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Compile Data Set for Download or QSAR

Found 719 hits with Last Name = 'finch' and Initial = 'h'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(RAT)
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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0.148n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM81962
PNG
(S-L-365,260)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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0.148n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50005463
PNG
((R)-1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-...)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)c2cc3ccccc3[nH]2)C1=O)c1ccccc1
Show InChI InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
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0.148n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type A receptor of rat pancreatic membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472889
PNG
(CHEMBL415240)
Show SMILES OCc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C34H36N4O4/c39-20-22-7-6-8-26(16-22)35-33(42)36-30-31(40)37(21-34-17-23-13-24(18-34)15-25(14-23)19-34)28-11-4-5-12-29(28)38(32(30)41)27-9-2-1-3-10-27/h1-12,16,23-25,30,39H,13-15,17-21H2,(H2,35,36,42)/t23-,24+,25-,30?,34?
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0.178n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472863
PNG
(CHEMBL333979)
Show SMILES CC(C)CCN1c2ccccc2N(c2ccccc2F)C(=O)C(NC(=O)Nc2cccc(c2)N(C)C)C1=O
Show InChI InChI=1S/C29H32FN5O3/c1-19(2)16-17-34-24-14-7-8-15-25(24)35(23-13-6-5-12-22(23)30)28(37)26(27(34)36)32-29(38)31-20-10-9-11-21(18-20)33(3)4/h5-15,18-19,26H,16-17H2,1-4H3,(H2,31,32,38)
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0.209n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472878
PNG
(CHEMBL331872)
Show SMILES Fc1ccccc1N1c2ccccc2N(CCC2CCCC2)C(=O)C(NC(=O)Nc2cccc(c2)C2N=NN=N2)C1=O
Show InChI InChI=1S/C30H29FN8O3/c31-22-12-3-4-13-23(22)39-25-15-6-5-14-24(25)38(17-16-19-8-1-2-9-19)28(40)26(29(39)41)33-30(42)32-21-11-7-10-20(18-21)27-34-36-37-35-27/h3-7,10-15,18-19,26-27H,1-2,8-9,16-17H2,(H2,32,33,42)
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0.224n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472863
PNG
(CHEMBL333979)
Show SMILES CC(C)CCN1c2ccccc2N(c2ccccc2F)C(=O)C(NC(=O)Nc2cccc(c2)N(C)C)C1=O
Show InChI InChI=1S/C29H32FN5O3/c1-19(2)16-17-34-24-14-7-8-15-25(24)35(23-13-6-5-12-22(23)30)28(37)26(27(34)36)32-29(38)31-20-10-9-11-21(18-20)33(3)4/h5-15,18-19,26H,16-17H2,1-4H3,(H2,31,32,38)
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0.251n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472898
PNG
(CHEMBL332902)
Show SMILES CC(C)(C)CCN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C2N=NN=N2)C1=O
Show InChI InChI=1S/C29H30N8O3/c1-29(2,3)16-17-36-22-14-7-8-15-23(22)37(21-12-5-4-6-13-21)27(39)24(26(36)38)31-28(40)30-20-11-9-10-19(18-20)25-32-34-35-33-25/h4-15,18,24-25H,16-17H2,1-3H3,(H2,30,31,40)
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0.288n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472855
PNG
(CHEMBL331468)
Show SMILES Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C33H35N5O3/c34-24-7-6-8-25(16-24)35-32(41)36-29-30(39)37(20-33-17-21-13-22(18-33)15-23(14-21)19-33)27-11-4-5-12-28(27)38(31(29)40)26-9-2-1-3-10-26/h1-12,16,21-23,29H,13-15,17-20,34H2,(H2,35,36,41)/t21-,22+,23-,29?,33?
