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Compile Data Set for Download or QSAR

Found 99 hits with Last Name = 'negash' and Initial = 'la'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235244
PNG
(US9365558, 67)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccc(cc1)C(F)F
Show InChI InChI=1/C27H25F9N2O5S/c1-44(41,42)38-24(40)21-18(15-5-7-16(8-6-15)22(29)30)14-25(27(34,35)36,37-23(21)39)19-10-9-17(13-20(19)28)43-12-4-2-3-11-26(31,32)33/h5-10,13,22H,2-4,11-12,14H2,1H3,(H,37,39)(H,38,40)/t25-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235245
PNG
(US9365558, 68)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccc(cc1)C1CC1
Show InChI InChI=1/C29H29F7N2O5S/c1-44(41,42)38-26(40)24-21(19-9-7-18(8-10-19)17-5-6-17)16-27(29(34,35)36,37-25(24)39)22-12-11-20(15-23(22)30)43-14-4-2-3-13-28(31,32)33/h7-12,15,17H,2-6,13-14,16H2,1H3,(H,37,39)(H,38,40)/t27-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235247
PNG
(US9365558, 70)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ncc(s2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C26H24F7N3O5S2/c27-18-10-14(41-9-1-8-25(28,29)30)4-7-17(18)24(26(31,32)33)11-16(23-34-12-19(42-23)13-2-3-13)20(21(37)35-24)22(38)36-43(39,40)15-5-6-15/h4,7,10,12-13,15H,1-3,5-6,8-9,11H2,(H,35,37)(H,36,38)/t24-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235250
PNG
(US9365558, 73)
Show SMILES FC(F)(F)CCCCc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H30F6N4O4S/c29-27(30,31)13-2-1-3-17-6-8-19(9-7-17)26(28(32,33)34)15-21(22-12-14-38(36-22)16-18-4-5-18)23(24(39)35-26)25(40)37-43(41,42)20-10-11-20/h6-9,12,14,18,20H,1-5,10-11,13,15-16H2,(H,35,39)(H,37,40)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235259
PNG
(US9365558, 82)
Show SMILES CCc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C)(C1)c1ccc(OCCCC(F)(F)F)cc1
Show InChI InChI=1/C28H31F3N2O5S/c1-3-18-5-7-19(8-6-18)23-17-27(2,20-9-11-21(12-10-20)38-16-4-15-28(29,30)31)32-25(34)24(23)26(35)33-39(36,37)22-13-14-22/h5-12,22H,3-4,13-17H2,1-2H3,(H,32,34)(H,33,35)/t27-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235217
PNG
(US9365558, 40)
Show SMILES CCCCCCCc1cnc(s1)[C@@]1(CC(=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1/C27H32F3N3O4S2/c1-3-4-5-6-7-8-19-16-31-25(38-19)26(27(28,29)30)15-21(18-11-9-17(2)10-12-18)22(23(34)32-26)24(35)33-39(36,37)20-13-14-20/h9-12,16,20H,3-8,13-15H2,1-2H3,(H,32,34)(H,33,35)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235228
PNG
(US9365558, 51)
Show SMILES CC(C)n1ccc(c1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1/C28H30F7N3O4S/c1-16(2)38-12-10-18(15-38)20-14-26(28(33,34)35,36-24(39)23(20)25(40)37-43(41,42)19-7-8-19)21-9-6-17(13-22(21)29)5-3-4-11-27(30,31)32/h6,9-10,12-13,15-16,19H,3-5,7-8,11,14H2,1-2H3,(H,36,39)(H,37,40)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235256
PNG
(US9365558, 79)
Show SMILES FC(F)(F)CCCCCOc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C29H32F6N4O5S/c30-28(31,32)13-2-1-3-15-44-20-8-6-19(7-9-20)27(29(33,34)35)16-22(23-12-14-39(37-23)17-18-4-5-18)24(25(40)36-27)26(41)38-45(42,43)21-10-11-21/h6-9,12,14,18,21H,1-5,10-11,13,15-17H2,(H,36,40)(H,38,41)/t27-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235199
PNG
(US9365558, 22)
