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Compile Data Set for Download or QSAR

Found 83 hits with Last Name = 'gibson' and Initial = 'kh'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102078
PNG
(CHEMBL56936 | N-{2-[4-(3-Chloro-4-fluoro-phenylami...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCNCCN(C)C
Show InChI InChI=1S/C21H25ClFN5O2/c1-28(2)8-6-24-7-9-30-20-11-15-18(12-19(20)29-3)25-13-26-21(15)27-14-4-5-17(23)16(22)10-14/h4-5,10-13,24H,6-9H2,1-3H3,(H,25,26,27)
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n/an/a 2n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102091
PNG
(1-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-qui...)
Show SMILES CNCC(O)COc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1/C19H20ClFN4O3/c1-22-8-12(26)9-28-18-6-13-16(7-17(18)27-2)23-10-24-19(13)25-11-3-4-15(21)14(20)5-11/h3-7,10,12,22,26H,8-9H2,1-2H3,(H,23,24,25)
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AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102093
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-m-tolyl-amine | 6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C17H17N3O2/c1-11-5-4-6-12(7-11)20-17-13-8-15(21-2)16(22-3)9-14(13)18-10-19-17/h4-10H,1-3H3,(H,18,19,20)
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102088
PNG
(1-[Bis-(2-hydroxy-ethyl)-amino]-3-[4-(3-chloro-4-f...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCC(O)CN(CCO)CCO
Show InChI InChI=1/C22H26ClFN4O5/c1-32-20-10-19-16(9-21(20)33-12-15(31)11-28(4-6-29)5-7-30)22(26-13-25-19)27-14-2-3-18(24)17(23)8-14/h2-3,8-10,13,15,29-31H,4-7,11-12H2,1H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102085
PNG
(1-Amino-3-[4-(3-chloro-4-fluoro-phenylamino)-7-met...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCC(O)CN
Show InChI InChI=1/C18H18ClFN4O3/c1-26-16-6-15-12(5-17(16)27-8-11(25)7-21)18(23-9-22-15)24-10-2-3-14(20)13(19)4-10/h2-6,9,11,25H,7-8,21H2,1H3,(H,22,23,24)
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n/an/a 6n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290631
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-isoquinolin-4-yl-a...)
Show SMILES COc1cc2ncnc(Nc3cncc4ccccc34)c2cc1OC
Show InChI InChI=1S/C19H16N4O2/c1-24-17-7-14-15(8-18(17)25-2)21-11-22-19(14)23-16-10-20-9-12-5-3-4-6-13(12)16/h3-11H,1-2H3,(H,21,22,23)
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n/an/a 6.40n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102080
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(2-dimethylamino-eth...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN(C)C
Show InChI InChI=1S/C19H20ClFN4O2/c1-25(2)6-7-27-18-9-13-16(10-17(18)26-3)22-11-23-19(13)24-12-4-5-15(21)14(20)8-12/h4-5,8-11H,6-7H2,1-3H3,(H,22,23,24)
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n/an/a 7n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102081
PNG
((3-Chloro-4-fluoro-phenyl)-{7-methoxy-6-[2-(2-meth...)
Show SMILES COCCNCCOc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1S/C20H22ClFN4O3/c1-27-7-5-23-6-8-29-19-10-14-17(11-18(19)28-2)24-12-25-20(14)26-13-3-4-16(22)15(21)9-13/h3-4,9-12,23H,5-8H2,1-2H3,(H,24,25,26)
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n/an/a 8n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102069
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-methyla...)
Show SMILES CNCCOc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1S/C18H18ClFN4O2/c1-21-5-6-26-17-8-12-15(9-16(17)25-2)22-10-23-18(12)24-11-3-4-14(20)13(19)7-11/h3-4,7-10,21H,5-6H2,1-2H3,(H,22,23,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102071
PNG
(1-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-qui...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCC(O)Cn1ccnc1
Show InChI InChI=1/C21H19ClFN5O3/c1-30-19-8-18-15(7-20(19)31-10-14(29)9-28-5-4-24-12-28)21(26-11-25-18)27-13-2-3-17(23)16(22)6-13/h2-8,11-12,14,29H,9-10H2,1H3,(H,25,26,27)
