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Compile Data Set for Download or QSAR

Found 63 hits with Last Name = 'owens' and Initial = 'bs'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50070919
PNG
(C,C,C-Trifluoro-N-{3-[(2R,3S,4R)-6-(5-fluoro-benzo...)
Show SMILES C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1
Show InChI InChI=1S/C26H22F4N2O5S2/c1-14-19(10-15-3-2-4-17(9-15)32-39(34,35)26(28,29)30)25(33)20-12-18(6-7-22(20)37-14)36-13-24-31-21-11-16(27)5-8-23(21)38-24/h2-9,11-12,14,19,25,32-33H,10,13H2,1H3/t14-,19-,25-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50023198
PNG
(8-[4-(4-phenylbutyloxy)benzoyl]amino-2-(tetrazol-5...)
Show SMILES O=C(Nc1cccc2c1oc(cc2=O)-c1nnn[nH]1)c1ccc(OCCCCc2ccccc2)cc1
Show InChI InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
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0.800n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Stromelysin-1


(Homo sapiens (Human))
BDBM50073839
PNG
(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CCc1ccccc1)CP(O)(=O)CCCCN1C(=O)c2ccccc2C1=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C35H42N3O6P/c1-25(2)23-31(33(40)36-28-15-7-4-8-16-28)37-32(39)27(20-19-26-13-5-3-6-14-26)24-45(43,44)22-12-11-21-38-34(41)29-17-9-10-18-30(29)35(38)42/h3-10,13-18,25,27,31H,11-12,19-24H2,1-2H3,(H,36,40)(H,37,39)(H,43,44)/t27-,31-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-3 (MMP-3)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50073277
PNG
(CHEMBL332680 | N-{3-[(3S,4R)-6-(5,6-Difluoro-benzo...)
Show SMILES COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C
Show InChI InChI=1S/C28H25F5N2O6S2/c1-27(2)18(9-14-8-15(4-6-22(14)39-3)35-43(37,38)28(31,32)33)26(36)17-10-16(5-7-23(17)41-27)40-13-25-34-21-11-19(29)20(30)12-24(21)42-25/h4-8,10-12,18,26,35-36H,9,13H2,1-3H3/t18-,26-/m0/s1
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2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50009073
PNG
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Show SMILES COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
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2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50073279
PNG
(CHEMBL119214 | N-{3-[(3S,4R)-6-(7-Chloro-quinolin-...)
Show SMILES COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C
Show InChI InChI=1S/C30H28ClF3N2O6S/c1-29(2)24(13-18-12-20(8-10-26(18)40-3)36-43(38,39)30(32,33)34)28(37)23-15-22(9-11-27(23)42-29)41-16-21-7-5-17-4-6-19(31)14-25(17)35-21/h4-12,14-15,24,28,36-37H,13,16H2,1-3H3/t24-,28-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50073276
PNG
(CHEMBL120200 | N-{4-Chloro-3-[(3S,4R)-6-(5,6-diflu...)
Show SMILES CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl
Show InChI InChI=1S/C27H22ClF5N2O5S2/c1-26(2)17(8-13-7-14(3-5-18(13)28)35-42(37,38)27(31,32)33)25(36)16-9-15(4-6-22(16)40-26)39-12-24-34-21-10-19(29)20(30)11-23(21)41-24/h3-7,9-11,17,25,35-36H,8,12H2,1-2H3/t17-,25-/m0/s1
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4n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50073275
PNG
(CHEMBL331884 | N-(3-{(3S,4R)-6-[(E)-2-(7-Chloro-qu...)
Show SMILES COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(\C=C\c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C
Show InChI InChI=1S/C31H28ClF3N2O5S/c1-30(2)25(16-20-15-23(11-13-27(20)41-3)37-43(39,40)31(33,34)35)29(38)24-14-18(5-12-28(24)42-30)4-9-22-10-7-19-6-8-21(32)17-26(19)36-22/h4-15,17,25,29,37-38H,16H2,1-3H3/b9-4+/t25-,29-/m0/s1
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5n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50073823
PNG
(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CCc1ccccc1)CP(O)(=O)CCCCNC(=O)[C@@H]1CCCN1C(C)=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C34H49N4O6P/c1-25(2)23-30(33(41)36-29-15-8-5-9-16-29)37-32(40)28(19-18-27-13-6-4-7-14-27)24-45(43,44)22-11-10-20-35-34(42)31-17-12-21-38(31)26(3)39/h4-9,13-16,25,28,30-31H,10-12,17-24H2,1-3H3,(H,35,42)(H,36,41)(H,37,40)(H,43,44)/t28-,30-,31+/m1/s1
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6.10n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-2 (MMP-2)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50073278
PNG
(CHEMBL331747 | N-{3-[(3S,4R)-6-(5,6-Difluoro-benzo...)
