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Compile Data Set for Download or QSAR

Found 3213 hits with Last Name = 'chen' and Initial = 'yk'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM50067040
PNG
(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Show SMILES COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
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1.03E+4n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM50059989
PNG
((1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-phenyl)-he...)
Show SMILES Oc1ccc(C=CC(=O)CC(=O)C=Cc2ccc(O)cc2)cc1
Show InChI InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2
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1.82E+4n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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2.44E+4n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM50295287
PNG
(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...)
Show SMILES Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C
Show InChI InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)
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8.78E+4n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM50027952
PNG
(5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acet...)
Show SMILES Cc1cc(CC(O)=O)n(C)c1C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H14ClNO3/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10/h3-7H,8H2,1-2H3,(H,18,19)
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3.35E+5n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM54705
PNG
(CHEMBL1297 | Fenoprofen | UNM-0000306101 | calcium...)
Show SMILES CC(C(O)=O)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)
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3.83E+5n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Glyoxalase 1 (GLO1)


(Homo sapiens (Human))
BDBM50022271
PNG
(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)
Show SMILES CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
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8.43E+5n/an/an/an/an/an/an/an/a



Sun Yat-Sen University

Curated by ChEMBL


Assay Description
Inhibition of human glyoxalase 1


Bioorg Med Chem Lett 21: 4243-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.095
BindingDB Entry DOI: 10.7270/Q23R0T76
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301097
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methylpyrimidin...)
Show SMILES Cc1ncc(cn1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC(N)CC1
Show InChI InChI=1S/C21H21N7/c1-14-24-11-17(12-25-14)19-13-26-21(28-8-6-18(23)7-9-28)27-20(19)16-4-2-15(10-22)3-5-16/h2-5,11-13,18H,6-9,23H2,1H3
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n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301098
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(3H- benzimidazol-5...)
Show SMILES NC1CCN(CC1)c1ncc(-c2ccc3nc[nH]c3c2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H21N7/c24-12-15-1-3-16(4-2-15)22-19(17-5-6-20-21(11-17)28-14-27-20)13-26-23(29-22)30-9-7-18(25)8-10-30/h1-6,11,13-14,18H,7-10,25H2,(H,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301099
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2,3- dimcthylindaz...)
Show SMILES Cc1n(C)nc2ccc(cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7/c1-15-20-11-16(5-6-23(20)31-32(15)2)21-14-29-25(33-9-7-19(28)8-10-33)30-24(21)17-3-4-18(13-27)22(26)12-17/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301100
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1,3- dimethylindaz...)
Show SMILES Cc1nn(C)c2ccc(cc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H24FN7/c1-15-20-11-16(5-6-23(20)32(2)31-15)21-14-29-25(33-9-7-19(28)8-10-33)30-24(21)17-3-4-18(13-27)22(26)12-17/h3-6,11-12,14,19H,7-10,28H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301101
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(3- hydroxyoxola...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCOC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C22H22FN5O2/c23-19-11-15(1-2-16(19)12-24)20-17(3-6-22(29)7-10-30-14-22)13-26-21(27-20)28-8-4-18(25)5-9-28/h1-2,11,13,18,29H,4-5,7-10,14,25H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301102
PNG
(4-[5-(3-amino-2-methylindazol-5-yl)- 2-(4-aminopip...)
Show SMILES Cn1nc2ccc(cc2c1N)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN8/c1-32-23(28)18-10-14(4-5-21(18)31-32)19-13-29-24(33-8-6-17(27)7-9-33)30-22(19)15-2-3-16(12-26)20(25)11-15/h2-5,10-11,13,17H,6-9,27-28H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301103
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methylbenzotria...)
