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Compile Data Set for Download or QSAR

Found 4 hits with Last Name = 'oikawa' and Initial = 'm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIK1


(Homo sapiens (Human))
BDBM85740
PNG
(Dysiherbaine)
Show SMILES CN[C@H]1[C@H]2O[C@](C[C@H](N)C(O)=O)(C[C@H]2OC[C@H]1O)C(O)=O
Show InChI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
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0.740n/an/an/an/an/an/an/an/a



Yokohama City University

Curated by ChEMBL


Assay Description
Displacement of [3H]kianic acid from recombinant GluK1 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hr


Bioorg Med Chem Lett 26: 5164-5167 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.074
BindingDB Entry DOI: 10.7270/Q2ZG6V6F
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM85740
PNG
(Dysiherbaine)
Show SMILES CN[C@H]1[C@H]2O[C@](C[C@H](N)C(O)=O)(C[C@H]2OC[C@H]1O)C(O)=O
Show InChI InChI=1S/C12H20N2O7/c1-14-8-6(15)4-20-7-3-12(11(18)19,21-9(7)8)2-5(13)10(16)17/h5-9,14-15H,2-4,13H2,1H3,(H,16,17)(H,18,19)/t5-,6+,7+,8+,9-,12+/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Yokohama City University

Curated by ChEMBL


Assay Description
Displacement of [3H]kianic acid from recombinant GluK2 kainate receptor (unknown origin) expressed in HEK293 cell membranes measured after 1 hr


Bioorg Med Chem Lett 26: 5164-5167 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.074
BindingDB Entry DOI: 10.7270/Q2ZG6V6F
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50427677
PNG
(CHEMBL2323527)
Show SMILES OC(=O)C[C@@]12O[C@H]3C=CCN[C@H]3[C@@H]1C(=O)NC2C(O)=O
Show InChI InChI=1S/C12H14N2O6/c15-6(16)4-12-7(10(17)14-9(12)11(18)19)8-5(20-12)2-1-3-13-8/h1-2,5,7-9,13H,3-4H2,(H,14,17)(H,15,16)(H,18,19)/t5-,7+,8+,9?,12+/m0/s1
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5.60E+5n/an/an/an/an/an/an/an/a



Yokohama City University

Curated by ChEMBL


Assay Description
Binding affinity to GluA2 ligand binding domain (unknown origin) by competitive binding assay


J Med Chem 56: 2283-93 (2013)


Article DOI: 10.1021/jm301590z
BindingDB Entry DOI: 10.7270/Q2SJ1MZN
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2


(Rattus norvegicus)
BDBM50178141
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(4-carboxybenzyl)...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccc(cc2)C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-1-3-10(4-2-9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1
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n/an/a 2.90E+5n/an/an/an/an/an/a



Yokohama City University

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat GluA2 ligand binding domain after 1 hr


J Med Chem 56: 2283-93 (2013)


Article DOI: 10.1021/jm301590z
BindingDB Entry DOI: 10.7270/Q2SJ1MZN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)