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Compile Data Set for Download or QSAR

Found 157 hits with Last Name = 'bursuker' and Initial = 'i'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Presenilin-1


(Homo sapiens (Human))
BDBM50477923
PNG
(CHEMBL437977)
Show SMILES C[C@H](CCCNS(C)(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H24Cl2N2O5S2/c1-14(4-3-11-22-29(2,25)26)23(19-12-17(21)6-5-15(19)13-24)30(27,28)18-9-7-16(20)8-10-18/h5-10,12,14,22,24H,3-4,11,13H2,1-2H3/t14-/m1/s1
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n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM29012
PNG
(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)
Show SMILES C[C@H](CCCN(C)S(C)(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H26Cl2N2O5S2/c1-15(5-4-12-23(2)30(3,26)27)24(20-13-18(22)7-6-16(20)14-25)31(28,29)19-10-8-17(21)9-11-19/h6-11,13,15,25H,4-5,12,14H2,1-3H3/t15-/m1/s1
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n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM29013
PNG
(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Show SMILES C[C@H](CCCn1cnnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21Cl2N5O3S/c1-14(3-2-10-25-13-22-23-24-25)26(19-11-17(21)5-4-15(19)12-27)30(28,29)18-8-6-16(20)7-9-18/h4-9,11,13-14,27H,2-3,10,12H2,1H3/t14-/m1/s1
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n/an/a 0.510n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477936
PNG
(CHEMBL252052)
Show SMILES C[C@H](CCCn1nnnc1N(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26Cl2N6O3S/c1-15(5-4-12-28-21(27(2)3)24-25-26-28)29(20-13-18(23)7-6-16(20)14-30)33(31,32)19-10-8-17(22)9-11-19/h6-11,13,15,30H,4-5,12,14H2,1-3H3/t15-/m1/s1
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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477922
PNG
(CHEMBL252051)
Show SMILES C[C@H](CCCn1nnnc1C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23Cl2N5O3S/c1-14(4-3-11-26-15(2)23-24-25-26)27(20-12-18(22)6-5-16(20)13-28)31(29,30)19-9-7-17(21)8-10-19/h5-10,12,14,28H,3-4,11,13H2,1-2H3/t14-/m1/s1
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n/an/a 0.75n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477915
PNG
(CHEMBL252846)
Show SMILES C[C@H](CCCn1ccnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-11-25-12-10-23-24-25)26(20-13-18(22)5-4-16(20)14-27)30(28,29)19-8-6-17(21)7-9-19/h4-10,12-13,15,27H,2-3,11,14H2,1H3/t15-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477917
PNG
(CHEMBL253295)
Show SMILES C[C@H](CCCN1CCCS1(=O)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26Cl2N2O5S2/c1-16(4-2-11-24-12-3-13-31(24,27)28)25(21-14-19(23)6-5-17(21)15-26)32(29,30)20-9-7-18(22)8-10-20/h5-10,14,16,26H,2-4,11-13,15H2,1H3/t16-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477945
PNG
(CHEMBL429838)
Show SMILES C[C@H](CCCn1ncnn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21Cl2N5O3S/c1-14(3-2-10-25-23-13-22-24-25)26(19-11-17(21)5-4-15(19)12-27)30(28,29)18-8-6-16(20)7-9-18/h4-9,11,13-14,27H,2-3,10,12H2,1H3/t14-/m1/s1
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n/an/a 1.20n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477932
PNG
(CHEMBL253091)
Show SMILES C[C@H](CCCNC(=O)[C@H](O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28Cl2N2O5S/c1-18(6-5-15-29-26(33)25(32)19-7-3-2-4-8-19)30(24-16-22(28)10-9-20(24)17-31)36(34,35)23-13-11-21(27)12-14-23/h2-4,7-14,16,18,25,31-32H,5-6,15,17H2,1H3,(H,29,33)/t18-,25-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5666
PNG
(2-amino-5-thio-substituted thiazole 40 | 3-(5-{[(5...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Nc3c(F)cccc3F)s2)o1
Show InChI InChI=1S/C18H18F2N4O2S2/c1-18(2,3)12-7-21-13(26-12)9-27-14-8-22-17(28-14)24-16(25)23-15-10(19)5-4-6-11(15)20/h4-8H,9H2,1-3H3,(H2,22,23,24,25)
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n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477939
PNG
(CHEMBL253092)
Show SMILES C[C@H](CCCNC(=O)[C@@H](O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28Cl2N2O5S/c1-18(6-5-15-29-26(33)25(32)19-7-3-2-4-8-19)30(24-16-22(28)10-9-20(24)17-31)36(34,35)23-13-11-21(27)12-14-23/h2-4,7-14,16,18,25,31-32H,5-6,15,17H2,1H3,(H,29,33)/t18-,25+/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5667
PNG
(2-amino-5-thio-substituted thiazole 41 | 3-(5-{[(5...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Nc3c(Cl)cccc3Cl)s2)o1
Show InChI InChI=1S/C18H18Cl2N4O2S2/c1-18(2,3)12-7-21-13(26-12)9-27-14-8-22-17(28-14)24-16(25)23-15-10(19)5-4-6-11(15)20/h4-8H,9H2,1-3H3,(H2,22,23,24,25)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5668
PNG
(2-amino-5-thio-substituted thiazole 45 | BMS-38703...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Cc3ccc(CNC(CO)CO)cc3)s2)o1
Show InChI InChI=1S/C23H30N4O4S2/c1-23(2,3)18-10-25-20(31-18)14-32-21-11-26-22(33-21)27-19(30)8-15-4-6-16(7-5-15)9-24-17(12-28)13-29/h4-7,10-11,17,24,28-29H,8-9,12-14H2,1-3H3,(H,26,27,30)
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5708
PNG
(2-amino-5-thio-substituted thiazole 76 | N-(5-{[(2...)
