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Compile Data Set for Download or QSAR

Found 239 hits with Last Name = 'günther' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259295
PNG
(US9499547, 36)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-13-2-1-3-15-12(13)8-16(25-15)14-9-21-17-4-5-18(22-23(14)17)24-11-6-10(20)7-11/h1-5,8-11H,6-7,20H2/t10-,11-
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n/an/a 1n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333401
PNG
(2-{[3-(Furo[2,3-c]pyridin-2-yl)imidazo[1,2-b]pyrid...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccncc4o3)n2n1
Show InChI InChI=1S/C21H20FN5O2S2/c1-11-7-26-21(31-11)13-3-2-12(6-14(13)22)8-24-19-20-25-9-15(27(20)5-4-23-19)18-17(29)16(28)10-30-18/h2-7,9,16-18,28-29H,8,10H2,1H3,(H,23,24)/t16-,17-,18+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333402
PNG
(2-{[3-(Furo[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyrid...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4cnccc4o3)n2n1
Show InChI InChI=1S/C20H19FN6O3S/c1-10-25-26-20(30-10)12-3-2-11(6-13(12)21)7-23-18-19-24-8-14(27(19)5-4-22-18)17-16(29)15(28)9-31-17/h2-6,8,15-17,28-29H,7,9H2,1H3,(H,22,23)/t15-,16-,17+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223024
PNG
(US9320737, II.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)=O)nn12
Show InChI InChI=1S/C19H19N3O4S/c1-24-15-5-3-6-16-13(15)11-17(26-16)14-12-20-18-7-8-19(21-22(14)18)25-9-4-10-27(2)23/h3,5-8,11-12H,4,9-10H2,1-2H3
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n/an/a 2n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223030
PNG
(US9320737, III.3)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-20-18-7-8-19(21-22(14)18)26-9-4-10-28(2,23)24/h3,5-8,11-12H,4,9-10H2,1-2H3
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n/an/a 2n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223043
PNG
(US9320737, IV.2)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=N)=O)nn12
Show InChI InChI=1S/C19H20N4O4S/c1-25-15-5-3-6-16-13(15)11-17(27-16)14-12-21-18-7-8-19(22-23(14)18)26-9-4-10-28(2,20)24/h3,5-8,11-12,20H,4,9-10H2,1-2H3
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n/an/a 2n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259295
PNG
(US9499547, 36)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4c(F)cccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-13-2-1-3-15-12(13)8-16(25-15)14-9-21-17-4-5-18(22-23(14)17)24-11-6-10(20)7-11/h1-5,8-11H,6-7,20H2/t10-,11-
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n/an/a 2n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333382
PNG
(3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]p...)
Show SMILES CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18F2N4O2S/c19-11-2-1-10(12(20)7-11)3-4-21-17-18-23-8-13(24(18)6-5-22-17)16-15(26)14(25)9-27-16/h1-2,5-8,14-16,25-26H,3-4,9H2,(H,21,22)/t14-,15-,16+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333390
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(CC(O)c1cccnc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16ClFN4O2S/c18-10-3-9(4-11(19)5-10)6-21-16-17-22-7-12(23(17)2-1-20-16)15-14(25)13(24)8-26-15/h1-5,7,13-15,24-25H,6,8H2,(H,20,21)/t13-,14-,15+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259297
PNG
(US9499547, 38)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(O[C@H]3C[C@H](N)C3)nn12
Show InChI InChI=1S/C19H18N4O3/c1-24-13-2-3-16-11(6-13)7-17(26-16)15-10-21-18-4-5-19(22-23(15)18)25-14-8-12(20)9-14/h2-7,10,12,14H,8-9,20H2,1H3/t12-,14-
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n/an/a 3n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259298
PNG
(US9499547, 39)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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n/an/a 3n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259260
PNG
(US9499547, 1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCCN)nn12
Show InChI InChI=1S/C19H20N4O3/c1-24-15-5-4-6-16-13(15)11-17(26-16)14-12-21-18-7-8-19(22-23(14)18)25-10-3-2-9-20/h4-8,11-12H,2-3,9-10,20H2,1H3
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n/an/a 3n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333403
PNG
(2-{[3-(4-Methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1
