BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 258 hits with Last Name = 'green' and Initial = 't'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-HT3A Serotonin Receptor


(Mus musculus (house mouse))
BDBM82473
PNG
(CAS_124006 | GR 65630 | NSC_124006)
Show SMILES Cc1nc[nH]c1CCC(=O)c1cc2ccccc2n1C
Show InChI InChI=1S/C16H17N3O/c1-11-13(18-10-17-11)7-8-16(20)15-9-12-5-3-4-6-14(12)19(15)2/h3-6,9-10H,7-8H2,1-2H3,(H,17,18)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents

Article
PubMed
0.210n/an/an/an/an/an/an/an/a



Medical Research Council Centre

Curated by PDSP Ki Database




J Biol Chem 270: 6056-61 (1995)


Article DOI: 10.1016/j.bioorg.2014.12.001
BindingDB Entry DOI: 10.7270/Q2NV9GR6
More data for this
Ligand-Target Pair
5-HT3A Serotonin Receptor


(Mus musculus (house mouse))
BDBM82474
PNG
(1-(3-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE | CAS_21...)
Show SMILES NC(N)=NC(N)=Nc1cccc(Cl)c1
Show InChI InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
0.940n/an/an/an/an/an/an/an/a



Medical Research Council Centre

Curated by PDSP Ki Database




J Biol Chem 270: 6056-61 (1995)


Article DOI: 10.1016/j.bioorg.2014.12.001
BindingDB Entry DOI: 10.7270/Q2NV9GR6
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50252103
PNG
((2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-MET...)
Show SMILES C[C@H](\C=C\C=C(/C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4+/t9-,10+,11-,13+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.5n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5-HT3A Serotonin Receptor


(Mus musculus (house mouse))
BDBM50241143
PNG
((MDL 72222)3,5-Dichloro-benzoic acid 8-methyl-8-az...)
Show SMILES CN1C2CCC1CC(C2)OC(=O)c1cc(Cl)cc(Cl)c1
Show InChI InChI=1/C15H17Cl2NO2/c1-18-12-2-3-13(18)8-14(7-12)20-15(19)9-4-10(16)6-11(17)5-9/h4-6,12-14H,2-3,7-8H2,1H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



Medical Research Council Centre

Curated by PDSP Ki Database




J Biol Chem 270: 6056-61 (1995)


Article DOI: 10.1016/j.bioorg.2014.12.001
BindingDB Entry DOI: 10.7270/Q2NV9GR6
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM85740
PNG
(Dysiherbaine)
Show SMILES CN[C@H]1[C@H]2O[C@](C[C@H](N)C(O)=O)(C[C@H]2OC[C@H]1O)C(O)=O
Show InChI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
26n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
62n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA3


(RAT)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
62n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA3


(RAT)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
89n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA3


(RAT)
BDBM85740
PNG
(Dysiherbaine)
Show SMILES CN[C@H]1[C@H]2O[C@](C[C@H](N)C(O)=O)(C[C@H]2OC[C@H]1O)C(O)=O
Show InChI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
153n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50252103
PNG
((2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-MET...)
Show SMILES C[C@H](\C=C\C=C(/C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4+/t9-,10+,11-,13+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
927n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM50002343
PNG
(2-Methylamino-succinic acid | CHEMBL275325 | NMDA)
Show SMILES CNC(CC(O)=O)C(O)=O
Show InChI InChI=1/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
3.90E+3n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
GRIA3


(RAT)
BDBM85740
PNG
(Dysiherbaine)
Show SMILES CN[C@H]1[C@H]2O[C@](C[C@H](N)C(O)=O)(C[C@H]2OC[C@H]1O)C(O)=O
Show InChI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Kitasato University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 296: 650-8 (2001)


Article DOI: 10.1111/cbdd.12703
BindingDB Entry DOI: 10.7270/Q2M0440C
More data for this
Ligand-Target Pair
Lactate dehydrogenase A (LDHA)