Show SMILES Cn1nnc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H21FN8/c1-31-21-5-4-14(11-20(21)29-30-31)18-13-27-23(32-8-6-17(26)7-9-32)28-22(18)15-2-3-16(12-25)19(24)10-15/h2-5,10-11,13,17H,6-9,26H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301104
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(4- hydroxyoxan-...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCOCC2)c(n1)-c1ccc(C#N)c(F)c1
Show InChI InChI=1S/C23H24FN5O2/c24-20-13-16(1-2-17(20)14-25)21-18(3-6-23(30)7-11-31-12-8-23)15-27-22(28-21)29-9-4-19(26)5-10-29/h1-2,13,15,19,30H,4-5,7-12,26H2
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301105
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(3- methyltriazo...)
Show SMILES Cn1nncc1C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C21H19FN8/c1-29-18(13-26-28-29)5-4-16-12-25-21(30-8-6-17(24)7-9-30)27-20(16)14-2-3-15(11-23)19(22)10-14/h2-3,10,12-13,17H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301106
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- methylpyrazo...)
Show SMILES Cn1ccc(n1)C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C22H20FN7/c1-29-9-8-19(28-29)5-4-17-14-26-22(30-10-6-18(25)7-11-30)27-21(17)15-2-3-16(13-24)20(23)12-15/h2-3,8-9,12,14,18H,6-7,10-11,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301107
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- methyltriazo...)
Show SMILES Cn1cc(nn1)C#Cc1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)CC1
Show InChI InChI=1S/C21H19FN8/c1-29-13-18(27-28-29)5-4-16-12-25-21(30-8-6-17(24)7-9-30)26-20(16)14-2-3-15(11-23)19(22)10-14/h2-3,10,12-13,17H,6-9,24H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301108
PNG
(4-[2-(4-amino-3-hydroxypiperidin-1- yl)-5-(1-methy...)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(nc1-c1ccc(C#N)c(F)c1)N1CCC(N)C(O)C1
Show InChI InChI=1S/C24H22FN7O/c1-31-21-5-4-14(8-17(21)11-29-31)18-12-28-24(32-7-6-20(27)22(33)13-32)30-23(18)15-2-3-16(10-26)19(25)9-15/h2-5,8-9,11-12,20,22,33H,6-7,13,27H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301008
PNG
(4-[5-(4-methylphenyl)-1-[[(3R)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(29-26)11-13-30(25)17-20-10-12-28-16-20/h2-9,11,13-14,20,28H,10,12,16-17H2,1H3/t20-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301010
PNG
(4-[5-(4-methylphenyl)-1-[[(3S)- pyrrolidin-3-yl]me...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(29-26)11-13-30(25)17-20-10-12-28-16-20/h2-9,11,13-14,20,28H,10,12,16-17H2,1H3/t20-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301012
PNG
(4-[5-(4-fluorophenyl)-1-[[(3S)- pyrrolidin-3-yl]me...)
Show SMILES Fc1ccc(cc1)-c1nc2ccn(C[C@H]3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H21FN4/c26-21-7-5-20(6-8-21)25-22(19-3-1-17(14-27)2-4-19)13-24-23(29-25)10-12-30(24)16-18-9-11-28-15-18/h1-8,10,12-13,18,28H,9,11,15-16H2/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301014
PNG
(4-[5-morpholin-4-yl-1-[[(3S)- pyrrolidin-3-yl]meth...)
Show SMILES N#Cc1ccc(cc1)-c1cc2n(C[C@H]3CCNC3)ccc2nc1N1CCOCC1
Show InChI InChI=1S/C23H25N5O/c24-14-17-1-3-19(4-2-17)20-13-22-21(26-23(20)27-9-11-29-12-10-27)6-8-28(22)16-18-5-7-25-15-18/h1-4,6,8,13,18,25H,5,7,9-12,15-16H2/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301016
PNG
(4-[1-[(3-fluoropyrrolidin-3-yl)methyl]- 5-(4-methy...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(CC3(F)CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H23FN4/c1-18-2-6-21(7-3-18)25-22(20-8-4-19(15-28)5-9-20)14-24-23(30-25)10-13-31(24)17-26(27)11-12-29-16-26/h2-10,13-14,29H,11-12,16-17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301017
PNG
(4-[5-(4-methylphenyl)-1-[[(2R)- morpholin-2-yl]met...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(C[C@H]3CNCCO3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N4O/c1-18-2-6-21(7-3-18)26-23(20-8-4-19(15-27)5-9-20)14-25-24(29-26)10-12-30(25)17-22-16-28-11-13-31-22/h2-10,12,14,22,28H,11,13,16-17H2,1H3/t22-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301018
PNG
(4-[5-(4-fluorophenyl)-1-[[(2R)- morpholin-2-yl]met...)