Show SMILES COc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1/C29H29F7N2O6S/c1-43-18-7-5-17(6-8-18)21-16-27(29(34,35)36,37-25(39)24(21)26(40)38-45(41,42)20-10-11-20)22-12-9-19(15-23(22)30)44-14-4-2-3-13-28(31,32)33/h5-9,12,15,20H,2-4,10-11,13-14,16H2,1H3,(H,37,39)(H,38,40)/t27-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235242
PNG
(US9365558, 65)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccc(s1)C1CC1
Show InChI InChI=1/C25H23F7N2O5S2/c1-41(37,38)34-22(36)20-15(19-8-7-18(40-19)13-3-4-13)12-23(25(30,31)32,33-21(20)35)16-6-5-14(11-17(16)26)39-10-2-9-24(27,28)29/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,33,35)(H,34,36)/t23-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235271
PNG
(US9365558, 94)
Show SMILES FC(F)(F)CCCCCCn1cc(cn1)[C@@]1(CC(=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)c1ccc2CCCCc2c1)C(F)(F)F
Show InChI InChI=1/C30H34F6N4O4S/c31-29(32,33)13-5-1-2-6-14-40-18-22(17-37-40)28(30(34,35)36)16-24(21-10-9-19-7-3-4-8-20(19)15-21)25(26(41)38-28)27(42)39-45(43,44)23-11-12-23/h9-10,15,17-18,23H,1-8,11-14,16H2,(H,38,41)(H,39,42)/t28-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235276
PNG
(US9365558, 99)
Show SMILES COc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C29H29F7N2O6S/c1-43-18-7-5-17(6-8-18)21-16-27(29(34,35)36,37-25(39)24(21)26(40)38-45(41,42)20-10-11-20)22-12-9-19(15-23(22)30)44-14-4-2-3-13-28(31,32)33/h5-9,12,15,20H,2-4,10-11,13-14,16H2,1H3,(H,37,39)(H,38,40)/t27-/m0/s1
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235197
PNG
(US9365558, 20)
Show SMILES CC(C)(C)c1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C32H36F6N2O5S/c1-29(2,3)21-9-7-20(8-10-21)25-19-30(32(36,37)38,39-27(41)26(25)28(42)40-46(43,44)24-15-16-24)22-11-13-23(14-12-22)45-18-6-4-5-17-31(33,34)35/h7-14,24H,4-6,15-19H2,1-3H3,(H,39,41)(H,40,42)/t30-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235192
PNG
(US9365558, 15)
Show SMILES CCCCCCC#C[C@@]1(CC(=C(C(=O)NS(C)(=O)=O)C(=O)N1)c1ccc(C)cc1)C(F)(F)F
Show InChI InChI=1/C23H27F3N2O4S/c1-4-5-6-7-8-9-14-22(23(24,25)26)15-18(17-12-10-16(2)11-13-17)19(20(29)27-22)21(30)28-33(3,31)32/h10-13H,4-8,15H2,1-3H3,(H,27,29)(H,28,30)/t22-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235249
PNG
(US9365558, 72)
Show SMILES CC(C)n1ccc(c1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C29H33F6N3O5S/c1-18(2)38-14-12-19(17-38)23-16-27(29(33,34)35,36-25(39)24(23)26(40)37-44(41,42)22-10-11-22)20-6-8-21(9-7-20)43-15-5-3-4-13-28(30,31)32/h6-9,12,14,17-18,22H,3-5,10-11,13,15-16H2,1-2H3,(H,36,39)(H,37,40)/t27-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235236
PNG
(US9365558, 59)
Show SMILES FC(F)(F)CCCCCn1cc(cn1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C26H28F6N4O4S2/c27-25(28,29)10-2-1-3-11-36-14-16(13-33-36)24(26(30,31)32)12-18(20-9-8-19(41-20)15-4-5-15)21(22(37)34-24)23(38)35-42(39,40)17-6-7-17/h8-9,13-15,17H,1-7,10-12H2,(H,34,37)(H,35,38)/t24-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235200
PNG
(US9365558, 23)
Show SMILES FC(F)(F)CCCCCOc1ccc(cc1)[C@@]1(CC(=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)c1ccc(CC2CC2)cc1)C(F)(F)F
Show InChI InChI=1/C32H34F6N2O5S/c33-31(34,35)16-2-1-3-17-45-24-12-10-23(11-13-24)30(32(36,37)38)19-26(22-8-6-21(7-9-22)18-20-4-5-20)27(28(41)39-30)29(42)40-46(43,44)25-14-15-25/h6-13,20,25H,1-5,14-19H2,(H,39,41)(H,40,42)/t30-/s2