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0.295n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472870
PNG
(CHEMBL331975)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C30H35N5O3/c1-30(2,3)18-19-34-24-16-9-10-17-25(24)35(22-13-7-6-8-14-22)28(37)26(27(34)36)32-29(38)31-21-12-11-15-23(20-21)33(4)5/h6-17,20,26H,18-19H2,1-5H3,(H2,31,32,38)
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0.302n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472884
PNG
(CHEMBL121021)
Show SMILES CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1
Show InChI InChI=1S/C28H29FN4O3S/c1-18(2)15-16-32-23-13-6-7-14-24(23)33(22-12-5-4-11-21(22)29)27(35)25(26(32)34)31-28(36)30-19-9-8-10-20(17-19)37-3/h4-14,17-18,25H,15-16H2,1-3H3,(H2,30,31,36)
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0.331n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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0.355n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472854
PNG
(CHEMBL330977)
Show SMILES O=C(NC1C(=O)N(CC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C33H34N4O3/c38-30-29(35-32(40)34-25-9-3-1-4-10-25)31(39)37(26-11-5-2-6-12-26)28-14-8-7-13-27(28)36(30)21-33-18-22-15-23(19-33)17-24(16-22)20-33/h1-14,22-24,29H,15-21H2,(H2,34,35,40)/t22-,23+,24-,29?,33?
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0.372n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472887
PNG
(CHEMBL330773)
Show SMILES CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C29H32N4O3S/c1-29(2,3)17-18-32-23-15-8-9-16-24(23)33(21-12-6-5-7-13-21)27(35)25(26(32)34)31-28(36)30-20-11-10-14-22(19-20)37-4/h5-16,19,25H,17-18H2,1-4H3,(H2,30,31,36)
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0.490n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472864
PNG
(CHEMBL402702)
Show SMILES O=C(NC1C(=O)N(CC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(c1)C(=O)OCCN1CCOCC1
Show InChI InChI=1S/C40H45N5O6/c46-36-35(42-39(49)41-31-8-6-7-30(22-31)38(48)51-18-15-43-13-16-50-17-14-43)37(47)45(32-9-2-1-3-10-32)34-12-5-4-11-33(34)44(36)26-40-23-27-19-28(24-40)21-29(20-27)25-40/h1-12,22,27-29,35H,13-21,23-26H2,(H2,41,42,49)/t27-,28+,29-,35?,40?
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0.562n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472853
PNG
(CHEMBL331244)
Show SMILES Oc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C33H34N4O4/c38-26-10-6-7-24(16-26)34-32(41)35-29-30(39)36(20-33-17-21-13-22(18-33)15-23(14-21)19-33)27-11-4-5-12-28(27)37(31(29)40)25-8-2-1-3-9-25/h1-12,16,21-23,29,38H,13-15,17-20H2,(H2,34,35,41)/t21-,22+,23-,29?,33?
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0.575n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472876
PNG
(CHEMBL332568)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1
Show InChI InChI=1S/C30H34FN5O3/c1-30(2,3)17-18-35-24-15-8-9-16-25(24)36(23-14-7-6-13-22(23)31)28(38)26(27(35)37)33-29(39)32-20-11-10-12-21(19-20)34(4)5/h6-16,19,26H,17-18H2,1-5H3,(H2,32,33,39)
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0.603n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472885
PNG
(CHEMBL118622)
Show SMILES CC(C)(C)CCN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C#N)C1=O
Show InChI InChI=1S/C29H29N5O3/c1-29(2,3)16-17-33-23-14-7-8-15-24(23)34(22-12-5-4-6-13-22)27(36)25(26(33)35)32-28(37)31-21-11-9-10-20(18-21)19-30/h4-15,18,25H,16-17H2,1-3H3,(H2,31,32,37)
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0.646n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472871
PNG
(CHEMBL118954)
Show SMILES Oc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)cc1
Show InChI InChI=1S/C33H34N4O4/c38-26-12-10-24(11-13-26)34-32(41)35-29-30(39)36(20-33-17-21-14-22(18-33)16-23(15-21)19-33)27-8-4-5-9-28(27)37(31(29)40)25-6-2-1-3-7-25/h1-13,21-23,29,38H,14-20H2,(H2,34,35,41)/t21-,22+,23-,29?,33?
