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Compile Data Set for Download or QSAR

Found 161 hits with Last Name = 'correll' and Initial = 'tl'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432665
PNG
(CHEMBL2347375)
Show SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23-,25+,29+/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50229787
PNG
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432665
PNG
(CHEMBL2347375)
Show SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23-,25+,29+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50397778
PNG
(CHEMBL2177813 | US9593129, Example 35)
Show SMILES OC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20-,22-/m1/s1
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n/an/a 34n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383255
PNG
(CHEMBL2032202)
Show SMILES Fc1ccc(NC(=O)N2CCc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H18F4N2O/c24-18-9-11-19(12-10-18)28-22(30)29-14-13-15-3-1-2-4-20(15)21(29)16-5-7-17(8-6-16)23(25,26)27/h1-12,21H,13-14H2,(H,28,30)
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n/an/a 53n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383263
PNG
(CHEMBL2032210)
Show SMILES Fc1ccc(NC(=O)N2CCc3ccccc3[C@H]2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H18F4N2O/c24-18-9-11-19(12-10-18)28-22(30)29-14-13-15-3-1-2-4-20(15)21(29)16-5-7-17(8-6-16)23(25,26)27/h1-12,21H,13-14H2,(H,28,30)/t21-/m1/s1
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n/an/a 56n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432651
PNG
(CHEMBL2347394)
Show SMILES COc1cccc2O[C@@H](C3=C(N(C)c4ncnn4[C@H]3c3ccc(Br)cc3)c12)c1ccc(Br)cc1
Show InChI InChI=1S/C26H20Br2N4O2/c1-31-24-21-19(33-2)4-3-5-20(21)34-25(16-8-12-18(28)13-9-16)22(24)23(32-26(31)29-14-30-32)15-6-10-17(27)11-7-15/h3-14,23,25H,1-2H3/t23-,25+/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432637
PNG
(CHEMBL2177203 | US9593129, Example 41)
Show SMILES OC(=O)C[C@@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20+,22+/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432636
PNG
(CHEMBL2347383)
Show SMILES CCC[C@@H](N1[C@@H]([C@@H](O[C@@H](Cc2ccc(F)cc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C28H26Cl2FNO4/c1-2-3-23(28(34)35)32-25(18-6-10-20(29)11-7-18)26(19-8-12-21(30)13-9-19)36-24(27(32)33)16-17-4-14-22(31)15-5-17/h4-15,23-26H,2-3,16H2,1H3,(H,34,35)/t23-,24+,25-,26+/m1/s1
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n/an/a 86n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50229787
PNG
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/a 89n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383252
PNG
(CHEMBL2032199)
Show SMILES Fc1ccc(NC(=O)N2CCc3scnc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F4N3OS/c21-14-5-7-15(8-6-14)26-19(28)27-10-9-16-17(25-11-29-16)18(27)12-1-3-13(4-2-12)20(22,23)24/h1-8,11,18H,9-10H2,(H,26,28)
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n/an/a 93n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50443210
PNG
(CHEMBL3087352)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)Nc1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C15H11Cl2N3O2S/c16-11-7-12(17)9-15(8-11)23(21,22)19-13-1-3-14(4-2-13)20-6-5-18-10-20/h1-10,19H
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 (unknown origin) after 10 mins


