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Compile Data Set for Download or QSAR

Found 820 hits with Last Name = 'donello' and Initial = 'je'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187126
PNG
(US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...)
Show SMILES CCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)
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n/an/a 0.120n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125523
PNG
(US8772316, 6)
Show SMILES CCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)
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n/an/a 0.120n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194437
PNG
(US9200016, 119)
Show SMILES COCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O5S/c1-30-13-20-18-11-22(32-3)21(31-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(23(14)26-16)27-33(24,28)29/h4-8,10-12,27H,9,13H2,1-3H3,(H2,24,28,29)
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n/an/a 0.180n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125567
PNG
(US8772316, 50)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O4/c1-6-8-23-20-15-25(34-5)24(33-4)14-19(20)21(27(31)30-23)13-17-11-16-12-18(32-3)9-10-22(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 0.280n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187169
PNG
(US9670181, 48 6,7-dimethoxy-4-((6-methoxy-2-(methy...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O4/c1-6-8-23-20-15-25(34-5)24(33-4)14-19(20)21(27(31)30-23)13-17-11-16-12-18(32-3)9-10-22(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 0.280n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125603
PNG
(US8772316, 86)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H32FN3O4/c1-6-9-22-19-14-26(35-5)25(34-4)13-18(19)20(28(33)32-22)11-17-10-16-12-24(36-8-3)21(29)15-23(16)31-27(17)30-7-2/h10,12-15H,6-9,11H2,1-5H3,(H,30,31)(H,32,33)
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n/an/a 0.300n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187210
PNG
(US9670181, 86 4-((6-ethoxy-2-(ethylamino)-7-fluoro...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)c(F)cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H32FN3O4/c1-6-9-22-19-14-26(35-5)25(34-4)13-18(19)20(28(33)32-22)11-17-10-16-12-24(36-8-3)21(29)15-23(16)31-27(17)30-7-2/h10,12-15H,6-9,11H2,1-5H3,(H,30,31)(H,32,33)
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n/an/a 0.300n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125565
PNG
(US8772316, 48)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H29N3O4/c1-6-7-22-19-14-24(33-5)23(32-4)13-18(19)20(26(30)29-22)12-16-10-15-11-17(31-3)8-9-21(15)28-25(16)27-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)
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n/an/a 0.340n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187169
PNG
(US9670181, 48 6,7-dimethoxy-4-((6-methoxy-2-(methy...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O4/c1-6-8-23-20-15-25(34-5)24(33-4)14-19(20)21(27(31)30-23)13-17-11-16-12-18(32-3)9-10-22(16)29-26(17)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 0.340n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125557
PNG
(US8772316, 40)
Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c2cc(OC)c(OC)cc2c(CC)[nH]c1=O
Show InChI InChI=1S/C26H29N3O4/c1-6-21-19-14-24(33-5)23(32-4)13-18(19)20(26(30)29-21)12-16-10-15-11-17(31-3)8-9-22(15)28-25(16)27-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)
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n/an/a 0.400n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187209
PNG
(US9670181, 85 1-ethyl-6,7-dimethoxy-4-((6-methoxyq...)
Show SMILES CCc1nc(O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O4/c1-5-20-18-12-23(30-4)22(29-3)11-17(18)19(24(27)26-20)9-14-8-15-10-16(28-2)6-7-21(15)25-13-14/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)
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n/an/a 0.400n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187160
PNG
(US9670181, 40 1-ethyl-4-((2-(ethylamino)-6-methoxy...)
Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H29N3O4/c1-6-21-19-14-24(33-5)23(32-4)13-18(19)20(26(30)29-21)12-16-10-15-11-17(31-3)8-9-22(15)28-25(16)27-7-2/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)
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n/an/a 0.400n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125602
PNG
(US8772316, 85)