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US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235183
PNG
(US9365558, 6)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1/C29H29F7N2O5S/c1-17-5-7-18(8-6-17)21-16-27(29(34,35)36,37-25(39)24(21)26(40)38-44(41,42)20-10-11-20)22-12-9-19(15-23(22)30)43-14-4-2-3-13-28(31,32)33/h5-9,12,15,20H,2-4,10-11,13-14,16H2,1H3,(H,37,39)(H,38,40)/t27-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235207
PNG
(US9365558, 30)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C(F)(F)F)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C25H21F9N2O5S/c1-14-3-5-15(6-4-14)18-13-22(24(29,30)31,16-7-9-17(10-8-16)41-12-2-11-23(26,27)28)35-20(37)19(18)21(38)36-42(39,40)25(32,33)34/h3-10H,2,11-13H2,1H3,(H,35,37)(H,36,38)/t22-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235240
PNG
(US9365558, 63)
Show SMILES FC(F)(F)CCCOc1ccc(cc1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C27H26F6N2O5S2/c28-26(29,30)12-1-13-40-17-6-4-16(5-7-17)25(27(31,32)33)14-19(21-11-10-20(41-21)15-2-3-15)22(23(36)34-25)24(37)35-42(38,39)18-8-9-18/h4-7,10-11,15,18H,1-3,8-9,12-14H2,(H,34,36)(H,35,37)/t25-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235187
PNG
(US9365558, 10)
Show SMILES CCc1ccc(s1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C28H30F6N2O5S2/c1-2-19-10-13-22(42-19)21-16-26(28(32,33)34,35-24(37)23(21)25(38)36-43(39,40)20-11-12-20)17-6-8-18(9-7-17)41-15-5-3-4-14-27(29,30)31/h6-10,13,20H,2-5,11-12,14-16H2,1H3,(H,35,37)(H,36,38)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235241
PNG
(US9365558, 64)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)c1ccc(s1)C1CC1
Show InChI InChI=1/C25H24F6N2O5S2/c1-40(36,37)33-22(35)20-17(19-10-9-18(39-19)14-3-4-14)13-23(25(29,30)31,32-21(20)34)15-5-7-16(8-6-15)38-12-2-11-24(26,27)28/h5-10,14H,2-4,11-13H2,1H3,(H,32,34)(H,33,35)/t23-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235214
PNG
(US9365558, 37)
Show SMILES FC(F)Oc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C29H28F8N2O6S/c30-26(31)45-20-8-4-17(5-9-20)22-16-27(29(35,36)37,38-24(40)23(22)25(41)39-46(42,43)21-12-13-21)18-6-10-19(11-7-18)44-15-3-1-2-14-28(32,33)34/h4-11,21,26H,1-3,12-16H2,(H,38,40)(H,39,41)/t27-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235266
PNG
(US9365558, 89 | US9365558, 92)
Show SMILES Fc1cc(OCCCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H29F7N4O5S/c29-21-14-17(44-13-3-1-2-11-27(30,31)32)6-9-20(21)26(28(33,34)35)15-19(22-10-12-39(37-22)16-4-5-16)23(24(40)36-26)25(41)38-45(42,43)18-7-8-18/h6,9-10,12,14,16,18H,1-5,7-8,11,13,15H2,(H,36,40)(H,38,41)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235190
PNG
(US9365558, 13)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C25H24F6N2O5S/c1-15-4-6-16(7-5-15)19-14-23(25(29,30)31,32-21(34)20(19)22(35)33-39(2,36)37)17-8-10-18(11-9-17)38-13-3-12-24(26,27)28/h4-11H,3,12-14H2,1-2H3,(H,32,34)(H,33,35)/t23-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235266
PNG
(US9365558, 89 | US9365558, 92)
Show SMILES Fc1cc(OCCCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H29F7N4O5S/c29-21-14-17(44-13-3-1-2-11-27(30,31)32)6-9-20(21)26(28(33,34)35)15-19(22-10-12-39(37-22)16-4-5-16)23(24(40)36-26)25(41)38-45(42,43)18-7-8-18/h6,9-10,12,14,16,18H,1-5,7-8,11,13,15H2,(H,36,40)(H,38,41)/t26-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235260