Show SMILES CC(C)(C)c1ncc(CSc2cnc(NC(=O)Cc3ccccc3)s2)o1
Show InChI InChI=1S/C19H21N3O2S2/c1-19(2,3)17-20-10-14(24-17)12-25-16-11-21-18(26-16)22-15(23)9-13-7-5-4-6-8-13/h4-8,10-11H,9,12H2,1-3H3,(H,21,22,23)
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Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477933
PNG
(CHEMBL253041)
Show SMILES C[C@H](CCCN1CCOCC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H28Cl2N2O4S/c1-17(3-2-10-25-11-13-30-14-12-25)26(22-15-20(24)5-4-18(22)16-27)31(28,29)21-8-6-19(23)7-9-21/h4-9,15,17,27H,2-3,10-14,16H2,1H3/t17-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5661
PNG
(2-amino-5-thio-substituted thiazole 26 | N-[5-({[5...)
Show SMILES CC(=O)Nc1ncc(SCc2ncc(CC3CCCCC3)o2)s1
Show InChI InChI=1S/C16H21N3O2S2/c1-11(20)19-16-18-9-15(23-16)22-10-14-17-8-13(21-14)7-12-5-3-2-4-6-12/h8-9,12H,2-7,10H2,1H3,(H,18,19,20)
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477943
PNG
(CHEMBL437405)
Show SMILES C[C@H](CCCn1cncn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-10-25-14-23-13-24-25)26(20-11-18(22)5-4-16(20)12-27)30(28,29)19-8-6-17(21)7-9-19/h4-9,11,13-15,27H,2-3,10,12H2,1H3/t15-/m1/s1
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5669
PNG
(2-amino-5-thio-substituted thiazole 46 | N-(5-{[(5...)
Show SMILES CCc1cnc(CSc2cnc(NC(=O)C(C)C)s2)o1
Show InChI InChI=1S/C13H17N3O2S2/c1-4-9-5-14-10(18-9)7-19-11-6-15-13(20-11)16-12(17)8(2)3/h5-6,8H,4,7H2,1-3H3,(H,15,16,17)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50476940
PNG
(CHEMBL233362)
Show SMILES CCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H21Cl2NO3S/c1-3-4-13(2)21(18-11-16(20)6-5-14(18)12-22)25(23,24)17-9-7-15(19)8-10-17/h5-11,13,22H,3-4,12H2,1-2H3/t13-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5670
PNG
(2-amino-5-thio-substituted thiazole 47 | N-(5-{[(5...)
Show SMILES CCc1cnc(CSc2cnc(NC(=O)Cc3cccnc3)s2)o1
Show InChI InChI=1S/C16H16N4O2S2/c1-2-12-8-18-14(22-12)10-23-15-9-19-16(24-15)20-13(21)6-11-4-3-5-17-7-11/h3-5,7-9H,2,6,10H2,1H3,(H,19,20,21)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5660
PNG
(2-amino-5-thio-substituted thiazole 25 | 2-aminoth...)
Show SMILES CC(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C13H17N3O2S2/c1-8(17)16-12-15-6-11(20-12)19-7-10-14-5-9(18-10)13(2,3)4/h5-6H,7H2,1-4H3,(H,15,16,17)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5662
PNG
(2-amino-5-thio-substituted thiazole 29 | N-(5-{[(5...)
Show SMILES CC(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O2S2/c1-9(2)13(19)18-14-17-7-12(22-14)21-8-11-16-6-10(20-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477929
PNG
(CHEMBL253283)
Show SMILES C[C@H](CCCNC=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H22Cl2N2O4S/c1-14(3-2-10-22-13-25)23(19-11-17(21)5-4-15(19)12-24)28(26,27)18-8-6-16(20)7-9-18/h4-9,11,13-14,24H,2-3,10,12H2,1H3,(H,22,25)/t14-/m1/s1
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n/an/a 5.10n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477925
PNG
(CHEMBL251856)
Show SMILES C[C@H](CCCn1nnc(n1)N(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26Cl2N6O3S/c1-15(5-4-12-28-25-21(24-26-28)27(2)3)29(20-13-18(23)7-6-16(20)14-30)33(31,32)19-10-8-17(22)9-11-19/h6-11,13,15,30H,4-5,12,14H2,1-3H3/t15-/m1/s1
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n/an/a 5.60n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5659
PNG
(2-amino-5-thio-substituted thiazole 24 | N-[5-({[5...)
Show SMILES CC(C)c1cnc(CSc2cnc(NC(C)=O)s2)o1
Show InChI InChI=1S/C12H15N3O2S2/c1-7(2)9-4-13-10(17-9)6-18-11-5-14-12(19-11)15-8(3)16/h4-5,7H,6H2,1-3H3,(H,14,15,16)
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5684
PNG
((2R)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]s...)
Show SMILES C[C@@H](C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1)c1ccccc1
Show InChI InChI=1S/C20H23N3O2S2/c1-13(14-8-6-5-7-9-14)18(24)23-19-22-11-17(27-19)26-12-16-21-10-15(25-16)20(2,3)4/h5-11,13H,12H2,1-4H3,(H,22,23,24)/t13-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477921
PNG
(CHEMBL404294)
Show SMILES C[C@H](CCCn1nnc(C)n1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H23Cl2N5O3S/c1-14(4-3-11-26-24-15(2)23-25-26)27(20-12-18(22)6-5-16(20)13-28)31(29,30)19-9-7-17(21)8-10-19/h5-10,12,14,28H,3-4,11,13H2,1-2H3/t14-/m1/s1
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n/an/a 6.10n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477937
PNG
(CHEMBL253727)
Show SMILES C[C@H](CCCN(C)C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H26Cl2N2O3S/c1-15(5-4-12-23(2)3)24(20-13-18(22)7-6-16(20)14-25)28(26,27)19-10-8-17(21)9-11-19/h6-11,13,15,25H,4-5,12,14H2,1-3H3/t15-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477940
PNG
(CHEMBL252305)
Show SMILES COCC(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26Cl2N2O5S/c1-15(4-3-11-24-21(27)14-30-2)25(20-12-18(23)6-5-16(20)13-26)31(28,29)19-9-7-17(22)8-10-19/h5-10,12,15,26H,3-4,11,13-14H2,1-2H3,(H,24,27)/t15-/m1/s1
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n/an/a 6.90n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477942
