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Compile Data Set for Download or QSAR

Found 181 hits with Last Name = 'lagisetti' and Initial = 'c'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SRSF protein kinase 1


(Mus musculus)
BDBM50235034
PNG
(CHEMBL4064277)
Show SMILES FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
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890n/an/an/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of mouse His6-tagged SRPK1 expressed in Escherichia coli(BL21)


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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n/an/a 6n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235035
PNG
(CHEMBL4066861)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235036
PNG
(CHEMBL4082309)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235024
PNG
(CHEMBL4088144)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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n/an/a 17n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235019
PNG
(CHEMBL4067013)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235021
PNG
(CHEMBL4104657)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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n/an/a 21n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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n/an/a 25n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235023
PNG
(CHEMBL4073318)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235019
PNG
(CHEMBL4067013)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235021
PNG
(CHEMBL4104657)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235031
PNG
(CHEMBL4064123)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235021
PNG
(CHEMBL4104657)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235037
PNG
(CHEMBL4102101)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m0/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235031
PNG
(CHEMBL4064123)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m0/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235019
PNG
(CHEMBL4067013)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m1/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235030
PNG
(CHEMBL4091876)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235035
PNG
(CHEMBL4066861)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m0/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235035
PNG
(CHEMBL4066861)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235036
PNG
(CHEMBL4082309)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235031
PNG
(CHEMBL4064123)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C22H29ClN8O/c1-12(2)31-11-25-19-20(27-16-9-14(23)8-15(10-16)26-13(3)32)29-22(30-21(19)31)28-18-7-5-4-6-17(18)24/h8-12,17-18H,4-7,24H2,1-3H3,(H,26,32)(H2,27,28,29,30)/t17-,18+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235030
PNG
(CHEMBL4091876)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235023
PNG
(CHEMBL4073318)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235037
PNG
(CHEMBL4102101)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235023
PNG
(CHEMBL4073318)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16+/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235037
PNG
(CHEMBL4102101)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235024
PNG
(CHEMBL4088144)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16-/m0/s1
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n/an/a 78n/an/an/an/an/an/a



SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235024
PNG
(CHEMBL4088144)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235029
PNG
(CHEMBL4084116)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235030
PNG
(CHEMBL4091876)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCNC3)nc12
Show InChI InChI=1S/C19H25ClN8/c1-11(2)28-10-23-16-17(24-15-7-12(20)6-13(21)8-15)26-19(27-18(16)28)25-14-4-3-5-22-9-14/h6-8,10-11,14,22H,3-5,9,21H2,1-2H3,(H2,24,25,26,27)/t14-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50073765
PNG
(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Show SMILES CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50073765
PNG
(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Show SMILES CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235029
PNG
(CHEMBL4084116)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235025
PNG
(CHEMBL4104505)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H26ClN7/c1-12(2)28-11-23-17-18(24-14-7-5-6-13(21)10-14)26-20(27-19(17)28)25-16-9-4-3-8-15(16)22/h5-7,10-12,15-16H,3-4,8-9,22H2,1-2H3,(H2,24,25,26,27)/t15-,16-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235036
PNG
(CHEMBL4082309)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50073765
PNG
(CHEMBL367625 | N*2*-((1R,2S)-2-Amino-cyclohexyl)-N...)
Show SMILES CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15+/m0/s1
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SRI International

Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235032
PNG
(CHEMBL4100324)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16-/m1/s1
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Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235026
PNG
(CHEMBL4080283)
Show SMILES CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12
Show InChI InChI=1S/C19H24ClN7/c1-2-27-11-22-16-17(23-13-7-5-6-12(20)10-13)25-19(26-18(16)27)24-15-9-4-3-8-14(15)21/h5-7,10-11,14-15H,2-4,8-9,21H2,1H3,(H2,23,24,25,26)/t14-,15-/m0/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235032
PNG
(CHEMBL4100324)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@H]3N)nc12
Show InChI InChI=1S/C20H27ClN8/c1-11(2)29-10-24-17-18(25-14-8-12(21)7-13(22)9-14)27-20(28-19(17)29)26-16-6-4-3-5-15(16)23/h7-11,15-16H,3-6,22-23H2,1-2H3,(H2,25,26,27,28)/t15-,16-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK1 using substrate ERMRPRKRQGSVRRRV in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4


(Homo sapiens (Human))
BDBM50235029
PNG
(CHEMBL4084116)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCNC3)nc12
Show InChI InChI=1S/C18H23ClN8/c1-10(2)27-9-22-15-16(23-14-6-11(19)5-12(20)7-14)25-18(26-17(15)27)24-13-3-4-21-8-13/h5-7,9-10,13,21H,3-4,8,20H2,1-2H3,(H2,23,24,25,26)/t13-/m1/s1
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Curated by ChEMBL


Assay Description
Inhibition of human CLK4 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter method


Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
BindingDB Entry DOI: 10.7270/Q27946ZF
More data for this
Ligand-Target Pair
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