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Compile Data Set for Download or QSAR

Found 442 hits with Last Name = 'cleary' and Initial = 'b'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50518833
PNG
(CHEMBL4528993)
Show SMILES Fc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H14FN3O3S/c19-15-11-13(17-8-4-5-9-20-17)10-14(12-15)18(23)21-22-26(24,25)16-6-2-1-3-7-16/h1-12,22H,(H,21,23)
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n/an/a 2n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527224
PNG
(CHEMBL4468833)
Show SMILES COc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H16FN3O4S/c1-27-15-11-13(17-7-4-5-9-21-17)10-14(12-15)19(24)22-23-28(25,26)18-8-3-2-6-16(18)20/h2-12,23H,1H3,(H,22,24)
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n/an/a 5n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527244
PNG
(CHEMBL4437798)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1)-c1ccco1
Show InChI InChI=1S/C17H12ClFN2O4S/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
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n/an/a 5.5n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527381
PNG
(CHEMBL4466823)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C18H14FN3O3S/c19-15-8-1-2-10-17(15)26(24,25)22-21-18(23)14-7-5-6-13(12-14)16-9-3-4-11-20-16/h1-12,22H,(H,21,23)
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n/an/a 6n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527355
PNG
(CHEMBL4456585)
Show SMILES Fc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)
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n/an/a 6.30n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527250
PNG
(CHEMBL4475883)
Show SMILES Cc1ccn(n1)-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-9-14(11-15(10-12)23-8-7-13(2)21-23)18(24)20-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,20,24)
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n/an/a 7n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527238
PNG
(CHEMBL4539384)
Show SMILES Cc1cc(cc(c1)-c1ccccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H16FN3O3S/c1-13-10-14(17-7-4-5-9-21-17)12-15(11-13)19(24)22-23-27(25,26)18-8-3-2-6-16(18)20/h2-12,23H,1H3,(H,22,24)
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n/an/a 8n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50518832
PNG
(CHEMBL4455897)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-c1ccccc1
Show InChI InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
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n/an/a 8n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527245
PNG
(CHEMBL4521125)
Show SMILES Fc1cc(cc(c1)-n1nccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C15H11F2N5O3S/c16-11-7-10(8-12(9-11)22-18-5-6-19-22)15(23)20-21-26(24,25)14-4-2-1-3-13(14)17/h1-9,21H,(H,20,23)
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n/an/a 9n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527328
PNG
(CHEMBL4441439)
Show SMILES Cc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN4O3S/c1-12-9-13(17-20-7-4-8-21-17)11-14(10-12)18(24)22-23-27(25,26)16-6-3-2-5-15(16)19/h2-11,23H,1H3,(H,22,24)
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n/an/a 9n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527225
PNG
(CHEMBL4565790)
Show SMILES Fc1cc(cc(c1)-c1ccco1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H12F2N2O4S/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
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PubMed
n/an/a 9.40n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50518831
PNG
(CHEMBL4464835)
Show SMILES Fc1c(Cl)cc(cc1C(=O)NNS(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H14ClFN2O3S/c20-17-12-14(13-7-3-1-4-8-13)11-16(18(17)21)19(24)22-23-27(25,26)15-9-5-2-6-10-15/h1-12,23H,(H,22,24)
PDB

UniProtKB/SwissProt

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UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527243
PNG
(CHEMBL4458272)
Show SMILES Cc1cc(cc(c1)-c1ccco1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN2O4S/c1-12-9-13(16-6-4-8-25-16)11-14(10-12)18(22)20-21-26(23,24)17-7-3-2-5-15(17)19/h2-11,21H,1H3,(H,20,22)
PDB