Bioorg Med Chem Lett 23: 6447-54 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.041
BindingDB Entry DOI: 10.7270/Q2C53N9S
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383256
PNG
(CHEMBL2032203)
Show SMILES Fc1ccc(NC(=O)N2CCc3c(F)cccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F5N2O/c24-16-8-10-17(11-9-16)29-22(31)30-13-12-18-19(2-1-3-20(18)25)21(30)14-4-6-15(7-5-14)23(26,27)28/h1-11,21H,12-13H2,(H,29,31)
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383227
PNG
(CHEMBL2032173)
Show SMILES Clc1ccccc1C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H17ClN2OS/c21-17-9-5-4-8-15(17)19-16-11-13-25-18(16)10-12-23(19)20(24)22-14-6-2-1-3-7-14/h1-9,11,13,19H,10,12H2,(H,22,24)
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n/an/a 140n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432638
PNG
(CHEMBL2347377)
Show SMILES OC(=O)C[C@@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21+/m0/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383249
PNG
(CHEMBL2032195)
Show SMILES Fc1ccc(NC(=O)N2CCc3ccsc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N2OS/c22-16-5-7-17(8-6-16)26-20(28)27-11-9-14-10-12-29-19(14)18(27)13-1-3-15(4-2-13)21(23,24)25/h1-8,10,12,18H,9,11H2,(H,26,28)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383251
PNG
(CHEMBL2032198)
Show SMILES Fc1ccc(NC(=O)N2CCn3cccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H17F4N3O/c22-16-7-9-17(10-8-16)26-20(29)28-13-12-27-11-1-2-18(27)19(28)14-3-5-15(6-4-14)21(23,24)25/h1-11,19H,12-13H2,(H,26,29)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383258
PNG
(CHEMBL2032205)
Show SMILES Fc1ccc(NC(=O)N2CCc3ccc(F)cc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F5N2O/c24-17-7-9-19(10-8-17)29-22(31)30-12-11-14-3-6-18(25)13-20(14)21(30)15-1-4-16(5-2-15)23(26,27)28/h1-10,13,21H,11-12H2,(H,29,31)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50443208
PNG
(CHEMBL3087355)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)Nc1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C17H12Cl2N2O2S/c18-14-9-15(19)11-17(10-14)24(22,23)21-16-3-1-12(2-4-16)13-5-7-20-8-6-13/h1-11,21H
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 (unknown origin) after 10 mins


