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Compile Data Set for Download or QSAR

Found 56 hits with Last Name = 'cesati' and Initial = 'rr'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263653
PNG
(2-(tert-butyl)-4-chloro-5-((3-(3-fluoropropoxyl)be...)
Show SMILES CC(C)(C)n1ncc(OCc2cccc(OCCCF)c2)c(Cl)c1=O
Show InChI InChI=1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(11-21-22)25-12-13-6-4-7-14(10-13)24-9-5-8-20/h4,6-7,10-11H,5,8-9,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263621
PNG
(2-(tert-butyl)-4-chloro-5-((2,3,5-dichloro-4-(3-fl...)
Show SMILES CC(C)(C)n1ncc(OCc2cc(Cl)c(OCCCF)c(Cl)c2Cl)c(Cl)c1=O
Show InChI InChI=1S/C18H19Cl4FN2O3/c1-18(2,3)25-17(26)14(21)12(8-24-25)28-9-10-7-11(19)16(15(22)13(10)20)27-6-4-5-23/h7-8H,4-6,9H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263604
PNG
(US9713651, 9 | US9713651, flurpiridaz)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263629
PNG
(2-(tert-butyl)-4-chloro-5-((4-(6-fluoropyridin-3-y...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2ccc(F)nc2)c(Cl)c1=O
Show InChI InChI=1S/C20H19ClFN3O2/c1-20(2,3)25-19(26)18(21)16(11-24-25)27-12-13-4-6-14(7-5-13)15-8-9-17(22)23-10-15/h4-11H,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263649
PNG
(2-(tert-butyl)-4-chloro-5-((2-chloro-4-(3-fluoropr...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(OCCCF)cc2Cl)c(Cl)c1=O
Show InChI InChI=1S/C18H21Cl2FN2O3/c1-18(2,3)23-17(24)16(20)15(10-22-23)26-11-12-5-6-13(9-14(12)19)25-8-4-7-21/h5-6,9-10H,4,7-8,11H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263648
PNG
(3-fluoropropyl 4-(((1-(tert-butyl)-5-chloro-6-oxo-...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)C(=O)OCCCF)c(Cl)c1=O
Show InChI InChI=1S/C19H22ClFN2O4/c1-19(2,3)23-17(24)16(20)15(11-22-23)27-12-13-5-7-14(8-6-13)18(25)26-10-4-9-21/h5-8,11H,4,9-10,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263612
PNG
(2-(tert-butyl)-4-chloro-5-((4-(4-fluorobut-1-yn-1-...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)C#CCCF)c(Cl)c1=O
Show InChI InChI=1S/C19H20ClFN2O2/c1-19(2,3)23-18(24)17(20)16(12-22-23)25-13-15-9-7-14(8-10-15)6-4-5-11-21/h7-10,12H,5,11,13H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263646
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-fluoropyridin-3-...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(Oc3cccnc3F)cc2)c(Cl)c1=O
Show InChI InChI=1S/C20H19ClFN3O3/c1-20(2,3)25-19(26)17(21)16(11-24-25)27-12-13-6-8-14(9-7-13)28-15-5-4-10-23-18(15)22/h4-11H,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263645
PNG
(2-(tert-butyl)-4-chloro-5-((3,5-dichloro-4-(3-fluo...)
