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Compile Data Set for Download or QSAR

Found 147 hits with Last Name = 'bonner' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079161
PNG
(5-Methyl-1-[1-(3-methyl-benzyl)-piperidin-4-yl]-4-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2cccc(C)c2)CC1)-c1ccccc1
Show InChI InChI=1S/C23H27N3O/c1-17-7-6-8-19(15-17)16-25-13-11-21(12-14-25)26-18(2)22(24-23(26)27)20-9-4-3-5-10-20/h3-10,15,21H,11-14,16H2,1-2H3,(H,24,27)
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0.330n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077001
PNG
(1-Benzyl-4-(3-methyl-4-phenyl-pyrazol-1-yl)-piperi...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)17-25(23-18)21-12-14-24(15-13-21)16-19-8-4-2-5-9-19/h2-11,17,21H,12-16H2,1H3
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0.390n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079175
PNG
(1-[1-(3-Chloro-benzyl)-piperidin-4-yl]-5-methyl-4-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2cccc(Cl)c2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(18-7-3-2-4-8-18)24-22(27)26(16)20-10-12-25(13-11-20)15-17-6-5-9-19(23)14-17/h2-9,14,20H,10-13,15H2,1H3,(H,24,27)
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0.460n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079177
PNG
(5-Methyl-1-(1-phenethyl-piperidin-4-yl)-4-phenyl-1...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(CCc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C23H27N3O/c1-18-22(20-10-6-3-7-11-20)24-23(27)26(18)21-13-16-25(17-14-21)15-12-19-8-4-2-5-9-19/h2-11,21H,12-17H2,1H3,(H,24,27)
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0.560n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079173
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-4-phenyl-1,3-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H25N3O/c1-17-21(19-10-6-3-7-11-19)23-22(26)25(17)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h2-11,20H,12-16H2,1H3,(H,23,26)
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0.600n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079153
PNG
(1-[1-(3-Methoxy-benzyl)-piperidin-4-yl]-5-methyl-4...)
Show SMILES COc1cccc(CN2CCC(CC2)n2c(C)c([nH]c2=O)-c2ccccc2)c1
Show InChI InChI=1S/C23H27N3O2/c1-17-22(19-8-4-3-5-9-19)24-23(27)26(17)20-11-13-25(14-12-20)16-18-7-6-10-21(15-18)28-2/h3-10,15,20H,11-14,16H2,1-2H3,(H,24,27)
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0.640n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079159
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-(4-chloro-phenyl)-5-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(18-7-9-19(23)10-8-18)24-22(27)26(16)20-11-13-25(14-12-20)15-17-5-3-2-4-6-17/h2-10,20H,11-15H2,1H3,(H,24,27)
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0.710n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079181
PNG
(1-(1-Benzyl-piperidin-4-yl)-3,5-dimethyl-4-phenyl-...)
Show SMILES Cc1c(-c2ccccc2)n(C)c(=O)n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H27N3O/c1-18-22(20-11-7-4-8-12-20)24(2)23(27)26(18)21-13-15-25(16-14-21)17-19-9-5-3-6-10-19/h3-12,21H,13-17H2,1-2H3
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0.75n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079158
PNG
(1-(1-Benzyl-piperidin-4-yl)-3-methyl-4-phenyl-1,3-...)
Show SMILES Cn1c(cn(C2CCN(Cc3ccccc3)CC2)c1=O)-c1ccccc1
Show InChI InChI=1S/C22H25N3O/c1-23-21(19-10-6-3-7-11-19)17-25(22(23)26)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h2-11,17,20H,12-16H2,1H3
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0.840n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079169
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-ethyl-4-phenyl-1,3-d...)