Bioorg Med Chem Lett 23: 6447-54 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.041
BindingDB Entry DOI: 10.7270/Q2C53N9S
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383217
PNG
(CHEMBL2032197)
Show SMILES Fc1ccc(NC(=O)N2CCc3ccoc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N2O2/c22-16-5-7-17(8-6-16)26-20(28)27-11-9-14-10-12-29-19(14)18(27)13-1-3-15(4-2-13)21(23,24)25/h1-8,10,12,18H,9,11H2,(H,26,28)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383224
PNG
(CHEMBL2032170)
Show SMILES FC(F)(F)c1ccccc1C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H17F3N2OS/c22-21(23,24)17-9-5-4-8-15(17)19-16-11-13-28-18(16)10-12-26(19)20(27)25-14-6-2-1-3-7-14/h1-9,11,13,19H,10,12H2,(H,25,27)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383250
PNG
(CHEMBL2032196)
Show SMILES Fc1ccc(NC(=O)N2CCc3occc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N2O2/c22-15-5-7-16(8-6-15)26-20(28)27-11-9-18-17(10-12-29-18)19(27)13-1-3-14(4-2-13)21(23,24)25/h1-8,10,12,19H,9,11H2,(H,26,28)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383254
PNG
(CHEMBL2032201)
Show SMILES Cn1cnc2C(N(CCc12)C(=O)Nc1ccc(F)cc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F4N4O/c1-28-12-26-18-17(28)10-11-29(20(30)27-16-8-6-15(22)7-9-16)19(18)13-2-4-14(5-3-13)21(23,24)25/h2-9,12,19H,10-11H2,1H3,(H,27,30)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383226
PNG
(CHEMBL2032172)
Show SMILES FC(F)(F)c1ccc(cc1)C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C21H17F3N2OS/c22-21(23,24)15-8-6-14(7-9-15)19-17-11-13-28-18(17)10-12-26(19)20(27)25-16-4-2-1-3-5-16/h1-9,11,13,19H,10,12H2,(H,25,27)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432639
PNG
(CHEMBL2347376)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20-,21-/m1/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383219
PNG
(CHEMBL2032165)
Show SMILES CCCC1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C17H20N2OS/c1-2-6-15-14-10-12-21-16(14)9-11-19(15)17(20)18-13-7-4-3-5-8-13/h3-5,7-8,10,12,15H,2,6,9,11H2,1H3,(H,18,20)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383257
PNG
(CHEMBL2032204)
Show SMILES Fc1ccc(NC(=O)N2CCc3cc(F)ccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F5N2O/c24-17-5-8-19(9-6-17)29-22(31)30-12-11-15-13-18(25)7-10-20(15)21(30)14-1-3-16(4-2-14)23(26,27)28/h1-10,13,21H,11-12H2,(H,29,31)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383247
PNG
(CHEMBL2032193)
Show SMILES Fc1ccc(NC(=O)N2CCc3sccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F4N2OS/c22-15-5-7-16(8-6-15)26-20(28)27-11-9-18-17(10-12-29-18)19(27)13-1-3-14(4-2-13)21(23,24)25/h1-8,10,12,19H,9,11H2,(H,26,28)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383262
PNG
(CHEMBL2032209)
Show SMILES Fc1ccc(NC(=O)N2Cc3ccccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H16F4N2O/c23-17-9-11-18(12-10-17)27-21(29)28-13-15-3-1-2-4-19(15)20(28)14-5-7-16(8-6-14)22(24,25)26/h1-12,20H,13H2,(H,27,29)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50397778
PNG
(CHEMBL2177813 | US9593129, Example 35)
Show SMILES OC(=O)C[C@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20-,22-/m1/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383237
PNG
(CHEMBL2032183)
Show SMILES Fc1ccccc1C(=O)N1CCc2sccc2C1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H15F4NOS/c22-17-4-2-1-3-15(17)20(27)26-11-9-18-16(10-12-28-18)19(26)13-5-7-14(8-6-13)21(23,24)25/h1-8,10,12,19H,9,11H2
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383240
PNG
(CHEMBL2032186)
Show SMILES CC(C)NC(=O)N1CCc2sccc2C1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N2OS/c1-11(2)22-17(24)23-9-7-15-14(8-10-25-15)16(23)12-3-5-13(6-4-12)18(19,20)21/h3-6,8,10-11,16H,7,9H2,1-2H3,(H,22,24)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383229
PNG
(CHEMBL2032175)
Show SMILES Clc1ccc(cc1)C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H17ClN2OS/c21-15-8-6-14(7-9-15)19-17-11-13-25-18(17)10-12-23(19)20(24)22-16-4-2-1-3-5-16/h1-9,11,13,19H,10,12H2,(H,22,24)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383245
PNG
(CHEMBL2032191)
Show SMILES Fc1ccccc1NC(=O)N1CCc2sccc2C1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H16F4N2OS/c22-16-3-1-2-4-17(16)26-20(28)27-11-9-18-15(10-12-29-18)19(27)13-5-7-14(8-6-13)21(23,24)25/h1-8,10,12,19H,9,11H2,(H,26,28)
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Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432652
PNG
(CHEMBL2347393)
Show SMILES CC[C@@H](CO)N1[C@@H]([C@@H](O[C@@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23Cl2NO5/c1-2-17(12-26)25-20(13-6-8-15(23)9-7-13)21(14-4-3-5-16(24)10-14)30-18(22(25)29)11-19(27)28/h3-10,17-18,20-21,26H,2,11-12H2,1H3,(H,27,28)/t17-,18-,20+,21-/m0/s1
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50443201
PNG
(CHEMBL3087042)
Show SMILES CCc1cc(ccn1)-c1ccc(NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F6N2O2S/c1-2-17-9-14(7-8-28-17)13-3-5-18(6-4-13)29-32(30,31)19-11-15(20(22,23)24)10-16(12-19)21(25,26)27/h3-12,29H,2H2,1H3
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n/an/a 700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 (unknown origin) after 10 mins


Bioorg Med Chem Lett 23: 6447-54 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.041
BindingDB Entry DOI: 10.7270/Q2C53N9S
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50443202
PNG
(CHEMBL3087041)
Show SMILES FC(F)(F)c1cc(cc(c1)S(=O)(=O)Nc1ccc(cc1)-c1ccnc(C=C)c1)C(F)(F)F
Show InChI InChI=1S/C21H14F6N2O2S/c1-2-17-9-14(7-8-28-17)13-3-5-18(6-4-13)29-32(30,31)19-11-15(20(22,23)24)10-16(12-19)21(25,26)27/h2-12,29H,1H2
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n/an/a 700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 (unknown origin) after 10 mins


