BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 536 hits with Last Name = 'madauss' and Initial = 'kp'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
PubMed
0.251n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
PubMed
10n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50474916
PNG
(CHEMBL364712)
Show SMILES C[C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-9-21(24(22,23)13-5-3-12(17)4-6-13)20-16(10)11-2-7-14(18)15(19)8-11/h2-8,10H,9H2,1H3/t10-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
20n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474916
PNG
(CHEMBL364712)
Show SMILES C[C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-9-21(24(22,23)13-5-3-12(17)4-6-13)20-16(10)11-2-7-14(18)15(19)8-11/h2-8,10H,9H2,1H3/t10-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
25n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474911
PNG
(CHEMBL192314)
Show SMILES CN(C)c1ccc(cc1)C1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474917
PNG
(CHEMBL366252)
Show SMILES CC1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-9-21(24(22,23)13-5-3-12(17)4-6-13)20-16(10)11-2-7-14(18)15(19)8-11/h2-8,10H,9H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474914
PNG
(CHEMBL190198)
Show SMILES CC1CC(=NN1S(=O)(=O)c1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-8-16(11-2-7-14(18)15(19)9-11)20-21(10)24(22,23)13-5-3-12(17)4-6-13/h2-7,9-10H,8H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474912
PNG
(CHEMBL190264)
Show SMILES CN(C)c1ccc(cc1)[C@@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3/t20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
100n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474919
PNG
(CHEMBL364924)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(C(=N1)c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H15Cl3N2O2S/c22-16-7-9-17(10-8-16)29(27,28)26-13-18(14-4-2-1-3-5-14)21(25-26)15-6-11-19(23)20(24)12-15/h1-12,18H,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
100n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474914
PNG
(CHEMBL190198)
Show SMILES CC1CC(=NN1S(=O)(=O)c1ccc(Cl)cc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-8-16(11-2-7-14(18)15(19)9-11)20-21(10)24(22,23)13-5-3-12(17)4-6-13/h2-7,9-10H,8H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
200n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474915
PNG
(CHEMBL190900)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1N=C(CC1c1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H15Cl3N2O2S/c22-16-7-9-17(10-8-16)29(27,28)26-21(14-4-2-1-3-5-14)13-20(25-26)15-6-11-18(23)19(24)12-15/h1-12,21H,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
398n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474911
PNG
(CHEMBL192314)
Show SMILES CN(C)c1ccc(cc1)C1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
794n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474912
PNG
(CHEMBL190264)
Show SMILES CN(C)c1ccc(cc1)[C@@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3/t20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
1.59E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474913
PNG
(CHEMBL192859)
Show SMILES C[C@@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-9-21(24(22,23)13-5-3-12(17)4-6-13)20-16(10)11-2-7-14(18)15(19)8-11/h2-8,10H,9H2,1H3/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
2.00E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474918
PNG
(CHEMBL373299)
Show SMILES CN(C)c1ccc(cc1)[C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3/t20-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
<3.16E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474913
PNG
(CHEMBL192859)
Show SMILES C[C@@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13Cl3N2O2S/c1-10-9-21(24(22,23)13-5-3-12(17)4-6-13)20-16(10)11-2-7-14(18)15(19)8-11/h2-8,10H,9H2,1H3/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
5.01E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of 4 nM progesterone-stimulated transactivation of MMTV-Luc reporter in CV-1 cells expressing PR-B


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474915
PNG
(CHEMBL190900)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1N=C(CC1c1ccccc1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H15Cl3N2O2S/c22-16-7-9-17(10-8-16)29(27,28)26-21(14-4-2-1-3-5-14)13-20(25-26)15-6-11-18(23)19(24)12-15/h1-12,21H,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
7.94E+3n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50474918
PNG
(CHEMBL373299)
Show SMILES CN(C)c1ccc(cc1)[C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20Cl3N3O2S/c1-28(2)18-8-3-15(4-9-18)20-14-29(32(30,31)19-10-6-17(24)7-11-19)27-23(20)16-5-12-21(25)22(26)13-16/h3-13,20H,14H2,1-2H3/t20-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
<1.00E+4n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Displacement of fluorescent ligand from binding domain of progesterone receptor


Bioorg Med Chem Lett 15: 3203-6 (2005)

More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479034
PNG
(CHEMBL515482)
Show SMILES CC(=O)c1cc(OCCc2ccccc2)c(=O)n2[C@@H](CCc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H26N2O4/c1-16(26)18-15-21(29-14-11-17-7-3-2-4-8-17)23(28)25-19(18)9-10-20(25)22(27)24-12-5-6-13-24/h2-4,7-8,15,20H,5-6,9-14H2,1H3/t20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50316818
PNG
(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Show SMILES O=C([C@@H]1C[C@H]1c1ccccc1)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)N1CCSC1
Show InChI InChI=1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50415020
PNG
(CHEMBL570708)
Show SMILES Cc1c(C#N)c(Cl)nc2c3C(CC(=O)Nc3sc12)c1ccccc1Cl
Show InChI InChI=1S/C18H11Cl2N3OS/c1-8-11(7-21)17(20)23-15-14-10(9-4-2-3-5-12(9)19)6-13(24)22-18(14)25-16(8)15/h2-5,10H,6H2,1H3,(H,22,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.51n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at progesterone receptor in human T47D cell after 24 hrs by alkaline phosphatase assay


