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Compile Data Set for Download or QSAR

Found 542 hits with Last Name = 'frydenvang' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA3


(RAT)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00220n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00270n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00390n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.00520n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0170n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0210n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0220n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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0.0400n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.0440n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.0450n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.0800n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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0.0810n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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0.150n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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0.200n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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0.390n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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0.730n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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0.75n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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1.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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1.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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1.60n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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2.40n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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2.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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2.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426285
PNG
(CHEMBL2312403)
Show SMILES CN(O)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C9H16N2O6/c1-11(17)7(12)3-2-5(8(13)14)4-6(10)9(15)16/h5-6,17H,2-4,10H2,1H3,(H,13,14)(H,15,16)/t5-,6+/s2
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3.40n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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3.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50349983
PNG
(CHEMBL1812596)
Show SMILES N[C@@H](Cn1c2cscc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1/C9H9N3O4S/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h2-3,5H,1,10H2,(H,14,15)(H,11,13,16)/t5-/s2
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3.90n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50252920
PNG
((S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno...)
Show SMILES N[C@@H](Cn1c2CSCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1/C9H11N3O4S/c10-5(8(14)15)1-12-6-3-17-2-4(6)7(13)11-9(12)16/h5H,1-3,10H2,(H,14,15)(H,11,13,16)/t5-/s2
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5.20n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50252922
PNG
((S)-1-(2'-Amino-2'-carboxyethyl)thieno[3,2-d]pyrim...)
Show SMILES N[C@@H](Cn1c2ccsc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1/C9H9N3O4S/c10-4(8(14)15)3-12-5-1-2-17-6(5)7(13)11-9(12)16/h1-2,4H,3,10H2,(H,14,15)(H,11,13,16)/t4-/s2
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5.29n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50349981
PNG
(CHEMBL1812598)
Show SMILES N[C@@H](Cn1c2sccc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1/C9H9N3O4S/c10-5(8(14)15)3-12-7-4(1-2-17-7)6(13)11-9(12)16/h1-2,5H,3,10H2,(H,14,15)(H,11,13,16)/t5-/s2
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5.89n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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7.70n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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10n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426289
PNG
(CHEMBL2312683)
Show SMILES N[C@@H](C[C@@H](CCC(=O)NO)C(O)=O)C(O)=O
Show InChI InChI=1/C8H14N2O6/c9-5(8(14)15)3-4(7(12)13)1-2-6(11)10-16/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5+/s2
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13n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O
Show InChI InChI=1/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/s2
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17n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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17n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cells


J Med Chem 53: 8354-8361 (2010)


Article DOI: 10.1021/jm101218a
BindingDB Entry DOI: 10.7270/Q20Z73HW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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19n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]KA from rat recombinant GluR6 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50002368
PNG
((R,S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)p...)
Show SMILES Cc1onc(C(O)=O)c1CC(N)C(O)=O
Show InChI InChI=1/C8H10N2O5/c1-3-4(2-5(9)7(11)12)6(8(13)14)10-15-3/h5H,2,9H2,1H3,(H,11,12)(H,13,14)
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20n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by PDSP Ki Database




Chirality 13: 523-32 (2001)


Article DOI: 10.1002/chir.1172
BindingDB Entry DOI: 10.7270/Q2Z31X6K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA3


(RAT)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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21n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cells


J Med Chem 53: 8354-8361 (2010)


Article DOI: 10.1021/jm101218a
BindingDB Entry DOI: 10.7270/Q20Z73HW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor 1 (GluA1)


(Rattus norvegicus (Rat))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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22n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cells


J Med Chem 53: 8354-8361 (2010)


Article DOI: 10.1021/jm101218a
BindingDB Entry DOI: 10.7270/Q20Z73HW
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50207593
PNG
((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...)
Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O
Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
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23n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50316376
PNG
((S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)pro...)
Show SMILES Cc1onc(C(O)=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1/C8H10N2O5/c1-3-4(2-5(9)7(11)12)6(8(13)14)10-15-3/h5H,2,9H2,1H3,(H,11,12)(H,13,14)/t5-/s2
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25n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by PDSP Ki Database