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n/an/a 11n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527263
PNG
(CHEMBL4465716)
Show SMILES COc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O4S/c1-26-14-10-12(9-13(11-14)22-8-4-7-19-22)17(23)20-21-27(24,25)16-6-3-2-5-15(16)18/h2-11,21H,1H3,(H,20,23)
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n/an/a 13n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527246
PNG
(CHEMBL4445473)
Show SMILES Cc1ccnn1-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-9-14(11-15(10-12)23-13(2)7-8-20-23)18(24)21-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,21,24)
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PubMed
n/an/a 13n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527232
PNG
(CHEMBL4436877)
Show SMILES Cc1cnn(c1)-c1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H17FN4O3S/c1-12-7-14(9-15(8-12)23-11-13(2)10-20-23)18(24)21-22-27(25,26)17-6-4-3-5-16(17)19/h3-11,22H,1-2H3,(H,21,24)
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n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527240
PNG
(CHEMBL4541948)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C17H13FN2O3S2/c18-15-6-1-2-7-16(15)25(22,23)20-19-17(21)13-5-3-4-12(10-13)14-8-9-24-11-14/h1-11,20H,(H,19,21)
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n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527235
PNG
(CHEMBL4516984)
Show SMILES Fc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H12F2N4O3S/c18-13-9-11(16-20-6-3-7-21-16)8-12(10-13)17(24)22-23-27(25,26)15-5-2-1-4-14(15)19/h1-10,23H,(H,22,24)
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n/an/a 14n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527366
PNG
(CHEMBL4449163)
Show SMILES CC(C)Oc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H19FN2O4S/c1-11(2)24-14-9-12(3)8-13(10-14)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h4-11,20H,1-3H3,(H,19,21)
PDB

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n/an/a 15n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527382
PNG
(CHEMBL4518462)
Show SMILES Cc1cc(OCC=C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H17FN2O4S/c1-3-8-24-14-10-12(2)9-13(11-14)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h3-7,9-11,20H,1,8H2,2H3,(H,19,21)
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n/an/a 16n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527313
PNG
(CHEMBL4446917)
Show SMILES CCOc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H17FN2O4S/c1-3-23-13-9-11(2)8-12(10-13)16(20)18-19-24(21,22)15-7-5-4-6-14(15)17/h4-10,19H,3H2,1-2H3,(H,18,20)
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n/an/a 16n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50518867
PNG
(CHEMBL4460509)
Show SMILES Fc1ccc(cc1C(=O)NNS(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H15FN2O3S/c20-18-12-11-15(14-7-3-1-4-8-14)13-17(18)19(23)21-22-26(24,25)16-9-5-2-6-10-16/h1-13,22H,(H,21,23)
PDB

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UniChem
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n/an/a 17n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527302
PNG
(CHEMBL4573736)
Show SMILES CC(=C)COc1cc(C)c(F)c(c1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19FN2O4S/c1-12(2)11-25-14-9-13(3)17(19)16(10-14)18(22)20-21-26(23,24)15-7-5-4-6-8-15/h4-10,21H,1,11H2,2-3H3,(H,20,22)
PDB