PNG
(US9365558, 83)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F)c1ccn(n1)C1CC1
Show InChI InChI=1/C26H28F6N4O5S/c1-42(39,40)35-23(38)21-19(20-11-13-36(34-20)17-7-8-17)15-24(26(30,31)32,33-22(21)37)16-5-9-18(10-6-16)41-14-4-2-3-12-25(27,28)29/h5-6,9-11,13,17H,2-4,7-8,12,14-15H2,1H3,(H,33,37)(H,35,38)/t24-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235221
PNG
(US9365558, 44)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccn(n1)C1CCC1
Show InChI InChI=1/C25H25F7N4O5S/c1-42(39,40)35-22(38)20-16(19-8-10-36(34-19)14-4-2-5-14)13-23(25(30,31)32,33-21(20)37)17-7-6-15(12-18(17)26)41-11-3-9-24(27,28)29/h6-8,10,12,14H,2-5,9,11,13H2,1H3,(H,33,37)(H,35,38)/t23-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235198
PNG
(US9365558, 21)
Show SMILES CC(C)(C)c1ccc(cc1)C1=C(C(=O)NS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C30H34F6N2O5S/c1-27(2,3)20-10-8-19(9-11-20)23-18-28(30(34,35)36,37-25(39)24(23)26(40)38-44(4,41)42)21-12-14-22(15-13-21)43-17-7-5-6-16-29(31,32)33/h8-15H,5-7,16-18H2,1-4H3,(H,37,39)(H,38,40)/t28-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235273
PNG
(US9365558, 96)
Show SMILES CCOc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1/C28H27F7N2O6S/c1-2-42-17-6-4-16(5-7-17)20-15-26(28(33,34)35,36-24(38)23(20)25(39)37-44(40,41)19-9-10-19)21-11-8-18(14-22(21)29)43-13-3-12-27(30,31)32/h4-8,11,14,19H,2-3,9-10,12-13,15H2,1H3,(H,36,38)(H,37,39)/t26-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235239
PNG
(US9365558, 62)
Show SMILES FC(F)(F)CCCCOc1ccc(cc1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H28F6N2O5S2/c29-27(30,31)13-1-2-14-41-18-7-5-17(6-8-18)26(28(32,33)34)15-20(22-12-11-21(42-22)16-3-4-16)23(24(37)35-26)25(38)36-43(39,40)19-9-10-19/h5-8,11-12,16,19H,1-4,9-10,13-15H2,(H,35,37)(H,36,38)/t26-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235267
PNG
(US9365558, 90)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)c1ccn(CC2CCC2)n1
Show InChI InChI=1/C26H28F6N4O5S/c1-42(39,40)35-23(38)21-19(20-10-12-36(34-20)15-16-4-2-5-16)14-24(26(30,31)32,33-22(21)37)17-6-8-18(9-7-17)41-13-3-11-25(27,28)29/h6-10,12,16H,2-5,11,13-15H2,1H3,(H,33,37)(H,35,38)/t24-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235204
PNG
(US9365558, 27)
Show SMILES COc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C27H26F6N2O6S/c1-40-18-7-3-16(4-8-18)21-15-25(27(31,32)33,17-5-9-19(10-6-17)41-14-2-13-26(28,29)30)34-23(36)22(21)24(37)35-42(38,39)20-11-12-20/h3-10,20H,2,11-15H2,1H3,(H,34,36)(H,35,37)/t25-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235219
PNG
(US9365558, 42 | US9365558, 49)
Show SMILES CC(C)n1ccc(n1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1/C26H27F7N4O5S/c1-14(2)37-10-8-20(35-37)17-13-24(26(31,32)33,34-22(38)21(17)23(39)36-43(40,41)16-5-6-16)18-7-4-15(12-19(18)27)42-11-3-9-25(28,29)30/h4,7-8,10,12,14,16H,3,5-6,9,11,13H2,1-2H3,(H,34,38)(H,36,39)/t24-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235180
PNG
(US9365558, 3)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ncc(CCCCCCC(F)(F)F)s1)C(F)(F)F
Show InChI InChI=1/C27H29F6N3O4S2/c1-16-7-9-17(10-8-16)20-14-25(27(31,32)33,35-22(37)21(20)23(38)36-42(39,40)19-11-12-19)24-34-15-18(41-24)6-4-2-3-5-13-26(28,29)30/h7-10,15,19H,2-6,11-14H2,1H3,(H,35,37)(H,36,38)/t25-/s2
