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Compile Data Set for Download or QSAR

Found 351 hits with Last Name = 'mcarthur' and Initial = 'ra'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033857
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C24H32N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,10-12,14,20H,5,7-9,13,15-19H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033852
PNG
(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccn3)CCCc12
Show InChI InChI=1S/C23H31N3O/c1-27-22-11-5-9-20-19(7-4-10-21(20)22)8-6-14-25-15-17-26(18-16-25)23-12-2-3-13-24-23/h2-3,5,9,11-13,19H,4,6-8,10,14-18H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289537
PNG
(1-(3-Phenyl-propyl)-3-((Z)-styryl)-piperidine | CH...)
Show SMILES C(CN1CCCC(C1)\C=C/c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H27N/c1-3-9-20(10-4-1)13-7-17-23-18-8-14-22(19-23)16-15-21-11-5-2-6-12-21/h1-6,9-12,15-16,22H,7-8,13-14,17-19H2/b16-15-
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TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289553
PNG
(1-Phenethyl-3-((Z)-styryl)-piperidine | CHEMBL3697...)
Show SMILES C(Cc1ccccc1)N1CCCC(C1)\C=C/c1ccccc1
Show InChI InChI=1S/C21H25N/c1-3-8-19(9-4-1)13-14-21-12-7-16-22(18-21)17-15-20-10-5-2-6-11-20/h1-6,8-11,13-14,21H,7,12,15-18H2/b14-13-
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TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289552
PNG
(1-(3-Methyl-but-2-enyl)-3-((Z)-styryl)-piperidine ...)
Show SMILES CC(C)=CCN1CCCC(C1)\C=C/c1ccccc1
Show InChI InChI=1S/C18H25N/c1-16(2)12-14-19-13-6-9-18(15-19)11-10-17-7-4-3-5-8-17/h3-5,7-8,10-12,18H,6,9,13-15H2,1-2H3/b11-10-
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TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50070198
PNG
((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...)
Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1nccs1
Show InChI InChI=1S/C23H28N4OS/c1-23(2,3)17-6-5-15-16-9-14(21(28)26-22-24-7-8-29-22)12-27(4)18(16)10-13-11-25-20(17)19(13)15/h5-8,11,14,16,18,25H,9-10,12H2,1-4H3,(H,24,26,28)/t14-,16-,18-/m1/s1
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Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat pre frontal cortex


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289539
PNG
(1-Cyclohexyl-3-((Z)-styryl)-piperidine | CHEMBL398...)
Show SMILES C1CCC(CC1)N1CCCC(C1)\C=C/c1ccccc1
Show InChI InChI=1S/C19H27N/c1-3-8-17(9-4-1)13-14-18-10-7-15-20(16-18)19-11-5-2-6-12-19/h1,3-4,8-9,13-14,18-19H,2,5-7,10-12,15-16H2/b14-13-
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TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50070187
PNG
(1-Acetyl-3-((6aR,9S,10aR)-3-tert-butyl-7-methyl-4,...)
Show SMILES CN1C[C@H](CNC(=S)NC(C)=O)C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C
Show InChI InChI=1S/C23H32N4OS/c1-13(28)26-22(29)25-10-14-8-17-16-6-7-18(23(2,3)4)21-20(16)15(11-24-21)9-19(17)27(5)12-14/h6-7,11,14,17,19,24H,8-10,12H2,1-5H3,(H2,25,26,28,29)/t14-,17+,19+/m0/s1
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Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat pre frontal cortex


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50070192
PNG
((6aR,9R,10aR)-3-tert-Butyl-7-methyl-4,6,6a,7,8,9,1...)
Show SMILES CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c(ccc2c13)C(C)(C)C)C(=O)Nc1ccc(Cl)nn1
Show InChI InChI=1S/C24H28ClN5O/c1-24(2,3)17-6-5-15-16-9-14(23(31)27-20-8-7-19(25)28-29-20)12-30(4)18(16)10-13-11-26-22(17)21(13)15/h5-8,11,14,16,18,26H,9-10,12H2,1-4H3,(H,27,29,31)/t14-,16-,18-/m1/s1
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Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor in rat pre frontal cortex


