(31-22)18-5-9-33(10-6-18)25-20(14-27)23(28)29-16-30-25/h3-4,13,15-16,18H,2,5-12H2,1H3,(H2,28,29,30)
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n/an/a 0.700n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182671
PNG
(US9145392, 372)
Show SMILES CC(C)CNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F4N8/c1-16(2)13-33-7-10-38-14-22(18-3-4-21(27)20(11-18)26(28,29)30)36-24(38)17-5-8-37(9-6-17)25-19(12-31)23(32)34-15-35-25/h3-4,11,14-17,33H,5-10,13H2,1-2H3,(H2,32,34,35)
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n/an/a 0.700n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182688
PNG
(US9145392, 389)
Show SMILES Cc1cc(ccc1F)-c1cn(CCNC2CCCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
Show InChI InChI=1S/C27H33FN8/c1-18-14-20(6-7-23(18)28)24-16-36(13-10-31-21-4-2-3-5-21)26(34-24)19-8-11-35(12-9-19)27-22(15-29)25(30)32-17-33-27/h6-7,14,16-17,19,21,31H,2-5,8-13H2,1H3,(H2,30,32,33)
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n/an/a 0.700n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182462
PNG
(US9145392, 163)
Show SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H32FN9/c1-17-12-19(4-5-21(17)27)22-15-36(11-10-34(2)3)25(33-22)18-6-8-35(9-7-18)26-23(20-13-31-32-14-20)24(28)29-16-30-26/h4-5,12-16,18H,6-11H2,1-3H3,(H,31,32)(H2,28,29,30)
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n/an/a 0.730n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182656
PNG
(US9145392, 357)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCO)-c2ccc(F)c(c2)C(F)(F)F)c1C#N
Show InChI InChI=1S/C22H21F4N7O/c23-17-2-1-14(9-16(17)22(24,25)26)18-11-33(7-8-34)20(31-18)13-3-5-32(6-4-13)21-15(10-27)19(28)29-12-30-21/h1-2,9,11-13,34H,3-8H2,(H2,28,29,30)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182680
PNG
(US9145392, 381)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCNC2CCCC2)-c2ccc(F)c(c2)C(F)(F)F)c1C#N
Show InChI InChI=1S/C27H30F4N8/c28-22-6-5-18(13-21(22)27(29,30)31)23-15-39(12-9-34-19-3-1-2-4-19)25(37-23)17-7-10-38(11-8-17)26-20(14-32)24(33)35-16-36-26/h5-6,13,15-17,19,34H,1-4,7-12H2,(H2,33,35,36)
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n/an/a 0.800n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182602
PNG
(US9145392, 303)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(CC)CC)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C27H38FN7O/c1-5-33(6-2)14-15-35-17-23(21-8-9-22(28)19(4)16-21)32-26(35)20-10-12-34(13-11-20)27-24(36-7-3)25(29)30-18-31-27/h8-9,16-18,20H,5-7,10-15H2,1-4H3,(H2,29,30,31)
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n/an/a 0.800n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182606
PNG
(US9145392, 307)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2ccc(F)c(Cl)c2)c1C#N
Show InChI InChI=1S/C25H28ClFN8/c26-20-13-18(3-4-21(20)27)22-15-35(12-11-33-7-1-2-8-33)24(32-22)17-5-9-34(10-6-17)25-19(14-28)23(29)30-16-31-25/h3-4,13,15-17H,1-2,5-12H2,(H2,29,30,31)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182678
PNG
(US9145392, 379)
Show SMILES CC(C)N(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H33FN8/c1-17(2)33(4)11-12-35-15-23(20-5-6-22(27)18(3)13-20)32-25(35)19-7-9-34(10-8-19)26-21(14-28)24(29)30-16-31-26/h5-6,13,15-17,19H,7-12H2,1-4H3,(H2,29,30,31)
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n/an/a 0.800n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182677
PNG
(US9145392, 378)
Show SMILES Cc1cc(ccc1F)-c1cn(CCNCC2CC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