Bioorg Med Chem Lett 19: 4916-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.100
BindingDB Entry DOI: 10.7270/Q2F76DSM
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479006
PNG
(CHEMBL476508)
Show SMILES CC(=O)c1cc(OCCc2ccc(F)cc2)c(=O)n2[C@@H](CCc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H25FN2O4/c1-15(27)18-14-21(30-13-10-16-4-6-17(24)7-5-16)23(29)26-19(18)8-9-20(26)22(28)25-11-2-3-12-25/h4-7,14,20H,2-3,8-13H2,1H3/t20-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50412519
PNG
(CHEMBL455662)
Show SMILES CCN(C[C@](O)(CNC(=O)c1cnn(c1N)-c1ccc(F)cc1)C(F)(F)F)C(=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H21Cl2F4N5O3/c1-2-33(21(36)18-16(24)4-3-5-17(18)25)12-22(37,23(27,28)29)11-31-20(35)15-10-32-34(19(15)30)14-8-6-13(26)7-9-14/h3-10,37H,2,11-12,30H2,1H3,(H,31,35)/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to glucocorticoid receptor


Bioorg Med Chem Lett 18: 6097-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.10.021
BindingDB Entry DOI: 10.7270/Q2668FDB
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479013
PNG
(CHEMBL476950)
Show SMILES Fc1cc(F)cc(COc2cc(c3CC[C@@H](C(=O)N4CCCC4)n3c2=O)S(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C26H24F2N2O5S/c27-18-12-17(13-19(28)14-18)16-35-23-15-24(36(33,34)20-6-2-1-3-7-20)21-8-9-22(30(21)26(23)32)25(31)29-10-4-5-11-29/h1-3,6-7,12-15,22H,4-5,8-11,16H2/t22-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304973
PNG
((S)-4-((2-bromobenzyl)(1-(methylsulfonyl)pyrrolidi...)
Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N(Cc1ccccc1Br)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C19H19BrClN3O2S/c1-27(25,26)23-9-8-17(13-23)24(12-15-4-2-3-5-18(15)20)16-7-6-14(11-22)19(21)10-16/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304972
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-(methylsulfonyl...)
Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C19H19Cl2N3O2S/c1-27(25,26)23-9-8-17(13-23)24(12-15-4-2-3-5-18(15)20)16-7-6-14(11-22)19(21)10-16/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479014
PNG
(CHEMBL477998)
Show SMILES CC(=O)c1cc(OCc2ccc(F)c(F)c2)c(=O)n2[C@@H](CCc12)C(=O)N1CCCC1
Show InChI InChI=1S/C22H22F2N2O4/c1-13(27)15-11-20(30-12-14-4-5-16(23)17(24)10-14)22(29)26-18(15)6-7-19(26)21(28)25-8-2-3-9-25/h4-5,10-11,19H,2-3,6-9,12H2,1H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 7n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298032
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-(cyanomethyl)py...)
Show SMILES Clc1ccccc1CN([C@H]1CCN(CC#N)C1)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2N4/c21-19-4-2-1-3-16(19)13-26(18-7-9-25(14-18)10-8-23)17-6-5-15(12-24)20(22)11-17/h1-6,11,18H,7,9-10,13-14H2/t18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to PR by fluorescence polarization based competition binding assay


Bioorg Med Chem Lett 19: 4777-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.055
BindingDB Entry DOI: 10.7270/Q2TB16XG
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298033
PNG
((S)-ethyl 2-(3-((3-chloro-4-cyanophenyl)(2-chlorob...)
Show SMILES CCOC(=O)CN1CC[C@@H](C1)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C22H23Cl2N3O2/c1-2-29-22(28)15-26-10-9-19(14-26)27(13-17-5-3-4-6-20(17)23)18-8-7-16(12-25)21(24)11-18/h3-8,11,19H,2,9-10,13-15H2,1H3/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to PR by fluorescence polarization based competition binding assay