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM21395
PNG
(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was evaluated using [3H]- ketanserin as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054990
PNG
(1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES COc1ccc2CCC(CCN3CCN(CC3)c3ccccc3)Cc2c1
Show InChI InChI=1S/C23H30N2O/c1-26-23-10-9-20-8-7-19(17-21(20)18-23)11-12-24-13-15-25(16-14-24)22-5-3-2-4-6-22/h2-6,9-10,18-19H,7-8,11-17H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054999
PNG
(1-[2-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES COc1ccc2CC(CCN3CCN(CC3)c3ccccc3)CCc2c1
Show InChI InChI=1S/C23H30N2O/c1-26-23-10-9-20-17-19(7-8-21(20)18-23)11-12-24-13-15-25(16-14-24)22-5-3-2-4-6-22/h2-6,9-10,18-19H,7-8,11-17H2,1H3
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Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289538
PNG
(1-Allyl-3-((E)-styryl)-piperidine | CHEMBL39735)
Show SMILES C=CCN1CCCC(C1)\C=C\c1ccccc1
Show InChI InChI=1S/C16H21N/c1-2-12-17-13-6-9-16(14-17)11-10-15-7-4-3-5-8-15/h2-5,7-8,10-11,16H,1,6,9,12-14H2/b11-10+
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TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289541
PNG
(1-(3-Phenyl-propyl)-3-((E)-styryl)-piperidine | CH...)
Show SMILES C(CN1CCCC(C1)\C=C\c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H27N/c1-3-9-20(10-4-1)13-7-17-23-18-8-14-22(19-23)16-15-21-11-5-2-6-12-21/h1-6,9-12,15-16,22H,7-8,13-14,17-19H2/b16-15+
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n/an/a 4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 4.80n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Affinity towards Dopamine receptor D2 was evaluated in rat striatal membrane using [3H]spiperone as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 4.80n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 was evaluated using [3H]- spiroperidol as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM21393
PNG
(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054997
PNG
(1-[3-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2C(CCCN3CCN(CC3)c3ccccc3)CCCc2c1
Show InChI InChI=1S/C24H32N2O/c1-27-23-12-13-24-20(7-5-8-21(24)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,10-13,19-20H,5-9,14-18H2,1H3
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n/an/a 5.40n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289547
PNG
(1-Phenethyl-3-((E)-styryl)-piperidine | CHEMBL2879...)
Show SMILES C(Cc1ccccc1)N1CCCC(C1)\C=C\c1ccccc1
Show InChI InChI=1S/C21H25N/c1-3-8-19(9-4-1)13-14-21-12-7-16-22(18-21)17-15-20-10-5-2-6-11-20/h1-6,8-11,13-14,21H,7,12,15-18H2/b14-13+
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289549
PNG
(1-Cyclohexyl-3-((E)-styryl)-piperidine | CHEMBL291...)
Show SMILES C1CCC(CC1)N1CCCC(C1)\C=C\c1ccccc1
Show InChI InChI=1S/C19H27N/c1-3-8-17(9-4-1)13-14-18-10-7-15-20(16-18)19-11-5-2-6-12-19/h1,3-4,8-9,13-14,18-19H,2,5-7,10-12,15-16H2/b14-13+
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Adrenergic receptor alpha-2


(RAT-NEONATAL RAT-Rattus norvegicus (rat))
BDBM50070193
PNG
(1-((6aR,9R,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,...)
Show SMILES CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](Cc3c[nH]c4cc(cc2c34)C(C)(C)C)N(C)C1
Show InChI InChI=1S/C28H43N5O2/c1-8-29-27(35)33(11-9-10-31(5)6)26(34)19-12-21-22-14-20(28(2,3)4)15-23-25(22)18(16-30-23)13-24(21)32(7)17-19/h14-16,19,21,24,30H,8-13,17H2,1-7H3,(H,29,35)/t19-,21-,24-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]yohimbine from Alpha-2 adrenergic receptor in rat frontal cortex