(Homo sapiens (Human))
BDBM23222
PNG
(Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...)
Show SMILES NC(=O)C(O)=O
Show InChI InChI=1S/C2H3NO3/c3-1(4)2(5)6/h(H2,3,4)(H,5,6)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents

PDB
Article
PubMed
2.60E+4n/an/an/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human LDH-A


J Med Chem 56: 1023-40 (2013)


Article DOI: 10.1021/jm3014844
BindingDB Entry DOI: 10.7270/Q2QC04TB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12255
PNG
(AZD0530 | CHEMBL217092 | Compound 33 | N-(5-chloro...)
Show SMILES CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 2.70n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12241
PNG
(AZD0530 analogue 19 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCOc3ccncc3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H25ClN4O6/c28-20-1-2-22-26(37-16-36-22)25(20)32-27-24-21(30-15-31-27)13-19(14-23(24)38-18-5-9-33-10-6-18)35-12-11-34-17-3-7-29-8-4-17/h1-4,7-8,13-15,18H,5-6,9-12,16H2,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12243
PNG
(AZD0530 analogue 21 | N-(2-chloro-5-methoxyphenyl)...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCN(C)CC4)cc(OC4CCOCC4)c23)c1
Show InChI InChI=1S/C28H36ClN5O4/c1-33-9-11-34(12-10-33)8-3-13-37-22-17-25-27(26(18-22)38-20-6-14-36-15-7-20)28(31-19-30-25)32-24-16-21(35-2)4-5-23(24)29/h4-5,16-20H,3,6-15H2,1-2H3,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6211
PNG
(Benzodioxole deriv. 20 | N-(5-Bromo-1,3-benzodioxo...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Br)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25BrN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12247
PNG
(AZD0530 analogue 25 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CN1CCN(CCCOc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C28H34ClN5O5/c1-33-8-10-34(11-9-33)7-2-12-36-20-15-22-25(24(16-20)39-19-5-13-35-14-6-19)28(31-17-30-22)32-26-21(29)3-4-23-27(26)38-18-37-23/h3-4,15-17,19H,2,5-14,18H2,1H3,(H,30,31,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12250
PNG
(AZD0530 analogue 28 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES CN1CCC(CC1)Oc1cc(OCCF)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12
Show InChI InChI=1S/C23H24ClFN4O4/c1-29-7-4-14(5-8-29)33-19-11-15(30-9-6-25)10-17-20(19)23(27-12-26-17)28-21-16(24)2-3-18-22(21)32-13-31-18/h2-3,10-12,14H,4-9,13H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12252
PNG
(AZD0530 analogue 30 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES CC(C)Oc1cc(OCCCN2CCCC2)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12
Show InChI InChI=1S/C25H29ClN4O4/c1-16(2)34-21-13-17(31-11-5-10-30-8-3-4-9-30)12-19-22(21)25(28-14-27-19)29-23-18(26)6-7-20-24(23)33-15-32-20/h6-7,12-14,16H,3-5,8-11,15H2,1-2H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6219
PNG
(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCCCC1
Show InChI InChI=1S/C24H27ClN4O4/c1-30-20-12-16-18(13-21(20)31-11-5-10-29-8-3-2-4-9-29)26-14-27-24(16)28-22-17(25)6-7-19-23(22)33-15-32-19/h6-7,12-14H,2-5,8-11,15H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a<4n/an/an/an/an/a25