Bioorg Med Chem Lett 23: 6447-54 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.041
BindingDB Entry DOI: 10.7270/Q2C53N9S
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383246
PNG
(CHEMBL2032192)
Show SMILES Fc1cccc(NC(=O)N2CCc3sccc3C2c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C21H16F4N2OS/c22-15-2-1-3-16(12-15)26-20(28)27-10-8-18-17(9-11-29-18)19(27)13-4-6-14(7-5-13)21(23,24)25/h1-7,9,11-12,19H,8,10H2,(H,26,28)
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n/an/a 780n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383259
PNG
(CHEMBL2032206)
Show SMILES Fc1ccc(NC(=O)N2CCc3cccc(F)c3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H17F5N2O/c24-17-8-10-18(11-9-17)29-22(31)30-13-12-14-2-1-3-19(25)20(14)21(30)15-4-6-16(7-5-15)23(26,27)28/h1-11,21H,12-13H2,(H,29,31)
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n/an/a 790n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432646
PNG
(CHEMBL2347388)
Show SMILES OCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H23Cl2NO3/c23-17-8-6-15(7-9-17)20-21(16-2-1-3-18(24)12-16)28-19(10-11-26)22(27)25(20)13-14-4-5-14/h1-3,6-9,12,14,19-21,26H,4-5,10-11,13H2/t19-,20+,21-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383248
PNG
(CHEMBL2032194)
Show SMILES Fc1ccc(CC(=O)N2CCc3sccc3C2c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H17F4NOS/c23-17-7-1-14(2-8-17)13-20(28)27-11-9-19-18(10-12-29-19)21(27)15-3-5-16(6-4-15)22(24,25)26/h1-8,10,12,21H,9,11,13H2
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n/an/a 890n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432651
PNG
(CHEMBL2347394)
Show SMILES COc1cccc2O[C@@H](C3=C(N(C)c4ncnn4[C@H]3c3ccc(Br)cc3)c12)c1ccc(Br)cc1
Show InChI InChI=1S/C26H20Br2N4O2/c1-31-24-21-19(33-2)4-3-5-20(21)34-25(16-8-12-18(28)13-9-16)22(24)23(32-26(31)29-14-30-32)15-6-10-17(27)11-7-15/h3-14,23,25H,1-2H3/t23-,25+/m0/s1
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n/an/a 960n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432658
PNG
(CHEMBL2347399)
Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Br)cc1)c1ccc(Br)cc1
Show InChI InChI=1S/C24H21Br2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432637
PNG
(CHEMBL2177203 | US9593129, Example 41)
Show SMILES OC(=O)C[C@@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO3/c24-18-8-6-15(7-9-18)22-20(16-2-1-3-19(25)10-16)11-17(12-21(27)28)23(29)26(22)13-14-4-5-14/h1-3,6-10,14,17,20,22H,4-5,11-13H2,(H,27,28)/t17-,20+,22+/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383241
PNG
(CHEMBL2032187)
Show SMILES FC(F)(F)c1ccc(cc1)C1N(CCc2sccc12)C(=O)NC1CC1
Show InChI InChI=1S/C18H17F3N2OS/c19-18(20,21)12-3-1-11(2-4-12)16-14-8-10-25-15(14)7-9-23(16)17(24)22-13-5-6-13/h1-4,8,10,13,16H,5-7,9H2,(H,22,24)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383236
PNG
(CHEMBL2032182)
Show SMILES CC(C)C(=O)N1CCc2sccc2C1c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H18F3NOS/c1-11(2)17(23)22-9-7-15-14(8-10-24-15)16(22)12-3-5-13(6-4-12)18(19,20)21/h3-6,8,10-11,16H,7,9H2,1-2H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432644
PNG
(CHEMBL2347391)
Show SMILES OC(=O)CC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO4/c24-17-8-6-15(7-9-17)21-22(16-2-1-3-18(25)12-16)30-19(10-11-20(27)28)23(29)26(21)13-14-4-5-14/h1-3,6-9,12,14,19,21-22H,4-5,10-11,13H2,(H,27,28)/t19-,21+,22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50383231
PNG
(CHEMBL2032177)
Show SMILES Fc1cccc(c1)C1N(CCc2sccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C20H17FN2OS/c21-15-6-4-5-14(13-15)19-17-10-12-25-18(17)9-11-23(19)20(24)22-16-7-2-1-3-8-16/h1-8,10,12-13,19H,9,11H2,(H,22,24)
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n/an/a 1.32E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced Ca2+ influx incubated 2.5 mins prior icilin inductio...


J Med Chem 55: 1593-611 (2012)


Article DOI: 10.1021/jm2013634
BindingDB Entry DOI: 10.7270/Q2TT4S0C
More data for this
Ligand-Target Pair
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