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Compile Data Set for Download or QSAR

Found 255 hits with Last Name = 'peat' and Initial = 'ts'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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0.790n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 7


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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1.70n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 7


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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2.5n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071814
PNG
(CHEMBL3410763)
Show SMILES NS(=O)(=O)c1nnc(NCc2cn(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nn2)s1
Show InChI InChI=1/C11H17N7O8S2/c12-28(23,24)11-16-15-10(27-11)13-1-4-2-18(17-14-4)26-9-8(22)7(21)6(20)5(3-19)25-9/h2,5-9,19-22H,1,3H2,(H,13,15)(H2,12,23,24)/t5-,6-,7+,8-,9+/s2
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2.70n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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5.70n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004514
PNG
(CHEMBL3233394)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C15H11N5O5S2/c16-26(22,23)11-3-1-2-9(6-11)13-8-20(19-17-13)10-4-5-12-14(7-10)27(24,25)18-15(12)21/h1-8H,(H,18,21)(H2,16,22,23)
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8.60n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071815
PNG
(CHEMBL3410762)
Show SMILES NS(=O)(=O)c1nnc(NCc2cn(nn2)-c2ccccc2)s1
Show InChI InChI=1S/C11H11N7O2S2/c12-22(19,20)11-16-15-10(21-11)13-6-8-7-18(17-14-8)9-4-2-1-3-5-9/h1-5,7H,6H2,(H,13,15)(H2,12,19,20)
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9.10n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004514
PNG
(CHEMBL3233394)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C15H11N5O5S2/c16-26(22,23)11-3-1-2-9(6-11)13-8-20(19-17-13)10-4-5-12-14(7-10)27(24,25)18-15(12)21/h1-8H,(H,18,21)(H2,16,22,23)
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9.5n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 7


(Homo sapiens (Human))
BDBM29278
PNG
(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)
Show SMILES O=C1NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
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10n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 6 (CA-VI)


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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11n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 6 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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12n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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12n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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12n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 13 (CA XIII)


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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16n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 13 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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25n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic Anhydrase XIV


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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41n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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48n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004512
PNG
(CHEMBL3233392)
Show SMILES Cc1cc(ccc1F)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H11FN4O3S/c1-9-6-10(2-5-13(9)17)14-8-21(20-18-14)11-3-4-12-15(7-11)25(23,24)19-16(12)22/h2-8H,1H3,(H,19,22)
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48n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004515
PNG
(CHEMBL3233395)
Show SMILES OC[C@H]1O[C@@H](OCc2cn(nn2)-c2ccc3C(=O)NS(=O)(=O)c3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C16H18N4O9S/c21-5-10-12(22)13(23)14(24)16(29-10)28-6-7-4-20(19-17-7)8-1-2-9-11(3-8)30(26,27)18-15(9)25/h1-4,10,12-14,16,21-24H,5-6H2,(H,18,25)/t10-,12-,13+,14-,16-/s2
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50n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004509
PNG
(CHEMBL3233389)
Show SMILES Cc1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H12N4O3S/c1-10-3-2-4-11(7-10)14-9-20(19-17-14)12-5-6-13-15(8-12)24(22,23)18-16(13)21/h2-9H,1H3,(H,18,21)
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57n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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63n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 4


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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74n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 4