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Bristol-Myers Squibb Company

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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235246
PNG
(US9365558, 69)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1Cl)C(F)(F)F
Show InChI InChI=1/C27H25ClF6N2O5S/c1-15-3-5-16(6-4-15)19-14-25(27(32,33)34,35-23(37)22(19)24(38)36-42(39,40)18-8-9-18)20-10-7-17(13-21(20)28)41-12-2-11-26(29,30)31/h3-7,10,13,18H,2,8-9,11-12,14H2,1H3,(H,35,37)(H,36,38)/t25-/s2
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Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235229
PNG
(US9365558, 52)
Show SMILES Fc1cc(CCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H29F7N4O4S/c29-21-13-16(3-1-2-11-27(30,31)32)6-9-20(21)26(28(33,34)35)14-19(22-10-12-39(37-22)15-17-4-5-17)23(24(40)36-26)25(41)38-44(42,43)18-7-8-18/h6,9-10,12-13,17-18H,1-5,7-8,11,14-15H2,(H,36,40)(H,38,41)/t26-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235179
PNG
(US9365558, 2 | US9365558, 33)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(C#CCCCCCC(F)(F)F)C(F)(F)F
Show InChI InChI=1/C25H26F6N2O4S/c1-16-7-9-17(10-8-16)19-15-23(25(29,30)31,13-5-3-2-4-6-14-24(26,27)28)32-21(34)20(19)22(35)33-38(36,37)18-11-12-18/h7-10,18H,2-4,6,11-12,14-15H2,1H3,(H,32,34)(H,33,35)/t23-/s2
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n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235188
PNG
(US9365558, 11)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C29H30F6N2O5S/c1-18-5-7-19(8-6-18)23-17-27(29(33,34)35,36-25(38)24(23)26(39)37-43(40,41)22-13-14-22)20-9-11-21(12-10-20)42-16-4-2-3-15-28(30,31)32/h5-12,22H,2-4,13-17H2,1H3,(H,36,38)(H,37,39)/t27-/s2
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n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235184
PNG
(US9365558, 7)
Show SMILES CCc1ccc(s1)C1=C(C(=O)NS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C24H24F6N2O5S2/c1-3-16-9-10-18(38-16)17-13-22(24(28,29)30,31-20(33)19(17)21(34)32-39(2,35)36)14-5-7-15(8-6-14)37-12-4-11-23(25,26)27/h5-10H,3-4,11-13H2,1-2H3,(H,31,33)(H,32,34)/t22-/s2
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n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235248
PNG
(US9365558, 71)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccc(cc1)C(F)F
Show InChI InChI=1/C25H21F9N2O5S/c1-42(39,40)36-22(38)19-16(13-3-5-14(6-4-13)20(27)28)12-23(25(32,33)34,35-21(19)37)17-8-7-15(11-18(17)26)41-10-2-9-24(29,30)31/h3-8,11,20H,2,9-10,12H2,1H3,(H,35,37)(H,36,38)/t23-/s2
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n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235235
PNG
(US9365558, 58)
Show SMILES FC(F)(F)CCCCCn1cc(cn1)[C@@]1(CC(=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)c1ccc2CCCCc2c1)C(F)(F)F
Show InChI InChI=1/C29H32F6N4O4S/c30-28(31,32)12-4-1-5-13-39-17-21(16-36-39)27(29(33,34)35)15-23(20-9-8-18-6-2-3-7-19(18)14-20)24(25(40)37-27)26(41)38-44(42,43)22-10-11-22/h8-9,14,16-17,22H,1-7,10-13,15H2,(H,37,40)(H,38,41)/t27-/s2
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235233
PNG
(US9365558, 56)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C27H27F7N4O5S/c28-20-12-16(43-11-1-9-26(29,30)31)4-7-19(20)25(27(32,33)34)13-18(21-8-10-38(36-21)14-15-2-3-15)22(23(39)35-25)24(40)37-44(41,42)17-5-6-17/h4,7-8,10,12,15,17H,1-3,5-6,9,11,13-14H2,(H,35,39)(H,37,40)/t25-/s2