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n/an/a 8n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 9n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102083
PNG
((3-Chloro-4-fluoro-phenyl)-{7-methoxy-6-[2-(4-meth...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN1CCN(C)CC1
Show InChI InChI=1S/C22H25ClFN5O2/c1-28-5-7-29(8-6-28)9-10-31-21-12-16-19(13-20(21)30-2)25-14-26-22(16)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,5-10H2,1-2H3,(H,25,26,27)
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AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290640
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(2-phenyl-cyclopro...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OC
Show InChI InChI=1/C19H19N3O2/c1-23-17-9-14-15(10-18(17)24-2)20-11-21-19(14)22-16-8-13(16)12-6-4-3-5-7-12/h3-7,9-11,13,16H,8H2,1-2H3,(H,20,21,22)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50451193
PNG
(CHEMBL14699)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN1CCOCC1
Show InChI InChI=1S/C21H22ClFN4O3/c1-28-19-12-18-15(11-20(19)30-9-6-27-4-7-29-8-5-27)21(25-13-24-18)26-14-2-3-17(23)16(22)10-14/h2-3,10-13H,4-9H2,1H3,(H,24,25,26)
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AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM5447
PNG
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
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n/an/a 23n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290638
PNG
(CHEMBL91484 | [6-(3-Dimethylamino-propoxy)-7-metho...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OCCCN(C)C
Show InChI InChI=1/C23H28N4O2/c1-27(2)10-7-11-29-22-13-18-19(14-21(22)28-3)24-15-25-23(18)26-20-12-17(20)16-8-5-4-6-9-16/h4-6,8-9,13-15,17,20H,7,10-12H2,1-3H3,(H,24,25,26)
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n/an/a 27n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102082
PNG
(2-[{2-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN(CCO)CCO
Show InChI InChI=1S/C21H24ClFN4O4/c1-30-19-12-18-15(11-20(19)31-9-6-27(4-7-28)5-8-29)21(25-13-24-18)26-14-2-3-17(23)16(22)10-14/h2-3,10-13,28-29H,4-9H2,1H3,(H,24,25,26)
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n/an/a 35n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102070
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(3-dimethylamino-pro...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN(C)C
Show InChI InChI=1S/C20H22ClFN4O2/c1-26(2)7-4-8-28-19-10-14-17(11-18(19)27-3)23-12-24-20(14)25-13-5-6-16(22)15(21)9-13/h5-6,9-12H,4,7-8H2,1-3H3,(H,23,24,25)
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n/an/a 49n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102074
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(3-diethylamino-prop...)
Show SMILES CCN(CC)CCCOc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1S/C22H26ClFN4O2/c1-4-28(5-2)9-6-10-30-21-12-16-19(13-20(21)29-3)25-14-26-22(16)27-15-7-8-18(24)17(23)11-15/h7-8,11-14H,4-6,9-10H2,1-3H3,(H,25,26,27)
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n/an/a 57n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102087
PNG
((6-{2-[Bis-(2-methoxy-ethyl)-amino]-ethoxy}-7-meth...)
Show SMILES COCCN(CCOC)CCOc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1S/C23H28ClFN4O4/c1-30-9-6-29(7-10-31-2)8-11-33-22-13-17-20(14-21(22)32-3)26-15-27-23(17)28-16-4-5-19(25)18(24)12-16/h4-5,12-15H,6-11H2,1-3H3,(H,26,27,28)
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n/an/a 61n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102094
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(2-imidazol-1-yl-eth...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCn1ccnc1
Show InChI InChI=1S/C20H17ClFN5O2/c1-28-18-10-17-14(9-19(18)29-7-6-27-5-4-23-12-27)20(25-11-24-17)26-13-2-3-16(22)15(21)8-13/h2-5,8-12H,6-7H2,1H3,(H,24,25,26)