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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75n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 4 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004512
PNG
(CHEMBL3233392)
Show SMILES Cc1cc(ccc1F)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H11FN4O3S/c1-9-6-10(2-5-13(9)17)14-8-21(20-18-14)11-3-4-12-15(7-11)25(23,24)19-16(12)22/h2-8H,1H3,(H,19,22)
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81n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071819
PNG
(CHEMBL3410758)
Show SMILES NS(=O)(=O)c1nnc(s1)N(Cc1cn(nn1)-c1ccccc1)Cc1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C20H18N10O2S2/c21-34(31,32)20-25-24-19(33-20)28(11-15-13-29(26-22-15)17-7-3-1-4-8-17)12-16-14-30(27-23-16)18-9-5-2-6-10-18/h1-10,13-14H,11-12H2,(H2,21,31,32)
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83n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004508
PNG
(CHEMBL3233388)
Show SMILES O=C1NS(=O)(=O)c2cc(ccc12)-n1cc(nn1)-c1ccccc1
Show InChI InChI=1S/C15H10N4O3S/c20-15-12-7-6-11(8-14(12)23(21,22)17-15)19-9-13(16-18-19)10-4-2-1-3-5-10/h1-9H,(H,17,20)
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86n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50004514
PNG
(CHEMBL3233394)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C15H11N5O5S2/c16-26(22,23)11-3-1-2-9(6-11)13-8-20(19-17-13)10-4-5-12-14(7-10)27(24,25)18-15(12)21/h1-8H,(H,18,21)(H2,16,22,23)
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87n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM50071814
PNG
(CHEMBL3410763)
Show SMILES NS(=O)(=O)c1nnc(NCc2cn(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nn2)s1
Show InChI InChI=1/C11H17N7O8S2/c12-28(23,24)11-16-15-10(27-11)13-1-4-2-18(17-14-4)26-9-8(22)7(21)6(20)5(3-19)25-9/h2,5-9,19-22H,1,3H2,(H,13,15)(H2,12,23,24)/t5-,6-,7+,8-,9+/s2
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87n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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88n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004509
PNG
(CHEMBL3233389)
Show SMILES Cc1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H12N4O3S/c1-10-3-2-4-11(7-10)14-9-20(19-17-14)12-5-6-13-15(8-12)24(22,23)18-16(13)21/h2-9H,1H3,(H,18,21)
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90n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004513
PNG
(CHEMBL3233393)
Show SMILES COc1ccc(-c2cn(nn2)-c2ccc3C(=O)NS(=O)(=O)c3c2)c(C)c1
Show InChI InChI=1S/C17H14N4O4S/c1-10-7-12(25-2)4-6-13(10)15-9-21(20-18-15)11-3-5-14-16(8-11)26(23,24)19-17(14)22/h3-9H,1-2H3,(H,19,22)
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96n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004484
PNG
(CHEMBL3233386)
Show SMILES [O-][N+](=O)c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C7H4N2O5S/c10-7-5-2-1-4(9(11)12)3-6(5)15(13,14)8-7/h1-3H,(H,8,10)
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96n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM29278
PNG
(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)
Show SMILES O=C1NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
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103n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071816
PNG
(CHEMBL3410760)
Show SMILES NS(=O)(=O)c1nnc(s1)N(Cc1cn(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1)Cc1cn(nn1)-c1ccccc1
Show InChI InChI=1/C20H24N10O8S2/c21-40(35,36)20-25-24-19(39-20)28(6-11-8-29(26-22-11)13-4-2-1-3-5-13)7-12-9-30(27-23-12)38-18-17(34)16(33)15(32)14(10-31)37-18/h1-5,8-9,14-18,31-34H,6-7,10H2,(H2,21,35,36)/t14-,15-,16+,17-,18+/s2
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114n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM50071815
PNG
(CHEMBL3410762)
Show SMILES NS(=O)(=O)c1nnc(NCc2cn(nn2)-c2ccccc2)s1
Show InChI InChI=1S/C11H11N7O2S2/c12-22(19,20)11-16-15-10(21-11)13-6-8-7-18(17-14-8)9-4-2-1-3-5-9/h1-5,7H,6H2,(H,13,15)(H2,12,19,20)
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141n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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154n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 5A expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071818
PNG
(CHEMBL3410759)
Show SMILES NS(=O)(=O)c1nnc(s1)N(Cc1cn(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1)Cc1cn(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)nn1
Show InChI InChI=1/C20H30N10O14S2/c21-46(39,40)20-25-24-19(45-20)28(1-7-3-29(26-22-7)43-17-15(37)13(35)11(33)9(5-31)41-17)2-8-4-30(27-23-8)44-18-16(38)14(36)12(34)10(6-32)42-18/h3-4,9-18,31-38H,1-2,5-6H2,(H2,21,39,40)/t9-,10-,11-,12-,13+,14+,15-,16-,17+,18+/s2
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201n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50071817
PNG
(CHEMBL3410761)
Show SMILES NS(=O)(=O)c1nnc(s1)N(CC#C)CC#C
Show InChI InChI=1S/C8H8N4O2S2/c1-3-5-12(6-4-2)7-10-11-8(15-7)16(9,13)14/h1-2H,5-6H2,(H2,9,13,14)
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201n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 2 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004513
PNG
(CHEMBL3233393)
Show SMILES COc1ccc(-c2cn(nn2)-c2ccc3C(=O)NS(=O)(=O)c3c2)c(C)c1
Show InChI InChI=1S/C17H14N4O4S/c1-10-7-12(25-2)4-6-13(10)15-9-21(20-18-15)11-3-5-14-16(8-11)26(23,24)19-17(14)22/h3-9H,1-2H3,(H,19,22)
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201n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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250n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 1 by CO2 hydration assay


