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Compile Data Set for Download or QSAR

Found 263 hits with Last Name = 'fujio' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218398
PNG
(CHEMBL1907861)
Show SMILES Fc1ccc(CCN2CC[C@@H](C2)NC(=O)C23CC4CC(CC(C4)C2)C3)cc1
Show InChI InChI=1S/C23H31FN2O/c24-20-3-1-16(2-4-20)5-7-26-8-6-21(15-26)25-22(27)23-12-17-9-18(13-23)11-19(10-17)14-23/h1-4,17-19,21H,5-15H2,(H,25,27)/t17?,18?,19?,21-,23?/m0/s1
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0.0900n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201292
PNG
(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1
Show InChI InChI=1S/C19H28Cl2N2O3/c1-23(2)19(11-22-6-3-14-4-7-24-8-5-14)12-25-17-9-15(20)16(21)10-18(17)26-13-19/h9-10,14,22H,3-8,11-13H2,1-2H3
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0.120n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218392
PNG
(CHEMBL79277)
Show SMILES Fc1ccccc1CCN1CCC(C1)NC(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H31FN2O/c24-21-4-2-1-3-19(21)5-7-26-8-6-20(15-26)25-22(27)23-12-16-9-17(13-23)11-18(10-16)14-23/h1-4,16-18,20H,5-15H2,(H,25,27)
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0.140n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50218388
PNG
(CHEMBL78986)
Show SMILES O=C(N[C@@H]1CCN(CCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H32N2O/c26-22(23-13-18-10-19(14-23)12-20(11-18)15-23)24-21-7-9-25(16-21)8-6-17-4-2-1-3-5-17/h1-5,18-21H,6-16H2,(H,24,26)/t18?,19?,20?,21-,23?/m1/s1
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0.170n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50218397
PNG
(CHEMBL83611)
Show SMILES O=C(NC1CCN(CCCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H34N2O/c27-23(24-14-19-11-20(15-24)13-21(12-19)16-24)25-22-8-10-26(17-22)9-4-7-18-5-2-1-3-6-18/h1-3,5-6,19-22H,4,7-17H2,(H,25,27)
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0.190n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201292
PNG
(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1
Show InChI InChI=1S/C19H28Cl2N2O3/c1-23(2)19(11-22-6-3-14-4-7-24-8-5-14)12-25-17-9-15(20)16(21)10-18(17)26-13-19/h9-10,14,22H,3-8,11-13H2,1-2H3
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0.220n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218396
PNG
(CHEMBL315259)
Show SMILES O=C(N[C@H]1CCN(CCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H32N2O/c26-22(23-13-18-10-19(14-23)12-20(11-18)15-23)24-21-7-9-25(16-21)8-6-17-4-2-1-3-5-17/h1-5,18-21H,6-16H2,(H,24,26)/t18?,19?,20?,21-,23?/m0/s1
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0.240n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218397
PNG
(CHEMBL83611)
Show SMILES O=C(NC1CCN(CCCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H34N2O/c27-23(24-14-19-11-20(15-24)13-21(12-19)16-24)25-22-8-10-26(17-22)9-4-7-18-5-2-1-3-6-18/h1-3,5-6,19-22H,4,7-17H2,(H,25,27)
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0.320n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218399
PNG
(CHEMBL79643)
Show SMILES Clc1ccc(CCN2CCC(C2)NC(=O)C23CC4CC(CC(C4)C2)C3)cc1
Show InChI InChI=1S/C23H31ClN2O/c24-20-3-1-16(2-4-20)5-7-26-8-6-21(15-26)25-22(27)23-12-17-9-18(13-23)11-19(10-17)14-23/h1-4,17-19,21H,5-15H2,(H,25,27)
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0.440n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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0.470n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50086855
PNG
(CHEMBL82884 | Cyclohexanecarboxylic acid ((S)-1-ph...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)C1CCCCC1
Show InChI InChI=1S/C20H30N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1,3-4,8-9,18-19H,2,5-7,10-16H2,(H,21,23)/t19-/m0/s1
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0.490n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50086855
PNG
(CHEMBL82884 | Cyclohexanecarboxylic acid ((S)-1-ph...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)C1CCCCC1
Show InChI InChI=1S/C20H30N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1,3-4,8-9,18-19H,2,5-7,10-16H2,(H,21,23)/t19-/m0/s1
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0.490n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50218400
PNG
(CHEMBL1907669)
Show SMILES Fc1ccc(CCN2CC[C@H](C2)NC(=O)C23CC4CC(CC(C4)C2)C3)cc1
Show InChI InChI=1S/C23H31FN2O/c24-20-3-1-16(2-4-20)5-7-26-8-6-21(15-26)25-22(27)23-12-17-9-18(13-23)11-19(10-17)14-23/h1-4,17-19,21H,5-15H2,(H,25,27)/t17?,18?,19?,21-,23?/m1/s1
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0.530n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50218391
PNG
(CHEMBL79528)
Show SMILES Fc1cccc(CCN2CCC(C2)NC(=O)C23CC4CC(CC(C4)C2)C3)c1
Show InChI InChI=1S/C23H31FN2O/c24-20-3-1-2-16(11-20)4-6-26-7-5-21(15-26)25-22(27)23-12-17-8-18(13-23)10-19(9-17)14-23/h1-3,11,17-19,21H,4-10,12-15H2,(H,25,27)
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0.550n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201280
PNG
(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Show SMILES CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1
Show InChI InChI=1S/C24H36N2O2/c1-26(2)24(16-27-21-5-3-4-6-22(21)28-17-24)15-25-8-7-23-12-18-9-19(13-23)11-20(10-18)14-23/h3-6,18-20,25H,7-17H2,1-2H3
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0.660n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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0.660n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]ketanserin