Show InChI InChI=1S/C19H20N8O2S/c1-26-24-17(23-25-26)12-4-2-3-11(7-12)8-21-18-19-22-9-13(27(19)6-5-20-18)16-15(29)14(28)10-30-16/h2-7,9,14-16,28-29H,8,10H2,1H3,(H,20,21)/t14-,15-,16+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214639
PNG
(US9284319, 7)
Show SMILES OC[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m1/s1
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n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223025
PNG
(US9320737, II.2)
Show SMILES CS(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O3S/c1-25(22)10-4-9-23-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)24-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223045
PNG
(US9320737, IV.4)
Show SMILES CS(=N)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O3S/c1-26(19,23)10-4-9-24-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12,19H,4,9-10H2,1H3
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n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259262
PNG
(US9499547, 3)
Show SMILES N[C@H]1C[C@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13+
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n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259279
PNG
(US9499547, 20)
Show SMILES NC[C@H]1CC(C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-10-12-7-14(8-12)24-19-6-5-18-21-11-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9,11-12,14H,7-8,10,20H2/t12-,14?
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n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259296
PNG
(US9499547, 37)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C18H15ClN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333388
PNG
(3-[(1R)-1-Hydroxy-2- {[3-(4-methoxy-1- benzofuran-...)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(nn12)N(C)C[C@H](O)c1cccc(O)c1
Show InChI InChI=1S/C17H16ClN3O2S2/c18-11-3-1-2-10(6-11)8-25-17-16-20-7-12(21(16)5-4-19-17)15-14(23)13(22)9-24-15/h1-7,13-15,22-23H,8-9H2/t13-,14-,15+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333389
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2S/c24-15-10-26-17(16(15)25)14-9-21-19-18(20-6-7-23(14)19)22-13-8-12(13)11-4-2-1-3-5-11/h1-7,9,12-13,15-17,24-25H,8,10H2,(H,20,22)/t12-,13+,15+,16+,17-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333391
PNG
((−)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]p...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H22N4O2S/c25-16-11-27-18(17(16)26)15-10-23-20-19(21-6-7-24(15)20)22-9-12-2-1-3-14(8-12)13-4-5-13/h1-3,6-8,10,13,16-18,25-26H,4-5,9,11H2,(H,21,22)/t16-,17-,18+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223026
PNG
(US9320737, II.3)
Show SMILES CS(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H19N3O3S/c1-26(23)11-5-4-10-24-19-9-8-18-20-13-15(22(18)21-19)17-12-14-6-2-3-7-16(14)25-17/h2-3,6-9,12-13H,4-5,10-11H2,1H3
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223028
PNG
(US9320737, III.1)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H17N3O4S/c1-26(22,23)10-4-9-24-18-8-7-17-19-12-14(21(17)20-18)16-11-13-5-2-3-6-15(13)25-16/h2-3,5-8,11-12H,4,9-10H2,1H3
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223029
PNG
(US9320737, III.2)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCS(C)(=O)=O)nn12
Show InChI InChI=1S/C19H19N3O5S/c1-25-14-4-5-16-13(10-14)11-17(27-16)15-12-20-18-6-7-19(21-22(15)18)26-8-3-9-28(2,23)24/h4-7,10-12H,3,8-9H2,1-2H3
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259260
PNG
(US9499547, 1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCCN)nn12
Show InChI InChI=1S/C19H20N4O3/c1-24-15-5-4-6-16-13(15)11-17(26-16)14-12-21-18-7-8-19(22-23(14)18)25-10-3-2-9-20/h4-8,11-12H,2-3,9-10,20H2,1H3
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259261
PNG
(US9499547, 2)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13-
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259263
PNG
(US9499547, 4)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-14-4-2-5-15-12(14)10-16(25-15)13-11-20-17-6-7-18(21-22(13)17)24-9-3-8-19/h2,4-7,10-11H,3,8-9,19H2,1H3
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259296
PNG
(US9499547, 37)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(Cl)ccc4o3)n2n1
Show InChI InChI=1S/C18H15ClN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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n/an/a 5n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
mknk1 high atp