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289551
PNG
(1-(4-Phenyl-butyl)-3-((Z)-styryl)-piperidine | CHE...)
Show SMILES C(CCc1ccccc1)CN1CCCC(C1)\C=C/c1ccccc1
Show InChI InChI=1S/C23H29N/c1-3-10-21(11-4-1)14-7-8-18-24-19-9-15-23(20-24)17-16-22-12-5-2-6-13-22/h1-6,10-13,16-17,23H,7-9,14-15,18-20H2/b17-16-
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289545
PNG
(1-(2-Cyclohexyl-ethyl)-3-((Z)-styryl)-piperidine |...)
Show SMILES C(CN1CCCC(C1)\C=C/c1ccccc1)C1CCCCC1
Show InChI InChI=1S/C21H31N/c1-3-8-19(9-4-1)13-14-21-12-7-16-22(18-21)17-15-20-10-5-2-6-11-20/h1,3-4,8-9,13-14,20-21H,2,5-7,10-12,15-18H2/b14-13-
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n/an/a 7n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054989
PNG
(1-[2-(7-Methoxy-3,4-dihydro-naphthalen-2-yl)-ethyl...)
Show SMILES COc1ccc2CCC(CCN3CCN(CC3)c3ccccc3)=Cc2c1
Show InChI InChI=1S/C23H28N2O/c1-26-23-10-9-20-8-7-19(17-21(20)18-23)11-12-24-13-15-25(16-14-24)22-5-3-2-4-6-22/h2-6,9-10,17-18H,7-8,11-16H2,1H3
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n/an/a 7.30n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033847
PNG
(CHEMBL108241 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C24H33N3O2/c1-28-23-12-6-7-19-20(23)8-5-9-21(19)25-13-14-26-15-17-27(18-16-26)22-10-3-4-11-24(22)29-2/h3-4,6-7,10-12,21,25H,5,8-9,13-18H2,1-2H3
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n/an/a 7.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054996
PNG
(1-[2-(6-Methoxy-3,4-dihydro-naphthalen-2-yl)-ethyl...)
Show SMILES COc1ccc2C=C(CCN3CCN(CC3)c3ccccc3)CCc2c1
Show InChI InChI=1S/C23H28N2O/c1-26-23-10-9-20-17-19(7-8-21(20)18-23)11-12-24-13-15-25(16-14-24)22-5-3-2-4-6-22/h2-6,9-10,17-18H,7-8,11-16H2,1H3
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n/an/a 8.20n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052561
PNG
(CHEMBL326017 | {2-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)N(C)CCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-26(22-11-6-9-21-20(22)8-7-13-24(21)29-2)14-15-27-16-18-28(19-17-27)23-10-4-5-12-25(23)30-3/h4-5,7-8,10,12-13,22H,6,9,11,14-19H2,1-3H3
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n/an/a 8.70n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033854
PNG
(1-[3-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1ccc2CCCC(CCCN3CCN(CC3)c3ccccc3)c2c1
Show InChI InChI=1S/C24H32N2O/c1-27-23-13-12-21-8-5-7-20(24(21)19-23)9-6-14-25-15-17-26(18-16-25)22-10-3-2-4-11-22/h2-4,10-13,19-20H,5-9,14-18H2,1H3
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n/an/a 9.20n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052569
PNG
(CHEMBL107486 | {3-[4-(2-Methoxy-phenyl)-piperazin-...)
Show SMILES COc1cccc2C(CCCc12)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C25H35N3O2/c1-29-24-13-6-8-20-21(24)9-5-10-22(20)26-14-7-15-27-16-18-28(19-17-27)23-11-3-4-12-25(23)30-2/h3-4,6,8,11-13,22,26H,5,7,9-10,14-19H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289536
PNG
(1-Benzyl-3-((E)-styryl)-piperidine | CHEMBL39855)
Show SMILES C(N1CCCC(C1)\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H23N/c1-3-8-18(9-4-1)13-14-20-12-7-15-21(17-20)16-19-10-5-2-6-11-19/h1-6,8-11,13-14,20H,7,12,15-17H2/b14-13+
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054991
PNG
(1-[2-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C23H30N2O/c1-26-23-12-6-10-21-19(7-5-11-22(21)23)13-14-24-15-17-25(18-16-24)20-8-3-2-4-9-20/h2-4,6,8-10,12,19H,5,7,11,13-18H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 2A receptor was evaluated using [3H]- ketanserin as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289554
PNG
(1-Pent-4-enyl-3-((E)-styryl)-piperidine | CHEMBL38...)
Show SMILES C=CCCCN1CCCC(C1)\C=C\c1ccccc1
Show InChI InChI=1S/C18H25N/c1-2-3-7-14-19-15-8-11-18(16-19)13-12-17-9-5-4-6-10-17/h2,4-6,9-10,12-13,18H,1,3,7-8,11,14-16H2/b13-12+
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50070203
PNG
(CHEMBL14048 | N-((6aR,9S,10aR)-7-Methyl-4,6,6a,7,8...)
Show SMILES CN1C[C@H](CNC(=O)c2ccccc2)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13
Show InChI InChI=1S/C23H25N3O/c1-26-14-15(12-25-23(27)16-6-3-2-4-7-16)10-19-18-8-5-9-20-22(18)17(13-24-20)11-21(19)26/h2-9,13,15,19,21,24H,10-12,14H2,1H3,(H,25,27)/t15-,19+,21+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289540
PNG
(1-(3-Phenoxy-propyl)-3-((Z)-styryl)-piperidine | C...)
Show SMILES C(COc1ccccc1)CN1CCCC(C1)\C=C/c1ccccc1
Show InChI InChI=1S/C22H27NO/c1-3-9-20(10-4-1)14-15-21-11-7-16-23(19-21)17-8-18-24-22-12-5-2-6-13-22/h1-6,9-10,12-15,21H,7-8,11,16-19H2/b15-14-
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50054998
PNG
(1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3)CCCc12
Show InChI InChI=1S/C25H34N2O/c1-28-25-15-8-13-23-21(10-7-14-24(23)25)9-5-6-16-26-17-19-27(20-18-26)22-11-3-2-4-12-22/h2-4,8,11-13,15,21H,5-7,9-10,14,16-20H2,1H3
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n/an/a 15n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(RAT)
BDBM50289544
PNG
(1-Phenyl-4-[3-((Z)-styryl)-piperidin-1-yl]-butan-1...)
Show SMILES O=C(CCCN1CCCC(C1)\C=C/c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H27NO/c25-23(22-12-5-2-6-13-22)14-8-18-24-17-7-11-21(19-24)16-15-20-9-3-1-4-10-20/h1-6,9-10,12-13,15-16,21H,7-8,11,14,17-19H2/b16-15-
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.