PNG
(CHEMBL252303)
Show SMILES C[C@H](CCCNC(C)=O)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H24Cl2N2O4S/c1-14(4-3-11-23-15(2)26)24(20-12-18(22)6-5-16(20)13-25)29(27,28)19-9-7-17(21)8-10-19/h5-10,12,14,25H,3-4,11,13H2,1-2H3,(H,23,26)/t14-/m1/s1
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n/an/a 7.30n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477912
PNG
(CHEMBL253296)
Show SMILES C[C@H](CCCNS(=O)(=O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26Cl2N2O5S2/c1-18(6-5-15-27-34(30,31)22-7-3-2-4-8-22)28(24-16-21(26)10-9-19(24)17-29)35(32,33)23-13-11-20(25)12-14-23/h2-4,7-14,16,18,27,29H,5-6,15,17H2,1H3/t18-/m1/s1
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n/an/a 7.40n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477927
PNG
(CHEMBL252304)
Show SMILES C[C@H](CCCNC(=O)CO)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H24Cl2N2O5S/c1-14(3-2-10-23-20(27)13-26)24(19-11-17(22)5-4-15(19)12-25)30(28,29)18-8-6-16(21)7-9-18/h4-9,11,14,25-26H,2-3,10,12-13H2,1H3,(H,23,27)/t14-/m1/s1
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n/an/a 8.10n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM5666
PNG
(2-amino-5-thio-substituted thiazole 40 | 3-(5-{[(5...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Nc3c(F)cccc3F)s2)o1
Show InChI InChI=1S/C18H18F2N4O2S2/c1-18(2,3)12-7-21-13(26-12)9-27-14-8-22-17(28-14)24-16(25)23-15-10(19)5-4-6-11(15)20/h4-8H,9H2,1-3H3,(H2,22,23,24,25)
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n/an/a 10n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477918
PNG
(CHEMBL403739)
Show SMILES C[C@H](CCCn1ccnc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O3S/c1-16(3-2-11-25-12-10-24-15-25)26(21-13-19(23)5-4-17(21)14-27)30(28,29)20-8-6-18(22)7-9-20/h4-10,12-13,15-16,27H,2-3,11,14H2,1H3/t16-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5665
PNG
(2-amino-5-thio-substituted thiazole 39 | 3-(5-{[(5...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Nc3ccc(F)cc3)s2)o1
Show InChI InChI=1S/C18H19FN4O2S2/c1-18(2,3)13-8-20-14(25-13)10-26-15-9-21-17(27-15)23-16(24)22-12-6-4-11(19)5-7-12/h4-9H,10H2,1-3H3,(H2,21,22,23,24)
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477916
PNG
(CHEMBL252645)
Show SMILES C[C@H](CCCn1nccn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H22Cl2N4O3S/c1-15(3-2-12-25-23-10-11-24-25)26(20-13-18(22)5-4-16(20)14-27)30(28,29)19-8-6-17(21)7-9-19/h4-11,13,15,27H,2-3,12,14H2,1H3/t15-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477941
PNG
(CHEMBL403841)
Show SMILES CCC(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H26Cl2N2O4S/c1-3-21(27)24-12-4-5-15(2)25(20-13-18(23)7-6-16(20)14-26)30(28,29)19-10-8-17(22)9-11-19/h6-11,13,15,26H,3-5,12,14H2,1-2H3,(H,24,27)/t15-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477914
PNG
(CHEMBL252694)
Show SMILES CC(C)C(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H28Cl2N2O4S/c1-15(2)22(28)25-12-4-5-16(3)26(21-13-19(24)7-6-17(21)14-27)31(29,30)20-10-8-18(23)9-11-20/h6-11,13,15-16,27H,4-5,12,14H2,1-3H3,(H,25,28)/t16-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477924
PNG
(CHEMBL428941)
Show SMILES C[C@H](CCCNC(=O)c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H26Cl2N2O4S/c1-18(6-5-15-28-25(31)19-7-3-2-4-8-19)29(24-16-22(27)10-9-20(24)17-30)34(32,33)23-13-11-21(26)12-14-23/h2-4,7-14,16,18,30H,5-6,15,17H2,1H3,(H,28,31)/t18-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477920
PNG
(CHEMBL404295)
Show SMILES C[C@H](CCCn1nnnc1-c1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H25Cl2N5O3S/c1-18(6-5-15-31-25(28-29-30-31)19-7-3-2-4-8-19)32(24-16-22(27)10-9-20(24)17-33)36(34,35)23-13-11-21(26)12-14-23/h2-4,7-14,16,18,33H,5-6,15,17H2,1H3/t18-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5663
PNG
(2-amino-5-thio-substituted thiazole 30 | N-(5-{[(5...)
Show SMILES CC(C)(C)C(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C16H23N3O2S2/c1-15(2,3)10-7-17-11(21-10)9-22-12-8-18-14(23-12)19-13(20)16(4,5)6/h7-8H,9H2,1-6H3,(H,18,19,20)
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM5664
PNG
(2-amino-5-thio-substituted thiazole 34 | [5-[[[5-t...)
Show SMILES CC(C)OC(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O3S2/c1-9(2)20-14(19)18-13-17-7-12(23-13)22-8-11-16-6-10(21-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 18n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477946
PNG
(CHEMBL252644)
Show SMILES C[C@H](CCCn1cccn1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O3S/c1-16(4-2-12-25-13-3-11-24-25)26(21-14-19(23)6-5-17(21)15-27)30(28,29)20-9-7-18(22)8-10-20/h3,5-11,13-14,16,27H,2,4,12,15H2,1H3/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM5665
PNG
(2-amino-5-thio-substituted thiazole 39 | 3-(5-{[(5...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)Nc3ccc(F)cc3)s2)o1
Show InChI InChI=1S/C18H19FN4O2S2/c1-18(2,3)13-8-20-14(25-13)10-26-15-9-21-17(27-15)23-16(24)22-12-6-4-11(19)5-7-12/h4-9H,10H2,1-3H3,(H2,21,22,23,24)
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n/an/a 19n/an/an/an/a8.030