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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0.660n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50165019
PNG
(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Show SMILES CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3
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0.780n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50165019
PNG
(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Show SMILES CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3
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1n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50218393
PNG
(CHEMBL79542)
Show SMILES O=C(N[C@@H]1CCN(CCc2ccccc2)C1)C1CCCCC1
Show InChI InChI=1S/C19H28N2O/c22-19(17-9-5-2-6-10-17)20-18-12-14-21(15-18)13-11-16-7-3-1-4-8-16/h1,3-4,7-8,17-18H,2,5-6,9-15H2,(H,20,22)/t18-/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(Rattus norvegicus (rat))
BDBM50218395
PNG
(CHEMBL311095)
Show SMILES O=C(NC1CCN(CCCCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C25H36N2O/c28-24(25-15-20-12-21(16-25)14-22(13-20)17-25)26-23-9-11-27(18-23)10-5-4-8-19-6-2-1-3-7-19/h1-3,6-7,20-23H,4-5,8-18H2,(H,26,28)
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1.10n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201280
PNG
(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Show SMILES CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1
Show InChI InChI=1S/C24H36N2O2/c1-26(2)24(16-27-21-5-3-4-6-22(21)28-17-24)15-25-8-7-23-12-18-9-19(13-23)11-20(10-18)14-23/h3-6,18-20,25H,7-17H2,1-2H3
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1.5n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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1.5n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperone


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50201292
PNG
(7,8-dichloro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyr...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1
Show InChI InChI=1S/C19H28Cl2N2O3/c1-23(2)19(11-22-6-3-14-4-7-24-8-5-14)12-25-17-9-15(20)16(21)10-18(17)26-13-19/h9-10,14,22H,3-8,11-13H2,1-2H3
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1.80n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201277
PNG
((4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][...)
Show SMILES CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1
Show InChI InChI=1S/C21H34N2O3/c1-23(2)21(15-25-19-5-3-4-6-20(19)26-16-21)14-22-12-11-17-7-9-18(13-24)10-8-17/h3-6,17-18,22,24H,7-16H2,1-2H3
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1.80n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201296
PNG
(4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][1...)
Show SMILES CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1
Show InChI InChI=1S/C20H32N2O3/c1-22(2)20(13-21-12-11-16-7-9-17(23)10-8-16)14-24-18-5-3-4-6-19(18)25-15-20/h3-6,16-17,21,23H,7-15H2,1-2H3
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1.90n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201285
PNG
(3-((2-cycloheptylethylamino)methyl)-N,N-dimethyl-3...)
Show SMILES CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C21H34N2O2/c1-23(2)21(15-22-14-13-18-9-5-3-4-6-10-18)16-24-19-11-7-8-12-20(19)25-17-21/h7-8,11-12,18,22H,3-6,9-10,13-17H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201277
PNG
((4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][...)
Show SMILES CN(C)C1(CNCCC2CCC(CO)CC2)COc2ccccc2OC1
Show InChI InChI=1S/C21H34N2O3/c1-23(2)21(15-25-19-5-3-4-6-20(19)26-16-21)14-22-12-11-17-7-9-18(13-24)10-8-17/h3-6,17-18,22,24H,7-16H2,1-2H3
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2.10n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201294
PNG
(3-((2-cyclopentylethylamino)methyl)-N,N-dimethyl-3...)
Show SMILES CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C19H30N2O2/c1-21(2)19(13-20-12-11-16-7-3-4-8-16)14-22-17-9-5-6-10-18(17)23-15-19/h5-6,9-10,16,20H,3-4,7-8,11-15H2,1-2H3
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2.40n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201283
PNG
(3-((2-cyclohexylethylamino)methyl)-N,N-dimethyl-3,...)
Show SMILES CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C20H32N2O2/c1-22(2)20(14-21-13-12-17-8-4-3-5-9-17)15-23-18-10-6-7-11-19(18)24-16-20/h6-7,10-11,17,21H,3-5,8-9,12-16H2,1-2H3
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2.5n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201285
PNG
(3-((2-cycloheptylethylamino)methyl)-N,N-dimethyl-3...)
Show SMILES CN(C)C1(CNCCC2CCCCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C21H34N2O2/c1-23(2)21(15-22-14-13-18-9-5-3-4-6-10-18)16-24-19-11-7-8-12-20(19)25-17-21/h7-8,11-12,18,22H,3-6,9-10,13-17H2,1-2H3
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2.70n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201296
PNG
(4-(2-((3-(dimethylamino)-3,4-dihydro-2H-benzo[b][1...)
Show SMILES CN(C)C1(CNCCC2CCC(O)CC2)COc2ccccc2OC1
Show InChI InChI=1S/C20H32N2O3/c1-22(2)20(13-21-12-11-16-7-9-17(23)10-8-16)14-24-18-5-3-4-6-19(18)25-15-20/h3-6,16-17,21,23H,7-15H2,1-2H3
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2.90n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(Homo sapiens (Human))
BDBM50218398
PNG
(CHEMBL1907861)
Show SMILES Fc1ccc(CCN2CC[C@@H](C2)NC(=O)C23CC4CC(CC(C4)C2)C3)cc1
Show InChI InChI=1S/C23H31FN2O/c24-20-3-1-16(2-4-20)5-7-26-8-6-21(15-26)25-22(27)23-12-17-9-18(13-23)11-19(10-17)14-23/h1-4,17-19,21H,5-15H2,(H,25,27)/t17?,18?,19?,21-,23?/m0/s1
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3n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Ability to displace [3H]-Prazosin binding to Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201294
PNG
(3-((2-cyclopentylethylamino)methyl)-N,N-dimethyl-3...)
Show SMILES CN(C)C1(CNCCC2CCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C19H30N2O2/c1-21(2)19(13-20-12-11-16-7-3-4-8-16)14-22-17-9-5-6-10-18(17)23-15-19/h5-6,9-10,16,20H,3-4,7-8,11-15H2,1-2H3
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3.30n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(Homo sapiens (Human))
BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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3.5n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Ability to displace [3H]-Prazosin binding to Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190686
PNG
((R)-3'-(2,3-dimethylbenzo[b]thiophen-5-yl)spiro[1-...)
Show SMILES Cc1oc2ccc(cc2c1C)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C19H22N2O3/c1-12-13(2)23-17-4-3-15(9-16(12)17)21-11-19(24-18(21)22)10-20-7-5-14(19)6-8-20/h3-4,9,14H,5-8,10-11H2,1-2H3/t19-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164606
PNG
((2R)-3'-(5-bromothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES Brc1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C13H15BrN2O2S/c14-10-1-2-11(19-10)16-8-13(18-12(16)17)7-15-5-3-9(13)4-6-15/h1-2,9H,3-8H2/t13-/m1/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190677
PNG
((R)-3'-(3-bromobenzo[b]thiophen-5-yl)spiro[1-azabi...)
Show SMILES Brc1coc2ccc(cc12)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C17H17BrN2O3/c18-14-8-22-15-2-1-12(7-13(14)15)20-10-17(23-16(20)21)9-19-5-3-11(17)4-6-19/h1-2,7-8,11H,3-6,9-10H2/t17-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190696
PNG
((2S)-3'-(5-bromothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES Brc1ccc(s1)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C13H15BrN2O2S/c14-10-1-2-11(19-10)16-8-13(18-12(16)17)7-15-5-3-9(13)4-6-15/h1-2,9H,3-8H2/t13-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201299
PNG
(7-fluoro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyran-4...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1
Show InChI InChI=1S/C19H29FN2O3/c1-22(2)19(12-21-8-5-15-6-9-23-10-7-15)13-24-17-4-3-16(20)11-18(17)25-14-19/h3-4,11,15,21H,5-10,12-14H2,1-2H3
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4.20n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50086861
PNG
(3-Methylsulfanyl-N-((S)-1-phenethyl-pyrrolidin-2-y...)
Show SMILES CSc1cccc(c1)C(=O)NC[C@@H]1CCCN1CCc1ccccc1
Show InChI InChI=1S/C21H26N2OS/c1-25-20-11-5-9-18(15-20)21(24)22-16-19-10-6-13-23(19)14-12-17-7-3-2-4-8-17/h2-5,7-9,11,15,19H,6,10,12-14,16H2,1H3,(H,22,24)/t19-/m0/s1
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4.30n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50086856
PNG
(CHEMBL147279 | N-((S)-1-Phenethyl-pyrrolidin-2-ylm...)
Show SMILES O=C(NC[C@@H]1CCCN1CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H24N2O/c23-20(18-10-5-2-6-11-18)21-16-19-12-7-14-22(19)15-13-17-8-3-1-4-9-17/h1-6,8-11,19H,7,12-16H2,(H,21,23)/t19-/m0/s1
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4.60n/an/an/an/an/an/an/an/a