Show SMILES CC(C)(C)n1ncc(OCc2cc(Cl)c(OCCCF)c(Cl)c2)c(Cl)c1=O
Show InChI InChI=1S/C18H20Cl3FN2O3/c1-18(2,3)24-17(25)15(21)14(9-23-24)27-10-11-7-12(19)16(13(20)8-11)26-6-4-5-22/h7-9H,4-6,10H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263644
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-nitropyridin-3-y...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(Oc3cccnc3[N+]([O-])=O)cc2)c(Cl)c1=O
Show InChI InChI=1S/C20H19ClN4O5/c1-20(2,3)24-19(26)17(21)16(11-23-24)29-12-13-6-8-14(9-7-13)30-15-5-4-10-22-18(15)25(27)28/h4-11H,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263643
PNG
(2-(tert-butyl)-4-chloro-5-((3-chloro-4-(3-fluoropr...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(OCCCF)c(Cl)c2)c(Cl)c1=O
Show InChI InChI=1S/C18H21Cl2FN2O3/c1-18(2,3)23-17(24)16(20)15(10-22-23)26-11-12-5-6-14(13(19)9-12)25-8-4-7-21/h5-6,9-10H,4,7-8,11H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263627
PNG
(2-(tert-butyl)-4-chloro-5-((4-(6-nitropyridin-3-yl...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2ccc(nc2)[N+]([O-])=O)c(Cl)c1=O
Show InChI InChI=1S/C20H19ClN4O4/c1-20(2,3)24-19(26)18(21)16(11-23-24)29-12-13-4-6-14(7-5-13)15-8-9-17(22-10-15)25(27)28/h4-11H,12H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263618
PNG
(4-bromo-2-(tert-butyl)-5-((4-((2-fluoroethoxy)meth...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)cc2)c(Br)c1=O
Show InChI InChI=1S/C18H22BrFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263607
PNG
(2-(tert-butyl)-4-chloro-5-((6-(3-fluoropropoxyl)py...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(OCCCF)nc2)c(Cl)c1=O
Show InChI InChI=1S/C17H21ClFN3O3/c1-17(2,3)22-16(23)15(18)13(10-21-22)25-11-12-5-6-14(20-9-12)24-8-4-7-19/h5-6,9-10H,4,7-8,11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263639
PNG
(5-((3-bromo-4-((2-fluoroethoxy)methyl)benzyl)oxy)-...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)c(Br)c2)c(Cl)c1=O
Show InChI InChI=1S/C18H21BrClFN2O3/c1-18(2,3)23-17(24)16(20)15(9-22-23)26-10-12-4-5-13(14(19)8-12)11-25-7-6-21/h4-5,8-9H,6-7,10-11H2,1-3H3
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n/an/a<100n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263610
PNG
(2-(tert-butyl)-5-((4-((2-fluoroethoxy)benzyl)oxy)-...)
Show SMILES Cc1c(OCc2ccc(COCCF)cc2)cnn(c1=O)C(C)(C)C
Show InChI InChI=1S/C19H25FN2O3/c1-14-17(11-21-22(18(14)23)19(2,3)4)25-13-16-7-5-15(6-8-16)12-24-10-9-20/h5-8,11H,9-10,12-13H2,1-4H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263614
PNG
(2-fluoroethyl 4-(((1-(tert-butyl)-5-chloro-6-oxo-1...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)C(=O)OCCF)c(Cl)c1=O
Show InChI InChI=1S/C18H20ClFN2O4/c1-18(2,3)22-16(23)15(19)14(10-21-22)26-11-12-4-6-13(7-5-12)17(24)25-9-8-20/h4-7,10H,8-9,11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263636
PNG
(2-(tert-butyl)-4-chloro-5-((4-(2-chloropyrimidin-5...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2cnc(Cl)nc2)c(Cl)c1=O
Show InChI InChI=1S/C19H18Cl2N4O2/c1-19(2,3)25-17(26)16(20)15(10-24-25)27-11-12-4-6-13(7-5-12)14-8-22-18(21)23-9-14/h4-10H,11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263635
PNG
(2-(tert-butyl)-4-chloro-5-((4′-fluoro-[1,1&#...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2ccc(F)cc2)c(Cl)c1=O
Show InChI InChI=1S/C21H20ClFN2O2/c1-21(2,3)25-20(26)19(22)18(12-24-25)27-13-14-4-6-15(7-5-14)16-8-10-17(23)11-9-16/h4-12H,13H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263604
PNG
(US9713651, 9 | US9713651, flurpiridaz)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C18H22ClFN2O3/c1-18(2,3)22-17(23)16(19)15(10-21-22)25-12-14-6-4-13(5-7-14)11-24-9-8-20/h4-7,10H,8-9,11-12H2,1-3H3
PDB

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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263661
PNG
(2-((4-(((1-(tert-butyl)-5-chloro-6-oxo-1,6-dihydro...)
Show SMILES COC(=O)OCCOCc1ccc(COc2cnn(c(=O)c2Cl)C(C)(C)C)cc1
Show InChI InChI=1S/C20H25ClN2O6/c1-20(2,3)23-18(24)17(21)16(11-22-23)29-13-15-7-5-14(6-8-15)12-27-9-10-28-19(25)26-4/h5-8,11H,9-10,12-13H2,1-4H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263642
PNG
(2-(tert-butyl)-4-chloro-5-((2-fluoropyridin-3-yl)o...)