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n/an/a 13n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235186
PNG
(US9365558, 9)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)NS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C27H28F6N2O5S/c1-17-6-8-18(9-7-17)21-16-25(27(31,32)33,34-23(36)22(21)24(37)35-41(2,38)39)19-10-12-20(13-11-19)40-15-5-3-4-14-26(28,29)30/h6-13H,3-5,14-16H2,1-2H3,(H,34,36)(H,35,37)/t25-/s2
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n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235224
PNG
(US9365558, 47)
Show SMILES CS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F)c1ccn(n1)C1CC1
Show InChI InChI=1/C24H23F7N4O5S/c1-41(38,39)34-21(37)19-15(18-7-9-35(33-18)13-3-4-13)12-22(24(29,30)31,32-20(19)36)16-6-5-14(11-17(16)25)40-10-2-8-23(26,27)28/h5-7,9,11,13H,2-4,8,10,12H2,1H3,(H,32,36)(H,34,37)/t22-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235222
PNG
(US9365558, 45 | US9365558, 50)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CCC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C27H27F7N4O5S/c28-20-13-16(43-12-2-10-26(29,30)31)5-8-19(20)25(27(32,33)34)14-18(21-9-11-38(36-21)15-3-1-4-15)22(23(39)35-25)24(40)37-44(41,42)17-6-7-17/h5,8-9,11,13,15,17H,1-4,6-7,10,12,14H2,(H,35,39)(H,37,40)/t25-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235178
PNG
(US9365558, 1)
Show SMILES CCS(=O)(=O)NC(=O)C1=C(C[C@](NC1=O)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F)c1ccc(C)cc1
Show InChI InChI=1/C28H30F6N2O5S/c1-3-42(39,40)36-25(38)23-22(19-9-7-18(2)8-10-19)17-26(28(32,33)34,35-24(23)37)20-11-13-21(14-12-20)41-16-6-4-5-15-27(29,30)31/h7-14H,3-6,15-17H2,1-2H3,(H,35,37)(H,36,38)/t26-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235222
PNG
(US9365558, 45 | US9365558, 50)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CCC2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C27H27F7N4O5S/c28-20-13-16(43-12-2-10-26(29,30)31)5-8-19(20)25(27(32,33)34)14-18(21-9-11-38(36-21)15-3-1-4-15)22(23(39)35-25)24(40)37-44(41,42)17-6-7-17/h5,8-9,11,13,15,17H,1-4,6-7,10,12,14H2,(H,35,39)(H,37,40)/t25-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235181
PNG
(US9365558, 4)
Show SMILES CN(C)c1ccc(cc1)C1=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1/C30H33F6N3O5S/c1-39(2)21-10-6-19(7-11-21)24-18-28(30(34,35)36,37-26(40)25(24)27(41)38-45(42,43)23-14-15-23)20-8-12-22(13-9-20)44-17-5-3-4-16-29(31,32)33/h6-13,23H,3-5,14-18H2,1-2H3,(H,37,40)(H,38,41)/t28-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
Monoacylglycerol acyltransferase type 2 (h-MGAT2)


(Homo sapiens (Human))
BDBM235251
PNG
(US9365558, 74)
Show SMILES FC(F)(F)CCCOc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CCC3)n2)=C(C(=O)NS(=O)(=O)C2CC2)C(=O)N1)C(F)(F)F
Show InChI InChI=1/C28H30F6N4O5S/c29-27(30,31)12-2-14-43-19-7-5-18(6-8-19)26(28(32,33)34)15-21(22-11-13-38(36-22)16-17-3-1-4-17)23(24(39)35-26)25(40)37-44(41,42)20-9-10-20/h5-8,11,13,17,20H,1-4,9-10,12,14-16H2,(H,35,39)(H,37,40)/t26-/s2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCON® 96-well Polypropylene plates, in a total volume of 60 μL of 50 mM Potassium Phosph...


Citation and Details
More data for this
Ligand-Target Pair
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