Show SMILES CCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H24N2O4/c1-5-20-18-12-23(30-4)22(29-3)11-17(18)19(24(27)26-20)9-14-8-15-10-16(28-2)6-7-21(15)25-13-14/h6-8,10-13H,5,9H2,1-4H3,(H,26,27)
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n/an/a 0.400n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194477
PNG
(US9200016, 159)
Show SMILES COc1cc2cncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C21H20N4O4S/c1-28-19-9-15-12-23-11-14(17(15)10-20(19)29-2)8-16-7-6-13-4-3-5-18(21(13)24-16)25-30(22,26)27/h3-7,9-12,25H,8H2,1-2H3,(H2,22,26,27)
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n/an/a 0.420n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187162
PNG
(US9670181, 42 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...)
Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O4/c1-6-10-28-26-17(11-16-12-18(32-3)8-9-23(16)29-26)13-21-19-14-24(33-4)25(34-5)15-20(19)22(7-2)30-27(21)31/h8-9,11-12,14-15H,6-7,10,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 0.5n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125524
PNG
(US8772316, 7)
Show SMILES CCCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H25NO4/c1-4-7-22-19-15-26(31-3)25(30-2)14-18(19)21(27(29)28-22)13-16-10-11-24-20(12-16)17-8-5-6-9-23(17)32-24/h5-6,8-12,14-15H,4,7,13H2,1-3H3,(H,28,29)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125559
PNG
(US8772316, 42)
Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c2cc(OC)c(OC)cc2c(CC)[nH]c1=O
Show InChI InChI=1S/C27H31N3O4/c1-6-10-28-26-17(11-16-12-18(32-3)8-9-23(16)29-26)13-21-19-14-24(33-4)25(34-5)15-20(19)22(7-2)30-27(21)31/h8-9,11-12,14-15H,6-7,10,13H2,1-5H3,(H,28,29)(H,30,31)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187127
PNG
(US9670181, 7 4-(dibenzo[b,d]furan-2-ylmethyl)-6,7-...)
Show SMILES CCCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H25NO4/c1-4-7-22-19-15-26(31-3)25(30-2)14-18(19)21(27(29)28-22)13-16-10-11-24-20(12-16)17-8-5-6-9-23(17)32-24/h5-6,8-12,14-15H,4,7,13H2,1-3H3,(H,28,29)
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n/an/a 0.5n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194402
PNG
(US9200016, 84)
Show SMILES CCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O4S/c1-4-19-18-12-22(31-3)21(30-2)11-17(18)15(13-25-19)10-16-9-8-14-6-5-7-20(23(14)26-16)27-32(24,28)29/h5-9,11-13,27H,4,10H2,1-3H3,(H2,24,28,29)
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n/an/a 0.530n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194474
PNG
(US9200016, 156)
Show SMILES COc1cc2c(C)ncc(Cc3ccc4cccc(NS(N)(=O)=O)c4n3)c2cc1OC
Show InChI InChI=1S/C22H22N4O4S/c1-13-17-10-20(29-2)21(30-3)11-18(17)15(12-24-13)9-16-8-7-14-5-4-6-19(22(14)25-16)26-31(23,27)28/h4-8,10-12,26H,9H2,1-3H3,(H2,23,27,28)
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n/an/a 0.710n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125570
PNG
(US8772316, 53)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H33N3O4/c1-7-8-24-21-15-26(35-6)25(34-5)14-20(21)22(28(32)31-24)13-18-11-17-12-19(33-4)9-10-23(17)30-27(18)29-16(2)3/h9-12,14-16H,7-8,13H2,1-6H3,(H,29,30)(H,31,32)
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n/an/a 0.800n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187174
PNG
(US9670181, 53 4-((2-(isopropylamino)-6-methoxyquin...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC(C)C)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H33N3O4/c1-7-8-24-21-15-26(35-6)25(34-5)14-20(21)22(28(32)31-24)13-18-11-17-12-19(33-4)9-10-23(17)30-27(18)29-16(2)3/h9-12,14-16H,7-8,13H2,1-6H3,(H,29,30)(H,31,32)
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n/an/a 0.800n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194403
PNG
(US9200016, 85)
Show SMILES CCCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C24H26N4O4S/c1-4-6-20-19-13-23(32-3)22(31-2)12-18(19)16(14-26-20)11-17-10-9-15-7-5-8-21(24(15)27-17)28-33(25,29)30/h5,7-10,12-14,28H,4,6,11H2,1-3H3,(H2,25,29,30)
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n/an/a 0.820n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM101157
PNG
(US8524917, 130 | US8524917, 165)
Show SMILES CC(C)Oc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccn3)c2c1
Show InChI InChI=1S/C28H29F2N3O2/c1-17(2)27-26(28(34)32-15-19-8-11-23(29)24(30)13-19)22-10-9-21(35-18(3)4)14-25(22)33(27)16-20-7-5-6-12-31-20/h5-14,17-18H,15-16H2,1-4H3,(H,32,34)
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n/an/a 0.900n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Inhibition assay using sphingosine-1-phosphate receptor 3.