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6204
PNG
(Benzofuran deriv. 13 | N-(3-Chloro-1-benzofuran-7-...)
Show SMILES COc1cc2c(Nc3cccc4c(Cl)coc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-21-12-17-20(13-22(21)32-9-3-6-29-7-10-31-11-8-29)26-15-27-24(17)28-19-5-2-4-16-18(25)14-33-23(16)19/h2,4-5,12-15H,3,6-11H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12231
PNG
(AZD0530 analogue 9 | N-(2-chloro-5-methoxyphenyl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOC4)c23)c1
Show InChI InChI=1/C26H31ClN4O5/c1-32-18-3-4-21(27)22(13-18)30-26-25-23(28-17-29-26)14-20(15-24(25)36-19-5-10-34-16-19)35-9-2-6-31-7-11-33-12-8-31/h3-4,13-15,17,19H,2,5-12,16H2,1H3,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12237
PNG
(AZD0530 analogue 15 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C27H31ClN4O5/c28-20-4-5-22-26(36-17-35-22)25(20)31-27-24-21(29-16-30-27)14-19(34-11-3-10-32-8-1-2-9-32)15-23(24)37-18-6-12-33-13-7-18/h4-5,14-16,18H,1-3,6-13,17H2,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a<4n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6210
PNG
(Benzodioxole deriv. 19 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C23H25ClN4O5/c1-29-19-11-15-17(12-20(19)31-8-2-5-28-6-9-30-10-7-28)25-13-26-23(15)27-21-16(24)3-4-18-22(21)33-14-32-18/h3-4,11-13H,2,5-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6218
PNG
(AZD0530 analogue 34 | Chlorobenzodioxole deriv. 27...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H25ClN4O4/c1-28-7-5-14(6-8-28)11-30-20-10-17-15(9-19(20)29-2)23(26-12-25-17)27-21-16(24)3-4-18-22(21)32-13-31-18/h3-4,9-10,12,14H,5-8,11,13H2,1-2H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174932
PNG
(CHEMBL197287 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Show SMILES COc1cnc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC(C)C)c23)c1
Show InChI InChI=1S/C24H30ClN5O4/c1-16(2)34-21-13-17(33-8-4-5-30-6-9-32-10-7-30)11-19-22(21)24(28-15-27-19)29-20-12-18(31-3)14-26-23(20)25/h11-16H,4-10H2,1-3H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12259
PNG
(AZD0530 analogue 37 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C23H25ClN4O4/c1-29-19-11-15-17(12-20(19)30-10-4-9-28-7-2-3-8-28)25-13-26-23(15)27-21-16(24)5-6-18-22(21)32-14-31-18/h5-6,11-13H,2-4,7-10,14H2,1H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174939
PNG
(CHEMBL424664 | N-(3-chloro-6-methoxypyridin-2-yl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOCC4)c23)n1
Show InChI InChI=1S/C26H32ClN5O5/c1-33-23-4-3-20(27)25(30-23)31-26-24-21(28-17-29-26)15-19(16-22(24)37-18-5-11-34-12-6-18)36-10-2-7-32-8-13-35-14-9-32/h3-4,15-18H,2,5-14H2,1H3,(H,28,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6218
PNG
(AZD0530 analogue 34 | Chlorobenzodioxole deriv. 27...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H25ClN4O4/c1-28-7-5-14(6-8-28)11-30-20-10-17-15(9-19(20)29-2)23(26-12-25-17)27-21-16(24)3-4-18-22(21)32-13-31-18/h3-4,9-10,12,14H,5-8,11,13H2,1-2H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/a25



