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Compile Data Set for Download or QSAR

Found 369 hits with Last Name = 'capparelli' and Initial = 'mp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase


(Homo sapiens (Human))
BDBM8465
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1
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8n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM8465
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1
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20n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13122
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C20H26N2O5S/c1-15(2)13-19(20(23)21-24)22(14-16-7-5-4-6-8-16)28(25,26)18-11-9-17(27-3)10-12-18/h4-12,15,19,24H,13-14H2,1-3H3,(H,21,23)/t19-/m1/s1
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23n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13133
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CC(C)(C)C)C(=O)NO
Show InChI InChI=1S/C21H28N2O5S/c1-21(2,3)14-19(20(24)22-25)23(15-16-8-6-5-7-9-16)29(26,27)18-12-10-17(28-4)11-13-18/h5-13,19,25H,14-15H2,1-4H3,(H,22,24)/t19-/m1/s1
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28n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13121
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](Cc1ccccc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-30-20-12-14-21(15-13-20)31(28,29)25(17-19-10-6-3-7-11-19)22(23(26)24-27)16-18-8-4-2-5-9-18/h2-15,22,27H,16-17H2,1H3,(H,24,26)/t22-/m1/s1
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29n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13127
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CCSC)C(=O)NO
Show InChI InChI=1S/C19H24N2O5S2/c1-26-16-8-10-17(11-9-16)28(24,25)21(14-15-6-4-3-5-7-15)18(12-13-27-2)19(22)20-23/h3-11,18,23H,12-14H2,1-2H3,(H,20,22)/t18-/m1/s1
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31n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(Homo sapiens (Human))
BDBM8465
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1
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33n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Stromelysin-1