Show SMILES CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1
Show InChI InChI=1S/C27H23F5N2O5S2/c1-26(2)18(9-14-4-3-5-15(8-14)34-41(36,37)27(30,31)32)25(35)17-10-16(6-7-22(17)39-26)38-13-24-33-21-11-19(28)20(29)12-23(21)40-24/h3-8,10-12,18,25,34-35H,9,13H2,1-2H3/t18-,25-/m0/s1
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7n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50070921
PNG
(3-[(3R,4R)-6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4...)
Show SMILES O[C@@H]1[C@H](Cc2cccc(c2)C(O)=O)COc2ccc(OCc3nc4cc(F)ccc4s3)cc12
Show InChI InChI=1S/C25H20FNO5S/c26-17-4-7-22-20(10-17)27-23(33-22)13-31-18-5-6-21-19(11-18)24(28)16(12-32-21)9-14-2-1-3-15(8-14)25(29)30/h1-8,10-11,16,24,28H,9,12-13H2,(H,29,30)/t16-,24-/m1/s1
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14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonism of Cysteinyl leukotriene receptor 1 from guinea pig lung membranes


Bioorg Med Chem Lett 8: 3577-82 (1999)


Article DOI: 10.1016/s0960-894x(98)00654-4
BindingDB Entry DOI: 10.7270/Q2833R5M
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))
BDBM50073839
PNG
(CHEMBL283066 | [4-(1,3-Dioxo-1,3-dihydro-isoindol-...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CCc1ccccc1)CP(O)(=O)CCCCN1C(=O)c2ccccc2C1=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C35H42N3O6P/c1-25(2)23-31(33(40)36-28-15-7-4-8-16-28)37-32(39)27(20-19-26-13-5-3-6-14-26)24-45(43,44)22-12-11-21-38-34(41)29-17-9-10-18-30(29)35(38)42/h3-10,13-18,25,27,31H,11-12,19-24H2,1-2H3,(H,36,40)(H,37,39)(H,43,44)/t27-,31-/m1/s1
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20n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-2 (MMP-2)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50073823
PNG
(CHEMBL24871 | {4-[((S)-1-Acetyl-pyrrolidine-2-carb...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CCc1ccccc1)CP(O)(=O)CCCCNC(=O)[C@@H]1CCCN1C(C)=O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C34H49N4O6P/c1-25(2)23-30(33(41)36-29-15-8-5-9-16-29)37-32(40)28(19-18-27-13-6-4-7-14-27)24-45(43,44)22-11-10-20-35-34(42)31-17-12-21-38(31)26(3)39/h4-9,13-16,25,28,30-31H,10-12,17-24H2,1-3H3,(H,35,42)(H,36,41)(H,37,40)(H,43,44)/t28-,30-,31+/m1/s1
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62n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-3 (MMP-3)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071633
PNG
(CHEMBL83166 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C35H38N4O8S/c1-23-7-3-6-10-32(23)48(43,44)37-33(40)25-12-11-24(31(20-25)45-2)19-26-22-39(35(42)38-15-17-46-18-16-38)30-14-13-27(21-29(26)30)36-34(41)47-28-8-4-5-9-28/h3,6-7,10-14,20-22,28H,4-5,8-9,15-19H2,1-2H3,(H,36,41)(H,37,40)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071631
PNG
(CHEMBL79952 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C38H38N4O7S/c1-25-11-7-10-16-35(25)50(46,47)40-36(43)27-18-17-26(34(22-27)48-3)21-28-24-42(38(45)41(2)30-12-5-4-6-13-30)33-20-19-29(23-32(28)33)39-37(44)49-31-14-8-9-15-31/h4-7,10-13,16-20,22-24,31H,8-9,14-15,21H2,1-3H3,(H,39,44)(H,40,43)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071637
PNG
(CHEMBL79366 | {1-Dimethylcarbamoyl-3-[2-methoxy-4-...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C33H36N4O7S/c1-21-9-5-8-12-30(21)45(41,42)35-31(38)23-14-13-22(29(18-23)43-4)17-24-20-37(33(40)36(2)3)28-16-15-25(19-27(24)28)34-32(39)44-26-10-6-7-11-26/h5,8-9,12-16,18-20,26H,6-7,10-11,17H2,1-4H3,(H,34,39)(H,35,38)
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n/an/a 0.400n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071638
PNG
(CHEMBL311868 | {1-Carbamoyl-3-[2-methoxy-4-(toluen...)