Show SMILES Fc1ccc(cc1)-c1nc2ccn(C[C@H]3CNCCO3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H21FN4O/c26-20-7-5-19(6-8-20)25-22(18-3-1-17(14-27)2-4-18)13-24-23(29-25)9-11-30(24)16-21-15-28-10-12-31-21/h1-9,11,13,21,28H,10,12,15-16H2/t21-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301019
PNG
(4-[1-(3-aminopropyl)-5-(4- methylphenyl)pyrrolo[3,...)
Show SMILES Cc1ccc(cc1)-c1nc2ccn(CCCN)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C24H22N4/c1-17-3-7-20(8-4-17)24-21(19-9-5-18(16-26)6-10-19)15-23-22(27-24)11-14-28(23)13-2-12-25/h3-11,14-15H,2,12-13,25H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301020
PNG
(4-[5-(4-methylphenyl)-1-(pyrrolidin-3- ylmethyl)py...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(CC3CCNC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C25H23N5/c1-17-2-6-21(7-3-17)25-22(20-8-4-18(13-26)5-9-20)12-24-23(29-25)15-28-30(24)16-19-10-11-27-14-19/h2-9,12,15,19,27H,10-11,14,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301021
PNG
(4-[5-(4-methylphenyl)-1-(piperidin-4- ylmethyl)pyr...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(CC3CCNCC3)c2cc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C26H25N5/c1-18-2-6-22(7-3-18)26-23(21-8-4-19(15-27)5-9-21)14-25-24(30-26)16-29-31(25)17-20-10-12-28-13-11-20/h2-9,14,16,20,28H,10-13,17H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301022
PNG
(4-[1-[[(1S,5R)-3- azabicyclo[3.1.0]hexan-6-yl]meth...)
Show SMILES Cc1ccc(cc1)-c1nc2cnn(C[C@H]3[C@@H]4CNC[C@H]34)c2cc1-c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C26H23N5/c1-16-3-5-18(6-4-16)26-20(17-7-9-19(27-2)10-8-17)11-25-24(30-26)14-29-31(25)15-23-21-12-28-13-22(21)23/h3-11,14,21-23,28H,12-13,15H2,1H3/t21-,22+,23+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50158880
PNG
(CHEMBL3785783 | US10131664, Example 16)
Show SMILES Cc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-2-6-19(7-3-16)21-15-27-23(26-14-18-10-11-25-13-18)28-22(21)20-8-4-17(12-24)5-9-20/h2-9,15,18,25H,10-11,13-14H2,1H3,(H,26,27,28)/t18-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301025
PNG
(4-[5-(4-fluorophenyl)-2-{[(3S)- pyrrolidin-3- ylme...)
Show SMILES Fc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20FN5/c23-19-7-5-17(6-8-19)20-14-27-22(26-13-16-9-10-25-12-16)28-21(20)18-3-1-15(11-24)2-4-18/h1-8,14,16,25H,9-10,12-13H2,(H,26,27,28)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301026
PNG
(4-[5-(4-chlorophenyl)-2-{[(3S)- pyrrolidin-3- ylme...)
Show SMILES Clc1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C22H20ClN5/c23-19-7-5-17(6-8-19)20-14-27-22(26-13-16-9-10-25-12-16)28-21(20)18-3-1-15(11-24)2-4-18/h1-8,14,16,25H,9-10,12-13H2,(H,26,27,28)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301027
PNG
(4-[5-(4-methylphenyl)-2-[(3R)- pyrrolidin-3-ylmeth...)