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n/an/a 17n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527277
PNG
(CHEMBL4593500)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1F)-c1ccccc1
Show InChI InChI=1S/C19H13ClF2N2O3S/c20-13-10-14(12-6-2-1-3-7-12)18(22)15(11-13)19(25)23-24-28(26,27)17-9-5-4-8-16(17)21/h1-11,24H,(H,23,25)
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n/an/a 17n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527346
PNG
(CHEMBL4566403)
Show SMILES Cc1cc(cc(c1)-n1nccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H14FN5O3S/c1-11-8-12(10-13(9-11)22-18-6-7-19-22)16(23)20-21-26(24,25)15-5-3-2-4-14(15)17/h2-10,21H,1H3,(H,20,23)
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n/an/a 18n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527251
PNG
(CHEMBL4588945)
Show SMILES Cc1ccn(n1)-c1cccc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O3S/c1-12-9-10-22(20-12)14-6-4-5-13(11-14)17(23)19-21-26(24,25)16-8-3-2-7-15(16)18/h2-11,21H,1H3,(H,19,23)
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n/an/a 18n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527365
PNG
(CHEMBL4455027)
Show SMILES Fc1cc(OCC=C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H14F2N2O4S/c1-2-7-24-13-9-11(8-12(17)10-13)16(21)19-20-25(22,23)15-6-4-3-5-14(15)18/h2-6,8-10,20H,1,7H2,(H,19,21)
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n/an/a 20n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527358
PNG
(CHEMBL4572653)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1ccco1
Show InChI InChI=1S/C17H13FN2O4S/c18-14-7-1-2-9-16(14)25(22,23)20-19-17(21)13-6-3-5-12(11-13)15-8-4-10-24-15/h1-11,20H,(H,19,21)
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n/an/a 20n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527221
PNG
(CHEMBL4464911)
Show SMILES Fc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C16H12F2N4O3S/c17-12-8-11(9-13(10-12)22-7-3-6-19-22)16(23)20-21-26(24,25)15-5-2-1-4-14(15)18/h1-10,21H,(H,20,23)
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n/an/a 23n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527360
PNG
(CHEMBL4456874)
Show SMILES Cc1ccn(n1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-7-23(21-11)14-9-12(8-13(18)10-14)17(24)20-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,20,24)
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n/an/a 23n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527241
PNG
(CHEMBL4593937)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cc(Cl)cc(c1)-c1cccs1
Show InChI InChI=1S/C17H12ClFN2O3S2/c18-13-9-11(15-5-3-7-25-15)8-12(10-13)17(22)20-21-26(23,24)16-6-2-1-4-14(16)19/h1-10,21H,(H,20,22)
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n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527327
PNG
(CHEMBL4453559)
Show SMILES COc1cc(cc(c1)-c1ncccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C18H15FN4O4S/c1-27-14-10-12(17-20-7-4-8-21-17)9-13(11-14)18(24)22-23-28(25,26)16-6-3-2-5-15(16)19/h2-11,23H,1H3,(H,22,24)
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n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527264
PNG
(CHEMBL4530056)
Show SMILES CCOCc1cc(C)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H19FN2O4S/c1-3-24-11-13-8-12(2)9-14(10-13)17(21)19-20-25(22,23)16-7-5-4-6-15(16)18/h4-10,20H,3,11H2,1-2H3,(H,19,21)
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n/an/a 24n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527242
PNG
(CHEMBL4454163)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C17H13FN2O3S2/c18-14-7-1-2-9-16(14)25(22,23)20-19-17(21)13-6-3-5-12(11-13)15-8-4-10-24-15/h1-11,20H,(H,19,21)
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n/an/a 25n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527364
PNG
(CHEMBL4445456)
Show SMILES Oc1ccc(F)c(c1)S(=O)(=O)NNC(=O)c1cc(F)cc(c1)-n1cccn1
Show InChI InChI=1S/C16H12F2N4O4S/c17-11-6-10(7-12(8-11)22-5-1-4-19-22)16(24)20-21-27(25,26)15-9-13(23)2-3-14(15)18/h1-9,21,23H,(H,20,24)
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n/an/a 26n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527348
PNG
(CHEMBL4454507)
Show SMILES Cc1cc(cc(c1)-n1cccn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H15FN4O3S/c1-12-9-13(11-14(10-12)22-8-4-7-19-22)17(23)20-21-26(24,25)16-6-3-2-5-15(16)18/h2-11,21H,1H3,(H,20,23)
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n/an/a 27n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527265
PNG
(CHEMBL4559662)
Show SMILES Cc1cc(OC2CC2)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H17FN2O4S/c1-11-8-12(10-14(9-11)24-13-6-7-13)17(21)19-20-25(22,23)16-5-3-2-4-15(16)18/h2-5,8-10,13,20H,6-7H2,1H3,(H,19,21)
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n/an/a 27n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6B