Show SMILES COc1cc(ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H32N4O7S/c1-19-7-3-6-10-28(19)43(39,40)34-29(36)21-12-11-20(27(16-21)41-2)15-22-18-35(30(32)37)26-14-13-23(17-25(22)26)33-31(38)42-24-8-4-5-9-24/h3,6-7,10-14,16-18,24H,4-5,8-9,15H2,1-2H3,(H2,32,37)(H,33,38)(H,34,36)
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071636
PNG
(CHEMBL79479 | {1-(2-Dimethylamino-ethylcarbamoyl)-...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C35H41N5O7S/c1-23-9-5-8-12-32(23)48(44,45)38-33(41)25-14-13-24(31(20-25)46-4)19-26-22-40(34(42)36-17-18-39(2)3)30-16-15-27(21-29(26)30)37-35(43)47-28-10-6-7-11-28/h5,8-9,12-16,20-22,28H,6-7,10-11,17-19H2,1-4H3,(H,36,42)(H,37,43)(H,38,41)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071632
PNG
(CHEMBL310446 | {1-Diethylcarbamoyl-3-[2-methoxy-4-...)
Show SMILES CCN(CC)C(=O)n1cc(Cc2ccc(cc2OC)C(=O)NS(=O)(=O)c2ccccc2C)c2cc(NC(=O)OC3CCCC3)ccc12
Show InChI InChI=1S/C35H40N4O7S/c1-5-38(6-2)35(42)39-22-26(29-21-27(17-18-30(29)39)36-34(41)46-28-12-8-9-13-28)19-24-15-16-25(20-31(24)45-4)33(40)37-47(43,44)32-14-10-7-11-23(32)3/h7,10-11,14-18,20-22,28H,5-6,8-9,12-13,19H2,1-4H3,(H,36,41)(H,37,40)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071639
PNG
(CHEMBL79741 | [3-[2-Methoxy-4-(toluene-2-sulfonyla...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C40H42N4O7S/c1-27-11-6-9-17-37(27)52(48,49)43-38(45)30-19-18-29(36(24-30)50-2)23-31-26-44(39(46)41-22-10-14-28-12-4-3-5-13-28)35-21-20-32(25-34(31)35)42-40(47)51-33-15-7-8-16-33/h3-6,9,11-13,17-21,24-26,33H,7-8,10,14-16,22-23H2,1-2H3,(H,41,46)(H,42,47)(H,43,45)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071640
PNG
(CHEMBL1048 | N-Dealkylated Derivative | {3-[2-Meth...)
Show SMILES COc1cc(ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C30H31N3O6S/c1-19-7-3-6-10-28(19)40(36,37)33-29(34)21-12-11-20(27(16-21)38-2)15-22-18-31-26-14-13-23(17-25(22)26)32-30(35)39-24-8-4-5-9-24/h3,6-7,10-14,16-18,24,31H,4-5,8-9,15H2,1-2H3,(H,32,35)(H,33,34)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071634
PNG
(CHEMBL78140 | {1-Difluoromethyl-3-[2-methoxy-4-(to...)
Show SMILES COc1cc(ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H31F2N3O6S/c1-19-7-3-6-10-28(19)43(39,40)35-29(37)21-12-11-20(27(16-21)41-2)15-22-18-36(30(32)33)26-14-13-23(17-25(22)26)34-31(38)42-24-8-4-5-9-24/h3,6-7,10-14,16-18,24,30H,4-5,8-9,15H2,1-2H3,(H,34,38)(H,35,37)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071635
PNG
(CHEMBL78141 | {1-Formyl-3-[2-methoxy-4-(toluene-2-...)
