Compile Data Set for Download or QSAR

Found 393 hits with Last Name = 'mateo' and Initial = 'ai'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186127 (CHEMBL378408 | N-[(R)-2-{4-[2-(acetyl-ethyl-amino)...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)C(C)=O Show InChI InChI=1S/C35H48ClN5O3/c1-3-39(25(2)42)24-33(27-9-5-4-6-10-27)40-17-19-41(20-18-40)35(44)32(21-26-13-15-29(36)16-14-26)38-34(43)23-30-22-28-11-7-8-12-31(28)37-30/h7-8,11-16,27,30,32-33,37H,3-6,9-10,17-24H2,1-2H3,(H,38,43)/t30?,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186127 (CHEMBL378408 | N-[(R)-2-{4-[2-(acetyl-ethyl-amino)...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)C(C)=O Show InChI InChI=1S/C35H48ClN5O3/c1-3-39(25(2)42)24-33(27-9-5-4-6-10-27)40-17-19-41(20-18-40)35(44)32(21-26-13-15-29(36)16-14-26)38-34(43)23-30-22-28-11-7-8-12-31(28)37-30/h7-8,11-16,27,30,32-33,37H,3-6,9-10,17-24H2,1-2H3,(H,38,43)/t30?,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50031704 ((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...) Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186128 (CHEMBL209990 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC)CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1 Show InChI InChI=1S/C35H50ClN5O2/c1-3-39(4-2)25-33(27-10-6-5-7-11-27)40-18-20-41(21-19-40)35(43)32(22-26-14-16-29(36)17-15-26)38-34(42)24-30-23-28-12-8-9-13-31(28)37-30/h8-9,12-17,27,30,32-33,37H,3-7,10-11,18-25H2,1-2H3,(H,38,42)/t30?,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186124 (CHEMBL410087 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)S(C)(=O)=O Show InChI InChI=1S/C34H48ClN5O4S/c1-3-40(45(2,43)44)24-32(26-9-5-4-6-10-26)38-17-19-39(20-18-38)34(42)31(21-25-13-15-28(35)16-14-25)37-33(41)23-29-22-27-11-7-8-12-30(27)36-29/h7-8,11-16,26,29,31-32,36H,3-6,9-10,17-24H2,1-2H3,(H,37,41)/t29?,31-,32?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186121 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(1-cyclopentyl-...) Show SMILES CCN(CC)CC(C1CCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C34H48ClN5O2/c1-3-38(4-2)24-32(26-9-5-6-10-26)39-17-19-40(20-18-39)34(42)31(21-25-13-15-29(35)16-14-25)37-33(41)30-22-27-11-7-8-12-28(27)23-36-30/h7-8,11-16,26,30-32,36H,3-6,9-10,17-24H2,1-2H3,(H,37,41)/t30-,31-,32?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186131 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(1-cyclohexyl-2...) Show SMILES CCN(CC)CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C35H50ClN5O2/c1-3-39(4-2)25-33(27-10-6-5-7-11-27)40-18-20-41(21-19-40)35(43)32(22-26-14-16-30(36)17-15-26)38-34(42)31-23-28-12-8-9-13-29(28)24-37-31/h8-9,12-17,27,31-33,37H,3-7,10-11,18-25H2,1-2H3,(H,38,42)/t31-,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186128 (CHEMBL209990 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC)CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1 Show InChI InChI=1S/C35H50ClN5O2/c1-3-39(4-2)25-33(27-10-6-5-7-11-27)40-18-20-41(21-19-40)35(43)32(22-26-14-16-29(36)17-15-26)38-34(42)24-30-23-28-12-8-9-13-31(28)37-30/h8-9,12-17,27,30,32-33,37H,3-7,10-11,18-25H2,1-2H3,(H,38,42)/t30?,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186125 (CHEMBL377825 | N-((R)-3-(4-chlorophenyl)-1-(4-(3-c...) Show SMILES CCN(CC)CC(CC1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1 Show InChI InChI=1S/C36H52ClN5O2/c1-3-40(4-2)26-32(22-27-10-6-5-7-11-27)41-18-20-42(21-19-41)36(44)34(23-28-14-16-30(37)17-15-28)39-35(43)25-31-24-29-12-8-9-13-33(29)38-31/h8-9,12-17,27,31-32,34,38H,3-7,10-11,18-26H2,1-2H3,(H,39,43)/t31?,32?,34-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186124 (CHEMBL410087 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)S(C)(=O)=O Show InChI InChI=1S/C34H48ClN5O4S/c1-3-40(45(2,43)44)24-32(26-9-5-4-6-10-26)38-17-19-39(20-18-38)34(42)31(21-25-13-15-28(35)16-14-25)37-33(41)23-29-22-27-11-7-8-12-30(27)36-29/h7-8,11-16,26,29,31-32,36H,3-6,9-10,17-24H2,1-2H3,(H,37,41)/t29?,31-,32?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088223 (CHEMBL61751 | E-2-Amino-4-(3-naphthalen-1-yl-allyl...