(Homo sapiens)
BDBM50518832
PNG
(CHEMBL4455897)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-c1ccccc1
Show InChI InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
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n/an/a 28n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged recombinant human KAT6B (431 to end residues) expressed in baculovirus infected Sf9 insect cells using acetyl coe...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527347
PNG
(CHEMBL4526110)
Show SMILES Cc1cc(cc(c1)-n1cc(F)cn1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-12(8-14(7-11)23-10-13(18)9-20-23)17(24)21-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,21,24)
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n/an/a 29n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527375
PNG
(CHEMBL4554392)
Show SMILES CCOCc1cc(C)c(F)c(c1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19FN2O4S/c1-3-24-11-13-9-12(2)16(18)15(10-13)17(21)19-20-25(22,23)14-7-5-4-6-8-14/h4-10,20H,3,11H2,1-2H3,(H,19,21)
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n/an/a 29n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527227
PNG
(CHEMBL4450971)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(OCC=C)c1
Show InChI InChI=1S/C16H15FN2O4S/c1-2-10-23-13-7-5-6-12(11-13)16(20)18-19-24(21,22)15-9-4-3-8-14(15)17/h2-9,11,19H,1,10H2,(H,18,20)
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n/an/a 30n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527247
PNG
(CHEMBL4446616)
Show SMILES Cc1ccnn1-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-6-7-20-23(11)14-9-12(8-13(18)10-14)17(24)21-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,21,24)
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n/an/a 31n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527359
PNG
(CHEMBL4441001)
Show SMILES Cc1cnn(c1)-c1cc(F)cc(c1)C(=O)NNS(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-9-20-23(10-11)14-7-12(6-13(18)8-14)17(24)21-22-27(25,26)16-5-3-2-4-15(16)19/h2-10,22H,1H3,(H,21,24)
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n/an/a 32n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527325
PNG
(CHEMBL4461380)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-n1nccn1
Show InChI InChI=1S/C16H14FN5O3S/c1-11-9-12(22-18-7-8-19-22)10-14(15(11)17)16(23)20-21-26(24,25)13-5-3-2-4-6-13/h2-10,21H,1H3,(H,20,23)
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n/an/a 38n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50518845
PNG
(CHEMBL4473722)
Show SMILES Fc1c(Cl)cccc1C(=O)NNS(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H12ClFN2O3S/c18-15-7-3-6-14(16(15)19)17(22)20-21-25(23,24)13-9-8-11-4-1-2-5-12(11)10-13/h1-10,21H,(H,20,22)
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n/an/a 43n/an/an/an/an/an/a



Cancer Therapeutics CRC

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 62: 7146-7159 (2019)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527220
PNG
(CHEMBL4451170)
Show SMILES Fc1ccccc1S(=O)(=O)NNC(=O)c1cccc(c1)-n1cccn1
Show InChI InChI=1S/C16H13FN4O3S/c17-14-7-1-2-8-15(14)25(23,24)20-19-16(22)12-5-3-6-13(11-12)21-10-4-9-18-21/h1-11,20H,(H,19,22)
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n/an/a 43n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527237
PNG
(CHEMBL4464974)
Show SMILES Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)c(F)c(c1)-c1ccccn1
Show InChI InChI=1S/C19H15F2N3O3S/c1-12-10-13(16-7-4-5-9-22-16)18(21)14(11-12)19(25)23-24-28(26,27)17-8-3-2-6-15(17)20/h2-11,24H,1H3,(H,23,25)
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n/an/a 44n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527276
PNG
(CHEMBL4444077)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1F)-c1ccccc1
Show InChI InChI=1S/C20H16F2N2O3S/c1-13-11-15(14-7-3-2-4-8-14)12-16(19(13)22)20(25)23-24-28(26,27)18-10-6-5-9-17(18)21/h2-12,24H,1H3,(H,23,25)
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527304
PNG
(CHEMBL4560554)
Show SMILES CCCOc1cc(C)c(F)c(c1)C(=O)NNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H19FN2O4S/c1-3-9-24-13-10-12(2)16(18)15(11-13)17(21)19-20-25(22,23)14-7-5-4-6-8-14/h4-8,10-11,20H,3,9H2,1-2H3,(H,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT6A


(Homo sapiens)
BDBM50527371
PNG
(CHEMBL4475866)
Show SMILES Cc1cc(cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F)-n1cc(F)cn1
Show InChI InChI=1S/C17H14F2N4O3S/c1-11-7-13(23-10-12(18)9-20-23)8-15(16(11)19)17(24)21-22-27(25,26)14-5-3-2-4-6-14/h2-10,22H,1H3,(H,21,24)
PDB

UniProtKB/SwissProt

GoogleScholar
UniChem
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl ...


J Med Chem 63: 4655-4684 (2020)


Article DOI: null
More data for this
Ligand-Target Pair
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