(Homo sapiens (Human))
BDBM13126
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C19H24N2O5S/c1-14(2)18(19(22)20-23)21(13-15-7-5-4-6-8-15)27(24,25)17-11-9-16(26-3)10-12-17/h4-12,14,18,23H,13H2,1-3H3,(H,20,22)/t18-/m1/s1
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34n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13119
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](C)C(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-13(17(20)18-21)19(12-14-6-4-3-5-7-14)25(22,23)16-10-8-15(24-2)9-11-16/h3-11,13,21H,12H2,1-2H3,(H,18,20)/t13-/m1/s1
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36n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13100
PNG
(2-[(2-cyclohexylethyl)(4-methoxybenzene)sulfonamid...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C17H26N2O5S/c1-24-15-7-9-16(10-8-15)25(22,23)19(13-17(20)18-21)12-11-14-5-3-2-4-6-14/h7-10,14,21H,2-6,11-13H2,1H3,(H,18,20)
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38n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13135
PNG
((2R,3S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-...)
Show SMILES CCC(C)[C@@H](N(Cc1ccccc1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO
Show InChI InChI=1S/C20H26N2O5S/c1-4-15(2)19(20(23)21-24)22(14-16-8-6-5-7-9-16)28(25,26)18-12-10-17(27-3)11-13-18/h5-13,15,19,24H,4,14H2,1-3H3,(H,21,23)/t15?,19-/m1/s1
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39n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13141
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](CC(C)(C)C)C(=O)NO
Show InChI InChI=1S/C20H27N3O5S/c1-20(2,3)12-18(19(24)22-25)23(14-15-6-5-11-21-13-15)29(26,27)17-9-7-16(28-4)8-10-17/h5-11,13,18,25H,12,14H2,1-4H3,(H,22,24)/t18-/m1/s1
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42n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM8465
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
Show InChI InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1
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43n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13134
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-3-cyc...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CC1CCCCC1)C(=O)NO
Show InChI InChI=1S/C23H30N2O5S/c1-30-20-12-14-21(15-13-20)31(28,29)25(17-19-10-6-3-7-11-19)22(23(26)24-27)16-18-8-4-2-5-9-18/h3,6-7,10-15,18,22,27H,2,4-5,8-9,16-17H2,1H3,(H,24,26)/t22-/m1/s1
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44n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13137
PNG
((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](CC(C)C)C(=O)NO
Show InChI InChI=1S/C19H25N3O5S/c1-14(2)11-18(19(23)21-24)22(13-15-5-4-10-20-12-15)28(25,26)17-8-6-16(27-3)7-9-17/h4-10,12,14,18,24H,11,13H2,1-3H3,(H,21,23)/t18-/m1/s1
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46n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13131
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-3-(te...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](COC(C)(C)C)C(=O)NO
Show InChI InChI=1S/C21H28N2O6S/c1-21(2,3)29-15-19(20(24)22-25)23(14-16-8-6-5-7-9-16)30(26,27)18-12-10-17(28-4)11-13-18/h5-13,19,25H,14-15H2,1-4H3,(H,22,24)/t19-/m1/s1
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48n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13136
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(CCN1CCOCC1)C(=O)NO
Show InChI InChI=1S/C22H29N3O6S/c1-30-19-7-9-20(10-8-19)32(28,29)25(17-18-5-3-2-4-6-18)21(22(26)23-27)11-12-24-13-15-31-16-14-24/h2-10,21,27H,11-17H2,1H3,(H,23,26)
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50n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13088
PNG
(2-[(4-butoxybenzene)(2-methylpropyl)sulfonamido]-N...)
Show SMILES CCCCOc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C16H26N2O5S/c1-4-5-10-23-14-6-8-15(9-7-14)24(21,22)18(11-13(2)3)12-16(19)17-20/h6-9,13,20H,4-5,10-12H2,1-3H3,(H,17,19)
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58 -43.0n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13091
PNG
(2-{[4-(cyclohexylmethoxy)benzene](2-methylpropyl)s...)
Show SMILES CC(C)CN(CC(=O)NO)S(=O)(=O)c1ccc(OCC2CCCCC2)cc1
Show InChI InChI=1S/C19H30N2O5S/c1-15(2)12-21(13-19(22)20-23)27(24,25)18-10-8-17(9-11-18)26-14-16-6-4-3-5-7-16/h8-11,15-16,23H,3-7,12-14H2,1-2H3,(H,20,22)
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61 -42.8n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13099
PNG
(2-[(cyclohexylmethyl)(4-methoxybenzene)sulfonamido...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC1CCCCC1)CC(=O)NO
Show InChI InChI=1S/C16H24N2O5S/c1-23-14-7-9-15(10-8-14)24(21,22)18(12-16(19)17-20)11-13-5-3-2-4-6-13/h7-10,13,20H,2-6,11-12H2,1H3,(H,17,19)
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61n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13090
PNG
(2-{[4-(hexyloxy)benzene](2-methylpropyl)sulfonamid...)
Show SMILES CCCCCCOc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C18H30N2O5S/c1-4-5-6-7-12-25-16-8-10-17(11-9-16)26(23,24)20(13-15(2)3)14-18(21)19-22/h8-11,15,22H,4-7,12-14H2,1-3H3,(H,19,21)
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63 -42.8n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13132
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(Cc1ccc(O)cc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O6S/c1-31-20-11-13-21(14-12-20)32(29,30)25(16-18-5-3-2-4-6-18)22(23(27)24-28)15-17-7-9-19(26)10-8-17/h2-14,22,26,28H,15-16H2,1H3,(H,24,27)
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65n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13095
PNG
(CGS 27023A Analog 23 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-24-15-7-9-16(10-8-15)25(22,23)19(13-17(20)18-21)12-11-14-5-3-2-4-6-14/h2-10,21H,11-13H2,1H3,(H,18,20)
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66 -42.6n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13130
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-6-(di...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CCCCN(C)C)C(=O)NO
Show InChI InChI=1S/C22H31N3O5S/c1-24(2)16-8-7-11-21(22(26)23-27)25(17-18-9-5-4-6-10-18)31(28,29)20-14-12-19(30-3)13-15-20/h4-6,9-10,12-15,21,27H,7-8,11,16-17H2,1-3H3,(H,23,26)/t21-/m1/s1
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69n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM11331
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccccc1
Show InChI InChI=1S/C16H18N2O5S/c1-23-14-7-9-15(10-8-14)24(21,22)18(12-16(19)17-20)11-13-5-3-2-4-6-13/h2-10,20H,11-12H2,1H3,(H,17,19)
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70 -42.5n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13111
PNG
(CGS 27023A Analog 39 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccc(OC)c1
Show InChI InChI=1S/C17H20N2O6S/c1-24-14-6-8-16(9-7-14)26(22,23)19(12-17(20)18-21)11-13-4-3-5-15(10-13)25-2/h3-10,21H,11-12H2,1-2H3,(H,18,20)
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70n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13129
PNG
(CGS 27023A Analog 61 | benzyl N-[(5R)-5-[benzyl(4-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CCCCNC(=O)OCc1ccccc1)C(=O)NO
Show InChI InChI=1S/C28H33N3O7S/c1-37-24-15-17-25(18-16-24)39(35,36)31(20-22-10-4-2-5-11-22)26(27(32)30-34)14-8-9-19-29-28(33)38-21-23-12-6-3-7-13-23/h2-7,10-13,15-18,26,34H,8-9,14,19-21H2,1H3,(H,29,33)(H,30,32)/t26-/m1/s1
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70n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13120
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(Cc1ccccc1)C(=O)NO
Show InChI InChI=1S/C23H24N2O5S/c1-30-20-12-14-21(15-13-20)31(28,29)25(17-19-10-6-3-7-11-19)22(23(26)24-27)16-18-8-4-2-5-9-18/h2-15,22,27H,16-17H2,1H3,(H,24,26)
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71n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13089
PNG
(CGS 27023A Analog 17 | N-hydroxy-2-{[4-(3-methylbu...)
Show SMILES CC(C)CCOc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C17H28N2O5S/c1-13(2)9-10-24-15-5-7-16(8-6-15)25(22,23)19(11-14(3)4)12-17(20)18-21/h5-8,13-14,21H,9-12H2,1-4H3,(H,18,20)
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78 -42.2n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13140
PNG
((2R)-6-(dimethylamino)-N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](CCCCN(C)C)C(=O)NO
Show InChI InChI=1S/C21H30N4O5S/c1-24(2)14-5-4-8-20(21(26)23-27)25(16-17-7-6-13-22-15-17)31(28,29)19-11-9-18(30-3)10-12-19/h6-7,9-13,15,20,27H,4-5,8,14,16H2,1-3H3,(H,23,26)/t20-/m1/s1
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81n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13128
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@H](CCS(C)(=O)=O)C(=O)NO
Show InChI InChI=1S/C19H24N2O7S2/c1-28-16-8-10-17(11-9-16)30(26,27)21(14-15-6-4-3-5-7-15)18(19(22)20-23)12-13-29(2,24)25/h3-11,18,23H,12-14H2,1-2H3,(H,20,22)/t18-/m1/s1
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85n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM11337
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(C)C(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-13(17(20)18-21)19(12-14-6-4-3-5-7-14)25(22,23)16-10-8-15(24-2)9-11-16/h3-11,13,21H,12H2,1-2H3,(H,18,20)
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86n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13115
PNG
(CGS 27023A Analog 43 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccccn1
Show InChI InChI=1S/C15H17N3O5S/c1-23-13-5-7-14(8-6-13)24(21,22)18(11-15(19)17-20)10-12-4-2-3-9-16-12/h2-9,20H,10-11H2,1H3,(H,17,19)
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90n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13125
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(C(C)C)C(=O)NO
Show InChI InChI=1S/C19H24N2O5S/c1-14(2)18(19(22)20-23)21(13-15-7-5-4-6-8-15)27(24,25)17-11-9-16(26-3)10-12-17/h4-12,14,18,23H,13H2,1-3H3,(H,20,22)
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92n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13098
PNG
(CGS 27023A Analog 26 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCC(C)C)CC(=O)NO
Show InChI InChI=1S/C14H22N2O5S/c1-11(2)8-9-16(10-14(17)15-18)22(19,20)13-6-4-12(21-3)5-7-13/h4-7,11,18H,8-10H2,1-3H3,(H,15,17)
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94n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13104
PNG
(2-{[(4-chlorophenyl)methyl](4-methoxybenzene)sulfo...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C16H17ClN2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19(11-16(20)18-21)10-12-2-4-13(17)5-3-12/h2-9,21H,10-11H2,1H3,(H,18,20)
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94n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13097
PNG
(CGS 27023A Analog 25 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C19H24N2O5S/c1-26-17-10-12-18(13-11-17)27(24,25)21(15-19(22)20-23)14-6-5-9-16-7-3-2-4-8-16/h2-4,7-8,10-13,23H,5-6,9,14-15H2,1H3,(H,20,22)
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100n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13105
PNG
(CGS 27023A Analog 33 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(CN(CC(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1
Show InChI InChI=1S/C17H20N2O6S/c1-24-14-5-3-13(4-6-14)11-19(12-17(20)18-21)26(22,23)16-9-7-15(25-2)8-10-16/h3-10,21H,11-12H2,1-2H3,(H,18,20)
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104n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13123
PNG
((2R)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@@H](C(=O)NO)c1ccccc1
Show InChI InChI=1S/C22H22N2O5S/c1-29-19-12-14-20(15-13-19)30(27,28)24(16-17-8-4-2-5-9-17)21(22(25)23-26)18-10-6-3-7-11-18/h2-15,21,26H,16H2,1H3,(H,23,25)/t21-/m1/s1
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104n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13106
PNG
(CGS 27023A Analog 34 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H22N2O5S/c1-29-20-11-13-21(14-12-20)30(27,28)24(16-22(25)23-26)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h2-14,26H,15-16H2,1H3,(H,23,25)
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107n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13114
PNG
(CGS 27023A Analog 42 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cccnc1
Show InChI InChI=1S/C15H17N3O5S/c1-23-13-4-6-14(7-5-13)24(21,22)18(11-15(19)17-20)10-12-3-2-8-16-9-12/h2-9,20H,10-11H2,1H3,(H,17,19)
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113n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13096
PNG
(CGS 27023A Analog 24 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCCc1ccccc1)CC(=O)NO
Show InChI InChI=1S/C18H22N2O5S/c1-25-16-9-11-17(12-10-16)26(23,24)20(14-18(21)19-22)13-5-8-15-6-3-2-4-7-15/h2-4,6-7,9-12,22H,5,8,13-14H2,1H3,(H,19,21)
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125n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13080
PNG
(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)CC(=O)NO
Show InChI InChI=1S/C13H20N2O5S/c1-10(2)8-15(9-13(16)14-17)21(18,19)12-6-4-11(20-3)5-7-12/h4-7,10,17H,8-9H2,1-3H3,(H,14,16)
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133 -40.8n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Stromelysin-1