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1cccc2ccccc12)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-14(17(20)21)9-4-8-13-7-3-6-12-5-1-2-10-15(12)13/h1-8,10,14,16H,9,11,19H2,(H,20,21)(H,22,23)/b8-4+/t14-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186138 (CHEMBL425609 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)n1cc2ccccc2c1)S(C)(=O)=O Show InChI InChI=1S/C33H44ClN5O4S/c1-3-39(44(2,42)43)24-31(26-9-5-4-6-10-26)36-17-19-37(20-18-36)32(40)30(21-25-13-15-29(34)16-14-25)35-33(41)38-22-27-11-7-8-12-28(27)23-38/h7-8,11-16,22-23,26,30-31H,3-6,9-10,17-21,24H2,1-2H3,(H,35,41)/t30-,31?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088197 (CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Grik5 (Homo sapiens (Human))	BDBM50002369 ((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...) Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088197 (CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186127 (CHEMBL378408 | N-[(R)-2-{4-[2-(acetyl-ethyl-amino)...) Show SMILES CCN(CC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1)C(C)=O Show InChI InChI=1S/C35H48ClN5O3/c1-3-39(25(2)42)24-33(27-9-5-4-6-10-27)40-17-19-41(20-18-40)35(44)32(21-26-13-15-29(36)16-14-26)38-34(43)23-30-22-28-11-7-8-12-31(28)37-30/h7-8,11-16,27,30,32-33,37H,3-6,9-10,17-24H2,1-2H3,(H,38,43)/t30?,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186122 (CHEMBL377313 | N-((R)-3-(4-chlorophenyl)-1-(4-(3-c...) Show SMILES Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CC2CCCCC2)CN2CCOCC2)cc1 Show InChI InChI=1S/C36H50ClN5O3/c37-30-12-10-28(11-13-30)23-34(39-35(43)25-31-24-29-8-4-5-9-33(29)38-31)36(44)42-16-14-41(15-17-42)32(22-27-6-2-1-3-7-27)26-40-18-20-45-21-19-40/h4-5,8-13,27,31-32,34,38H,1-3,6-7,14-26H2,(H,39,43)/t31?,32?,34-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Glutamate-Kainate 7 (Homo sapiens (Human))	BDBM50002369 ((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...) Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...				Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186132 (CHEMBL378411 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CN2C(=O)CCC2=O)C2CCCCC2)cc1 Show InChI InChI=1S/C35H44ClN5O4/c36-27-12-10-24(11-13-27)20-30(38-32(42)22-28-21-26-8-4-5-9-29(26)37-28)35(45)40-18-16-39(17-19-40)31(25-6-2-1-3-7-25)23-41-33(43)14-15-34(41)44/h4-5,8-13,25,28,30-31,37H,1-3,6-7,14-23H2,(H,38,42)/t28?,30-,31?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50031704 ((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...) Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Glutamate-Kainate 7 (Homo sapiens (Human))	BDBM50002369 ((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...) Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088229 (2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...) Show SMILES N[C@@H](C[C@@H](CC#C)C(O)=O)C(O)=O Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	11.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186120 (CHEMBL380391 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(...) Show SMILES Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CNC2CCC2)CC2CCCCC2)cc1 Show InChI InChI=1S/C36H50ClN5O2/c37-29-15-13-27(14-16-29)22-34(40-35(43)24-31-23-28-9-4-5-12-33(28)39-31)36(44)42-19-17-41(18-20-42)32(25-38-30-10-6-11-30)21-26-7-2-1-3-8-26/h4-5,9,12-16,26,30-32,34,38-39H,1-3,6-8,10-11,17-25H2,(H,40,43)/t31?,32?,34-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186135 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(3-cyclohexyl-1...) Show SMILES CCN(CC)CC(CC1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C36H52ClN5O2/c1-3-40(4-2)26-32(22-27-10-6-5-7-11-27)41-18-20-42(21-19-41)36(44)34(23-28-14-16-31(37)17-15-28)39-35(43)33-24-29-12-8-9-13-30(29)25-38-33/h8-9,12-17,27,32-34,38H,3-7,10-11,18-26H2,1-2H3,(H,39,43)/t32?,33-,34-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186119 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(1-cycloheptyl-...) Show SMILES CCN(CC)CC(C1CCCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C36H52ClN5O2/c1-3-40(4-2)26-34(28-11-7-5-6-8-12-28)41-19-21-42(22-20-41)36(44)33(23-27-15-17-31(37)18-16-27)39-35(43)32-24-29-13-9-10-14-30(29)25-38-32/h9-10,13-18,28,32-34,38H,3-8,11-12,19-26H2,1-2H3,(H,39,43)/t32-,33-,34?