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n/an/a 66n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50366684
PNG
(CHEMBL1788321)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC[C@H](O)CN1CCOCC1
Show InChI InChI=1/C22H24ClFN4O4/c1-30-20-10-19-16(9-21(20)32-12-15(29)11-28-4-6-31-7-5-28)22(26-13-25-19)27-14-2-3-18(24)17(23)8-14/h2-3,8-10,13,15,29H,4-7,11-12H2,1H3,(H,25,26,27)/t15-/s2
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n/an/a 67n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102075
PNG
(2-{2-[4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCNC(C)(CO)CO
Show InChI InChI=1S/C21H24ClFN4O4/c1-21(10-28,11-29)26-5-6-31-19-8-14-17(9-18(19)30-2)24-12-25-20(14)27-13-3-4-16(23)15(22)7-13/h3-4,7-9,12,26,28-29H,5-6,10-11H2,1-2H3,(H,24,25,27)
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n/an/a 69n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102079
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-pyrroli...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCCC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-29-20-13-19-16(12-21(20)30-10-4-9-28-7-2-3-8-28)22(26-14-25-19)27-15-5-6-18(24)17(23)11-15/h5-6,11-14H,2-4,7-10H2,1H3,(H,25,26,27)
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n/an/a 71n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102072
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(3-piperid...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C23H26ClFN4O2/c1-30-21-14-20-17(13-22(21)31-11-5-10-29-8-3-2-4-9-29)23(27-15-26-20)28-16-6-7-19(25)18(24)12-16/h6-7,12-15H,2-5,8-11H2,1H3,(H,26,27,28)
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n/an/a 79n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290632
PNG
(Acetic acid 7-methoxy-4-(2-phenyl-cyclopropylamino...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OC(C)=O
Show InChI InChI=1/C20H19N3O3/c1-12(24)26-19-9-15-16(10-18(19)25-2)21-11-22-20(15)23-17-8-14(17)13-6-4-3-5-7-13/h3-7,9-11,14,17H,8H2,1-2H3,(H,21,22,23)
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n/an/a 84n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102089
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-pyrroli...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN1CCCC1
Show InChI InChI=1S/C21H22ClFN4O2/c1-28-19-12-18-15(11-20(19)29-9-8-27-6-2-3-7-27)21(25-13-24-18)26-14-4-5-17(23)16(22)10-14/h4-5,10-13H,2-3,6-9H2,1H3,(H,24,25,26)
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n/an/a 87n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102086
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(2-diethylamino-etho...)
Show SMILES CCN(CC)CCOc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC
Show InChI InChI=1S/C21H24ClFN4O2/c1-4-27(5-2)8-9-29-20-11-15-18(12-19(20)28-3)24-13-25-21(15)26-14-6-7-17(23)16(22)10-14/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 93n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50366685
PNG
(CHEMBL1744086)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC[C@@H](O)CN1CCOCC1
Show InChI InChI=1/C22H24ClFN4O4/c1-30-20-10-19-16(9-21(20)32-12-15(29)11-28-4-6-31-7-5-28)22(26-13-25-19)27-14-2-3-18(24)17(23)8-14/h2-3,8-10,13,15,29H,4-7,11-12H2,1H3,(H,25,26,27)/t15-/s2
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n/an/a 95n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50005340
PNG
(2-Butyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Show SMILES CCCCc1nc2ccccc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H24N6/c1-2-3-12-24-26-22-10-6-7-11-23(22)31(24)17-18-13-15-19(16-14-18)20-8-4-5-9-21(20)25-27-29-30-28-25/h4-11,13-16H,2-3,12,17H2,1H3,(H,27,28,29,30)
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n/an/a 96n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membr...