Show SMILES CCc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C23H27N3O/c1-2-21-22(19-11-7-4-8-12-19)24-23(27)26(21)20-13-15-25(16-14-20)17-18-9-5-3-6-10-18/h3-12,20H,2,13-17H2,1H3,(H,24,27)
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0.860n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079171
PNG
(3-[4-(5-Methyl-2-oxo-4-phenyl-2,3-dihydro-imidazol...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2cccc(c2)C#N)CC1)-c1ccccc1
Show InChI InChI=1S/C23H24N4O/c1-17-22(20-8-3-2-4-9-20)25-23(28)27(17)21-10-12-26(13-11-21)16-19-7-5-6-18(14-19)15-24/h2-9,14,21H,10-13,16H2,1H3,(H,25,28)
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0.960n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079182
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-4-thiophen-2-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1cccs1
Show InChI InChI=1S/C20H23N3OS/c1-15-19(18-8-5-13-25-18)21-20(24)23(15)17-9-11-22(12-10-17)14-16-6-3-2-4-7-16/h2-8,13,17H,9-12,14H2,1H3,(H,21,24)
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1n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079164
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-(2-chloro-phenyl)-5-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccccc1Cl
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(19-9-5-6-10-20(19)23)24-22(27)26(16)18-11-13-25(14-12-18)15-17-7-3-2-4-8-17/h2-10,18H,11-15H2,1H3,(H,24,27)
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1.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079162
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-4-p-tolyl-1,3...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccc(C)cc1
Show InChI InChI=1S/C23H27N3O/c1-17-8-10-20(11-9-17)22-18(2)26(23(27)24-22)21-12-14-25(15-13-21)16-19-6-4-3-5-7-19/h3-11,21H,12-16H2,1-2H3,(H,24,27)
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1.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077003
PNG
(3-[4-(3-Methyl-4-phenyl-pyrazol-1-yl)-piperidin-1-...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C23H24N4/c1-18-23(21-8-3-2-4-9-21)17-27(25-18)22-10-12-26(13-11-22)16-20-7-5-6-19(14-20)15-24/h2-9,14,17,22H,10-13,16H2,1H3
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1.20n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079172
PNG
(1-[1-(4-Chloro-benzyl)-piperidin-4-yl]-5-methyl-4-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccc(Cl)cc2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(18-5-3-2-4-6-18)24-22(27)26(16)20-11-13-25(14-12-20)15-17-7-9-19(23)10-8-17/h2-10,20H,11-15H2,1H3,(H,24,27)
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079155
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-(4-fluoro-phenyl)-5-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H24FN3O/c1-16-21(18-7-9-19(23)10-8-18)24-22(27)26(16)20-11-13-25(14-12-20)15-17-5-3-2-4-6-17/h2-10,20H,11-15H2,1H3,(H,24,27)
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1.70n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079174
PNG
(1-(1-Cyclohexylmethyl-piperidin-4-yl)-5-methyl-4-p...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(CC2CCCCC2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H31N3O/c1-17-21(19-10-6-3-7-11-19)23-22(26)25(17)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h3,6-7,10-11,18,20H,2,4-5,8-9,12-16H2,1H3,(H,23,26)
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2n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079163
PNG
(1-[1-(2-Chloro-benzyl)-piperidin-4-yl]-5-methyl-4-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2Cl)CC1)-c1ccccc1
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(17-7-3-2-4-8-17)24-22(27)26(16)19-11-13-25(14-12-19)15-18-9-5-6-10-20(18)23/h2-10,19H,11-15H2,1H3,(H,24,27)
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2.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50076996
PNG
(1-Benzyl-4-(5-methyl-4-phenyl-pyrazol-1-yl)-piperi...)
Show SMILES Cc1c(cnn1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)16-23-25(18)21-12-14-24(15-13-21)17-19-8-4-2-5-9-19/h2-11,16,21H,12-15,17H2,1H3
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2.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077004
PNG
(1-(3-Chloro-benzyl)-4-(3-methyl-4-phenyl-pyrazol-1...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C22H24ClN3/c1-17-22(19-7-3-2-4-8-19)16-26(24-17)21-10-12-25(13-11-21)15-18-6-5-9-20(23)14-18/h2-9,14,16,21H,10-13,15H2,1H3
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3.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077010
PNG
(1-(3-Chloro-benzyl)-4-(5-methyl-4-phenyl-pyrazol-1...)