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174056 (CHEMBL381015 | Diethyl-[(S)-2-(2-fluoro-phenyl)-2-...) Show SMILES CCN(CC)C[C@@H](N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H28FN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088222 ((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50139027 ((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...) Show SMILES CCN(CC)Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1 Show InChI InChI=1S/C34H42ClN5O2/c1-3-38(4-2)24-28-11-7-8-12-32(28)39-17-19-40(20-18-39)34(42)31(21-25-13-15-29(35)16-14-25)37-33(41)30-22-26-9-5-6-10-27(26)23-36-30/h5-16,30-31,36H,3-4,17-24H2,1-2H3,(H,37,41)/t30-,31-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186133 (3,4-Dihydro-1H-isoquinoline-2-carboxylic acid ((R)...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)N1CCc2ccccc2C1)c1ccccc1F Show InChI InChI=1S/C35H43ClFN5O2/c1-3-39(4-2)25-33(30-11-7-8-12-31(30)37)40-19-21-41(22-20-40)34(43)32(23-26-13-15-29(36)16-14-26)38-35(44)42-18-17-27-9-5-6-10-28(27)24-42/h5-16,32-33H,3-4,17-25H2,1-2H3,(H,38,44)/t32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088222 ((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...				Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088222 ((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186126 (CHEMBL379051 | N-((R)-3-(4-chlorophenyl)-1-(4-(2,6...) Show SMILES CC(C)CC(CC(C)C)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1 Show InChI InChI=1S/C32H45ClN4O2/c1-22(2)17-28(18-23(3)4)36-13-15-37(16-14-36)32(39)30(19-24-9-11-26(33)12-10-24)35-31(38)21-27-20-25-7-5-6-8-29(25)34-27/h5-12,22-23,27-28,30,34H,13-21H2,1-4H3,(H,35,38)/t27?,30-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186132 (CHEMBL378411 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(CN2C(=O)CCC2=O)C2CCCCC2)cc1 Show InChI InChI=1S/C35H44ClN5O4/c36-27-12-10-24(11-13-27)20-30(38-32(42)22-28-21-26-8-4-5-9-29(26)37-28)35(45)40-18-16-39(17-19-40)31(25-6-2-1-3-7-25)23-41-33(43)14-15-34(41)44/h4-5,8-13,25,28,30-31,37H,1-3,6-7,14-23H2,(H,38,42)/t28?,30-,31?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50177561 ((R)-N-((R)-3-(4-chlorophenyl)-1-(4-(2-(diethylamin...) Show SMILES CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@H]1Cc2ccccc2CN1)c1ccccc1F Show InChI InChI=1S/C35H43ClFN5O2/c1-3-40(4-2)24-33(29-11-7-8-12-30(29)37)41-17-19-42(20-18-41)35(44)32(21-25-13-15-28(36)16-14-25)39-34(43)31-22-26-9-5-6-10-27(26)23-38-31/h5-16,31-33,38H,3-4,17-24H2,1-2H3,(H,39,43)/t31-,32-,33?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174055 (CHEMBL198379 | Diethyl-[2-(2-fluoro-phenyl)-2-(4-m...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1F Show InChI InChI=1S/C17H28FN3/c1-4-20(5-2)14-17(15-8-6-7-9-16(15)18)21-12-10-19(3)11-13-21/h6-9,17H,4-5,10-14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088212 (2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...) Show SMILES C\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2+/t6-,7+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088216 (CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...) Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186134 (CHEMBL209559 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-c...) Show SMILES CS(=O)(=O)NCC(C1CCCCC1)N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1Cc2ccccc2N1 Show InChI InChI=1S/C32H44ClN5O4S/c1-43(41,42)34-22-30(24-7-3-2-4-8-24)37-15-17-38(18-16-37)32(40)29(19-23-11-13-26(33)14-12-23)36-31(39)21-27-20-25-9-5-6-10-28(25)35-27/h5-6,9-14,24,27,29-30,34-35H,2-4,7-8,15-22H2,1H3,(H,36,39)/t27?,29-,30?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088228 (2-Amino-4-but-2-ynyl-pentanedioic acid | CHEMBL620...) Show SMILES CC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C9H13NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	28.