Yoshitomi Pharmaceutical Industries, Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat striata 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 10: 509-12 (2000)


Article DOI: 10.1016/s0960-894x(00)00030-5
BindingDB Entry DOI: 10.7270/Q24Q7T7T
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201284
PNG
(3-((cyclohexylmethylamino)methyl)-N,N-dimethyl-3,4...)
Show SMILES CN(C)C1(CNCC2CCCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C19H30N2O2/c1-21(2)19(13-20-12-16-8-4-3-5-9-16)14-22-17-10-6-7-11-18(17)23-15-19/h6-7,10-11,16,20H,3-5,8-9,12-15H2,1-2H3
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4.90n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201299
PNG
(7-fluoro-N,N-dimethyl-3-((2-(tetrahydro-2H-pyran-4...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2ccc(F)cc2OC1
Show InChI InChI=1S/C19H29FN2O3/c1-22(2)19(12-21-8-5-15-6-9-23-10-7-15)13-24-17-4-3-16(20)11-18(17)25-14-19/h3-4,11,15,21H,5-10,12-14H2,1-2H3
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5.10n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50093797
PNG
(Adamantane-1-carboxylic acid {1-[2-(4-cyano-phenyl...)
Show SMILES O=C(NC1CCN(CCc2ccc(cc2)C#N)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H31N3O/c25-15-18-3-1-17(2-4-18)5-7-27-8-6-22(16-27)26-23(28)24-12-19-9-20(13-24)11-21(10-19)14-24/h1-4,19-22H,5-14,16H2,(H,26,28)
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5.5n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 2 receptor from striata wistar rats by [3H]ketanserin displacement.