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12253
PNG
(AZD0530 analogue 31 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CC(C)Oc1cc(OCCN2CCOCC2)cc2ncnc(Nc3c4OCOc4ccc3Cl)c12
Show InChI InChI=1S/C24H27ClN4O5/c1-15(2)34-20-12-16(31-10-7-29-5-8-30-9-6-29)11-18-21(20)24(27-13-26-18)28-22-17(25)3-4-19-23(22)33-14-32-19/h3-4,11-13,15H,5-10,14H2,1-2H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12240
PNG
(AZD0530 analogue 18 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES CN1CCC(COc2cc(OC3CCOCC3)c3c(Nc4c5OCOc5ccc4Cl)ncnc3c2)CC1
Show InChI InChI=1S/C27H31ClN4O5/c1-32-8-4-17(5-9-32)14-34-19-12-21-24(23(13-19)37-18-6-10-33-11-7-18)27(30-15-29-21)31-25-20(28)2-3-22-26(25)36-16-35-22/h2-3,12-13,15,17-18H,4-11,14,16H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12238
PNG
(AZD0530 analogue 16 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCN3CCCC3)cc(OC3CCOCC3)c12
Show InChI InChI=1S/C26H29ClN4O5/c27-19-3-4-21-25(35-16-34-21)24(19)30-26-23-20(28-15-29-26)13-18(33-12-9-31-7-1-2-8-31)14-22(23)36-17-5-10-32-11-6-17/h3-4,13-15,17H,1-2,5-12,16H2,(H,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174934
PNG
(CHEMBL424839 | N-(3-chloro-6-methoxypyridin-2-yl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCCC4)cc(OC(C)C)c23)n1
Show InChI InChI=1S/C24H30ClN5O3/c1-16(2)33-20-14-17(32-12-6-11-30-9-4-5-10-30)13-19-22(20)24(27-15-26-19)29-23-18(25)7-8-21(28-23)31-3/h7-8,13-16H,4-6,9-12H2,1-3H3,(H,26,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174935
PNG
(CHEMBL371688 | N-(3-chloro-6-methoxypyridin-2-yl)-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCN4CCN(C)CC4)cc(OC(C)C)c23)n1
Show InChI InChI=1S/C24H31ClN6O3/c1-16(2)34-20-14-17(33-12-11-31-9-7-30(3)8-10-31)13-19-22(20)24(27-15-26-19)29-23-18(25)5-6-21(28-23)32-4/h5-6,13-16H,7-12H2,1-4H3,(H,26,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174929
PNG
(CHEMBL369899 | N-(2-chloro-5-methoxypyridin-3-yl)-...)
Show SMILES COc1cnc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOCC4)c23)c1
Show InChI InChI=1S/C26H32ClN5O5/c1-33-20-14-22(25(27)28-16-20)31-26-24-21(29-17-30-26)13-19(15-23(24)37-18-3-9-34-10-4-18)36-8-2-5-32-6-11-35-12-7-32/h13-18H,2-12H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12251
PNG
(AZD0530 analogue 29 | N-(5-chloro-2H-1,3-benzodiox...)
Show SMILES CC(C)COc1cc(OC2CCN(C)CC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C25H29ClN4O4/c1-15(2)12-31-17-10-19-22(21(11-17)34-16-6-8-30(3)9-7-16)25(28-13-27-19)29-23-18(26)4-5-20-24(23)33-14-32-20/h4-5,10-11,13,15-16H,6-9,12,14H2,1-3H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174936
PNG
(1-(4-(2-(4-(3-chloro-6-methoxypyrazin-2-ylamino)-5...)
Show SMILES COc1cnc(Cl)c(Nc2ncnc3cc(OCCN4CCN(CC4)C(C)=O)cc(OC(C)C)c23)n1
Show InChI InChI=1S/C24H30ClN7O4/c1-15(2)36-19-12-17(35-10-9-31-5-7-32(8-6-31)16(3)33)11-18-21(19)23(28-14-27-18)30-24-22(25)26-13-20(29-24)34-4/h11-15H,5-10H2,1-4H3,(H,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12246
PNG
(AZD0530 analogue 24 | N-(5-Chloro-1,3-benzodioxol-...)
Show SMILES COc1cc(OC2CCNCC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C21H21ClN4O4/c1-27-13-8-15-18(17(9-13)30-12-4-6-23-7-5-12)21(25-10-24-15)26-19-14(22)2-3-16-20(19)29-11-28-16/h2-3,8-10,12,23H,4-7,11H2,1H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.5n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6198
PNG
(AZD0530 analogue 35 | M475271 | Methoxy Aniline 7 ...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
Show InChI InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12228
PNG
(AZD0530 analogue 6 | N-(5-chloro-2H-1,3-benzodioxo...)
Show SMILES COc1cc(OC2CCN(C)CC2)c2c(Nc3c4OCOc4ccc3Cl)ncnc2c1
Show InChI InChI=1S/C22H23ClN4O4/c1-27-7-5-13(6-8-27)31-18-10-14(28-2)9-16-19(18)22(25-11-24-16)26-20-15(23)3-4-17-21(20)30-12-29-17/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 49: 6465-88 (2006)