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5658
PNG
(2-amino-5-thio-substituted thiazole 14 | N-(5-{[(5...)
Show SMILES CCc1cnc(CSc2cnc(NC(C)=O)s2)o1
Show InChI InChI=1S/C11H13N3O2S2/c1-3-8-4-12-9(16-8)6-17-10-5-13-11(18-10)14-7(2)15/h4-5H,3,6H2,1-2H3,(H,13,14,15)
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n/an/a 20n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5664
PNG
(2-amino-5-thio-substituted thiazole 34 | [5-[[[5-t...)
Show SMILES CC(C)OC(=O)Nc1ncc(SCc2ncc(o2)C(C)(C)C)s1
Show InChI InChI=1S/C15H21N3O3S2/c1-9(2)20-14(19)18-13-17-7-12(23-13)22-8-11-16-6-10(21-11)15(3,4)5/h6-7,9H,8H2,1-5H3,(H,17,18,19)
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n/an/a 25n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477938
PNG
(CHEMBL252894)
Show SMILES C[C@H](CCCNC(=O)Cc1ccccc1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H28Cl2N2O4S/c1-19(6-5-15-29-26(32)16-20-7-3-2-4-8-20)30(25-17-23(28)10-9-21(25)18-31)35(33,34)24-13-11-22(27)12-14-24/h2-4,7-14,17,19,31H,5-6,15-16,18H2,1H3,(H,29,32)/t19-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
CDK2/CycE