Show SMILES Cc1c(cnn1C1CCN(Cc2cccc(Cl)c2)CC1)-c1ccccc1
Show InChI InChI=1S/C22H24ClN3/c1-17-22(19-7-3-2-4-8-19)15-24-26(17)21-10-12-25(13-11-21)16-18-6-5-9-20(23)14-18/h2-9,14-15,21H,10-13,16H2,1H3
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3.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50050476
PNG
(4-[5-(4-Chloro-phenyl)-4-methyl-isoxazol-3-yl]-1-p...)
Show SMILES Cc1c(noc1-c1ccc(Cl)cc1)C1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H25ClN2O/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18/h2-10,19H,11-16H2,1H3
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3.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079167
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-4-pyridin-2-y...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccccn1
Show InChI InChI=1S/C21H24N4O/c1-16-20(19-9-5-6-12-22-19)23-21(26)25(16)18-10-13-24(14-11-18)15-17-7-3-2-4-8-17/h2-9,12,18H,10-11,13-15H2,1H3,(H,23,26)
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4.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079179
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-3,4-diphenyl-...)
Show SMILES Cc1c(-c2ccccc2)n(-c2ccccc2)c(=O)n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H29N3O/c1-22-27(24-13-7-3-8-14-24)31(25-15-9-4-10-16-25)28(32)30(22)26-17-19-29(20-18-26)21-23-11-5-2-6-12-23/h2-16,26H,17-21H2,1H3
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4.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077006
PNG
(1-Benzyl-4-(4-methyl-5-phenyl-1H-pyrazol-3-yl)-pip...)
Show SMILES Cc1c([nH]nc1-c1ccccc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3/c1-17-21(19-10-6-3-7-11-19)23-24-22(17)20-12-14-25(15-13-20)16-18-8-4-2-5-9-18/h2-11,20H,12-16H2,1H3,(H,23,24)
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4.70n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077002
PNG
(3-[4-(5-Methyl-4-phenyl-pyrazol-1-yl)-piperidin-1-...)
Show SMILES Cc1c(cnn1C1CCN(Cc2cccc(c2)C#N)CC1)-c1ccccc1
Show InChI InChI=1S/C23H24N4/c1-18-23(21-8-3-2-4-9-21)16-25-27(18)22-10-12-26(13-11-22)17-20-7-5-6-19(14-20)15-24/h2-9,14,16,22H,10-13,17H2,1H3
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5.20n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079157
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-(3-chloro-phenyl)-5-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1cccc(Cl)c1
Show InChI InChI=1S/C22H24ClN3O/c1-16-21(18-8-5-9-19(23)14-18)24-22(27)26(16)20-10-12-25(13-11-20)15-17-6-3-2-4-7-17/h2-9,14,20H,10-13,15H2,1H3,(H,24,27)
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5.20n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079156
PNG
(5-Methyl-4-phenyl-1-[1-(3-phenyl-propyl)-piperidin...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(CCCc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C24H29N3O/c1-19-23(21-12-6-3-7-13-21)25-24(28)27(19)22-14-17-26(18-15-22)16-8-11-20-9-4-2-5-10-20/h2-7,9-10,12-13,22H,8,11,14-18H2,1H3,(H,25,28)
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5.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079166
PNG
(1-(1-Benzyl-piperidin-4-yl)-3-isoquinolin-1-yl-ure...)
Show SMILES O=C(NC1CCN(Cc2ccccc2)CC1)Nc1nccc2ccccc12
Show InChI InChI=1S/C22H24N4O/c27-22(25-21-20-9-5-4-8-18(20)10-13-23-21)24-19-11-14-26(15-12-19)16-17-6-2-1-3-7-17/h1-10,13,19H,11-12,14-16H2,(H2,23,24,25,27)
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5.5n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50077001
PNG
(1-Benzyl-4-(3-methyl-4-phenyl-pyrazol-1-yl)-piperi...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)17-25(23-18)21-12-14-24(15-13-21)16-19-8-4-2-5-9-19/h2-11,17,21H,12-16H2,1H3
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6.10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D2 expressed in CHO cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50079182
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-4-thiophen-2-...)