Show InChI InChI=1S/C26H31FN8/c1-17-12-20(4-5-22(17)27)23-15-35(11-8-30-14-18-2-3-18)25(33-23)19-6-9-34(10-7-19)26-21(13-28)24(29)31-16-32-26/h4-5,12,15-16,18-19,30H,2-3,6-11,14H2,1H3,(H2,29,31,32)
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n/an/a 0.800n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182504
PNG
(US9145392, 205)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2cnc(F)c(Cl)c2)c1C#N
Show InChI InChI=1S/C23H25ClFN9/c24-18-10-16(12-28-20(18)25)19-13-34(9-8-32-4-1-5-32)22(31-19)15-2-6-33(7-3-15)23-17(11-26)21(27)29-14-30-23/h10,12-15H,1-9H2,(H2,27,29,30)
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n/an/a 0.800n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182588
PNG
(US9145392, 289)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H33ClFN7O/c1-2-36-23-24(29)30-17-31-26(23)34-11-7-18(8-12-34)25-32-22(19-5-6-21(28)20(27)15-19)16-35(25)14-13-33-9-3-4-10-33/h5-6,15-18H,2-4,7-14H2,1H3,(H2,29,30,31)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182536
PNG
(US9145392, 237)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2ccc(F)cc2)c1Cl
Show InChI InChI=1S/C24H29ClFN7/c25-21-22(27)28-16-29-24(21)32-11-7-18(8-12-32)23-30-20(17-3-5-19(26)6-4-17)15-33(23)14-13-31-9-1-2-10-31/h3-6,15-16,18H,1-2,7-14H2,(H2,27,28,29)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182615
PNG
(US9145392, 316)
Show SMILES Cc1ccc(cc1C(F)(F)F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
Show InChI InChI=1S/C26H29F3N8/c1-17-3-4-19(13-21(17)26(27,28)29)22-15-37(12-11-35-7-2-8-35)24(34-22)18-5-9-36(10-6-18)25-20(14-30)23(31)32-16-33-25/h3-4,13,15-16,18H,2,5-12H2,1H3,(H2,31,32,33)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182537
PNG
(US9145392, 238)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2ccc(F)c(F)c2)c1Cl
Show InChI InChI=1S/C24H28ClF2N7/c25-21-22(28)29-15-30-24(21)33-9-5-16(6-10-33)23-31-20(17-3-4-18(26)19(27)13-17)14-34(23)12-11-32-7-1-2-8-32/h3-4,13-16H,1-2,5-12H2,(H2,28,29,30)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182693
PNG
(US9145392, 394)
Show SMILES CNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C23H27FN8/c1-15-11-17(3-4-19(15)24)20-13-32(10-7-27-2)22(30-20)16-5-8-31(9-6-16)23-18(12-25)21(26)28-14-29-23/h3-4,11,13-14,16,27H,5-10H2,1-2H3,(H2,26,28,29)
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Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182688
PNG
(US9145392, 389)
Show SMILES Cc1cc(ccc1F)-c1cn(CCNC2CCCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
Show InChI InChI=1S/C27H33FN8/c1-18-14-20(6-7-23(18)28)24-16-36(13-10-31-21-4-2-3-5-21)26(34-24)19-8-11-35(12-9-19)27-22(15-29)25(30)32-17-33-27/h6-7,14,16-17,19,21,31H,2-5,8-13H2,1H3,(H2,30,32,33)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182454
PNG
(US9145392, 155)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2C2CCNCC2)-c2ccc(F)c(c2)C(F)(F)F)c1C#N
Show InChI InChI=1S/C25H26F4N8/c26-20-2-1-16(11-19(20)25(27,28)29)21-13-37(17-3-7-32-8-4-17)23(35-21)15-5-9-36(10-6-15)24-18(12-30)22(31)33-14-34-24/h1-2,11,13-15,17,32H,3-10H2,(H2,31,33,34)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182408
PNG
(US9145392, 109)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1cnoc1
Show InChI InChI=1S/C27H28F4N8O/c28-21-3-2-18(12-20(21)27(29,30)31)22-14-39(11-10-37-6-1-7-37)25(36-22)17-4-8-38(9-5-17)26-23(19-13-35-40-15-19)24(32)33-16-34-26/h2-3,12-17H,1,4-11H2,(H2,32,33,34)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182669
PNG
(US9145392, 370)