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50201276
PNG
(3-((2-(3,6-dihydro-2H-thiopyran-4-yl)ethylamino)me...)
Show SMILES CN(C)C1(CNCCC2=CCSCC2)COc2ccccc2OC1
Show InChI InChI=1S/C19H28N2O2S/c1-21(2)19(13-20-10-7-16-8-11-24-12-9-16)14-22-17-5-3-4-6-18(17)23-15-19/h3-6,8,20H,7,9-15H2,1-2H3
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5.80n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M3 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50201280
PNG
(CHEMBL394137 | {3-[(2-adamantan-1-yl-ethylamino)-m...)
Show SMILES CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1
Show InChI InChI=1S/C24H36N2O2/c1-26(2)24(16-27-21-5-3-4-6-22(21)28-17-24)15-25-8-7-23-12-18-9-19(13-23)11-20(10-18)14-23/h3-6,18-20,25H,7-17H2,1-2H3
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5.90n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M1 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201287
PNG
(CHEMBL435353 | N,N-dimethyl-3-((2-(tetrahydro-2H-p...)
Show SMILES CN(C)C1(CNCCC2CCOCC2)COc2ccccc2OC1
Show InChI InChI=1S/C19H30N2O3/c1-21(2)19(13-20-10-7-16-8-11-22-12-9-16)14-23-17-5-3-4-6-18(17)24-15-19/h3-6,16,20H,7-15H2,1-2H3
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6n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(Homo sapiens (Human))
BDBM50201283
PNG
(3-((2-cyclohexylethylamino)methyl)-N,N-dimethyl-3,...)
Show SMILES CN(C)C1(CNCCC2CCCCC2)COc2ccccc2OC1
Show InChI InChI=1S/C20H32N2O2/c1-22(2)20(14-21-13-12-17-8-4-3-5-9-17)15-23-18-10-6-7-11-19(18)24-16-20/h6-7,10-11,17,21H,3-5,8-9,12-16H2,1-2H3
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6.20n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of 1-[N-methyl- 3H]scopolamine from human muscarinic M2 receptor expressed in Sf9 cells


Bioorg Med Chem Lett 17: 925-31 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.058
BindingDB Entry DOI: 10.7270/Q2DB81HZ
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-1


(Homo sapiens (Human))
BDBM50218396
PNG
(CHEMBL315259)
Show SMILES O=C(N[C@H]1CCN(CCc2ccccc2)C1)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C23H32N2O/c26-22(23-13-18-10-19(14-23)12-20(11-18)15-23)24-21-7-9-25(16-21)8-6-17-4-2-1-3-5-17/h1-5,18-21H,6-16H2,(H,24,26)/t18?,19?,20?,21-,23?/m0/s1
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6.40n/an/an/an/an/an/an/an/a



Welfide Corporation

Curated by ChEMBL


Assay Description
Ability to displace [3H]-Prazosin binding to Alpha-1 adrenergic receptor


Bioorg Med Chem Lett 10: 2457-61 (2001)


Article DOI: 10.1016/s0960-894x(00)00492-3
BindingDB Entry DOI: 10.7270/Q2VT1SN2
More data for this
Ligand-Target Pair
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