US Patent US8524917 (2013)


BindingDB Entry DOI: 10.7270/Q2G15ZG2
More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens (Human))
BDBM187126
PNG
(US9670181, 6 4-(dibenzo[b,d]furan-2-ylmethyl)-1-et...)
Show SMILES CCc1nc(O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)
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n/an/a 0.900n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125579
PNG
(US8772316, 62)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc4OCOc4cc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O5/c1-5-6-19-17-11-22(32-4)21(31-3)10-16(17)18(26(30)29-19)8-15-7-14-9-23-24(34-13-33-23)12-20(14)28-25(15)27-2/h7,9-12H,5-6,8,13H2,1-4H3,(H,27,28)(H,29,30)
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n/an/a 1.10n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187184
PNG
(US9670181, 62 6,7-dimethoxy-4-((6-(methylamino)-[1...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O5/c1-5-6-19-17-11-22(32-4)21(31-3)10-16(17)18(26(30)29-19)8-15-7-14-9-23-24(34-13-33-23)12-20(14)28-25(15)27-2/h7,9-12H,5-6,8,13H2,1-4H3,(H,27,28)(H,29,30)
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n/an/a 1.10n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125581
PNG
(US8772316, 64)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)
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n/an/a 1.20n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
Sphingosine 1-phosphate receptor 3


(Homo sapiens (Human))
BDBM101041
PNG
(US8524917, 14)
Show SMILES CC(C)COc1ccc2c(C(=O)NCc3ccc(F)c(F)c3)c(C(C)C)n(Cc3ccccc3)c2c1
Show InChI InChI=1S/C30H32F2N2O2/c1-19(2)18-36-23-11-12-24-27(15-23)34(17-21-8-6-5-7-9-21)29(20(3)4)28(24)30(35)33-16-22-10-13-25(31)26(32)14-22/h5-15,19-20H,16-18H2,1-4H3,(H,33,35)
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Allergan, Inc.

US Patent


Assay Description
Inhibition assay using sphingosine-1-phosphate receptor 3.


US Patent US8524917 (2013)