Show SMILES CC(C)(C)n1ncc(Oc2cccnc2F)c(Cl)c1=O
Show InChI InChI=1S/C13H13ClFN3O2/c1-13(2,3)18-12(19)10(14)9(7-17-18)20-8-5-4-6-16-11(8)15/h4-7H,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263647
PNG
(5-((3-bromo-4-(3-fluoropropoxy)-5-methoxybenzyl)ox...)
Show SMILES COc1cc(COc2cnn(c(=O)c2Cl)C(C)(C)C)cc(Br)c1OCCCF
Show InChI InChI=1S/C19H23BrClFN2O4/c1-19(2,3)24-18(25)16(21)15(10-23-24)28-11-12-8-13(20)17(14(9-12)26-4)27-7-5-6-22/h8-10H,5-7,11H2,1-4H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263650
PNG
(2-(tert-butyl)-4-chloro-5-((4-(2-hydroxypropan-2-y...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)C(C)(C)O)c(Cl)c1=O
Show InChI InChI=1S/C18H23ClN2O3/c1-17(2,3)21-16(22)15(19)14(10-20-21)24-11-12-6-8-13(9-7-12)18(4,5)23/h6-10,23H,11H2,1-5H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263651
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)met...)
Show SMILES COc1cc(COCCF)ccc1COc1cnn(c(=O)c1Cl)C(C)(C)C
Show InChI InChI=1S/C19H24ClFN2O4/c1-19(2,3)23-18(24)17(20)16(10-22-23)27-12-14-6-5-13(9-15(14)25-4)11-26-8-7-21/h5-6,9-10H,7-8,11-12H2,1-4H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263652
PNG
(2-(tert-butyl)-4-chloro-5-((4-(2-(2-fluoroethoxyl)...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)C(C)(C)OCCF)c(Cl)c1=O
Show InChI InChI=1S/C20H26ClFN2O3/c1-19(2,3)24-18(25)17(21)16(12-23-24)26-13-14-6-8-15(9-7-14)20(4,5)27-11-10-22/h6-9,12H,10-11,13H2,1-5H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263641
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)met...)
Show SMILES Cc1cc(COc2cnn(c(=O)c2Cl)C(C)(C)C)c(C)cc1COCCF
Show InChI InChI=1S/C20H26ClFN2O3/c1-13-9-16(14(2)8-15(13)11-26-7-6-22)12-27-17-10-23-24(20(3,4)5)19(25)18(17)21/h8-10H,6-7,11-12H2,1-5H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263640
PNG
(2-(tert-butyl)-4-chloro-5-((2-nitropyridin-3-yl)ox...)
Show SMILES CC(C)(C)n1ncc(Oc2cccnc2[N+]([O-])=O)c(Cl)c1=O
Show InChI InChI=1S/C13H13ClN4O4/c1-13(2,3)17-12(19)10(14)9(7-16-17)22-8-5-4-6-15-11(8)18(20)21/h4-7H,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263638
PNG
(2-(tert-butyl)-4-chloro-5-((4-(2-fluoropyrimidin-5...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2cnc(F)nc2)c(Cl)c1=O
Show InChI InChI=1S/C19H18ClFN4O2/c1-19(2,3)25-17(26)16(20)15(10-24-25)27-11-12-4-6-13(7-5-12)14-8-22-18(21)23-9-14/h4-10H,11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263637
PNG
(2-(tert-butyl)-4-chloro-5-((5-((2-fluoroethoxy)met...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)cn2)c(Cl)c1=O
Show InChI InChI=1S/C17H21ClFN3O3/c1-17(2,3)22-16(23)15(18)14(9-21-22)25-11-13-5-4-12(8-20-13)10-24-7-6-19/h4-5,8-9H,6-7,10-11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263633
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-fluoroethoxy)met...)