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0.661n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472886
PNG
(CHEMBL421271)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1
Show InChI InChI=1S/C31H34FN5O3/c1-35(2)23-13-9-12-22(20-23)33-31(40)34-28-29(38)36(19-18-21-10-3-4-11-21)26-16-7-8-17-27(26)37(30(28)39)25-15-6-5-14-24(25)32/h5-9,12-17,20-21,28H,3-4,10-11,18-19H2,1-2H3,(H2,33,34,40)
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0.676n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472848
PNG
(CHEMBL420728)
Show SMILES CC(C)(C)CCN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C28H30N4O3/c1-28(2,3)18-19-31-22-16-10-11-17-23(22)32(21-14-8-5-9-15-21)26(34)24(25(31)33)30-27(35)29-20-12-6-4-7-13-20/h4-17,24H,18-19H2,1-3H3,(H2,29,30,35)
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0.676n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472851
PNG
(CHEMBL331763)
Show SMILES CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C36H41N5O5/c1-22(42)32(43)37-26-8-7-9-27(17-26)38-35(46)39-31-33(44)40(21-36-18-23-14-24(19-36)16-25(15-23)20-36)29-12-5-6-13-30(29)41(34(31)45)28-10-3-2-4-11-28/h2-13,17,22-25,31-32,37,42-43H,14-16,18-21H2,1H3,(H2,38,39,46)/t22?,23-,24+,25-,31?,32?,36?
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0.676n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472854
PNG
(CHEMBL330977)
Show SMILES O=C(NC1C(=O)N(CC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C33H34N4O3/c38-30-29(35-32(40)34-25-9-3-1-4-10-25)31(39)37(26-11-5-2-6-12-26)28-14-8-7-13-27(28)36(30)21-33-18-22-15-23(19-33)17-24(16-22)20-33/h1-14,22-24,29H,15-21H2,(H2,34,35,40)/t22-,23+,24-,29?,33?
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0.708n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472895
PNG
(CHEMBL120296)
Show SMILES Fc1ccccc1N1c2ccccc2N(CCC2CCCC2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C29H29FN4O3/c30-22-14-6-7-15-23(22)34-25-17-9-8-16-24(25)33(19-18-20-10-4-5-11-20)27(35)26(28(34)36)32-29(37)31-21-12-2-1-3-13-21/h1-3,6-9,12-17,20,26H,4-5,10-11,18-19H2,(H2,31,32,37)
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0.724n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472882
PNG
(CHEMBL332403)
Show SMILES CSc1cccc(NC(=O)NC2C(=O)N(CCC(C)(C)C)c3ccccc3N(c3ccccc3F)C2=O)c1
Show InChI InChI=1S/C29H31FN4O3S/c1-29(2,3)16-17-33-23-14-7-8-15-24(23)34(22-13-6-5-12-21(22)30)27(36)25(26(33)35)32-28(37)31-19-10-9-11-20(18-19)38-4/h5-15,18,25H,16-17H2,1-4H3,(H2,31,32,37)
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0.724n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472847
PNG
(CHEMBL121331)
Show SMILES CSc1cccc(NC(=O)NC2C(=O)N(CCC3CCCC3)c3ccccc3N(c3ccccc3F)C2=O)c1
Show InChI InChI=1S/C30H31FN4O3S/c1-39-22-12-8-11-21(19-22)32-30(38)33-27-28(36)34(18-17-20-9-2-3-10-20)25-15-6-7-16-26(25)35(29(27)37)24-14-5-4-13-23(24)31/h4-8,11-16,19-20,27H,2-3,9-10,17-18H2,1H3,(H2,32,33,38)
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0.759n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472857
PNG
(CHEMBL121028)
Show SMILES Brc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C33H33BrN4O3/c34-24-7-6-8-25(16-24)35-32(41)36-29-30(39)37(20-33-17-21-13-22(18-33)15-23(14-21)19-33)27-11-4-5-12-28(27)38(31(29)40)26-9-2-1-3-10-26/h1-12,16,21-23,29H,13-15,17-20H2,(H2,35,36,41)/t21-,22+,23-,29?,33?
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0.832n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472854
PNG
(CHEMBL330977)
Show SMILES O=C(NC1C(=O)N(CC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C33H34N4O3/c38-30-29(35-32(40)34-25-9-3-1-4-10-25)31(39)37(26-11-5-2-6-12-26)28-14-8-7-13-27(28)36(30)21-33-18-22-15-23(19-33)17-24(16-22)20-33/h1-14,22-24,29H,15-21H2,(H2,34,35,40)/t22-,23+,24-,29?,33?