Show SMILES CC(C)NCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C(N)=O)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H30F4N8O/c1-14(2)32-7-10-37-12-19(16-3-4-18(26)17(11-16)25(27,28)29)35-23(37)15-5-8-36(9-6-15)24-20(22(31)38)21(30)33-13-34-24/h3-4,11-15,32H,5-10H2,1-2H3,(H2,31,38)(H2,30,33,34)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182624
PNG
(US9145392, 325)
Show SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C#N)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C24H29FN8/c1-16-12-18(4-5-20(16)25)21-14-33(11-10-31(2)3)23(30-21)17-6-8-32(9-7-17)24-19(13-26)22(27)28-15-29-24/h4-5,12,14-15,17H,6-11H2,1-3H3,(H2,27,28,29)
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US Patent
n/an/a 0.900n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182539
PNG
(US9145392, 240)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2cccc(F)c2)c1C=C
Show InChI InChI=1S/C26H32FN7/c1-2-22-24(28)29-18-30-26(22)33-12-8-19(9-13-33)25-31-23(20-6-5-7-21(27)16-20)17-34(25)15-14-32-10-3-4-11-32/h2,5-7,16-19H,1,3-4,8-15H2,(H2,28,29,30)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182378
PNG
(US9145392, 79)
Show SMILES NC(=O)c1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C24H28ClFN8O/c25-17-12-16(2-3-18(17)26)19-13-34(11-10-32-6-1-7-32)23(31-19)15-4-8-33(9-5-15)24-20(22(28)35)21(27)29-14-30-24/h2-3,12-15H,1,4-11H2,(H2,28,35)(H2,27,29,30)
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n/an/a 0.900n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182374
PNG
(US9145392, 75)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(Cl)c2)c1C#N
Show InChI InChI=1S/C24H26ClFN8/c25-19-12-17(2-3-20(19)26)21-14-34(11-10-32-6-1-7-32)23(31-21)16-4-8-33(9-5-16)24-18(13-27)22(28)29-15-30-24/h2-3,12,14-16H,1,4-11H2,(H2,28,29,30)
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n/an/a 1n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182517
PNG
(US9145392, 218)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1Cl
Show InChI InChI=1S/C24H26ClF4N7/c25-20-21(30)31-14-32-23(20)35-8-4-15(5-9-35)22-33-19(13-36(22)11-10-34-6-1-7-34)16-2-3-18(26)17(12-16)24(27,28)29/h2-3,12-15H,1,4-11H2,(H2,30,31,32)
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n/an/a 1n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM182586
PNG
(US9145392, 287)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCCC2)-c2ccc(F)c(c2)C(F)(F)F)c1C=O
Show InChI InChI=1S/C26H29F4N7O/c27-21-4-3-18(13-20(21)26(28,29)30)22-14-37(12-11-35-7-1-2-8-35)24(34-22)17-5-9-36(10-6-17)25-19(15-38)23(31)32-16-33-25/h3-4,13-17H,1-2,5-12H2,(H2,31,32,33)
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n/an/a 1n/an/an/an/a7.5n/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50215758
PNG
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27)
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PubMed
n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Bioorg Med Chem Lett 17: 4378-81 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.075
BindingDB Entry DOI: 10.7270/Q28K78S7
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM182426
PNG
(US9145392, 127)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCNCCCCl)-c2ccnc(c2)C(F)(F)F)c1Br
Show InChI InChI=1S/C23H27BrClF3N8/c24-19-20(29)32-14-33-22(19)35-9-3-15(4-10-35)21-34-17(13-36(21)11-8-30-6-1-5-25)16-2-7-31-18(12-16)23(26,27)28/h2,7,12-15,30H,1,3-6,8-11H2,(H2,29,32,33)
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n/an/a 1n/an/an/an/a7.525



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)


BindingDB Entry DOI: 10.7270/Q2NZ86D2
More data for this
Ligand-Target Pair
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