Show SMILES CC(C)(C)n1ncc(CCc2ccc(COCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C19H24ClFN2O2/c1-19(2,3)23-18(24)17(20)16(12-22-23)9-8-14-4-6-15(7-5-14)13-25-11-10-21/h4-7,12H,8-11,13H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263632
PNG
(2-(tert-butyl)-4-chloro-5-((4-(fluoromethyl)benzyl...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(CF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C16H18ClFN2O2/c1-16(2,3)20-15(21)14(17)13(9-19-20)22-10-12-6-4-11(8-18)5-7-12/h4-7,9H,8,10H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263630
PNG
(2-(tert-butyl)-4-chloro-5-((4-(((2-fluoroethyl)ami...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(CNCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C18H23ClFN3O2/c1-18(2,3)23-17(24)16(19)15(11-22-23)25-12-14-6-4-13(5-7-14)10-21-9-8-20/h4-7,11,21H,8-10,12H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263628
PNG
(2-(tert-butyl)-4-chloro-5-((4-((2-fluoropropoxy)et...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCOCCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C21H28ClFN2O4/c1-21(2,3)25-20(26)19(22)18(13-24-25)29-15-17-7-5-16(6-8-17)14-28-12-11-27-10-4-9-23/h5-8,13H,4,9-12,14-15H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263626
PNG
(2-(tert-butyl)-4-chloro-5-((4-(1-(2-fluoroethoxyl)...)
Show SMILES CC(OCCF)c1ccc(COc2cnn(c(=O)c2Cl)C(C)(C)C)cc1
Show InChI InChI=1S/C19H24ClFN2O3/c1-13(25-10-9-21)15-7-5-14(6-8-15)12-26-16-11-22-23(19(2,3)4)18(24)17(16)20/h5-8,11,13H,9-10,12H2,1-4H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263625
PNG
(2-(tert-butyl)-4-chloro-5-(4-(3-fluoropropyl)pheno...)
Show SMILES CC(C)(C)n1ncc(Oc2ccc(CCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C17H20ClFN2O2/c1-17(2,3)21-16(22)15(18)14(11-20-21)23-13-8-6-12(7-9-13)5-4-10-19/h6-9,11H,4-5,10H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263624
PNG
(2-(tert-butyl)-4-chloro-5-((4-(2-(2-fluoroethoxyl)...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(OCCOCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C19H24ClFN2O4/c1-19(2,3)23-18(24)17(20)16(12-22-23)27-13-14-4-6-15(7-5-14)26-11-10-25-9-8-21/h4-7,12H,8-11,13H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263623
PNG
(2-(tert-butyl)-4-chloro-5-(4-((2-fluoroethoxy)meth...)
Show SMILES CC(C)(C)n1ncc(c(Cl)c1=O)-c1ccc(COCCF)cc1
Show InChI InChI=1S/C17H20ClFN2O2/c1-17(2,3)21-16(22)15(18)14(10-20-21)13-6-4-12(5-7-13)11-23-9-8-19/h4-7,10H,8-9,11H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263620
PNG
(4-chloro-2-cyclohexyl-5-((4-((2-fluoroethoxy)methy...)
Show SMILES CC(C)c1c(OCc2ccc(COCCF)cc2)cnn(c1=O)C(C)(C)C
Show InChI InChI=1S/C21H29FN2O3/c1-15(2)19-18(12-23-24(20(19)25)21(3,4)5)27-14-17-8-6-16(7-9-17)13-26-11-10-22/h6-9,12,15H,10-11,13-14H2,1-5H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263619
PNG
(2-(tert-butyl)-4-chloro-5-((4-(4-(fluoromethyl)phe...)
Show SMILES CC(C)(C)n1ncc(OCCC#Cc2ccc(CF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C19H20ClFN2O2/c1-19(2,3)23-18(24)17(20)16(13-22-23)25-11-5-4-6-14-7-9-15(12-21)10-8-14/h7-10,13H,5,11-12H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263616
PNG
(2-(tert-butyl)-4-chloro-5-((4′-(3-fluoroprop...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(cc2)-c2ccc(OCCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C24H26ClFN2O3/c1-24(2,3)28-23(29)22(25)21(15-27-28)31-16-17-5-7-18(8-6-17)19-9-11-20(12-10-19)30-14-4-13-26/h5-12,15H,4,13-14,16H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263615
PNG
(2-(tert-butyl)-5-((4-((2-fluoroethoxy)methyl)benzy...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCF)cc2)cc1=O
Show InChI InChI=1S/C18H23FN2O3/c1-18(2,3)21-17(22)10-16(11-20-21)24-13-15-6-4-14(5-7-15)12-23-9-8-19/h4-7,10-11H,8-9,12-13H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263613
PNG
(4-chloro-2-cyclohexyl-5-((4-((2-fluoroethoxy)methy...)