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0.933n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472893
PNG
(CHEMBL333517)
Show SMILES O=Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C34H34N4O4/c39-20-22-7-6-8-26(16-22)35-33(42)36-30-31(40)37(21-34-17-23-13-24(18-34)15-25(14-23)19-34)28-11-4-5-12-29(28)38(32(30)41)27-9-2-1-3-10-27/h1-12,16,20,23-25,30H,13-15,17-19,21H2,(H2,35,36,42)/t23-,24+,25-,30?,34?
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0.955n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472865
PNG
(CHEMBL331971)
Show SMILES CC(C)(C)CCN1c2ccccc2N(c2ccccc2F)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C28H29FN4O3/c1-28(2,3)17-18-32-22-15-9-10-16-23(22)33(21-14-8-7-13-20(21)29)26(35)24(25(32)34)31-27(36)30-19-11-5-4-6-12-19/h4-16,24H,17-18H2,1-3H3,(H2,30,31,36)
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0.955n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472873
PNG
(CHEMBL120363)
Show SMILES OC(=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C34H34N4O5/c39-30-29(36-33(43)35-25-8-6-7-24(16-25)32(41)42)31(40)38(26-9-2-1-3-10-26)28-12-5-4-11-27(28)37(30)20-34-17-21-13-22(18-34)15-23(14-21)19-34/h1-12,16,21-23,29H,13-15,17-20H2,(H,41,42)(H2,35,36,43)/t21-,22+,23-,29?,34?
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0.977n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472892
PNG
(CHEMBL331262)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(C3CC4CCC3C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C31H33N5O3/c1-34(2)24-12-8-9-22(19-24)32-31(39)33-28-29(37)35(23-10-4-3-5-11-23)25-13-6-7-14-26(25)36(30(28)38)27-18-20-15-16-21(27)17-20/h3-14,19-21,27-28H,15-18H2,1-2H3,(H2,32,33,39)
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1n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472866
PNG
(CHEMBL120021)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C35H39N5O3/c1-38(2)28-12-8-9-26(18-28)36-34(43)37-31-32(41)39(22-35-19-23-15-24(20-35)17-25(16-23)21-35)29-13-6-7-14-30(29)40(33(31)42)27-10-4-3-5-11-27/h3-14,18,23-25,31H,15-17,19-22H2,1-2H3,(H2,36,37,43)/t23-,24+,25-,31?,35?
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1.10n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472890
PNG
(CHEMBL339879)
Show SMILES CC(C)C(C)CN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C28H30N4O3/c1-19(2)20(3)18-31-23-16-10-11-17-24(23)32(22-14-8-5-9-15-22)27(34)25(26(31)33)30-28(35)29-21-12-6-4-7-13-21/h4-17,19-20,25H,18H2,1-3H3,(H2,29,30,35)
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1.10n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472875
PNG
(CHEMBL333930)
Show SMILES CN(C)c1cccc(NC(=O)NC2C(=O)N(CC3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C35H39N5O3/c1-38(2)28-12-8-9-26(20-28)36-35(43)37-32-33(41)39(21-29-24-16-22-15-23(18-24)19-25(29)17-22)30-13-6-7-14-31(30)40(34(32)42)27-10-4-3-5-11-27/h3-14,20,22-25,29,32H,15-19,21H2,1-2H3,(H2,36,37,43)/t22-,23+,24-,25+,29?,32?
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1.30n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472900
PNG
(CHEMBL331119)
Show SMILES CC(=O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C35H37N5O4/c1-22(41)36-26-8-7-9-27(17-26)37-34(44)38-31-32(42)39(21-35-18-23-14-24(19-35)16-25(15-23)20-35)29-12-5-6-13-30(29)40(33(31)43)28-10-3-2-4-11-28/h2-13,17,23-25,31H,14-16,18-21H2,1H3,(H,36,41)(H2,37,38,44)/t23-,24+,25-,31?,35?
