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Compile Data Set for Download or QSAR

Found 139 hits with Last Name = 'kuramochi' and Initial = 'k'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153106
PNG
(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H48O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h9,19-20,22-26H,6-8,10-18H2,1-5H3,(H,30,31)/t20-,22+,23?,24-,25?,26?,28+,29-/m1/s1
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PubMed
3.75E+3n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153111
PNG
(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC[C@H]4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H50O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h19-26H,6-18H2,1-5H3,(H,30,31)/t20-,21+,22+,23?,24-,25?,26?,28+,29-/m1/s1
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7.84E+3n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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9.85E+3n/an/an/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153113
PNG
(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Show SMILES CC[C@H](\C=C\[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O)C(C)C
Show InChI InChI=1S/C31H50O3/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(34-19-29(32)33)14-16-30(23,5)28(25)15-17-31(26,27)6/h8-10,20-22,24-28H,7,11-19H2,1-6H3,(H,32,33)/b9-8+/t21-,22-,24+,25?,26-,27?,28?,30+,31-/m1/s1
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1.12E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha non competitively on dNTP substrate


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153111
PNG
(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC[C@H]4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H50O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h19-26H,6-18H2,1-5H3,(H,30,31)/t20-,21+,22+,23?,24-,25?,26?,28+,29-/m1/s1
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1.38E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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1.81E+4n/an/an/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153106
PNG
(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H48O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h9,19-20,22-26H,6-8,10-18H2,1-5H3,(H,30,31)/t20-,22+,23?,24-,25?,26?,28+,29-/m1/s1
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1.85E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153113
PNG
(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Show SMILES CC[C@H](\C=C\[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O)C(C)C
Show InChI InChI=1S/C31H50O3/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(34-19-29(32)33)14-16-30(23,5)28(25)15-17-31(26,27)6/h8-10,20-22,24-28H,7,11-19H2,1-6H3,(H,32,33)/b9-8+/t21-,22-,24+,25?,26-,27?,28?,30+,31-/m1/s1
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2.79E+4n/an/an/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibition constant against DNA polymerase alpha competitively on DNA template


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33388
PNG
(dehydroaltenusin derivative, 16)
Show SMILES CCCCCCCCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C26H34O6/c1-3-4-5-6-7-8-9-10-11-12-13-31-18-14-19-20-16-21(27)23(29)17-26(20,2)32-25(30)24(19)22(28)15-18/h14-16,28H,3-13,17H2,1-2H3
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n/an/a 60n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33387
PNG
(dehydroaltenusin derivative, 15)
Show SMILES CCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C20H22O6/c1-3-4-5-6-7-25-12-8-13-14-10-15(21)17(23)11-20(14,2)26-19(24)18(13)16(22)9-12/h8-10,22H,3-7,11H2,1-2H3
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n/an/a 90n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33386
PNG
(dehydroaltenusin derivative, 14)
Show SMILES CCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C17H16O6/c1-3-4-22-9-5-10-11-7-12(18)14(20)8-17(11,2)23-16(21)15(10)13(19)6-9/h5-7,19H,3-4,8H2,1-2H3
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n/an/a 180n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33389
PNG
(dehydroaltenusin derivative, 20)
Show SMILES CC12CC(=O)C(=O)C=C1c1cccc(O)c1C(=O)O2
Show InChI InChI=1S/C14H10O5/c1-14-6-11(17)10(16)5-8(14)7-3-2-4-9(15)12(7)13(18)19-14/h2-5,15H,6H2,1H3
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n/an/a 240n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33384
PNG
(dehydroaltenusin)
Show SMILES COc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-5,17H,6H2,1-2H3
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n/an/a 680n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA Polymerase alpha


(Bos taurus (bovine))
BDBM33385
PNG
(desmethyldehydroaltenusin, 2)
Show SMILES CC12CC(=O)C(=O)C=C1c1cc(O)cc(O)c1C(=O)O2
Show InChI InChI=1S/C14H10O6/c1-14-5-11(18)9(16)4-8(14)7-2-6(15)3-10(17)12(7)13(19)20-14/h2-4,15,17H,5H2,1H3
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n/an/a 890n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
Terminal deoxynucleotidyltransferase