J Med Chem 35: 877-85 (1992)


Article DOI: 10.1021/jm00083a011
BindingDB Entry DOI: 10.7270/Q23R0W37
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102077
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-piperid...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN1CCCCC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-29-20-13-19-16(12-21(20)30-10-9-28-7-3-2-4-8-28)22(26-14-25-19)27-15-5-6-18(24)17(23)11-15/h5-6,11-14H,2-4,7-10H2,1H3,(H,25,26,27)
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n/an/a 98n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102084
PNG
(CHEMBL57892 | [6-(2-tert-Butylamino-ethoxy)-7-meth...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCNC(C)(C)C
Show InChI InChI=1S/C21H24ClFN4O2/c1-21(2,3)26-7-8-29-19-10-14-17(11-18(19)28-4)24-12-25-20(14)27-13-5-6-16(23)15(22)9-13/h5-6,9-12,26H,7-8H2,1-4H3,(H,24,25,27)
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n/an/a 100n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290640
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(2-phenyl-cyclopro...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OC
Show InChI InChI=1/C19H19N3O2/c1-23-17-9-14-15(10-18(17)24-2)20-11-21-19(14)22-16-8-13(16)12-6-4-3-5-7-12/h3-7,9-11,13,16H,8H2,1-2H3,(H,20,21,22)
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n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290641
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-(3-methyl-benzyl)-...)
Show SMILES COc1cc2ncnc(NCc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C18H19N3O2/c1-12-5-4-6-13(7-12)10-19-18-14-8-16(22-2)17(23-3)9-15(14)20-11-21-18/h4-9,11H,10H2,1-3H3,(H,19,20,21)
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n/an/a 170n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290637
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-isoquinolin-1-yl-a...)
Show SMILES COc1cc2ncnc(Nc3nccc4ccccc34)c2cc1OC
Show InChI InChI=1S/C19H16N4O2/c1-24-16-9-14-15(10-17(16)25-2)21-11-22-19(14)23-18-13-6-4-3-5-12(13)7-8-20-18/h3-11H,1-2H3,(H,20,21,22,23)
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n/an/a 200n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290642
PNG
(CHEMBL420059 | [7-Methoxy-6-(2-morpholin-4-yl-etho...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OCCN1CCOCC1
Show InChI InChI=1/C24H28N4O3/c1-29-22-15-20-19(14-23(22)31-12-9-28-7-10-30-11-8-28)24(26-16-25-20)27-21-13-18(21)17-5-3-2-4-6-17/h2-6,14-16,18,21H,7-13H2,1H3,(H,25,26,27)
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50102076
PNG
((3-Chloro-4-fluoro-phenyl)-[6-(2-isopropylamino-et...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCNC(C)C
Show InChI InChI=1S/C20H22ClFN4O2/c1-12(2)23-6-7-28-19-9-14-17(10-18(19)27-3)24-11-25-20(14)26-13-4-5-16(22)15(21)8-13/h4-5,8-12,23H,6-7H2,1-3H3,(H,24,25,26)
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n/an/a 310n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Epidermal growth factor receptor (EGFR-TK) from A431 vulval squamous carcinoma cells using TKI assay


Bioorg Med Chem Lett 11: 1911-4 (2001)


Article DOI: 10.1016/s0960-894x(01)00344-4
BindingDB Entry DOI: 10.7270/Q2XD1261
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290638
PNG
(CHEMBL91484 | [6-(3-Dimethylamino-propoxy)-7-metho...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OCCCN(C)C
Show InChI InChI=1/C23H28N4O2/c1-27(2)10-7-11-29-22-13-18-19(14-21(22)28-3)24-15-25-23(18)26-20-12-17(20)16-8-5-4-6-9-16/h4-6,8-9,13-15,17,20H,7,10-12H2,1-3H3,(H,24,25,26)
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n/an/a 310n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290631
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-isoquinolin-4-yl-a...)
Show SMILES COc1cc2ncnc(Nc3cncc4ccccc34)c2cc1OC
Show InChI InChI=1S/C19H16N4O2/c1-24-17-7-14-15(8-18(17)25-2)21-11-22-19(14)23-16-10-20-9-12-5-3-4-6-13(12)16/h3-11H,1-2H3,(H,21,22,23)
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n/an/a 360n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290643
PNG
(7-Methoxy-4-(2-phenyl-cyclopropylamino)-quinazolin...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1O
Show InChI InChI=1/C18H17N3O2/c1-23-17-9-14-13(8-16(17)22)18(20-10-19-14)21-15-7-12(15)11-5-3-2-4-6-11/h2-6,8-10,12,15,22H,7H2,1H3,(H,19,20,21)
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n/an/a 390n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290635
PNG
(CHEMBL422066 | N-(3-Chloro-4-fluoro-phenyl)-N'-(6,...)
Show SMILES COc1cc2ncnc(NNc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClFN4O2/c1-23-14-6-10-13(7-15(14)24-2)19-8-20-16(10)22-21-9-3-4-12(18)11(17)5-9/h3-8,21H,1-2H3,(H,19,20,22)
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n/an/a 430n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50003399
PNG
(4'-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl...)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1C(O)=O
Show InChI InChI=1S/C22H23ClN2O3/c1-2-3-8-20-24-21(23)19(14-26)25(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22(27)28/h4-7,9-12,26H,2-3,8,13-14H2,1H3,(H,27,28)
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n/an/a 480n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Concentration required for 50% displacement of the specifically bound [3-[125I]-iodotyrosyl]-angiotensin II from angiotensin II receptor in the membr...