Show SMILES FCCOCc1ccc(COc2cnn(C3CCCCC3)c(=O)c2Cl)cc1
Show InChI InChI=1S/C20H24ClFN2O3/c21-19-18(12-23-24(20(19)25)17-4-2-1-3-5-17)27-14-16-8-6-15(7-9-16)13-26-11-10-22/h6-9,12,17H,1-5,10-11,13-14H2
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263611
PNG
(4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)...)
Show SMILES FCCOCc1ccc(COc2cnn(-c3ccccc3)c(=O)c2Cl)cc1
Show InChI InChI=1S/C20H18ClFN2O3/c21-19-18(12-23-24(20(19)25)17-4-2-1-3-5-17)27-14-16-8-6-15(7-9-16)13-26-11-10-22/h1-9,12H,10-11,13-14H2
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263609
PNG
(4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)...)
Show SMILES Cn1ncc(OCc2ccc(COCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C15H16ClFN2O3/c1-19-15(20)14(16)13(8-18-19)22-10-12-4-2-11(3-5-12)9-21-7-6-17/h2-5,8H,6-7,9-10H2,1H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263606
PNG
(4-chloro-5-((4-((2-fluoroethoxy)methyl)benzyl)oxy)...)
Show SMILES CC(C)n1ncc(OCc2ccc(COCCF)cc2)c(Cl)c1=O
Show InChI InChI=1S/C17H20ClFN2O3/c1-12(2)21-17(22)16(18)15(9-20-21)24-11-14-5-3-13(4-6-14)10-23-8-7-19/h3-6,9,12H,7-8,10-11H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263662
PNG
(2-(tert-butyl)-4-chloro-5-((4-(diisopropylfluorosi...)
Show SMILES CC(C)[Si](F)(C(C)C)c1ccc(COc2cnn(c(=O)c2Cl)C(C)(C)C)cc1
Show InChI InChI=1S/C21H30ClFN2O2Si/c1-14(2)28(23,15(3)4)17-10-8-16(9-11-17)13-27-18-12-24-25(21(5,6)7)20(26)19(18)22/h8-12,14-15H,13H2,1-7H3
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n/an/a>1.00E+3n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263605
PNG
(2-((4-(((1-(tert-butyl)-5-chloro-6-oxo-1,6-dihydro...)
Show SMILES CC(C)(C)n1ncc(OCc2ccc(COCCOC(=O)CC#N)cc2)c(Cl)c1=O
Show InChI InChI=1S/C21H24ClN3O5/c1-21(2,3)25-20(27)19(22)17(12-24-25)30-14-16-6-4-15(5-7-16)13-28-10-11-29-18(26)8-9-23/h4-7,12H,8,10-11,13-14H2,1-3H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263660
PNG
(2-(tert-butyl)-4-chloro-5-((4-(diisopropylsilyl)be...)
Show SMILES CC(C)[SiH](C(C)C)c1ccc(COc2cnn(c(=O)c2Cl)C(C)(C)C)cc1
Show InChI InChI=1S/C21H31ClN2O2Si/c1-14(2)27(15(3)4)17-10-8-16(9-11-17)13-26-18-12-23-24(21(5,6)7)20(25)19(18)22/h8-12,14-15,27H,13H2,1-7H3
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Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial


(Bos taurus)
BDBM263655
PNG
(2-(tert-butyl)-4-chloro-5-((3-(2-fluoroethoxyl)ben...)
Show SMILES CC(C)(C)n1ncc(OCc2cccc(OCCF)c2)c(Cl)c1=O
Show InChI InChI=1S/C17H20ClFN2O3/c1-17(2,3)21-16(22)15(18)14(10-20-21)24-11-12-5-4-6-13(9-12)23-8-7-19/h4-6,9-10H,7-8,11H2,1-3H3
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n/an/a<1.00E+3n/an/an/an/a7.4n/a



Lantheus Medical Imaging, Inc.

US Patent


Assay Description
The procedure for determining catalytic activity of submitochondrial particles was adapted from Satoh et al. (e.g., see Satoh T, Miyoshi H, Sakamoto ...


US Patent US9713651 (2017)


Article DOI: 10.1021/jm960839i
More data for this
Ligand-Target Pair
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