(Homo sapiens (Human))
BDBM50143524
PNG
((3aR,4R,7R,7aS)-3,5-Dihexadecyl-3a,4,7,7a-tetrahyd...)
Show SMILES CCCCCCCCCCCCCCCCC1=C(C[C@H]2[C@@H]1[C@@H](C(=O)OC)C(CCCCCCCCCCCCCCCC)=C[C@@H]2C(O)=O)C(O)=O
Show InChI InChI=1S/C45H78O6/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-36-34-39(43(46)47)38-35-40(44(48)49)37(42(38)41(36)45(50)51-3)33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2/h34,38-39,41-42H,4-33,35H2,1-3H3,(H,46,47)(H,48,49)/t38-,39+,41+,42-/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase


Bioorg Med Chem Lett 14: 1975-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.092
BindingDB Entry DOI: 10.7270/Q2W095C3
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase eta


(Homo sapiens (Human))
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase eta (amino acids 1 to 511) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA templ...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase iota


(Mus musculus)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged mouse DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleot...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA-directed DNA/RNA polymerase mu


(Homo sapiens (Human))
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate ...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153113
PNG
(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Show SMILES CC[C@H](\C=C\[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O)C(C)C
Show InChI InChI=1S/C31H50O3/c1-7-22(20(2)3)9-8-21(4)26-12-13-27-25-11-10-23-18-24(34-19-29(32)33)14-16-30(23,5)28(25)15-17-31(26,27)6/h8-10,20-22,24-28H,7,11-19H2,1-6H3,(H,32,33)/b9-8+/t21-,22-,24+,25?,26-,27?,28?,30+,31-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 8.10E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA nucleotidylexotransferase


(Bos taurus)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 8.40E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of calf thymus TdT using oligo(dT)18 (3'-OH) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase eta


(Homo sapiens (Human))
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 8.40E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase eta (amino acids 1 to 511) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA templ...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase iota


(Mus musculus)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 8.70E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged mouse DNA polymerase iota using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleot...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens (Human))
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.02E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA-directed DNA/RNA polymerase mu


(Homo sapiens (Human))
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.08E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate ...


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50153117
PNG
((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...)
Show SMILES C[C@@H](CCC(O)=O)[C@H]1CCC2C3CC[C@]4(C)CC(O)CC[C@]4(C)C3CC[C@]12C
Show InChI InChI=1S/C25H42O3/c1-16(5-8-22(27)28)19-6-7-20-18-10-12-23(2)15-17(26)9-14-25(23,4)21(18)11-13-24(19,20)3/h16-21,26H,5-15H2,1-4H3,(H,27,28)/t16-,17?,18?,19+,20?,21?,23+,24+,25+/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33388
PNG
(dehydroaltenusin derivative, 16)
Show SMILES CCCCCCCCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C26H34O6/c1-3-4-5-6-7-8-9-10-11-12-13-31-18-14-19-20-16-21(27)23(29)17-26(20,2)32-25(30)24(19)22(28)15-18/h14-16,28H,3-13,17H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.15E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of rat pol beta using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA nucleotidylexotransferase


(Bos taurus)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.19E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of calf thymus TdT using oligo(dT)18 (3'-OH) and dTTP as the DNA template-primer and nucleotide substrate after 60 mins


Bioorg Med Chem 19: 5803-12 (2011)


Article DOI: 10.1016/j.bmc.2011.08.023
BindingDB Entry DOI: 10.7270/Q2DZ0989
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50375301
PNG
(CHEMBL260980)
Show SMILES COc1cc(O)c2c(c1)c1C(C)CC(=O)c1oc2=O
Show InChI InChI=1S/C14H12O5/c1-6-3-10(16)13-11(6)8-4-7(18-2)5-9(15)12(8)14(17)19-13/h4-6,15H,3H2,1-2H3
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n/an/a 1.19E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 2939-44 (2008)