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1.30n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472851
PNG
(CHEMBL331763)
Show SMILES CC(O)C(O)Nc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C36H41N5O5/c1-22(42)32(43)37-26-8-7-9-27(17-26)38-35(46)39-31-33(44)40(21-36-18-23-14-24(19-36)16-25(15-23)20-36)29-12-5-6-13-30(29)41(34(31)45)28-10-3-2-4-11-28/h2-13,17,22-25,31-32,37,42-43H,14-16,18-21H2,1H3,(H2,38,39,46)/t22?,23-,24+,25-,31?,32?,36?
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1.30n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472874
PNG
(CHEMBL118189)
Show SMILES Brc1ccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)cc1
Show InChI InChI=1S/C33H33BrN4O3/c34-24-10-12-25(13-11-24)35-32(41)36-29-30(39)37(20-33-17-21-14-22(18-33)16-23(15-21)19-33)27-8-4-5-9-28(27)38(31(29)40)26-6-2-1-3-7-26/h1-13,21-23,29H,14-20H2,(H2,35,36,41)/t21-,22+,23-,29?,33?
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1.40n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472880
PNG
(CHEMBL338278)
Show SMILES CC(C)(C1CCCC1)N1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2cccc(c2)C2N=NN=N2)C1=O
Show InChI InChI=1S/C31H32N8O3/c1-31(2,21-12-6-7-13-21)39-25-18-9-8-17-24(25)38(23-15-4-3-5-16-23)28(40)26(29(39)41)33-30(42)32-22-14-10-11-20(19-22)27-34-36-37-35-27/h3-5,8-11,14-19,21,26-27H,6-7,12-13H2,1-2H3,(H2,32,33,42)
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1.5n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472850
PNG
(CHEMBL278018)
Show SMILES O=C(NC1C(=O)N(C2CC3CCC2C3)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C29H28N4O3/c34-27-26(31-29(36)30-21-9-3-1-4-10-21)28(35)33(25-18-19-15-16-20(25)17-19)24-14-8-7-13-23(24)32(27)22-11-5-2-6-12-22/h1-14,19-20,25-26H,15-18H2,(H2,30,31,36)
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1.5n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472859
PNG
(CHEMBL120031)
Show SMILES Cc1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C34H36N4O3/c1-22-8-7-9-26(14-22)35-33(41)36-30-31(39)37(21-34-18-23-15-24(19-34)17-25(16-23)20-34)28-12-5-6-13-29(28)38(32(30)40)27-10-3-2-4-11-27/h2-14,23-25,30H,15-21H2,1H3,(H2,35,36,41)/t23-,24+,25-,30?,34?
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1.5n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50211670
PNG
(CHEMBL103750)
Show SMILES CC(C)CCN1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C27H28N4O3/c1-19(2)17-18-30-22-15-9-10-16-23(22)31(21-13-7-4-8-14-21)26(33)24(25(30)32)29-27(34)28-20-11-5-3-6-12-20/h3-16,19,24H,17-18H2,1-2H3,(H2,28,29,34)
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1.5n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM81962
PNG
(S-L-365,260)
Show SMILES CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1S/C24H22N4O2/c1-16-9-8-12-18(15-16)25-24(30)27-22-23(29)28(2)20-14-7-6-13-19(20)21(26-22)17-10-4-3-5-11-17/h3-15,22H,1-2H3,(H2,25,27,30)/t22-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against human Cholecystokinin type B receptor


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472861
PNG
(CHEMBL121267)
Show SMILES Clc1cccc(NC(=O)NC2C(=O)N(C3CC4CCC3C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C29H27ClN4O3/c30-20-7-6-8-21(17-20)31-29(37)32-26-27(35)33(22-9-2-1-3-10-22)23-11-4-5-12-24(23)34(28(26)36)25-16-18-13-14-19(25)15-18/h1-12,17-19,25-26H,13-16H2,(H2,31,32,37)