J Med Chem 58: 1494-501 (2015)


Article DOI: 10.1021/jm501798g
BindingDB Entry DOI: 10.7270/Q2RV0QCP
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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250n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004511
PNG
(CHEMBL3233391)
Show SMILES COc1ccc(cc1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H12N4O4S/c1-24-12-5-2-10(3-6-12)14-9-20(19-17-14)11-4-7-13-15(8-11)25(22,23)18-16(13)21/h2-9H,1H3,(H,18,21)
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341n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM50004514
PNG
(CHEMBL3233394)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C15H11N5O5S2/c16-26(22,23)11-3-1-2-9(6-11)13-8-20(19-17-13)10-4-5-12-14(7-10)27(24,25)18-15(12)21/h1-8H,(H,18,21)(H2,16,22,23)
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354n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 1 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic Anhydrase XIV


(Homo sapiens (Human))
BDBM50092612
PNG
(CHEMBL3586274)
Show SMILES NS(=O)(=O)CCNC(=O)C(\Cc1ccc(O)c(Br)c1)=N\O
Show InChI InChI=1S/C11H14BrN3O5S/c12-8-5-7(1-2-10(8)16)6-9(15-18)11(17)14-3-4-21(13,19)20/h1-2,5,16,18H,3-4,6H2,(H,14,17)(H2,13,19,20)/b15-9+
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379n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 14 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay


J Med Chem 59: 5462-70 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00443
BindingDB Entry DOI: 10.7270/Q2TF0084
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004510
PNG
(CHEMBL3233390)
Show SMILES FC(F)(F)c1ccccc1-c1cn(nn1)-c1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C16H9F3N4O3S/c17-16(18,19)12-4-2-1-3-10(12)13-8-23(22-20-13)9-5-6-11-14(7-9)27(25,26)21-15(11)24/h1-8H,(H,21,24)
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443n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004507
PNG
(CHEMBL3233387)
Show SMILES [N-]=[N+]=Nc1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C7H4N4O3S/c8-11-9-4-1-2-5-6(3-4)15(13,14)10-7(5)12/h1-3H,(H,10,12)
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466n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004508
PNG
(CHEMBL3233388)
Show SMILES O=C1NS(=O)(=O)c2cc(ccc12)-n1cc(nn1)-c1ccccc1
Show InChI InChI=1S/C15H10N4O3S/c20-15-12-7-6-11(8-14(12)23(21,22)17-15)19-9-13(16-18-19)10-4-2-1-3-5-10/h1-9H,(H,17,20)
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484n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM50004515
PNG
(CHEMBL3233395)
Show SMILES OC[C@H]1O[C@@H](OCc2cn(nn2)-c2ccc3C(=O)NS(=O)(=O)c3c2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1/C16H18N4O9S/c21-5-10-12(22)13(23)14(24)16(29-10)28-6-7-4-20(19-17-7)8-1-2-9-11(3-8)30(26,27)18-15(9)25/h1-4,10,12-14,16,21-24H,5-6H2,(H,18,25)/t10-,12-,13+,14-,16-/s2
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572n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50004506
PNG
(6-Aminosaccharin | CHEMBL2016952 | Saccharin deriv...)
Show SMILES Nc1ccc2C(=O)NS(=O)(=O)c2c1
Show InChI InChI=1S/C7H6N2O3S/c8-4-1-2-5-6(3-4)13(11,12)9-7(5)10/h1-3H,8H2,(H,9,10)
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610n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
Carbonic anhydrase 12


(Homo sapiens (Human))
BDBM29278
PNG
(CHEMBL310671 | Garantose | SAC | Saccharimide | Sa...)
Show SMILES O=C1NS(=O)(=O)c2ccccc12
Show InChI InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
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633n/an/an/an/an/an/an/an/a



Griffith University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 12 expressed in Escherichia coli by stopped flow CO2 hydration assay


J Med Chem 57: 3522-31 (2014)


Article DOI: 10.1021/jm500255y
BindingDB Entry DOI: 10.7270/Q2NS0WF1
More data for this
Ligand-Target Pair
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