Show SMILES Cc1ccc(cc1)-c1cnc(OC[C@@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22N4O/c1-16-2-6-19(7-3-16)21-14-26-23(28-15-18-10-11-25-13-18)27-22(21)20-8-4-17(12-24)5-9-20/h2-9,14,18,25H,10-11,13,15H2,1H3/t18-/m1/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301028
PNG
(4-{2-[(3aR,6aS)-octahydropyrrolo[3,4- c]pyrrol-2-y...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1C[C@@H]2CNC[C@@H]2C1
Show InChI InChI=1S/C24H23N5/c1-16-2-6-18(7-3-16)22-13-27-24(29-14-20-11-26-12-21(20)15-29)28-23(22)19-8-4-17(10-25)5-9-19/h2-9,13,20-21,26H,11-12,14-15H2,1H3/t20-,21+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301029
PNG
(4-[5-(4-methylphenyl)-2-{octahydro- 1H-pyrrolo[3,4...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CCC2CNCC2C1
Show InChI InChI=1S/C25H25N5/c1-17-2-6-19(7-3-17)23-15-28-25(30-11-10-21-13-27-14-22(21)16-30)29-24(23)20-8-4-18(12-26)5-9-20/h2-9,15,21-22,27H,10-11,13-14,16H2,1H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301030
PNG
(4-{2-[(3aR,8aS)-decahydropyrrolo[3,4- d]azepin-6-y...)
Show SMILES Cc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC[C@@H]2CNC[C@@H]2CC1
Show InChI InChI=1S/C26H27N5/c1-18-2-6-20(7-3-18)24-17-29-26(30-25(24)21-8-4-19(14-27)5-9-21)31-12-10-22-15-28-16-23(22)11-13-31/h2-9,17,22-23,28H,10-13,15-16H2,1H3/t22-,23+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301031
PNG
(4-{2-[(3aR,8aS)-decahydropyrrolo[3,4- d]azepin-6-y...)
Show SMILES Fc1ccc(cc1)-c1cnc(nc1-c1ccc(cc1)C#N)N1CC[C@@H]2CNC[C@@H]2CC1
Show InChI InChI=1S/C25H24FN5/c26-22-7-5-18(6-8-22)23-16-29-25(30-24(23)19-3-1-17(13-27)2-4-19)31-11-9-20-14-28-15-21(20)10-12-31/h1-8,16,20-21,28H,9-12,14-15H2/t20-,21+
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301032
PNG
(4-(2-{[(3S)-pyrrolidin-3- ylmethyl]amino}-5-[4- (t...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cnc(NC[C@H]2CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H20F3N5/c24-23(25,26)19-7-5-17(6-8-19)20-14-30-22(29-13-16-9-10-28-12-16)31-21(20)18-3-1-15(11-27)2-4-18/h1-8,14,16,28H,9-10,12-13H2,(H,29,30,31)/t16-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301033
PNG
(4-[5-(2-cyclopropylethynyl)-2-{[(3S)- pyrrolidin-3...)
Show SMILES N#Cc1ccc(cc1)-c1nc(NC[C@H]2CCNC2)ncc1C#CC1CC1
Show InChI InChI=1S/C21H21N5/c22-11-16-4-6-18(7-5-16)20-19(8-3-15-1-2-15)14-25-21(26-20)24-13-17-9-10-23-12-17/h4-7,14-15,17,23H,1-2,9-10,12-13H2,(H,24,25,26)/t17-/m0/s1
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301035
PNG
((+-)-4-(2-{[(3-fluoropyrrolidin-3- yl)methyl]amino...)
Show SMILES Cc1ccc(cc1)-c1cnc(NCC2(F)CCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22FN5/c1-16-2-6-18(7-3-16)20-13-27-22(28-15-23(24)10-11-26-14-23)29-21(20)19-8-4-17(12-25)5-9-19/h2-9,13,26H,10-11,14-15H2,1H3,(H,27,28,29)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301036
PNG
((+-)-4-[5-(4-methylphenyl)-2- [(piperidin-3-yl)ami...)