(Homo sapiens (Human))
BDBM13116
PNG
(CGS 27023A Analog 44 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc2ccccc2n1
Show InChI InChI=1S/C19H19N3O5S/c1-27-16-8-10-17(11-9-16)28(25,26)22(13-19(23)21-24)12-15-7-6-14-4-2-3-5-18(14)20-15/h2-11,24H,12-13H2,1H3,(H,21,23)
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134n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13118
PNG
((2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hyd...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@@H](C)C(=O)NO
Show InChI InChI=1S/C17H20N2O5S/c1-13(17(20)18-21)19(12-14-6-4-3-5-7-14)25(22,23)16-10-8-15(24-2)9-11-16/h3-11,13,21H,12H2,1-2H3,(H,18,20)/t13-/m0/s1
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141n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13112
PNG
(CGS 27023A Analog 40 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C19H24N2O8S/c1-26-14-5-7-15(8-6-14)30(24,25)21(12-18(22)20-23)11-13-9-16(27-2)19(29-4)17(10-13)28-3/h5-10,23H,11-12H2,1-4H3,(H,20,22)
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151n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13113
PNG
(CGS 27023A Analog 41 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccncc1
Show InChI InChI=1S/C15H17N3O5S/c1-23-13-2-4-14(5-3-13)24(21,22)18(11-15(19)17-20)10-12-6-8-16-9-7-12/h2-9,20H,10-11H2,1H3,(H,17,19)
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192n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Stromelysin-1