Article DOI: 10.1016/j.bmc.2007.12.044
BindingDB Entry DOI: 10.7270/Q2J67HST
More data for this
Ligand-Target Pair
Terminal deoxynucleotidyltransferase


(Homo sapiens (Human))
BDBM50143526
PNG
(CHEMBL366792 | Untenone A)
Show SMILES CCCCCCCCCCCCCCCC[C@]1(O)C=CC(=O)[C@H]1C(=O)OC
Show InChI InChI=1S/C23H40O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-23(26)19-17-20(24)21(23)22(25)27-2/h17,19,21,26H,3-16,18H2,1-2H3/t21-,23-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase


Bioorg Med Chem Lett 14: 1975-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.092
BindingDB Entry DOI: 10.7270/Q2W095C3
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50375300
PNG
(TALAROFLAVONE)
Show SMILES COc1cc2c(C(=O)OC22C(C)CC(=O)C2=O)c(O)c1
Show InChI InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h4-6,15H,3H2,1-2H3
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n/an/a 1.63E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 2939-44 (2008)


Article DOI: 10.1016/j.bmc.2007.12.044
BindingDB Entry DOI: 10.7270/Q2J67HST
More data for this
Ligand-Target Pair
Terminal deoxynucleotidyltransferase


(Homo sapiens (Human))
BDBM50143528
PNG
((1S,2S)-2-Hexadecyl-2-methoxymethoxy-5-oxo-cyclope...)
Show SMILES CCCCCCCCCCCCCCCC[C@]1(OCOC)C=CC(=O)[C@H]1C(=O)OC
Show InChI InChI=1S/C25H44O5/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-25(30-21-28-2)20-18-22(26)23(25)24(27)29-3/h18,20,23H,4-17,19,21H2,1-3H3/t23-,25-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against human terminal deoxynucleotidyltransferase


Bioorg Med Chem Lett 14: 1975-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.092
BindingDB Entry DOI: 10.7270/Q2W095C3
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153111
PNG
(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC[C@H]4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H50O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h19-26H,6-18H2,1-5H3,(H,30,31)/t20-,21+,22+,23?,24-,25?,26?,28+,29-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33387
PNG
(dehydroaltenusin derivative, 15)
Show SMILES CCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C20H22O6/c1-3-4-5-6-7-25-12-8-13-14-10-15(21)17(23)11-20(14,2)26-19(24)18(13)16(22)9-12/h8-10,22H,3-7,11H2,1-2H3
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n/an/a 2.40E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50251277
PNG
(CHEMBL458178 | Kasanosin A)
Show SMILES COc1cc(C)c(C(=O)O[C@H]2CC3=C(COC(\C=C\CO)=C3)C(=O)[C@@]2(C)O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(26)30-18-9-13-8-14(5-4-6-23)29-11-16(13)20(25)22(18,2)27/h4-5,7-8,10,18,23-24,27H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 2.73E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 4594-9 (2008)


Article DOI: 10.1016/j.bmc.2008.02.037
BindingDB Entry DOI: 10.7270/Q2X066TH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153106
PNG
(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Show SMILES CC(C)CCC[C@@H](C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OCC(O)=O
Show InChI InChI=1S/C29H48O3/c1-19(2)7-6-8-20(3)24-11-12-25-23-10-9-21-17-22(32-18-27(30)31)13-15-28(21,4)26(23)14-16-29(24,25)5/h9,19-20,22-26H,6-8,10-18H2,1-5H3,(H,30,31)/t20-,22+,23?,24-,25?,26?,28+,29-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA Polymerase beta


(Rattus norvegicus)
BDBM33386
PNG
(dehydroaltenusin derivative, 14)
Show SMILES CCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1
Show InChI InChI=1S/C17H16O6/c1-3-4-22-9-5-10-11-7-12(18)14(20)8-17(11,2)23-16(21)15(10)13(19)6-9/h5-7,19H,3-4,8H2,1-2H3
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n/an/a 3.50E+4n/an/an/an/a7.537



Kyoto Prefectural University



Assay Description
For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...