(Homo sapiens (Human))
BDBM5683
PNG
(2-amino-5-thio-substituted thiazole 31 | BMS-38703...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)c3ccccc3)s2)o1
Show InChI InChI=1S/C18H19N3O2S2/c1-18(2,3)13-9-19-14(23-13)11-24-15-10-20-17(25-15)21-16(22)12-7-5-4-6-8-12/h4-10H,11H2,1-3H3,(H,20,21,22)
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n/an/a 26n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...


J Med Chem 45: 3905-27 (2002)


Article DOI: 10.1021/jm0201520
BindingDB Entry DOI: 10.7270/Q2GT5KC3
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477944
PNG
(CHEMBL252840)
Show SMILES C[C@H](CCCNC1CCCO1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H28Cl2N2O4S/c1-16(4-2-12-25-22-5-3-13-30-22)26(21-14-19(24)7-6-17(21)15-27)31(28,29)20-10-8-18(23)9-11-20/h6-11,14,16,22,25,27H,2-5,12-13,15H2,1H3/t16-,22?/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
Presenilin-1


(Homo sapiens (Human))
BDBM50477926
PNG
(CHEMBL253042)
Show SMILES C[C@H](CCCN1CCN(C)CC1)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H31Cl2N3O3S/c1-18(4-3-11-27-14-12-26(2)13-15-27)28(23-16-21(25)6-5-19(23)17-29)32(30,31)22-9-7-20(24)8-10-22/h5-10,16,18,29H,3-4,11-15,17H2,1-2H3/t18-/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels


Bioorg Med Chem Lett 18: 175-8 (2008)


BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair
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