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1.70n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50449787
PNG
(CHEMBL2062154 | PD-134308)
Show SMILES C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C(=O)NC[C@H](NC(=O)CCC(O)=O)c1ccccc1
Show InChI InChI=1S/C35H42N4O6/c1-35(18-26-19-36-28-10-6-5-9-27(26)28,39-34(44)45-32-24-14-21-13-22(16-24)17-25(32)15-21)33(43)37-20-29(23-7-3-2-4-8-23)38-30(40)11-12-31(41)42/h2-10,19,21-22,24-25,29,32,36H,11-18,20H2,1H3,(H,37,43)(H,38,40)(H,39,44)(H,41,42)/t21-,22+,24-,25+,29-,32?,35+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition by displacing [3H]CCK-8S against Cholecystokinin type B receptor of guinea pig


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472863
PNG
(CHEMBL333979)
Show SMILES CC(C)CCN1c2ccccc2N(c2ccccc2F)C(=O)C(NC(=O)Nc2cccc(c2)N(C)C)C1=O
Show InChI InChI=1S/C29H32FN5O3/c1-19(2)16-17-34-24-14-7-8-15-25(24)35(23-13-6-5-12-22(23)30)28(37)26(27(34)36)32-29(38)31-20-10-9-11-21(18-20)33(3)4/h5-15,18-19,26H,16-17H2,1-4H3,(H2,31,32,38)
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1.90n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472891
PNG
(CHEMBL334020)
Show SMILES O=C(NC1C(=O)N(CC2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1ccccc1
Show InChI InChI=1S/C33H34N4O3/c38-31-30(35-33(40)34-25-9-3-1-4-10-25)32(39)37(26-11-5-2-6-12-26)29-14-8-7-13-28(29)36(31)20-27-23-16-21-15-22(18-23)19-24(27)17-21/h1-14,21-24,27,30H,15-20H2,(H2,34,35,40)/t21-,22+,23-,24+,27?,30?
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1.90n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472869
PNG
(CHEMBL331405)
Show SMILES [O-][N+](=O)c1cccc(NC(=O)NC2C(=O)N(CC34C[C@H]5C[C@H](C[C@H](C5)C3)C4)c3ccccc3N(c3ccccc3)C2=O)c1
Show InChI InChI=1S/C33H33N5O5/c39-30-29(35-32(41)34-24-7-6-10-26(16-24)38(42)43)31(40)37(25-8-2-1-3-9-25)28-12-5-4-11-27(28)36(30)20-33-17-21-13-22(18-33)15-23(14-21)19-33/h1-12,16,21-23,29H,13-15,17-20H2,(H2,34,35,41)/t21-,22+,23-,29?,33?
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1.90n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472862
PNG
(CHEMBL332595)
Show SMILES CC(C)CC(C)N1c2ccccc2N(c2ccccc2)C(=O)C(NC(=O)Nc2ccccc2)C1=O
Show InChI InChI=1S/C28H30N4O3/c1-19(2)18-20(3)31-23-16-10-11-17-24(23)32(22-14-8-5-9-15-22)27(34)25(26(31)33)30-28(35)29-21-12-6-4-7-13-21/h4-17,19-20,25H,18H2,1-3H3,(H2,29,30,35)
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2.10n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (Human))
BDBM50472896
PNG
(CHEMBL331688)
Show SMILES O=C(NC1C(=O)N(C2[C@H]3C[C@@H]4C[C@@H](C[C@H]2C4)C3)c2ccccc2N(c2ccccc2)C1=O)Nc1cccc(c1)C1N=NN=N1
Show InChI InChI=1S/C33H32N8O3/c42-31-28(35-33(44)34-24-8-6-7-21(18-24)30-36-38-39-37-30)32(43)41(29-22-14-19-13-20(16-22)17-23(29)15-19)27-12-5-4-11-26(27)40(31)25-9-2-1-3-10-25/h1-12,18-20,22-23,28-30H,13-17H2,(H2,34,35,44)/t19-,20+,22-,23+,28?,29?
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2.10n/an/an/an/an/an/an/an/a



Glaxo Wellcome Medicines Research Centre

Curated by ChEMBL


Assay Description
In vitro inhibition of binding of [3H]pCCK-8 against Cholecystokinin type B receptor of guinea pig cerebral cortex membranes


J Med Chem 43: 3596-613 (2000)


BindingDB Entry DOI: 10.7270/Q26H4M5V
More data for this
Ligand-Target Pair
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