Bioorg Med Chem 17: 7227-38 (2009)


Article DOI: 10.1016/j.bmc.2009.08.051
BindingDB Entry DOI: 10.7270/Q2348HQK
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (Human))
BDBM50251277
PNG
(CHEMBL458178 | Kasanosin A)
Show SMILES COc1cc(C)c(C(=O)O[C@H]2CC3=C(COC(\C=C\CO)=C3)C(=O)[C@@]2(C)O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(26)30-18-9-13-8-14(5-4-6-23)29-11-16(13)20(25)22(18,2)27/h4-5,7-8,10,18,23-24,27H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Bioorg Med Chem 16: 4594-9 (2008)


Article DOI: 10.1016/j.bmc.2008.02.037
BindingDB Entry DOI: 10.7270/Q2X066TH
More data for this
Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon)


(Homo sapiens (Human))
BDBM50153117
PNG
((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...)
Show SMILES C[C@@H](CCC(O)=O)[C@H]1CCC2C3CC[C@]4(C)CC(O)CC[C@]4(C)C3CC[C@]12C
Show InChI InChI=1S/C25H42O3/c1-16(5-8-22(27)28)19-6-7-20-18-10-12-23(2)15-17(26)9-14-25(23,4)21(18)11-13-24(19,20)3/h16-21,26H,5-15H2,1-4H3,(H,27,28)/t16-,17?,18?,19+,20?,21?,23+,24+,25+/m0/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL


Assay Description
Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 units


J Med Chem 47: 4971-4 (2004)


Article DOI: 10.1021/jm030553v
BindingDB Entry DOI: 10.7270/Q2RN37BH
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 4.86E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase iota


(Mus musculus)
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 5.02E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant C-terminal-His6-tagged DNA polymerase iota assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 ...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase nu


(Homo sapiens (Human))
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 5.09E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of C-terminal-His6-tagged human pol nu expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(d...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase delta catalytic subunit


(Homo sapiens (Human))
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 5.45E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50379293
PNG
(CHEMBL2011648)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(O)[C@@H](OC(=O)c3c(C)cc(O)cc3O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,26)19(15(12)10-27-14)28-20(25)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,26H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 5.98E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...


J Nat Prod 75: 135-41 (2012)


Article DOI: 10.1021/np200523b
BindingDB Entry DOI: 10.7270/Q2T154NG
More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens (Human))
BDBM50375301
PNG
(CHEMBL260980)
Show SMILES COc1cc(O)c2c(c1)c1C(C)CC(=O)c1oc2=O
Show InChI InChI=1S/C14H12O5/c1-6-3-10(16)13-11(6)8-4-7(18-2)5-9(15)12(8)14(17)19-13/h4-6,15H,3H2,1-2H3
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n/an/a 5.98E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase kappa


Bioorg Med Chem 16: 2939-44 (2008)


Article DOI: 10.1016/j.bmc.2007.12.044
BindingDB Entry DOI: 10.7270/Q2J67HST
More data for this
Ligand-Target Pair
DNA polymerase beta


(Rattus norvegicus)
BDBM50251278
PNG
(CHEMBL457091 | Kasanosin B)
Show SMILES COc1cc(C)c(C(=O)O[C@@]2(C)[C@@H](O)CC3=C(COC(\C=C\CO)=C3)C2=O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(27)30-22(2)18(25)9-13-8-14(5-4-6-23)29-11-16(13)20(22)26/h4-5,7-8,10,18,23-25H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 6.01E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta


Bioorg Med Chem 16: 4594-9 (2008)


Article DOI: 10.1016/j.bmc.2008.02.037
BindingDB Entry DOI: 10.7270/Q2X066TH
More data for this
Ligand-Target Pair
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