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088216 (CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...) Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088203 (CHEMBL301915 | E-2-Amino-4-[3-(4-bromo-phenyl)-all...) Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Br)cc1)C(O)=O)C(O)=O Show InChI InChI=1S/C14H16BrNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50002369 ((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...) Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50002369 ((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...) Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 2 using cell membranes prepared from HEK293 cell...				Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB
					More data for this Ligand-Target Pair				3D Structure (crystal)
GRIK1 (Homo sapiens (Human))	BDBM50088235 (CHEMBL300368 | E-2-Amino-4-[3-(4-methylsulfanyl-ph...) Show SMILES CSc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1 Show InChI InChI=1S/C15H19NO4S/c1-21-12-7-5-10(6-8-12)3-2-4-11(14(17)18)9-13(16)15(19)20/h2-3,5-8,11,13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t11-,13+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic kainate (Homo sapiens (Human))	BDBM50091477 ((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...) Show SMILES N[C@@H](CC(C(O)=O)=C1CCCC1)C(O)=O Show InChI InChI=1S/C10H15NO4/c11-8(10(14)15)5-7(9(12)13)6-3-1-2-4-6/h8H,1-5,11H2,(H,12,13)(H,14,15)/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...				Bioorg Med Chem Lett 10: 1807-10 (2000) Article DOI: 10.1016/s0960-894x(00)00346-2 BindingDB Entry DOI: 10.7270/Q2765FVB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50186130 (CHEMBL211078 | N-((R)-3-(4-chlorophenyl)-1-(4-(dic...) Show SMILES Clc1ccc(C[C@@H](NC(=O)CC2Cc3ccccc3N2)C(=O)N2CCN(CC2)C(C2CCCCC2)C2CCCCC2)cc1 Show InChI InChI=1S/C36H49ClN4O2/c37-30-17-15-26(16-18-30)23-33(39-34(42)25-31-24-29-13-7-8-14-32(29)38-31)36(43)41-21-19-40(20-22-41)35(27-9-3-1-4-10-27)28-11-5-2-6-12-28/h7-8,13-18,27-28,31,33,35,38H,1-6,9-12,19-25H2,(H,39,42)/t31?,33-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125]I-NDP-alpha-MSH binding to human MC4R transfected in HEK293 cells				Bioorg Med Chem Lett 16: 3449-53 (2006) Article DOI: 10.1016/j.bmcl.2006.04.002 BindingDB Entry DOI: 10.7270/Q2ST7PFS
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088224 (CHEMBL305346 | E-2-Amino-4-[3-(3-methoxy-phenyl)-a...) Show SMILES COc1cccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)c1 Show InChI InChI=1S/C15H19NO5/c1-21-12-7-3-5-10(8-12)4-2-6-11(14(17)18)9-13(16)15(19)20/h2-5,7-8,11,13H,6,9,16H2,1H3,(H,17,18)(H,19,20)/b4-2+/t11-,13+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174062 (CHEMBL371896 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(Cc1ccccc1)N1CCN(C)CC1 Show InChI InChI=1S/C18H31N3/c1-4-20(5-2)16-18(15-17-9-7-6-8-10-17)21-13-11-19(3)12-14-21/h6-10,18H,4-5,11-16H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174050 (CHEMBL365184 | Diethyl-[2-(4-methyl-piperazin-1-yl...) Show SMILES CCN(CC)CC(N1CCN(C)CC1)c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H28F3N3/c1-4-23(5-2)14-17(24-12-10-22(3)11-13-24)15-8-6-7-9-16(15)18(19,20)21/h6-9,17H,4-5,10-14H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of [125I]-NDP MSH binding to human Melanocortin 4 receptor				Bioorg Med Chem Lett 15: 4973-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.018 BindingDB Entry DOI: 10.7270/Q2HT2NWT
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50088196 (2-Amino-4-(3-chloro-allyl)-pentanedioic acid | CHE...) Show SMILES N[C@@H](C[C@@H](C\C=C\Cl)C(O)=O)C(O)=O Show InChI InChI=1S/C8H12ClNO4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h1,3,5-6H,2,4,10H2,(H,11,12)(H,13,14)/b3-1+/t5-,6+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
					More data for this Ligand-Target Pair

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