Article DOI: 10.1021/jm060434q
BindingDB Entry DOI: 10.7270/Q2J67F5X
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6220
PNG
(4-[({4-[(5-chloro-2H-1,3-benzodioxol-4-yl)amino]-6...)
Show SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCc1ccnc(c1)C#N
Show InChI InChI=1S/C23H16ClN5O4/c1-30-19-7-15-17(8-20(19)31-10-13-4-5-26-14(6-13)9-25)27-11-28-23(15)29-21-16(24)2-3-18-22(21)33-12-32-18/h2-8,11H,10,12H2,1H3,(H,27,28,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10n/an/an/an/an/a25



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6216
PNG
(Benzodioxole deriv. 25 | N-(5-Chloro-1,3-benzodiox...)
Show SMILES Clc1ccc2OCOc2c1Nc1ncnc2cc(OCCCN3CCOCC3)ccc12
Show InChI InChI=1S/C22H23ClN4O4/c23-17-4-5-19-21(31-14-30-19)20(17)26-22-16-3-2-15(12-18(16)24-13-25-22)29-9-1-6-27-7-10-28-11-8-27/h2-5,12-13H,1,6-11,14H2,(H,24,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6202
PNG
(Benzofuran deriv. 11 | N-(6-Chloro-1-benzofuran-7-...)
Show SMILES COc1cc2c(Nc3c(Cl)ccc4ccoc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-20-13-17-19(14-21(20)32-9-2-6-29-7-11-31-12-8-29)26-15-27-24(17)28-22-18(25)4-3-16-5-10-33-23(16)22/h3-5,10,13-15H,2,6-9,11-12H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6200
PNG
(Benzofuran deriv. 9 | N-(5-Chloro-1-benzofuran-4-y...)
Show SMILES COc1cc2c(Nc3c(Cl)ccc4occc34)ncnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C24H25ClN4O4/c1-30-21-13-17-19(14-22(21)32-9-2-6-29-7-11-31-12-8-29)26-15-27-24(17)28-23-16-5-10-33-20(16)4-3-18(23)25/h3-5,10,13-15H,2,6-9,11-12H2,1H3,(H,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6196
PNG
(Methoxy Aniline 5 | N-(2-Chloro-5-methoxyphenyl)-6...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)c(OC)cc23)c1
Show InChI InChI=1S/C23H27ClN4O4/c1-29-16-4-5-18(24)20(12-16)27-23-17-13-21(30-2)22(14-19(17)25-15-26-23)32-9-3-6-28-7-10-31-11-8-28/h4-5,12-15H,3,6-11H2,1-2H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6198
PNG
(AZD0530 analogue 35 | M475271 | Methoxy Aniline 7 ...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
Show InChI InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...


J Med Chem 47: 871-87 (2004)


Article DOI: 10.1021/jm030317k
BindingDB Entry DOI: 10.7270/Q2930RCG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50174933
PNG
(1-(4-(2-(4-(3-chloro-6-methoxypyridin-2-ylamino)-5...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCN4CCN(CC4)C(C)=O)cc(OC(C)C)c23)n1
Show InChI InChI=1S/C25H31ClN6O4/c1-16(2)36-21-14-18(35-12-11-31-7-9-32(10-8-31)17(3)33)13-20-23(21)25(28-15-27-20)30-24-19(26)5-6-22(29-24)34-4/h5-6,13-16H,7-12H2,1-4H3,(H,27,28,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM12229
PNG
(AZD0530 analogue 7 | CHEMBL200217 | N-(2-Chloro-5-...)
Show SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC4CCOCC4)c23)c1
Show InChI InChI=1S/C27H33ClN4O5/c1-33-20-3-4-22(28)23(15-20)31-27-26-24(29-18-30-27)16-21(17-25(26)37-19-5-11-34-12-6-19)36-10-2-7-32-8-13-35-14-9-32/h3-4,15-19H,2,5-14H2,1H3,(H,29,30,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory activity against c-Src kinase


Bioorg Med Chem Lett 15: 5446-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.08.106
BindingDB Entry DOI: 10.7270/Q2765DWC
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 258 total )  |  Next  |  Last  >>
Jump to: