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Compile Data Set for Download or QSAR

Found 128 hits with Last Name = 'nielsen' and Initial = 'ja'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015711
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole-5-ca...)
Show SMILES N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H13N3/c15-8-10-1-2-14-12(7-10)13(9-17-14)11-3-5-16-6-4-11/h1-3,7,9,16-17H,4-6H2
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015714
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indol-5-ol ...)
Show SMILES Oc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H14N2O/c16-10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-16H,4-6H2
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n/an/a 1.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229040
PNG
(CHEMBL156140)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H17N3O4/c1-29-21(27)16-9-5-10-17(13-16)25-19-18(11-6-12-23-19)20(26)24(22(25)28)14-15-7-3-2-4-8-15/h2-13H,14H2,1H3
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015712
PNG
(5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Show SMILES Fc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13FN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 1.90n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM81498
PNG
(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Show SMILES COc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
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n/an/a 2n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229041
PNG
(CHEMBL351567)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CCCC2)c1=O
Show InChI InChI=1S/C21H21N3O4/c1-28-20(26)15-8-4-9-16(12-15)24-18-17(10-5-11-22-18)19(25)23(21(24)27)13-14-6-2-3-7-14/h4-5,8-12,14H,2-3,6-7,13H2,1H3
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n/an/a 2.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 2.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 2.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228824
PNG
(CHEMBL2112408)
Show SMILES COc1ccc(cc1O[C@@H]1CC2CCC1C2)C1CNC(=O)N1C
Show InChI InChI=1S/C18H24N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h5-6,9,11,13-14,16H,3-4,7-8,10H2,1-2H3,(H,19,21)/t11?,13?,14?,16-/m1/s1
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n/an/a 2.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]-5-HT as the radioligand


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228833
PNG
(CHEMBL318836)
Show SMILES COc1ccc(cc1OC1CC2CC1C=C2)C1CNC(=O)N1C
Show InChI InChI=1S/C18H22N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h3-6,9,11,13-14,16H,7-8,10H2,1-2H3,(H,19,21)
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n/an/a 3.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229038
PNG
(CHEMBL345917)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CC3CCC2C3)c1=O
Show InChI InChI=1S/C23H23N3O4/c1-30-22(28)16-4-2-5-18(12-16)26-20-19(6-3-9-24-20)21(27)25(23(26)29)13-17-11-14-7-8-15(17)10-14/h2-6,9,12,14-15,17H,7-8,10-11,13H2,1H3
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015709
PNG
(5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Show SMILES Brc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13BrN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 3.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015717
PNG
(5-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Show SMILES Clc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13ClN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 3.30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015718
PNG
(5-Nitro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13N3O2/c17-16(18)10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-15H,4-6H2
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM31023
PNG
(3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | CHE...)
Show SMILES C1CC(=CCN1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H14N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-5,9,14-15H,6-8H2
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n/an/a 3.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT as the radioligand.


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT as the radioligand.


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 5.20n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228829
PNG
(CHEMBL2111611)
Show SMILES COc1ccc(cc1O[C@H]1CC2CCC1C2)C1CNC(=O)N1C
Show InChI InChI=1S/C18H24N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h5-6,9,11,13-14,16H,3-4,7-8,10H2,1-2H3,(H,19,21)/t11?,13?,14?,16-/m0/s1
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n/an/a 7.70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228825
PNG
(CHEMBL2112409)
Show SMILES COc1ccc(cc1O[C@@H]1CC2CC1C1CCCC21)C1CNC(=O)N1C
Show InChI InChI=1S/C21H28N2O3/c1-23-17(11-22-21(23)24)12-6-7-18(25-2)20(9-12)26-19-10-13-8-16(19)15-5-3-4-14(13)15/h6-7,9,13-17,19H,3-5,8,10-11H2,1-2H3,(H,22,24)/t13?,14?,15?,16?,17?,19-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015709
PNG
(5-Bromo-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Show SMILES Brc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13BrN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM81498
PNG
(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Show SMILES COc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50218545
PNG
(NITRAQUAZONE | Nitraquazone)
Show SMILES CCn1c(=O)n(-c2cccc(c2)[N+]([O-])=O)c2ccccc2c1=O
Show InChI InChI=1S/C16H13N3O4/c1-2-17-15(20)13-8-3-4-9-14(13)18(16(17)21)11-6-5-7-12(10-11)19(22)23/h3-10H,2H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]rolipram binding to Phosphodiesterase 4 in rat brain


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM84737
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1,4-dihydro-py...)
Show SMILES O=c1ccc2[nH]cc(C3=CCNCC3)c2[nH]1
Show InChI InChI=1S/C12H11N3O/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8/h1-3,7,13H,4-6H2
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n/an/a 15n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM81497
PNG
(4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrr...)
Show SMILES CN1CCN(CC1)c1nc2cc(ccc2n2cccc12)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228822
PNG
(CHEMBL2112410)
Show SMILES COc1ccc(cc1O[C@@H]1CC2CC1c1ccccc21)C1CNC(=O)N1C
Show InChI InChI=1S/C22H24N2O3/c1-24-18(12-23-22(24)25)13-7-8-19(26-2)21(10-13)27-20-11-14-9-17(20)16-6-4-3-5-15(14)16/h3-8,10,14,17-18,20H,9,11-12H2,1-2H3,(H,23,25)/t14?,17?,18?,20-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50015710
PNG
(4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]q...)
Show SMILES FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C16H15F3N4/c17-16(18,19)11-3-4-13-12(10-11)21-15(14-2-1-7-23(13)14)22-8-5-20-6-9-22/h1-4,7,10,20H,5-6,8-9H2
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228831
PNG
(CHEMBL2111610)
Show SMILES COc1ccc(cc1O[C@H]1CC2CC1C1CCCC21)C1CNC(=O)N1C
Show InChI InChI=1S/C21H28N2O3/c1-23-17(11-22-21(23)24)12-6-7-18(25-2)20(9-12)26-19-10-13-8-16(19)15-5-3-4-14(13)15/h6-7,9,13-17,19H,3-5,8,10-11H2,1-2H3,(H,22,24)/t13?,14?,15?,16?,17?,19-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015717
PNG
(5-Chloro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Show SMILES Clc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13ClN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 26n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50007406
PNG
(1-(3-(trifluoromethyl)phenyl)piperazine | 1-(3-Tri...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCNCC1
Show InChI InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015714
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indol-5-ol ...)
Show SMILES Oc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H14N2O/c16-10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-16H,4-6H2
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n/an/a 30n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015711
PNG
(3-(1,2,3,6-Tetrahydro-pyridin-4-yl)-1H-indole-5-ca...)
Show SMILES N#Cc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H13N3/c15-8-10-1-2-14-12(7-10)13(9-17-14)11-3-5-16-6-4-11/h1-3,7,9,16-17H,4-6H2
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n/an/a 32n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM81497
PNG
(4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrr...)
Show SMILES CN1CCN(CC1)c1nc2cc(ccc2n2cccc12)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]-5-HT as the radioligand


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015718
PNG
(5-Nitro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-ind...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13N3O2/c17-16(18)10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-15H,4-6H2
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n/an/a 36n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015710
PNG
(4-Piperazin-1-yl-7-trifluoromethyl-pyrrolo[1,2-a]q...)
Show SMILES FC(F)(F)c1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C16H15F3N4/c17-16(18,19)11-3-4-13-12(10-11)21-15(14-2-1-7-23(13)14)22-8-5-20-6-9-22/h1-4,7,10,20H,5-6,8-9H2
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n/an/a 37n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (Human))
BDBM81498
PNG
(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Show SMILES COc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
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n/an/a 39n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory activity against 5-hydroxytryptamine 1D receptor of bovine caudate using [3H]-5-HT as the radioligand


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229040
PNG
(CHEMBL156140)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H17N3O4/c1-29-21(27)16-9-5-10-17(13-16)25-19-18(11-6-12-23-19)20(26)24(22(25)28)14-15-7-3-2-4-8-15/h2-13H,14H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50015712
PNG
(5-Fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Show SMILES Fc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C13H13FN2/c14-10-1-2-13-11(7-10)12(8-16-13)9-3-5-15-6-4-9/h1-3,7-8,15-16H,4-6H2
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n/an/a 65n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229041
PNG
(CHEMBL351567)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CCCC2)c1=O
Show InChI InChI=1S/C21H21N3O4/c1-28-20(26)15-8-4-9-16(12-15)24-18-17(10-5-11-22-18)19(25)23(21(24)27)13-14-6-2-3-7-14/h4-5,8-12,14H,2-3,6-7,13H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228834
PNG
(CHEMBL101172)
Show SMILES COc1ccc(cc1OC1CC2CCC1CC2)C1CNC(=O)N1C
Show InChI InChI=1S/C19H26N2O3/c1-21-15(11-20-19(21)22)14-7-8-16(23-2)18(10-14)24-17-9-12-3-5-13(17)6-4-12/h7-8,10,12-13,15,17H,3-6,9,11H2,1-2H3,(H,20,22)
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n/an/a 81n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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n/an/a 81n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
inhibitory activity against 5-hydroxytryptamine 1C receptor of pig choroid plexus using [3H]-mesulergine as the radioligand


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50229038
PNG
(CHEMBL345917)
Show SMILES COC(=O)c1cccc(c1)-n1c2ncccc2c(=O)n(CC2CC3CCC2C3)c1=O
Show InChI InChI=1S/C23H23N3O4/c1-30-22(28)16-4-2-5-18(12-16)26-20-19(6-3-9-24-20)21(27)25(23(26)29)13-17-11-14-7-8-15(17)10-14/h2-6,9,12,14-15,17H,7-8,10-11,13H2,1H3
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n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat brain cortex


J Med Chem 34: 624-8 (1991)


Article DOI: 10.1021/jm00106a024
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228832
PNG
(CHEMBL100679)
Show SMILES COc1ccc(cc1OC1CC2C1C1CCC2C1)C1CNC(=O)N1C
Show InChI InChI=1S/C20H26N2O3/c1-22-15(10-21-20(22)23)12-5-6-16(24-2)17(8-12)25-18-9-14-11-3-4-13(7-11)19(14)18/h5-6,8,11,13-15,18-19H,3-4,7,9-10H2,1-2H3,(H,21,23)
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n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228830
PNG
(CHEMBL101505)
Show SMILES COc1ccc(cc1OC1CC2CCC(C2)C1)C1CNC(=O)N1C
Show InChI InChI=1S/C19H26N2O3/c1-21-16(11-20-19(21)22)14-5-6-17(23-2)18(10-14)24-15-8-12-3-4-13(7-12)9-15/h5-6,10,12-13,15-16H,3-4,7-9,11H2,1-2H3,(H,20,22)
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n/an/a>100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228827
PNG
(CHEMBL2111609)
Show SMILES COc1ccc(cc1O[C@H]1CC2CC1c1ccccc21)C1CNC(=O)N1C
Show InChI InChI=1S/C22H24N2O3/c1-24-18(12-23-22(24)25)13-7-8-19(26-2)21(10-13)27-20-11-14-9-17(20)16-6-4-3-5-15(14)16/h3-8,10,14,17-18,20H,9,11-12H2,1-2H3,(H,23,25)/t14?,17?,18?,20-/m0/s1
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n/an/a>100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228826
PNG
(CHEMBL317379)
Show SMILES COc1ccc(cc1OC1C2CC3CC(C2)CC1C3)C1CNC(=O)N1C
Show InChI InChI=1S/C21H28N2O3/c1-23-17(11-22-21(23)24)14-3-4-18(25-2)19(10-14)26-20-15-6-12-5-13(8-15)9-16(20)7-12/h3-4,10,12-13,15-17,20H,5-9,11H2,1-2H3,(H,22,24)
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n/an/a>100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228823
PNG
(CHEMBL101504)
Show SMILES COc1ccc(cc1OC1CC2C3CCC(C3)C2C1)C1CNC(=O)N1C
Show InChI InChI=1S/C21H28N2O3/c1-23-18(11-22-21(23)24)14-5-6-19(25-2)20(8-14)26-15-9-16-12-3-4-13(7-12)17(16)10-15/h5-6,8,12-13,15-18H,3-4,7,9-11H2,1-2H3,(H,22,24)
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n/an/a>100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to rat cerebral cortex membranes


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228833
PNG
(CHEMBL318836)
Show SMILES COc1ccc(cc1OC1CC2CC1C=C2)C1CNC(=O)N1C
Show InChI InChI=1S/C18H22N2O3/c1-20-14(10-19-18(20)21)12-5-6-15(22-2)17(9-12)23-16-8-11-3-4-13(16)7-11/h3-6,9,11,13-14,16H,7-8,10H2,1-2H3,(H,19,21)
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n/an/a 130n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of calcium-independent Phosphodiesterase 4


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM31023
PNG
(3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | CHE...)
Show SMILES C1CC(=CCN1)c1c[nH]c2ccccc12
Show InChI InChI=1S/C13H14N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-5,9,14-15H,6-8H2
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n/an/a 140n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-8-OH-DPAT from rat cortex 5-hydroxytryptamine 1A receptor


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM81497
PNG
(4-(4-Methyl-piperazin-1-yl)-7-trifluoromethyl-pyrr...)
Show SMILES CN1CCN(CC1)c1nc2cc(ccc2n2cccc12)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3
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n/an/a 150n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat cortex using [3H]-5-HT


J Med Chem 33: 2087-93 (1990)


Article DOI: 10.1021/jm00170a007
BindingDB Entry DOI: 10.7270/Q2GQ6WR3
More data for this
Ligand-Target Pair
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