Show SMILES Cc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1cccs1
Show InChI InChI=1S/C20H23N3OS/c1-15-19(18-8-5-13-25-18)21-20(24)23(15)17-9-11-22(12-10-17)14-16-6-3-2-4-7-16/h2-8,13,17H,9-12,14H2,1H3,(H,21,24)
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7.80n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50079179
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-3,4-diphenyl-...)
Show SMILES Cc1c(-c2ccccc2)n(-c2ccccc2)c(=O)n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H29N3O/c1-22-27(24-13-7-3-8-14-24)31(25-15-9-4-10-16-25)28(32)30(22)26-17-19-29(20-18-26)21-23-11-5-2-6-12-23/h2-16,26H,17-21H2,1H3
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8.80n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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10n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
compound was tested for its affinity to displace [3H]-spiperone cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50079158
PNG
(1-(1-Benzyl-piperidin-4-yl)-3-methyl-4-phenyl-1,3-...)
Show SMILES Cn1c(cn(C2CCN(Cc3ccccc3)CC2)c1=O)-c1ccccc1
Show InChI InChI=1S/C22H25N3O/c1-23-21(19-10-6-3-7-11-19)17-25(22(23)26)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h2-11,17,20H,12-16H2,1H3
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11n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50059227
PNG
(1-Benzyl-4-(5-phenyl-1H-pyrazol-3-yl)-piperidine |...)
Show SMILES C(N1CCC(CC1)c1cc(n[nH]1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H23N3/c1-3-7-17(8-4-1)16-24-13-11-19(12-14-24)21-15-20(22-23-21)18-9-5-2-6-10-18/h1-10,15,19H,11-14,16H2,(H,22,23)
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11n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079176
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-(4-methoxy-phenyl)-5...)
Show SMILES COc1ccc(cc1)-c1[nH]c(=O)n(C2CCN(Cc3ccccc3)CC2)c1C
Show InChI InChI=1S/C23H27N3O2/c1-17-22(19-8-10-21(28-2)11-9-19)24-23(27)26(17)20-12-14-25(15-13-20)16-18-6-4-3-5-7-18/h3-11,20H,12-16H2,1-2H3,(H,24,27)
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12n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50077004
PNG
(1-(3-Chloro-benzyl)-4-(3-methyl-4-phenyl-pyrazol-1...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2cccc(Cl)c2)CC1
Show InChI InChI=1S/C22H24ClN3/c1-17-22(19-7-3-2-4-8-19)16-26(24-17)21-10-12-25(13-11-21)15-18-6-5-9-20(23)14-18/h2-9,14,16,21H,10-13,15H2,1H3
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15n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D2 expressed in CHO cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50076997
PNG
(1-Benzyl-4-(5-phenyl-pyrazol-1-yl)-piperidine | CH...)
Show SMILES C(N1CCC(CC1)n1nccc1-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H23N3/c1-3-7-18(8-4-1)17-23-15-12-20(13-16-23)24-21(11-14-22-24)19-9-5-2-6-10-19/h1-11,14,20H,12-13,15-17H2
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15n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50079179
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-methyl-3,4-diphenyl-...)
Show SMILES Cc1c(-c2ccccc2)n(-c2ccccc2)c(=O)n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H29N3O/c1-22-27(24-13-7-3-8-14-24)31(25-15-9-4-10-16-25)28(32)30(22)26-17-19-29(20-18-26)21-23-11-5-2-6-12-23/h2-16,26H,17-21H2,1H3
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15n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D3 (hD3) stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50079181
PNG
(1-(1-Benzyl-piperidin-4-yl)-3,5-dimethyl-4-phenyl-...)