Bioorg Med Chem Lett 7: 1525-1530 (1997)


Article DOI: 10.1016/S0960-894X(97)00253-9
BindingDB Entry DOI: 10.7270/Q2N58MCN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033835
PNG
(1-(2-Methoxy-phenyl)-4-[4-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C26H36N2O2/c1-29-25-15-8-11-22-21(10-7-12-23(22)25)9-5-6-16-27-17-19-28(20-18-27)24-13-3-4-14-26(24)30-2/h3-4,8,11,13-15,21H,5-7,9-10,12,16-20H2,1-2H3
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n/an/a 15n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against Dopamine receptor D2 in rat striatal membrane using [3H]spiroperidol as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50070201
PNG
(((6aR,9S,10aR)-2-tert-Butyl-7-methyl-4,6,6a,7,8,9,...)
Show SMILES CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]2[C@H]1Cc1c[nH]c3cc(cc2c13)C(C)(C)C
Show InChI InChI=1S/C28H35N3O2/c1-28(2,3)21-12-23-22-10-19(14-30-27(32)33-17-18-8-6-5-7-9-18)16-31(4)25(22)11-20-15-29-24(13-21)26(20)23/h5-9,12-13,15,19,22,25,29H,10-11,14,16-17H2,1-4H3,(H,30,32)/t19-,22+,25+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Pharmacia & Upjohn S.p.A.-CNS Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus


Bioorg Med Chem Lett 8: 1117-22 (1999)


Article DOI: 10.1016/s0960-894x(98)00166-8
BindingDB Entry DOI: 10.7270/Q2M61JF3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50052565
PNG
(5-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxy...)
Show SMILES COc1cccc2C(CCCc12)C(=O)NCCCN1CCN(CC1)c1ccccc1OC
Show InChI InChI=1S/C26H35N3O3/c1-31-24-13-6-8-20-21(24)9-5-10-22(20)26(30)27-14-7-15-28-16-18-29(19-17-28)23-11-3-4-12-25(23)32-2/h3-4,6,8,11-13,22H,5,7,9-10,14-19H2,1-2H3,(H,27,30)
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n/an/a 16n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity against serotonin 5-hydroxytryptamine 1A receptor in rat hippocampus membrane using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat Dopamine receptor D2 was evaluated using [3H]- spiroperidol as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50033839
PNG
(1-(2-Methoxy-phenyl)-4-[3-(5-methoxy-1,2,3,4-tetra...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3OC)CCCc12
Show InChI InChI=1S/C25H34N2O2/c1-28-24-14-6-10-21-20(8-5-11-22(21)24)9-7-15-26-16-18-27(19-17-26)23-12-3-4-13-25(23)29-2/h3-4,6,10,12-14,20H,5,7-9,11,15-19H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity to rat Dopamine receptor D2 expressed in CHO cells was determined using [125 I ] iodosulpride as radioligand


J Med Chem 39: 3195-202 (1996)


Article DOI: 10.1021/jm960087s
BindingDB Entry DOI: 10.7270/Q2GM87ZN
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50033850
PNG
(1-[3-(5-Methoxy-3,4-dihydro-naphthalen-1-yl)-propy...)
Show SMILES COc1cccc2C(CCCN3CCN(CC3)c3ccccc3)=CCCc12
Show InChI InChI=1S/C24H30N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h2-4,6,8,10-12,14H,5,7,9,13,15-19H2,1H3
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n/an/a 18n/an/an/an/an/an/a



Universit£ di Bari

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor was evaluated using [3H]8-OH-DPAT as radioligand


J Med Chem 39: 4928-34 (1997)


Article DOI: 10.1021/jm9604538
BindingDB Entry DOI: 10.7270/Q2ZG6SX1
More data for this
Ligand-Target Pair
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