Chirality 13: 523-32 (2001)


Article DOI: 10.1002/chir.1172
BindingDB Entry DOI: 10.7270/Q2Z31X6K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate kainate


(RAT)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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31n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50426290
PNG
(CHEMBL2312682)
Show SMILES N[C@@H](C[C@@H](CCC#N)C(O)=O)C(O)=O
Show InChI InChI=1/C8H12N2O4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-2,4,10H2,(H,11,12)(H,13,14)/t5-,6+/s2
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35n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluK3 receptor expressed in sf9 cells by liquid scintillation cou...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50426299
PNG
(CHEMBL2312398)
Show SMILES CN(C)C(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1/C10H18N2O5/c1-12(2)8(13)4-3-6(9(14)15)5-7(11)10(16)17/h6-7H,3-5,11H2,1-2H3,(H,14,15)(H,16,17)/t6-,7+/s2
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37n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]-(2S,4R)-4-methylglutamic acid from full length recombinant rat GluKK1(Q)1b receptor expressed in sf9 cells by liquid scintillati...


J Med Chem 56: 1614-28 (2013)


Article DOI: 10.1021/jm301433m
BindingDB Entry DOI: 10.7270/Q23F4R0N
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5


(Rattus norvegicus)
BDBM50211399
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazo...)
Show SMILES NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Show InChI InChI=1/C14H14N6O4/c15-10(14(22)23)6-9-11(24-18-13(9)21)12-16-19-20(17-12)7-8-4-2-1-3-5-8/h1-5,10H,6-7,15H2,(H,18,21)(H,22,23)
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39n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]KA from rat recombinant GluR6 expressed in Sf9 cells


J Med Chem 50: 2408-14 (2007)


Article DOI: 10.1021/jm061439q
BindingDB Entry DOI: 10.7270/Q2DZ0809
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM2219
PNG
((S)-Demethyl-ACPA | Demethyl-ACPA)
Show SMILES N[C@@H](Cc1conc1C(O)=O)C(O)=O
Show InChI InChI=1/C7H8N2O5/c8-4(6(10)11)1-3-2-14-9-5(3)7(12)13/h2,4H,1,8H2,(H,10,11)(H,12,13)/t4-/s2
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39n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by PDSP Ki Database




Chirality 13: 523-32 (2001)


Article DOI: 10.1002/chir.1172
BindingDB Entry DOI: 10.7270/Q2Z31X6K
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 4


(Rattus norvegicus)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cells


J Med Chem 53: 8354-8361 (2010)


Article DOI: 10.1021/jm101218a
BindingDB Entry DOI: 10.7270/Q20Z73HW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA3


(RAT)
BDBM50002370
PNG
((R,S)-alpha-amino-3-hydroxy-5-methyl-4-isooxazole-...)
Show SMILES Cc1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
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40n/an/an/an/an/an/an/an/a



The Royal Danish School of Pharmacy

Curated by PDSP Ki Database




Chirality 13: 523-32 (2001)


Article DOI: 10.1002/chir.1172
BindingDB Entry DOI: 10.7270/Q2Z31X6K
More data for this
Ligand-Target Pair
Glutamate kainate


(RAT)
BDBM50107595
PNG
((S)-1-(2-Amino-2-carboxyethyl)-6,7-dihydro-1H-cycl...)
Show SMILES N[C@@H](Cn1c2CCCc2c(=O)[nH]c1=O)C(O)=O
Show InChI InChI=1/C10H13N3O4/c11-6(9(15)16)4-13-7-3-1-2-5(7)8(14)12-10(13)17/h6H,1-4,11H2,(H,15,16)(H,12,14,17)/t6-/s2
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44n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from rat GluK1 expressed in Sf9 cells


J Med Chem 54: 4793-805 (2011)


Article DOI: 10.1021/jm2004078
BindingDB Entry DOI: 10.7270/Q2RR1ZM2
More data for this
Ligand-Target Pair
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