Show SMILES COc1cc(ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H31N3O7S/c1-20-7-3-6-10-29(20)42(38,39)33-30(36)22-12-11-21(28(16-22)40-2)15-23-18-34(19-35)27-14-13-24(17-26(23)27)32-31(37)41-25-8-4-5-9-25/h3,6-7,10-14,16-19,25H,4-5,8-9,15H2,1-2H3,(H,32,37)(H,33,36)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50009073
PNG
(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)
Show SMILES COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C31H33N3O6S/c1-20-8-4-7-11-29(20)41(37,38)33-30(35)22-13-12-21(28(17-22)39-3)16-23-19-34(2)27-15-14-24(18-26(23)27)32-31(36)40-25-9-5-6-10-25/h4,7-8,11-15,17-19,25H,5-6,9-10,16H2,1-3H3,(H,32,36)(H,33,35)
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n/an/a 2n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cysteinyl leukotriene receptor 1


(GUINEA PIG)
BDBM50071641
PNG
(CHEMBL313567 | {1-Diphenylcarbamoyl-3-[2-methoxy-4...)
Show SMILES COc1cc(ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Show InChI InChI=1S/C43H40N4O7S/c1-29-13-9-12-20-40(29)55(51,52)45-41(48)31-22-21-30(39(26-31)53-2)25-32-28-46(43(50)47(34-14-5-3-6-15-34)35-16-7-4-8-17-35)38-24-23-33(27-37(32)38)44-42(49)54-36-18-10-11-19-36/h3-9,12-17,20-24,26-28,36H,10-11,18-19,25H2,1-2H3,(H,44,49)(H,45,48)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Binding affinity against leukotriene D4 receptor in [3H]-LTD4 binding assay


Bioorg Med Chem Lett 8: 2451-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00442-9
BindingDB Entry DOI: 10.7270/Q2X63M30
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073830
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H41N2O4P/c1-32(2,3)29(31(36)33-4)34-30(35)28(20-19-24-11-7-5-8-12-24)23-39(37,38)22-27-17-15-26(16-18-27)21-25-13-9-6-10-14-25/h5-18,28-29H,19-23H2,1-4H3,(H,33,36)(H,34,35)(H,37,38)/t28?,29-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073822
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCCCOc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C34H45N2O5P/c1-34(2,3)31(33(38)35-4)36-32(37)29(15-11-12-22-41-30-16-9-6-10-17-30)25-42(39,40)24-28-20-18-27(19-21-28)23-26-13-7-5-8-14-26/h5-10,13-14,16-21,29,31H,11-12,15,22-25H2,1-4H3,(H,35,38)(H,36,37)(H,39,40)/t29?,31-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073824
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCC(F)(F)F)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C27H36F3N2O4P/c1-26(2,3)23(25(34)31-4)32-24(33)22(14-15-27(28,29)30)18-37(35,36)17-21-12-10-20(11-13-21)16-19-8-6-5-7-9-19/h5-13,22-23H,14-18H2,1-4H3,(H,31,34)(H,32,33)(H,35,36)/t22?,23-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073833
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C28H41N2O4P/c1-20(2)16-24(26(31)30-25(27(32)29-6)28(3,4)5)19-35(33,34)18-23-14-12-22(13-15-23)17-21-10-8-7-9-11-21/h7-15,20,24-25H,16-19H2,1-6H3,(H,29,32)(H,30,31)(H,33,34)/t24?,25-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073831
PNG
((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C29H41N2O4P/c1-29(2,3)26(28(33)30-4)31-27(32)25(18-22-11-8-12-22)20-36(34,35)19-24-15-13-23(14-16-24)17-21-9-6-5-7-10-21/h5-7,9-10,13-16,22,25-26H,8,11-12,17-20H2,1-4H3,(H,30,33)(H,31,32)(H,34,35)/t25?,26-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073833
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C28H41N2O4P/c1-20(2)16-24(26(31)30-25(27(32)29-6)28(3,4)5)19-35(33,34)18-23-14-12-22(13-15-23)17-21-10-8-7-9-11-21/h7-15,20,24-25H,16-19H2,1-6H3,(H,29,32)(H,30,31)(H,33,34)/t24?,25-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073831
PNG
((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C29H41N2O4P/c1-29(2,3)26(28(33)30-4)31-27(32)25(18-22-11-8-12-22)20-36(34,35)19-24-15-13-23(14-16-24)17-21-9-6-5-7-10-21/h5-7,9-10,13-16,22,25-26H,8,11-12,17-20H2,1-4H3,(H,30,33)(H,31,32)(H,34,35)/t25?,26-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073837
PNG
((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C28H39N2O4P/c1-28(2,3)25(27(32)29-4)30-26(31)24(17-22-10-11-22)19-35(33,34)18-23-14-12-21(13-15-23)16-20-8-6-5-7-9-20/h5-9,12-15,22,24-25H,10-11,16-19H2,1-4H3,(H,29,32)(H,30,31)(H,33,34)/t24?,25-/m0/s1
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Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073846
PNG
((4-Benzyl-benzyl)-{2-[(R)-2-(4-hydroxy-phenyl)-1-m...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C31H39N2O5P/c1-22(2)17-27(30(35)33-29(31(36)32-3)19-25-13-15-28(34)16-14-25)21-39(37,38)20-26-11-9-24(10-12-26)18-23-7-5-4-6-8-23/h4-16,22,27,29,34H,17-21H2,1-3H3,(H,32,36)(H,33,35)(H,37,38)/t27?,29-/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073828
PNG
(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccccc1)C(C)(C)C
Show InChI InChI=1S/C25H35N2O4P/c1-25(2,3)22(24(29)26-4)27-23(28)21(16-15-19-11-7-5-8-12-19)18-32(30,31)17-20-13-9-6-10-14-20/h5-14,21-22H,15-18H2,1-4H3,(H,26,29)(H,27,28)(H,30,31)/t21?,22-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM17807
PNG
(benzimidazole-urea, 34 | methyl N-(6-{[4-({[2-fluo...)
Show SMILES COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H17F4N5O3S/c1-35-22(34)32-20-29-17-9-7-15(11-19(17)30-20)36-14-5-3-13(4-6-14)28-21(33)31-18-10-12(23(25,26)27)2-8-16(18)24/h2-11H,1H3,(H2,28,31,33)(H2,29,30,32,34)
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n/an/a 340n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073830
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H41N2O4P/c1-32(2,3)29(31(36)33-4)34-30(35)28(20-19-24-11-7-5-8-12-24)23-39(37,38)22-27-17-15-26(16-18-27)21-25-13-9-6-10-14-25/h5-18,28-29H,19-23H2,1-4H3,(H,33,36)(H,34,35)(H,37,38)/t28?,29-/m0/s1
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n/an/a 690n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073834
PNG
((4-Benzoyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylca...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(cc1)C(=O)c1ccccc1)C(C)(C)C
Show InChI InChI=1S/C28H39N2O5P/c1-19(2)16-23(26(32)30-25(27(33)29-6)28(3,4)5)18-36(34,35)17-20-12-14-22(15-13-20)24(31)21-10-8-7-9-11-21/h7-15,19,23,25H,16-18H2,1-6H3,(H,29,33)(H,30,32)(H,34,35)/t23?,25-/m0/s1
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n/an/a 750n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073837
PNG
((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C28H39N2O4P/c1-28(2,3)25(27(32)29-4)30-26(31)24(17-22-10-11-22)19-35(33,34)18-23-14-12-21(13-15-23)16-20-8-6-5-7-9-20/h5-9,12-15,22,24-25H,10-11,16-19H2,1-4H3,(H,29,32)(H,30,31)(H,33,34)/t24?,25-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50073830
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H41N2O4P/c1-32(2,3)29(31(36)33-4)34-30(35)28(20-19-24-11-7-5-8-12-24)23-39(37,38)22-27-17-15-26(16-18-27)21-25-13-9-6-10-14-25/h5-18,28-29H,19-23H2,1-4H3,(H,33,36)(H,34,35)(H,37,38)/t28?,29-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-3 (MMP-3)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073841
PNG
((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CCCCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C31H45N2O4P/c1-31(2,3)28(30(35)32-4)33-29(34)27(20-24-13-9-6-10-14-24)22-38(36,37)21-26-17-15-25(16-18-26)19-23-11-7-5-8-12-23/h5,7-8,11-12,15-18,24,27-28H,6,9-10,13-14,19-22H2,1-4H3,(H,32,35)(H,33,34)(H,36,37)/t27?,28-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073824
PNG
((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCC(F)(F)F)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C27H36F3N2O4P/c1-26(2,3)23(25(34)31-4)32-24(33)22(14-15-27(28,29)30)18-37(35,36)17-21-12-10-20(11-13-21)16-19-8-6-5-7-9-19/h5-13,22-23H,14-18H2,1-4H3,(H,31,34)(H,32,33)(H,35,36)/t22?,23-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073829
PNG
((4-Benzenesulfonyl-benzyl)-{2-[(R)-2-(4-hydroxy-ph...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C30H37N2O7PS/c1-21(2)17-24(29(34)32-28(30(35)31-3)18-22-9-13-25(33)14-10-22)20-40(36,37)19-23-11-15-27(16-12-23)41(38,39)26-7-5-4-6-8-26/h4-16,21,24,28,33H,17-20H2,1-3H3,(H,31,35)(H,32,34)(H,36,37)/t24?,28-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073841
PNG
((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CC1CCCCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C31H45N2O4P/c1-31(2,3)28(30(35)32-4)33-29(34)27(20-24-13-9-6-10-14-24)22-38(36,37)21-26-17-15-25(16-18-26)19-23-11-7-5-8-12-23/h5,7-8,11-12,15-18,24,27-28H,6,9-10,13-14,19-22H2,1-4H3,(H,32,35)(H,33,34)(H,36,37)/t27?,28-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073827
PNG
((4-Cyclohexylmethyl-benzyl)-{2-[(R)-2-(4-hydroxy-p...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(CC2CCCCC2)cc1
Show InChI InChI=1S/C31H45N2O5P/c1-22(2)17-27(30(35)33-29(31(36)32-3)19-25-13-15-28(34)16-14-25)21-39(37,38)20-26-11-9-24(10-12-26)18-23-7-5-4-6-8-23/h9-16,22-23,27,29,34H,4-8,17-21H2,1-3H3,(H,32,36)(H,33,35)(H,37,38)/t27?,29-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))
BDBM50073826
PNG
((4-Benzyl-benzyl)-[4-cyclohexyl-2-((R)-2,2-dimethy...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCC1CCCCC1)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1)C(C)(C)C
Show InChI InChI=1S/C32H47N2O4P/c1-32(2,3)29(31(36)33-4)34-30(35)28(20-19-24-11-7-5-8-12-24)23-39(37,38)22-27-17-15-26(16-18-27)21-25-13-9-6-10-14-25/h6,9-10,13-18,24,28-29H,5,7-8,11-12,19-23H2,1-4H3,(H,33,36)(H,34,35)(H,37,38)/t28?,29-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant Matrix metalloproteinase-13 (MMP-13)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073842
PNG
((4-Benzylcarbamoyl-benzyl)-{2-[(R)-2-(4-methoxy-ph...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(OC)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C33H42N3O6P/c1-23(2)18-28(32(38)36-30(33(39)34-3)19-24-12-16-29(42-4)17-13-24)22-43(40,41)21-26-10-14-27(15-11-26)31(37)35-20-25-8-6-5-7-9-25/h5-17,23,28,30H,18-22H2,1-4H3,(H,34,39)(H,35,37)(H,36,38)(H,40,41)/t28?,30-/m1/s1
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n/an/a 2.10E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073835
PNG
(Biphenyl-4-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Show SMILES CNC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C30H37N2O5P/c1-21(2)17-26(29(34)32-28(30(35)31-3)18-22-11-15-27(33)16-12-22)20-38(36,37)19-23-9-13-25(14-10-23)24-7-5-4-6-8-24/h4-16,21,26,28,33H,17-20H2,1-3H3,(H,31,35)(H,32,34)(H,36,37)/t26?,28-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))
BDBM50073838
PNG
((4-Benzyl-benzyl)-[4-methyl-2-((R)-1-methylcarbamo...)
Show SMILES CNC(=O)[C@@H](C)NC(=O)C(CC(C)C)CP(O)(=O)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C25H35N2O4P/c1-18(2)14-23(25(29)27-19(3)24(28)26-4)17-32(30,31)16-22-12-10-21(11-13-22)15-20-8-6-5-7-9-20/h5-13,18-19,23H,14-17H2,1-4H3,(H,26,28)(H,27,29)(H,30,31)/t19-,23?/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))
BDBM50073828
PNG
(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Show SMILES CNC(=O)[C@H](NC(=O)C(CCc1ccccc1)CP(O)(=O)Cc1ccccc1)C(C)(C)C
Show InChI InChI=1S/C25H35N2O4P/c1-25(2,3)22(24(29)26-4)27-23(28)21(16-15-19-11-7-5-8-12-19)18-32(30,31)17-20-13-9-6-10-14-20/h5-14,21-22H,15-18H2,1-4H3,(H,26,29)(H,27,28)(H,30,31)/t21?,22-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of recombinant matrix metalloprotease-3 (MMP-3)


Bioorg Med Chem Lett 9: 127-32 (1999)


Article DOI: 10.1016/s0960-894x(98)00729-x
BindingDB Entry DOI: 10.7270/Q2JD4VZ4
More data for this
Ligand-Target Pair
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