Show SMILES Cc1c(-c2ccccc2)n(C)c(=O)n1C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H27N3O/c1-18-22(20-11-7-4-8-12-20)24(2)23(27)26(18)21-13-15-25(16-14-21)17-19-9-5-3-6-10-19/h3-12,21H,13-17H2,1-2H3
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15n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50077003
PNG
(3-[4-(3-Methyl-4-phenyl-pyrazol-1-yl)-piperidin-1-...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C23H24N4/c1-18-23(21-8-3-2-4-9-21)17-27(25-18)22-10-12-26(13-11-22)16-20-7-5-6-19(14-20)15-24/h2-9,14,17,22H,10-13,16H2,1H3
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15n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D2 expressed in CHO cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077008
PNG
(1-Benzyl-4-(5-methyl-4-phenyl-[1,2,3]triazol-1-yl)...)
Show SMILES Cc1c(nnn1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C21H24N4/c1-17-21(19-10-6-3-7-11-19)22-23-25(17)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h2-11,20H,12-16H2,1H3
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17n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50079154
PNG
(1-(1-Benzyl-piperidin-4-yl)-4-phenyl-1,3-dihydro-i...)
Show SMILES O=c1[nH]c(cn1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C21H23N3O/c25-21-22-20(18-9-5-2-6-10-18)16-24(21)19-11-13-23(14-12-19)15-17-7-3-1-4-8-17/h1-10,16,19H,11-15H2,(H,22,25)
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18n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D4 stably expressed in HEK-393 cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50076998
PNG
(1-Benzyl-4-(4-methyl-5-phenyl-[1,2,3]triazol-1-yl)...)
Show SMILES Cc1nnn(C2CCN(Cc3ccccc3)CC2)c1-c1ccccc1
Show InChI InChI=1S/C21H24N4/c1-17-21(19-10-6-3-7-11-19)25(23-22-17)20-12-14-24(15-13-20)16-18-8-4-2-5-9-18/h2-11,20H,12-16H2,1H3
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18n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50079169
PNG
(1-(1-Benzyl-piperidin-4-yl)-5-ethyl-4-phenyl-1,3-d...)
Show SMILES CCc1c([nH]c(=O)n1C1CCN(Cc2ccccc2)CC1)-c1ccccc1
Show InChI InChI=1S/C23H27N3O/c1-2-21-22(19-11-7-4-8-12-19)24-23(27)26(21)20-13-15-25(16-14-20)17-18-9-5-3-6-10-18/h3-12,20H,2,13-17H2,1H3,(H,24,27)
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26n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Affinity to displace [3H]-spiperone from cloned human Dopamine receptor D2 stably expressed in CHO cell lines


J Med Chem 42: 2706-15 (1999)


Article DOI: 10.1021/jm991029k
BindingDB Entry DOI: 10.7270/Q2P55MPV
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50076999
PNG
(1-Benzyl-4-(5-phenyl-tetrazol-2-yl)-piperidine | C...)
Show SMILES C(N1CCC(CC1)n1nnc(n1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H21N5/c1-3-7-16(8-4-1)15-23-13-11-18(12-14-23)24-21-19(20-22-24)17-9-5-2-6-10-17/h1-10,18H,11-15H2
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27n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50077001
PNG
(1-Benzyl-4-(3-methyl-4-phenyl-pyrazol-1-yl)-piperi...)
Show SMILES Cc1nn(cc1-c1ccccc1)C1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H25N3/c1-18-22(20-10-6-3-7-11-20)17-25(23-18)21-12-14-24(15-13-21)16-19-8-4-2-5-9-19/h2-11,17,21H,12-16H2,1H3
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28n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D3 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))
BDBM50077007
PNG
(1-Benzyl-4-(4-phenyl-[1,2,3]triazol-1-yl)-piperidi...)
Show SMILES C(N1CCC(CC1)n1cc(nn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-3-7-17(8-4-1)15-23-13-11-19(12-14-23)24-16-20(21-22-24)18-9-5-2-6-10-18/h1-10,16,19H,11-15H2
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32n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from human Dopamine receptor D4 expressed in HEK-293 cells


Bioorg Med Chem Lett 9: 1285-90 (1999)


Article DOI: 10.1016/s0960-894x(99)00169-9
BindingDB Entry DOI: 10.7270/Q2C53K1C
More data for this
Ligand-Target Pair
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