(Homo sapiens (Human))
BDBM333404
PNG
(2-{[3-(4-Ethoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2...)
Show SMILES CCOc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1
Show InChI InChI=1S/C19H19FN4O2S/c20-11-3-1-2-10(6-11)12-7-13(12)23-18-19-22-8-14(24(19)5-4-21-18)17-16(26)15(25)9-27-17/h1-6,8,12-13,15-17,25-26H,7,9H2,(H,21,23)/t12-,13+,15-,16-,17+/m1/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)

More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214635
PNG
(US9284319, 3)
Show SMILES OC1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259261
PNG
(US9499547, 2)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c19-12-8-13(9-12)23-18-6-5-17-20-10-14(22(17)21-18)16-7-11-3-1-2-4-15(11)24-16/h1-7,10,12-13H,8-9,19H2/t12-,13-
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259279
PNG
(US9499547, 20)
Show SMILES NC[C@H]1CC(C1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-10-12-7-14(8-12)24-19-6-5-18-21-11-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9,11-12,14H,7-8,10,20H2/t12-,14?
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259264
PNG
(US9499547, 5)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-13-3-2-4-14-11(13)9-15(24-14)12-10-19-16-5-6-17(20-21(12)16)23-8-7-18/h2-6,9-10H,7-8,18H2,1H3
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259265
PNG
(US9499547, 6)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCN)nn12
Show InChI InChI=1S/C17H16N4O3/c1-22-12-2-3-14-11(8-12)9-15(24-14)13-10-19-16-4-5-17(20-21(13)16)23-7-6-18/h2-5,8-10H,6-7,18H2,1H3
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259276
PNG
(US9499547, 17)
Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m1/s1
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259281
PNG
(US9499547, 22)
Show SMILES N[C@H]1C[C@H](COc2ccc3ncc(-c4cc5ccccc5o4)n3n2)C1
Show InChI InChI=1S/C19H18N4O2/c20-14-7-12(8-14)11-24-19-6-5-18-21-10-15(23(18)22-19)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14H,7-8,11,20H2/t12-,14-
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259297
PNG
(US9499547, 38)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(O[C@H]3C[C@H](N)C3)nn12
Show InChI InChI=1S/C19H18N4O3/c1-24-13-2-3-16-11(6-13)7-17(26-16)15-10-21-18-4-5-19(22-23(15)18)25-14-8-12(20)9-14/h2-7,10,12,14H,8-9,20H2,1H3/t12-,14-
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259298
PNG
(US9499547, 39)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H15FN4O2/c19-11-1-2-15-10(5-11)6-16(25-15)14-9-21-17-3-4-18(22-23(14)17)24-13-7-12(20)8-13/h1-6,9,12-13H,7-8,20H2/t12-,13-
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214633
PNG
(US9284319, 1)
Show SMILES OC[C@@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m0/s1
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BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223031
PNG
(US9320737, III.4)
Show SMILES CS(=O)(=O)CCCOc1ccc2ncc(-c3cc4cc(F)ccc4o3)n2n1
Show InChI InChI=1S/C18H16FN3O4S/c1-27(23,24)8-2-7-25-18-6-5-17-20-11-14(22(17)21-18)16-10-12-9-13(19)3-4-15(12)26-16/h3-6,9-11H,2,7-8H2,1H3
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223050
PNG
(US9320737, IV.8)
Show SMILES CS(=O)(CCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1)=NC#N
Show InChI InChI=1S/C19H17N5O3S/c1-28(25,22-13-20)10-4-9-26-19-8-7-18-21-12-15(24(18)23-19)17-11-14-5-2-3-6-16(14)27-17/h2-3,5-8,11-12H,4,9-10H2,1H3
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259266
PNG
(US9499547, 7)
Show SMILES C[C@H](N)COc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c1-11(18)10-22-17-7-6-16-19-9-13(21(16)20-17)15-8-12-4-2-3-5-14(12)23-15/h2-9,11H,10,18H2,1H3/t11-/m0/s1
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259267
PNG
(US9499547, 8)
Show SMILES NCCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c19-9-3-4-10-23-18-8-7-17-20-12-14(22(17)21-18)16-11-13-5-1-2-6-15(13)24-16/h1-2,5-8,11-12H,3-4,9-10,19H2
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259268
PNG
(US9499547, 9)
Show SMILES COc1ccc2oc(cc2c1)-c1cnc2ccc(OCCCN)nn12
Show InChI InChI=1S/C18H18N4O3/c1-23-13-3-4-15-12(9-13)10-16(25-15)14-11-20-17-5-6-18(21-22(14)17)24-8-2-7-19/h3-6,9-11H,2,7-8,19H2,1H3
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259284
PNG
(US9499547, 25)
Show SMILES N[C@H]1CCC[C@H]1Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c20-13-5-3-7-16(13)25-19-9-8-18-21-11-14(23(18)22-19)17-10-12-4-1-2-6-15(12)24-17/h1-2,4,6,8-11,13,16H,3,5,7,20H2/t13-,16+/m0/s1
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223048
PNG
(US9320737, IV.6)
Show SMILES CS(=N)(=O)CCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O3S/c1-27(20,24)11-5-4-10-25-19-9-8-18-21-13-15(23(18)22-19)17-12-14-6-2-3-7-16(14)26-17/h2-3,6-9,12-13,20H,4-5,10-11H2,1H3
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n/an/a 8n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259269
PNG
(US9499547, 10)
Show SMILES CC(C)(CCN)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H20N4O2/c1-19(2,9-10-20)25-18-8-7-17-21-12-14(23(17)22-18)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10,20H2,1-2H3
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n/an/a 8n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D)


(Homo sapiens (Human))
BDBM259270
PNG
(US9499547, 11)
Show SMILES NCCCOc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H16N4O2/c18-8-3-9-22-17-7-6-16-19-11-13(21(16)20-17)15-10-12-4-1-2-5-14(12)23-15/h1-2,4-7,10-11H,3,8-9,18H2
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n/an/a 8n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9499547 (2016)


BindingDB Entry DOI: 10.7270/Q2736PVK
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM223042
PNG
(US9320737, IV.1)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCCCS(C)(=O)=NC(=O)C(F)(F)F)nn12
Show InChI InChI=1S/C21H19F3N4O5S/c1-31-15-5-3-6-16-13(15)11-17(33-16)14-12-25-18-7-8-19(26-28(14)18)32-9-4-10-34(2,30)27-20(29)21(22,23)24/h3,5-8,11-12H,4,9-10H2,1-2H3
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n/an/a 9n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 mL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9320737 (2016)


BindingDB Entry DOI: 10.7270/Q22V2F00
More data for this
Ligand-Target Pair
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