BindingDB Entry DOI: 10.7270/Q2G15ZG2
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187186
PNG
(US9670181, 64 4-((6-(ethylamino)-[1,3]dioxolo[4,5-...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)
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n/an/a 1.20n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194392
PNG
(US9200016, 74)
Show SMILES COc1cc2cncc(Cc3cnc4cc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C22H20N2O2/c1-14-4-5-16-7-15(11-24-20(16)6-14)8-17-12-23-13-18-9-21(25-2)22(26-3)10-19(17)18/h4-7,9-13H,8H2,1-3H3
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n/an/a 1.20n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187206
PNG
(US9670181, 82 1-ethyl-4-((2-(ethylamino)-7-fluoro-...)
Show SMILES CCNc1nc2cc(F)c(OC)cc2cc1Cc1c(O)nc(CC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H28FN3O4/c1-6-20-17-12-24(34-5)23(33-4)11-16(17)18(26(31)30-20)9-15-8-14-10-22(32-3)19(27)13-21(14)29-25(15)28-7-2/h8,10-13H,6-7,9H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 1.40n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194391
PNG
(US9200016, 139 | US9200016, 73)
Show SMILES CCCc1ncc(Cc2ccc3cccc(OCC(N)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H27N3O4/c1-4-6-21-20-13-24(32-3)23(31-2)12-19(20)17(14-28-21)11-18-10-9-16-7-5-8-22(26(16)29-18)33-15-25(27)30/h5,7-10,12-14H,4,6,11,15H2,1-3H3,(H2,27,30)
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Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125599
PNG
(US8772316, 82)
Show SMILES CCNc1nc2cc(F)c(OC)cc2cc1Cc1c2cc(OC)c(OC)cc2c(CC)[nH]c1=O
Show InChI InChI=1S/C26H28FN3O4/c1-6-20-17-12-24(34-5)23(33-4)11-16(17)18(26(31)30-20)9-15-8-14-10-22(32-3)19(27)13-21(14)29-25(15)28-7-2/h8,10-13H,6-7,9H2,1-5H3,(H,28,29)(H,30,31)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125569
PNG
(US8772316, 52)
Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c2cc(OC)c(OC)cc2c(CCC)[nH]c1=O
Show InChI InChI=1S/C28H33N3O4/c1-6-8-24-21-16-26(35-5)25(34-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(33-3)9-10-23(17)30-27(18)29-11-7-2/h9-10,12-13,15-16H,6-8,11,14H2,1-5H3,(H,29,30)(H,31,32)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187173
PNG
(US9670181, 52 6,7-dimethoxy-4-((6-methoxy-2-(propy...)
Show SMILES CCCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(CCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H33N3O4/c1-6-8-24-21-16-26(35-5)25(34-4)15-20(21)22(28(32)31-24)14-18-12-17-13-19(33-3)9-10-23(17)30-27(18)29-11-7-2/h9-10,12-13,15-16H,6-8,11,14H2,1-5H3,(H,29,30)(H,31,32)
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ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125586
PNG
(US8772316, 69)
Show SMILES CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H32N4O5/c1-6-23-21-15-26(37-5)25(36-4)14-20(21)22(28(34)32-23)13-18-11-17-12-19(35-3)7-8-24(17)31-27(18)30-10-9-29-16(2)33/h7-8,11-12,14-15H,6,9-10,13H2,1-5H3,(H,29,33)(H,30,31)(H,32,34)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187155
PNG
(US9670181, 35 4-((2-(ethylamino)-6-methylquinolin-...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O3/c1-6-8-23-20-15-25(33-5)24(32-4)14-19(20)21(27(31)30-23)13-18-12-17-11-16(3)9-10-22(17)29-26(18)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 1.5n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125552
PNG
(US8772316, 35)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(C)ccc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H31N3O3/c1-6-8-23-20-15-25(33-5)24(32-4)14-19(20)21(27(31)30-23)13-18-12-17-11-16(3)9-10-22(17)29-26(18)28-7-2/h9-12,14-15H,6-8,13H2,1-5H3,(H,28,29)(H,30,31)
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n/an/a 1.5n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187192
PNG
(US9670181, 69 N-(2-((3-((1-ethyl-3-hydroxy-6,7-dim...)
Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C28H32N4O5/c1-6-23-21-15-26(37-5)25(36-4)14-20(21)22(28(34)32-23)13-18-11-17-12-19(35-3)7-8-24(17)31-27(18)30-10-9-29-16(2)33/h7-8,11-12,14-15H,6,9-10,13H2,1-5H3,(H,29,33)(H,30,31)(H,32,34)
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n/an/a 1.5n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194463
PNG
(US9200016, 145)
Show SMILES COc1cc2cncc(Cc3ccc4oc(nc4c3)-c3ccc(cc3)C([O-])=O)c2cc1OC