Show SMILES Cc1ccc(cc1)-c1cnc(NC2CCCNC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-4-8-18(9-5-16)21-15-26-23(27-20-3-2-12-25-14-20)28-22(21)19-10-6-17(13-24)7-11-19/h4-11,15,20,25H,2-3,12,14H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301037
PNG
(4-[5-(4-methylphenyl)-2-[(piperidin-4- yl)amino]py...)
Show SMILES Cc1ccc(cc1)-c1cnc(NC2CCNCC2)nc1-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N5/c1-16-2-6-18(7-3-16)21-15-26-23(27-20-10-12-25-13-11-20)28-22(21)19-8-4-17(14-24)5-9-19/h2-9,15,20,25H,10-13H2,1H3,(H,26,27,28)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301162
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[6- (dimethylamino)...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1ccc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C24H27N7O/c1-30(2)20-9-8-18(15-27-20)21-22(17-6-4-16(14-25)5-7-17)28-24(29-23(21)32-3)31-12-10-19(26)11-13-31/h4-9,15,19H,10-13,26H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301163
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2- (dimethylamino)...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnc(nc1)N(C)C)N1CCC(N)CC1
Show InChI InChI=1S/C23H26N8O/c1-30(2)22-26-13-17(14-27-22)19-20(16-6-4-15(12-24)5-7-16)28-23(29-21(19)32-3)31-10-8-18(25)9-11-31/h4-7,13-14,18H,8-11,25H2,1-3H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301164
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{3-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H22FN9O/c1-32-21-18(30-31-32)10-15(12-27-21)19-20(13-3-4-14(11-25)17(24)9-13)28-23(29-22(19)34-2)33-7-5-16(26)6-8-33/h3-4,9-10,12,16H,5-8,26H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301165
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{3-methy...)
Show SMILES COc1nc(nc(-c2ccc(cc2)C#N)c1-c1cnc2n(C)nnc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C23H23N9O/c1-31-21-18(29-30-31)11-16(13-26-21)19-20(15-5-3-14(12-24)4-6-15)27-23(28-22(19)33-2)32-9-7-17(25)8-10-32/h3-6,11,13,17H,7-10,25H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301166
PNG
(4-[2-(4-aminopiperidin-1-yl)-6- methoxy-5-{1-methy...)
Show SMILES COc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1cnc2n(C)ncc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C24H23FN8O/c1-32-22-17(13-29-32)9-16(12-28-22)20-21(14-3-4-15(11-26)19(25)10-14)30-24(31-23(20)34-2)33-7-5-18(27)6-8-33/h3-4,9-10,12-13,18H,5-8,27H2,1-2H3
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301167
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(2- methyl-2H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1-c1ccc2nn(C)cc2c1)N1CCC(N)CC1
Show InChI InChI=1S/C25H25FN8/c1-29-24-22(15-5-6-21-18(11-15)14-33(2)32-21)23(16-3-4-17(13-27)20(26)12-16)30-25(31-24)34-9-7-19(28)8-10-34/h3-6,11-12,14,19H,7-10,28H2,1-2H3,(H,29,30,31)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM301168
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-(1- methyl-1H-indaz...)
Show SMILES CNc1nc(nc(-c2ccc(C#N)c(F)c2)c1C1=CC2C=NN(C)C2C=C1)N1CCC(N)CC1
Show InChI InChI=1S/C25H27FN8/c1-29-24-22(15-5-6-21-18(11-15)14-30-33(21)2)23(16-3-4-17(13-27)20(26)12-16)31-25(32-24)34-9-7-19(28)8-10-34/h3-6,11-12,14,18-19,21H,7-10,28H2,1-2H3,(H,29,31,32)
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Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...


US Patent US10131664 (2018)


Article DOI: 10.1016/j.bmcl.2006.07.033
More data for this
Ligand-Target Pair
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