J Med Chem 35: 877-85 (1992)


Article DOI: 10.1021/jm00083a011
BindingDB Entry DOI: 10.7270/Q23R0W37
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290642
PNG
(CHEMBL420059 | [7-Methoxy-6-(2-morpholin-4-yl-etho...)
Show SMILES COc1cc2ncnc(NC3CC3c3ccccc3)c2cc1OCCN1CCOCC1
Show InChI InChI=1/C24H28N4O3/c1-29-22-15-20-19(14-23(22)31-12-9-28-7-10-30-11-8-28)24(26-16-25-20)27-21-13-18(21)17-5-3-2-4-6-17/h2-6,14-16,18,21H,7-13H2,1H3,(H,25,26,27)
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n/an/a 570n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230428
PNG
(CHEMBL352376)
Show SMILES CCCCCCc1nc2ccccc2n1Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H24N2O2/c1-2-3-4-5-10-20-22-18-8-6-7-9-19(18)23(20)15-16-11-13-17(14-12-16)21(24)25/h6-9,11-14H,2-5,10,15H2,1H3,(H,24,25)
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n/an/a 640n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [3-[125I]-iodotyrosyl]-angiotensin II binding to Angiotensin II receptors in the membrane preparations of guinea pig adrenal glands.


J Med Chem 35: 877-85 (1992)


Article DOI: 10.1021/jm00083a011
BindingDB Entry DOI: 10.7270/Q23R0W37
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290634
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-isoquinolin-3-yl-a...)
Show SMILES COc1cc2ncnc(Nc3cc4ccccc4cn3)c2cc1OC
Show InChI InChI=1S/C19H16N4O2/c1-24-16-8-14-15(9-17(16)25-2)21-11-22-19(14)23-18-7-12-5-3-4-6-13(12)10-20-18/h3-11H,1-2H3,(H,20,21,22,23)
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n/an/a 660n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290630
PNG
((3-Chloro-4-fluoro-phenyl)-(6,7-dimethoxy-quinazol...)
Show SMILES COc1cc2ncnc(\N=N\c3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H12ClFN4O2/c1-23-14-6-10-13(7-15(14)24-2)19-8-20-16(10)22-21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3/b22-21+
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n/an/a 730n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290644
PNG
((6,7-Dimethoxy-quinazolin-4-yl)-quinoxalin-2-yl-am...)
Show SMILES COc1cc2ncnc(Nc3cnc4ccccc4n3)c2cc1OC
Show InChI InChI=1S/C18H15N5O2/c1-24-15-7-11-14(8-16(15)25-2)20-10-21-18(11)23-17-9-19-12-5-3-4-6-13(12)22-17/h3-10H,1-2H3,(H,20,21,22,23)
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n/an/a 780n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50290635
PNG
(CHEMBL422066 | N-(3-Chloro-4-fluoro-phenyl)-N'-(6,...)
Show SMILES COc1cc2ncnc(NNc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H14ClFN4O2/c1-23-14-6-10-13(7-15(14)24-2)19-8-20-16(10)22-21-9-3-4-12(18)11(17)5-9/h3-8,21H,1-2H3,(H,19,20,22)
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n/an/a 780n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of EGF-stimulated proliferation of KB cells in culture


Bioorg Med Chem Lett 7: 2723-2728 (1997)


Article DOI: 10.1016/S0960-894X(97)10059-2
BindingDB Entry DOI: 10.7270/Q2TD9XCQ
More data for this
Ligand-Target Pair
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