Show InChI InChI=1S/C26H20N2O5/c1-31-23-11-19-14-27-13-18(20(19)12-24(23)32-2)9-15-3-8-22-21(10-15)28-25(33-22)16-4-6-17(7-5-16)26(29)30/h3-8,10-14H,9H2,1-2H3,(H,29,30)/p-1
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n/an/a 1.60n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187208
PNG
(US9670181, 84 6,7-dimethoxy-4-((6-methoxyquinolin-...)
Show SMILES CCCc1nc(O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O4/c1-5-6-22-19-13-24(31-4)23(30-3)12-18(19)20(25(28)27-22)10-15-9-16-11-17(29-2)7-8-21(16)26-14-15/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)
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n/an/a 1.60n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187159
PNG
(US9670181, 39 1-ethyl-6,7-dimethoxy-4-((6-methoxy-...)
Show SMILES CCc1nc(O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H27N3O4/c1-6-20-18-13-23(32-5)22(31-4)12-17(18)19(25(29)28-20)11-15-9-14-10-16(30-3)7-8-21(14)27-24(15)26-2/h7-10,12-13H,6,11H2,1-5H3,(H,26,27)(H,28,29)
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n/an/a 1.60n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125556
PNG
(US8772316, 39)
Show SMILES CCc1[nH]c(=O)c(Cc2cc3cc(OC)ccc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H27N3O4/c1-6-20-18-13-23(32-5)22(31-4)12-17(18)19(25(29)28-20)11-15-9-14-10-16(30-3)7-8-21(14)27-24(15)26-2/h7-10,12-13H,6,11H2,1-5H3,(H,26,27)(H,28,29)
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n/an/a 1.60n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125601
PNG
(US8772316, 84)
Show SMILES CCCc1[nH]c(=O)c(Cc2cnc3ccc(OC)cc3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C25H26N2O4/c1-5-6-22-19-13-24(31-4)23(30-3)12-18(19)20(25(28)27-22)10-15-9-16-11-17(29-2)7-8-21(16)26-14-15/h7-9,11-14H,5-6,10H2,1-4H3,(H,27,28)
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n/an/a 1.60n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187189
PNG
(US9670181, 67 4-((2-(ethylamino)-6-methoxyquinolin...)
Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c(O)nc(COC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H29N3O5/c1-6-27-25-16(9-15-10-17(32-3)7-8-21(15)28-25)11-20-18-12-23(33-4)24(34-5)13-19(18)22(14-31-2)29-26(20)30/h7-10,12-13H,6,11,14H2,1-5H3,(H,27,28)(H,29,30)
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n/an/a 1.80n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125605
PNG
(US8772316, 88)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(OCC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C30H36N4O5/c1-6-8-26-23-17-28(38-5)27(37-4)16-22(23)24(30(36)34-26)15-20-13-19-14-21(39-7-2)9-10-25(19)33-29(20)32-12-11-31-18(3)35/h9-10,13-14,16-17H,6-8,11-12,15H2,1-5H3,(H,31,35)(H,32,33)(H,34,36)
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n/an/a 1.80n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM187212
PNG
(US9670181, 88 N-(2-((6-ethoxy-3-((3-hydroxy-6,7-di...)
Show SMILES CCCc1nc(O)c(Cc2cc3cc(OCC)ccc3nc2NCCNC(C)=O)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C30H36N4O5/c1-6-8-26-23-17-28(38-5)27(37-4)16-22(23)24(30(36)34-26)15-20-13-19-14-21(39-7-2)9-10-25(19)33-29(20)32-12-11-31-18(3)35/h9-10,13-14,16-17H,6-8,11-12,15H2,1-5H3,(H,31,35)(H,32,33)(H,34,36)
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n/an/a 1.80n/an/an/an/a7.425



ALLERGAN, INC.; EXONHIT THERAPEUTICS SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE® from Perkin Elmer). This c...


US Patent US9670181 (2017)


BindingDB Entry DOI: 10.7270/Q21Z42KJ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125584
PNG
(US8772316, 67)
Show SMILES CCNc1nc2ccc(OC)cc2cc1Cc1c2cc(OC)c(OC)cc2c(COC)[nH]c1=O
Show InChI InChI=1S/C26H29N3O5/c1-6-27-25-16(9-15-10-17(32-3)7-8-21(15)28-25)11-20-18-12-23(33-4)24(34-5)13-19(18)22(14-31-2)29-26(20)30/h7-10,12-13H,6,11,14H2,1-5H3,(H,27,28)(H,29,30)
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Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125551
PNG
(US8772316, 34)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc(C)ccc3nc2NC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H29N3O3/c1-6-7-22-19-14-24(32-5)23(31-4)13-18(19)20(26(30)29-22)12-17-11-16-10-15(2)8-9-21(16)28-25(17)27-3/h8-11,13-14H,6-7,12H2,1-5H3,(H,27,28)(H,29,30)
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n/an/a 1.90n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
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