Bioorg Med Chem Lett 19: 4777-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.055
BindingDB Entry DOI: 10.7270/Q2TB16XG
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304987
PNG
((S)-4-((2-bromobenzyl)(1-propionylpyrrolidin-3-yl)...)
Show SMILES CCC(=O)N1CC[C@@H](C1)N(Cc1ccccc1Br)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H21BrClN3O/c1-2-21(27)25-10-9-18(14-25)26(13-16-5-3-4-6-19(16)22)17-8-7-15(12-24)20(23)11-17/h3-8,11,18H,2,9-10,13-14H2,1H3/t18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304978
PNG
((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-chloroben...)
Show SMILES COC(=O)N1CC[C@@H](C1)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19Cl2N3O2/c1-27-20(26)24-9-8-17(13-24)25(12-15-4-2-3-5-18(15)21)16-7-6-14(11-23)19(22)10-16/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479035
PNG
(CHEMBL478199)
Show SMILES CC(=O)c1cc(OCc2ccc(F)c(Cl)c2)c(=O)n2[C@@H](CCc12)C(=O)N1CCCC1
Show InChI InChI=1S/C22H22ClFN2O4/c1-13(27)15-11-20(30-12-14-4-5-17(24)16(23)10-14)22(29)26-18(15)6-7-19(26)21(28)25-8-2-3-9-25/h4-5,10-11,19H,2-3,6-9,12H2,1H3/t19-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298210
PNG
((S)-2-chloro-4-((2,5-dichlorobenzyl)(1-ethyl-5-oxo...)
Show SMILES CCN1C[C@H](CC1=O)N(Cc1cc(Cl)ccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H18Cl3N3O/c1-2-25-12-17(9-20(25)27)26(11-14-7-15(21)4-6-18(14)22)16-5-3-13(10-24)19(23)8-16/h3-8,17H,2,9,11-12H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298207
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-isopropyl-5-oxo...)
Show SMILES CC(C)N1C[C@H](CC1=O)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H21Cl2N3O/c1-14(2)25-13-18(10-21(25)27)26(12-16-5-3-4-6-19(16)22)17-8-7-15(11-24)20(23)9-17/h3-9,14,18H,10,12-13H2,1-2H3/t18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298208
PNG
((S)-2-chloro-4-((2-chloro-5-fluorobenzyl)(1-ethyl-...)
Show SMILES CCN1C[C@H](CC1=O)N(Cc1cc(F)ccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2FN3O/c1-2-25-12-17(9-20(25)27)26(11-14-7-15(23)4-6-18(14)21)16-5-3-13(10-24)19(22)8-16/h3-8,17H,2,9,11-12H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479012
PNG
(CHEMBL476951)
Show SMILES FC(F)(F)c1ccc(COc2cc(c3CC[C@@H](C(=O)N4CCCC4)n3c2=O)S(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C27H25F3N2O5S/c28-27(29,30)19-10-8-18(9-11-19)17-37-23-16-24(38(35,36)20-6-2-1-3-7-20)21-12-13-22(32(21)26(23)34)25(33)31-14-4-5-15-31/h1-3,6-11,16,22H,4-5,12-15,17H2/t22-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 11n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50478998
PNG
(CHEMBL514702)
Show SMILES Clc1cc(NCc2ccccc2)c(=O)n2[C@@H](CCc12)C(=O)N1CCCC1
Show InChI InChI=1S/C20H22ClN3O2/c21-15-12-16(22-13-14-6-2-1-3-7-14)19(25)24-17(15)8-9-18(24)20(26)23-10-4-5-11-23/h1-3,6-7,12,18,22H,4-5,8-11,13H2/t18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304977
PNG
((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-methylben...)
Show SMILES COC(=O)N1CC[C@@H](C1)N(Cc1ccccc1C)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H22ClN3O2/c1-15-5-3-4-6-17(15)13-25(18-8-7-16(12-23)20(22)11-18)19-9-10-24(14-19)21(26)27-2/h3-8,11,19H,9-10,13-14H2,1-2H3/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304975
PNG
((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-(trifluor...)
Show SMILES COC(=O)N1CC[C@@H](C1)N(Cc1ccccc1C(F)(F)F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H19ClF3N3O2/c1-30-20(29)27-9-8-17(13-27)28(16-7-6-14(11-26)19(22)10-16)12-15-4-2-3-5-18(15)21(23,24)25/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304976
PNG
((S)-methyl 3-((3-chloro-4-cyanophenyl)(2-fluoroben...)
Show SMILES COC(=O)N1CC[C@@H](C1)N(Cc1ccccc1F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19ClFN3O2/c1-27-20(26)24-9-8-17(13-24)25(12-15-4-2-3-5-19(15)22)16-7-6-14(11-23)18(21)10-16/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298030
PNG
((S)-2-chloro-4-((2-chlorobenzyl)(1-(3,3,3-trifluor...)
Show SMILES FC(F)(F)CCN1CC[C@@H](C1)N(Cc1ccccc1Cl)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H20Cl2F3N3/c22-19-4-2-1-3-16(19)13-29(17-6-5-15(12-27)20(23)11-17)18-7-9-28(14-18)10-8-21(24,25)26/h1-6,11,18H,7-10,13-14H2/t18-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to PR by fluorescence polarization based competition binding assay