(Homo sapiens (Human))
BDBM13109
PNG
(CGS 27023A Analog 37 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CCN1CCOCC1)CC(=O)NO
Show InChI InChI=1S/C15H23N3O6S/c1-23-13-2-4-14(5-3-13)25(21,22)18(12-15(19)16-20)7-6-17-8-10-24-11-9-17/h2-5,20H,6-12H2,1H3,(H,16,19)
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236n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13107
PNG
(CGS 27023A Analog 35 | N-hydroxy-2-[(4-methoxybenz...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(F)(F)F
Show InChI InChI=1S/C11H13F3N2O5S/c1-21-8-2-4-9(5-3-8)22(19,20)16(6-10(17)15-18)7-11(12,13)14/h2-5,18H,6-7H2,1H3,(H,15,17)
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305n/an/an/an/an/an/an/an/a



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM13092
PNG
(CGS 27023A Analog 20 | N-hydroxy-2-[(2-methylpropy...)
Show SMILES CC(C)CN(CC(=O)NO)S(=O)(=O)c1ccc(OC(C)C)cc1
Show InChI InChI=1S/C15H24N2O5S/c1-11(2)9-17(10-15(18)16-19)23(20,21)14-7-5-13(6-8-14)22-12(3)4/h5-8,11-12,19H,9-10H2,1-4H3,(H,16,18)
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336 -38.4n/an/an/an/an/a7.537



Novartis Pharmaceuticals



Assay Description
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...


J Med Chem 40: 2525-32 (1997)


Article DOI: 10.1021/jm960871c
BindingDB Entry DOI: 10.7270/Q2MW2FC7
More data for this
Ligand-Target Pair
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