Bioorg Med Chem Lett 19: 4777-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.055
BindingDB Entry DOI: 10.7270/Q2TB16XG
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304964
PNG
((S)-2-chloro-4-((1-(methylsulfonyl)pyrrolidin-3-yl...)
Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N(Cc1ccccc1C(F)(F)F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3O2S/c1-30(28,29)26-9-8-17(13-26)27(16-7-6-14(11-25)19(21)10-16)12-15-4-2-3-5-18(15)20(22,23)24/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50478997
PNG
(CHEMBL476985)
Show SMILES Fc1ccc(CNc2cc(Cl)c3CC[C@@H](C(=O)N4CCCC4)n3c2=O)cc1F
Show InChI InChI=1S/C20H20ClF2N3O2/c21-13-10-16(24-11-12-3-4-14(22)15(23)9-12)19(27)26-17(13)5-6-18(26)20(28)25-7-1-2-8-25/h3-4,9-10,18,24H,1-2,5-8,11H2/t18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298209
PNG
((S)-2-chloro-4-((1-ethyl-5-oxopyrrolidin-3-yl)(2-m...)
Show SMILES CCN1C[C@H](CC1=O)N(Cc1ccccc1C)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C21H22ClN3O/c1-3-24-14-19(11-21(24)26)25(13-17-7-5-4-6-15(17)2)18-9-8-16(12-23)20(22)10-18/h4-10,19H,3,11,13-14H2,1-2H3/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298219
PNG
((R)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifl...)
Show SMILES CN1CC[C@H](C1)N(Cc1ccccc1C(F)(F)F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3/c1-26-9-8-17(13-26)27(16-7-6-14(11-25)19(21)10-16)12-15-4-2-3-5-18(15)20(22,23)24/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


Bioorg Med Chem Lett 19: 4664-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.081
BindingDB Entry DOI: 10.7270/Q25H7G9T
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50304957
PNG
((S)-2-chloro-4-((2-methylbenzyl)(1-propionylpyrrol...)
Show SMILES CCC(=O)N1CC[C@@H](C1)N(Cc1ccccc1C)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C22H24ClN3O/c1-3-22(27)25-11-10-20(15-25)26(14-18-7-5-4-6-16(18)2)19-9-8-17(13-24)21(23)12-19/h4-9,12,20H,3,10-11,14-15H2,1-2H3/t20-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50298028
PNG
((S)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifl...)
Show SMILES CN1CC[C@@H](C1)N(Cc1ccccc1C(F)(F)F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3/c1-26-9-8-17(13-26)27(16-7-6-14(11-25)19(21)10-16)12-15-4-2-3-5-18(15)20(22,23)24/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50298028
PNG
((S)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifl...)
Show SMILES CN1CC[C@@H](C1)N(Cc1ccccc1C(F)(F)F)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H19ClF3N3/c1-26-9-8-17(13-26)27(16-7-6-14(11-25)19(21)10-16)12-15-4-2-3-5-18(15)20(22,23)24/h2-7,10,17H,8-9,12-13H2,1H3/t17-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

PDB
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to PR by fluorescence polarization based competition binding assay


Bioorg Med Chem Lett 19: 4777-80 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.055
BindingDB Entry DOI: 10.7270/Q2TB16XG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50304974
PNG
((S)-2-chloro-4-((2-methylbenzyl)(1-(methylsulfonyl...)
Show SMILES Cc1ccccc1CN([C@H]1CCN(C1)S(C)(=O)=O)c1ccc(C#N)c(Cl)c1
Show InChI InChI=1S/C20H22ClN3O2S/c1-15-5-3-4-6-17(15)13-24(18-8-7-16(12-22)20(21)11-18)19-9-10-23(14-19)27(2,25)26/h3-8,11,19H,9-10,13-14H2,1-2H3/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PR


Bioorg Med Chem Lett 20: 371-4 (2010)


Article DOI: 10.1016/j.bmcl.2009.10.092
BindingDB Entry DOI: 10.7270/Q2057G17
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50479022
PNG
(CHEMBL515786)
Show SMILES Fc1ccc(CNc2cc(Cl)c3CC[C@@H](C(=O)N4CCCC4)n3c2=O)cc1
Show InChI InChI=1S/C20H21ClFN3O2/c21-15-11-16(23-12-13-3-5-14(22)6-4-13)19(26)25-17(15)7-8-18(25)20(27)24-9-1-2-10-24/h3-6,11,18,23H,1-2,7-10,12H2/t18-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 17n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant POP expressed in sEscherichia coli


Bioorg Med Chem Lett 18: 4360-3 (2008)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 536 total )  |  Next  |  Last  >>
Jump to: