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Compile Data Set for Download or QSAR

Found 1655 hits with Last Name = 'schio' and Initial = 'l'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50059435
PNG
(CHEMBL3393498)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C27H24N4O4/c1-2-34-26(33)25-24-17(14-28-25)22(23-20(29-24)11-6-12-21(23)32)15-7-5-8-16(13-15)35-27-30-18-9-3-4-10-19(18)31-27/h3-5,7-10,13-14,22,28-29H,2,6,11-12H2,1H3,(H,30,31)/t22-/m0/s1
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990n/an/an/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assay


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM21363
PNG
(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Show SMILES Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12
Show InChI InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
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2.47E+3n/an/an/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assay


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen receptor


(Homo sapiens (Human))
BDBM263892
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES Oc1ccc2c(CCCC(c3ccc(cc3)N3CCCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C34H39FN2O2/c35-18-4-19-36-22-17-31(24-36)39-30-14-9-26(10-15-30)34-32(6-3-5-27-23-29(38)13-16-33(27)34)25-7-11-28(12-8-25)37-20-1-2-21-37/h7-16,23,31,38H,1-6,17-22,24H2/t31-/m0/s1
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n/an/a 0n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50134434
PNG
(CHEMBL3746046)
Show SMILES Cc1c(nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc12)S(C)(=O)=O
Show InChI InChI=1S/C17H15Cl2N5O3S/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)28(2,26)27)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25)
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n/an/a 0.0300n/an/an/an/an/an/a



Sanofi Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay


Bioorg Med Chem Lett 26: 454-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.093
BindingDB Entry DOI: 10.7270/Q2X92D4M
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50134433
PNG
(CHEMBL3745968)
Show SMILES COc1cccc(Nc2c3C(=O)NCCc3nc3c(C)c(nn23)S(C)(=O)=O)c1
Show InChI InChI=1S/C18H19N5O4S/c1-10-15-21-13-7-8-19-17(24)14(13)16(23(15)22-18(10)28(3,25)26)20-11-5-4-6-12(9-11)27-2/h4-6,9,20H,7-8H2,1-3H3,(H,19,24)
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n/an/a 0.100n/an/an/an/an/an/a



Sanofi Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay


Bioorg Med Chem Lett 26: 454-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.093
BindingDB Entry DOI: 10.7270/Q2X92D4M
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50134429
PNG
(CHEMBL3746964)
Show SMILES CN(C)C(=O)c1cccc(c1)S(=O)(=O)c1nn2c(Nc3cc(Cl)cc(Cl)c3)c(cnc2c1C)C(N)=O
Show InChI InChI=1S/C23H20Cl2N6O4S/c1-12-20-27-11-18(19(26)32)21(28-16-9-14(24)8-15(25)10-16)31(20)29-22(12)36(34,35)17-6-4-5-13(7-17)23(33)30(2)3/h4-11,28H,1-3H3,(H2,26,32)
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n/an/a 0.200n/an/an/an/an/an/a



Sanofi Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay


Bioorg Med Chem Lett 26: 454-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.093
BindingDB Entry DOI: 10.7270/Q2X92D4M
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50134432
PNG
(CHEMBL3747036)
Show SMILES CSc1nn2c(Nc3cc(Cl)cc(Cl)c3)c3C(=O)NCCc3nc2c1C
Show InChI InChI=1S/C17H15Cl2N5OS/c1-8-14-22-12-3-4-20-16(25)13(12)15(24(14)23-17(8)26-2)21-11-6-9(18)5-10(19)7-11/h5-7,21H,3-4H2,1-2H3,(H,20,25)
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n/an/a 0.200n/an/an/an/an/an/a



Sanofi Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay


Bioorg Med Chem Lett 26: 454-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.093
BindingDB Entry DOI: 10.7270/Q2X92D4M
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50059435
PNG
(CHEMBL3393498)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C27H24N4O4/c1-2-34-26(33)25-24-17(14-28-25)22(23-20(29-24)11-6-12-21(23)32)15-7-5-8-16(13-15)35-27-30-18-9-3-4-10-19(18)31-27/h3-5,7-10,13-14,22,28-29H,2,6,11-12H2,1H3,(H,30,31)/t22-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))
BDBM50134428
PNG
(CHEMBL3746007)
Show SMILES COc1cccc(Nc2c(cnc3c(C)c(nn23)S(=O)(=O)c2cccc(c2)C(=O)N(C)C)C(N)=O)c1
Show InChI InChI=1S/C24H24N6O5S/c1-14-21-26-13-19(20(25)31)22(27-16-8-6-9-17(12-16)35-4)30(21)28-23(14)36(33,34)18-10-5-7-15(11-18)24(32)29(2)3/h5-13,27H,1-4H3,(H2,25,31)
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n/an/a 0.700n/an/an/an/an/an/a



Sanofi Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assay


Bioorg Med Chem Lett 26: 454-9 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.093
BindingDB Entry DOI: 10.7270/Q2X92D4M
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50004205
PNG
(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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n/an/a 0.700n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin)


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263706
PNG
(6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Show SMILES CCOc1ccc(c(Cl)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H35ClFNO3/c1-2-37-26-12-14-29(31(33)20-26)30-6-3-5-23-19-24(36)9-13-28(23)32(30)22-7-10-25(11-8-22)38-27-15-18-35(21-27)17-4-16-34/h7-14,19-20,27,36H,2-6,15-18,21H2,1H3/t27-/m0/s1
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n/an/a 0.800n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50447088
PNG
(CHEMBL3112850)
Show SMILES Brc1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3/c19-13-2-1-3-14-12(13)4-5-23(14)18(25)10-15-20-16(11-17(24)21-15)22-6-8-26-9-7-22/h1-3,11H,4-10H2,(H,20,21,24)
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n/an/a 1n/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
This test is based on measuring the expression of the AKT protein phosphorylated on serine 473 (P-AKT-S473), in the PC3 human prostate carcinoma line...


US Patent US8993565 (2015)


BindingDB Entry DOI: 10.7270/Q2FQ9V9P
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263755
PNG
(6-(2- chloro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3...)
Show SMILES COc1ccc(c(Cl)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H33ClFNO3/c1-36-25-11-13-28(30(32)19-25)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)37-26-14-17-34(20-26)16-3-15-33/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1
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n/an/a 1n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM47224
PNG
(US9073917, 2-inventive)
Show SMILES CCc1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...


US Patent US9073917 (2015)


BindingDB Entry DOI: 10.7270/Q2H993X4
More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM47224
PNG
(US9073917, 2-inventive)
Show SMILES CCc1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)


BindingDB Entry DOI: 10.7270/Q2H993X4
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50277545
PNG
(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Show SMILES COc1cc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2OC)ccc1C(O)=O
Show InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
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n/an/a 1n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of aurora A (unknown origin)


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Aurora kinase B


(Homo sapiens (Human))
BDBM50059435
PNG
(CHEMBL3393498)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1S/C27H24N4O4/c1-2-34-26(33)25-24-17(14-28-25)22(23-20(29-24)11-6-12-21(23)32)15-7-5-8-16(13-15)35-27-30-18-9-3-4-10-19(18)31-27/h3-5,7-10,13-14,22,28-29H,2,6,11-12H2,1H3,(H,30,31)/t22-/m0/s1
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263860
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES Cn1cnc2cc(ccc12)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H34FN3O2/c1-35-21-34-30-19-24(8-13-31(30)35)28-5-2-4-23-18-25(37)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-36(20-27)16-3-15-33/h6-13,18-19,21,27,37H,2-5,14-17,20H2,1H3/t27-/m0/s1
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n/an/a 1n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50447088
PNG
(CHEMBL3112850)
Show SMILES Brc1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1
Show InChI InChI=1S/C18H19BrN4O3/c19-13-2-1-3-14-12(13)4-5-23(14)18(25)10-15-20-16(11-17(24)21-15)22-6-8-26-9-7-22/h1-3,11H,4-10H2,(H,20,21,24)
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n/an/a 1n/an/an/an/an/an/a



Sanofi

Curated by ChEMBL


Assay Description
Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...


J Med Chem 57: 903-20 (2014)


Article DOI: 10.1021/jm401642q
BindingDB Entry DOI: 10.7270/Q2R212VJ
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263893
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES Cc1nc2cc(ccc2o1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H33FN2O3/c1-21-34-30-19-24(8-13-31(30)37-21)28-5-2-4-23-18-25(36)9-12-29(23)32(28)22-6-10-26(11-7-22)38-27-14-17-35(20-27)16-3-15-33/h6-13,18-19,27,36H,2-5,14-17,20H2,1H3/t27-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263900
PNG
(6-[2,3- difluoro-4- (1-piperidyl)- phenyl]-5- [4-[...)
Show SMILES Oc1ccc2c(CCCC(c3ccc(N4CCCCC4)c(F)c3F)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C35H39F3N2O2/c36-17-5-18-39-21-16-28(23-39)42-27-11-8-24(9-12-27)33-29-13-10-26(41)22-25(29)6-4-7-30(33)31-14-15-32(35(38)34(31)37)40-19-2-1-3-20-40/h8-15,22,28,41H,1-7,16-21,23H2/t28-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263911
PNG
(US9714221, Example 207)
Show SMILES Oc1ccc2c(CCCC(C3=CCC(F)(F)CC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C30H34F3NO2/c31-16-2-17-34-18-13-26(20-34)36-25-8-5-22(6-9-25)29-27(21-11-14-30(32,33)15-12-21)4-1-3-23-19-24(35)7-10-28(23)29/h5-11,19,26,35H,1-4,12-18,20H2/t26-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263707
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES COc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H36FNO3/c1-22-19-27(36-2)12-14-29(22)31-6-3-5-24-20-25(35)9-13-30(24)32(31)23-7-10-26(11-8-23)37-28-15-18-34(21-28)17-4-16-33/h7-14,19-20,28,35H,3-6,15-18,21H2,1-2H3/t28-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263709
PNG
(6-(4- ethoxy-2- methyl- phenyl)-1- fluoro-5-[4- [(...)
Show SMILES CCOc1ccc(c(C)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1
Show InChI InChI=1S/C33H37F2NO3/c1-3-38-25-12-13-27(22(2)20-25)28-6-4-7-30-29(14-15-31(37)33(30)35)32(28)23-8-10-24(11-9-23)39-26-16-19-36(21-26)18-5-17-34/h8-15,20,26,37H,3-7,16-19,21H2,1-2H3/t26-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263712
PNG
(6-(2,3- dihydro- 1,4- benzodioxin-6-yl)-5- [4-[(3S...)
Show SMILES Oc1ccc2c(CCCC(c3ccc4OCCOc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C32H34FNO4/c33-14-2-15-34-16-13-27(21-34)38-26-9-5-22(6-10-26)32-28(4-1-3-23-19-25(35)8-11-29(23)32)24-7-12-30-31(20-24)37-18-17-36-30/h5-12,19-20,27,35H,1-4,13-18,21H2/t27-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263719
PNG
(6-(1,3- benzoxazol- 5-yl)-5-[4- [(3S)-1-(3- fluoro...)
Show SMILES Oc1ccc2c(CCCC(c3ccc4ocnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C31H31FN2O3/c32-14-2-15-34-16-13-26(19-34)37-25-9-5-21(6-10-25)31-27(23-7-12-30-29(18-23)33-20-36-30)4-1-3-22-17-24(35)8-11-28(22)31/h5-12,17-18,20,26,35H,1-4,13-16,19H2/t26-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263764
PNG
(6-(2,2- dimethyl- 3H- benzo- furan-5-yl)-5- [4-[(3...)
Show SMILES CC1(C)Cc2cc(ccc2O1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C34H38FNO3/c1-34(2)21-26-19-25(9-14-32(26)39-34)30-6-3-5-24-20-27(37)10-13-31(24)33(30)23-7-11-28(12-8-23)38-29-15-18-36(22-29)17-4-16-35/h7-14,19-20,29,37H,3-6,15-18,21-22H2,1-2H3/t29-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263774
PNG
(US9714221, Example 108)
Show SMILES COc1ccc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C30H33FN2O3/c1-35-29-13-8-23(19-32-29)27-5-2-4-22-18-24(34)9-12-28(22)30(27)21-6-10-25(11-7-21)36-26-14-17-33(20-26)16-3-15-31/h6-13,18-19,26,34H,2-5,14-17,20H2,1H3/t26-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263775
PNG
(US9714221, Example 109)
Show SMILES COc1cc(ccn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C30H33FN2O3/c1-35-29-19-23(12-15-32-29)27-5-2-4-22-18-24(34)8-11-28(22)30(27)21-6-9-25(10-7-21)36-26-13-17-33(20-26)16-3-14-31/h6-12,15,18-19,26,34H,2-5,13-14,16-17,20H2,1H3/t26-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263737
PNG
(6-(6- ethoxy-2- fluoro-3- pyridyl)-5- [4-[(3S)- 1-...)
Show SMILES CCOc1ccc(c(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H34F2N2O3/c1-2-37-29-14-13-28(31(33)34-29)27-6-3-5-22-19-23(36)9-12-26(22)30(27)21-7-10-24(11-8-21)38-25-15-18-35(20-25)17-4-16-32/h7-14,19,25,36H,2-6,15-18,20H2,1H3/t25-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263743
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES COc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H34FNO3/c1-35-27-7-2-5-24(20-27)29-8-3-6-23-19-25(34)11-14-30(23)31(29)22-9-12-26(13-10-22)36-28-15-18-33(21-28)17-4-16-32/h2,5,7,9-14,19-20,28,34H,3-4,6,8,15-18,21H2,1H3/t28-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263748
PNG
(US9714221, Example 82)
Show SMILES CCOc1ccc(c(F)n1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)c(F)c2CCC1
Show InChI InChI=1S/C31H33F3N2O3/c1-2-38-28-14-12-26(31(34)35-28)23-5-3-6-25-24(11-13-27(37)30(25)33)29(23)20-7-9-21(10-8-20)39-22-15-18-36(19-22)17-4-16-32/h7-14,22,37H,2-6,15-19H2,1H3/t22-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263847
PNG
(6-(2,2-dimethylindolin-5-yl)-5-[4-[(3S)-1-(3-fluor...)
Show SMILES CC1(C)Cc2cc(ccc2N1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(cc2CCC1)C(O)=O
Show InChI InChI=1S/C35H39FN2O3/c1-35(2)21-27-20-25(10-14-32(27)37-35)30-6-3-5-24-19-26(34(39)40)9-13-31(24)33(30)23-7-11-28(12-8-23)41-29-15-18-38(22-29)17-4-16-36/h7-14,19-20,29,37H,3-6,15-18,21-22H2,1-2H3,(H,39,40)/t29-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50447089
PNG
(CHEMBL3112849)
Show SMILES Clc1cccc2N(CCc12)C(=O)Cc1nc(cc(=O)[nH]1)N1CCOCC1
Show InChI InChI=1S/C18H19ClN4O3/c19-13-2-1-3-14-12(13)4-5-23(14)18(25)10-15-20-16(11-17(24)21-15)22-6-8-26-9-7-22/h1-3,11H,4-10H2,(H,20,21,24)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...


J Med Chem 57: 903-20 (2014)


Article DOI: 10.1021/jm401642q
BindingDB Entry DOI: 10.7270/Q2R212VJ
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50059432
PNG
(CHEMBL3393486)
Show SMILES Cl.CCOC(=O)c1[nH]cc2[C@H](c3ccc(Sc4nc5c(F)cccc5[nH]4)o3)C3=C(CN(CC3=O)C(=O)CN)Nc12
Show InChI InChI=1S/C26H23FN6O5S.ClH/c1-2-37-25(36)24-22-12(9-29-24)20(21-15(30-22)10-33(11-16(21)34)18(35)8-28)17-6-7-19(38-17)39-26-31-14-5-3-4-13(27)23(14)32-26;/h3-7,9,20,29-30H,2,8,10-11,28H2,1H3,(H,31,32);1H/t20-;/m1./s1
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263759
PNG
(6-(2,3- difluoro-4- methoxy- phenyl)-5- [4-[(3S)-1...)
Show SMILES COc1ccc(c(F)c1F)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H32F3NO3/c1-37-28-13-12-27(30(33)31(28)34)26-5-2-4-21-18-22(36)8-11-25(21)29(26)20-6-9-23(10-7-20)38-24-14-17-35(19-24)16-3-15-32/h6-13,18,24,36H,2-5,14-17,19H2,1H3/t24-/m0/s1
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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM50059454
PNG
(CHEMBL3393470)
Show SMILES COC(=O)c1[nH]cc2C(c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1S/C24H20N4O4S/c1-31-23(30)22-21-12(11-25-22)19(20-15(26-21)7-4-8-16(20)29)17-9-10-18(32-17)33-24-27-13-5-2-3-6-14(13)28-24/h2-3,5-6,9-11,19,25-26H,4,7-8H2,1H3,(H,27,28)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50059443
PNG
(CHEMBL3393472)
Show SMILES CCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CNCC3=O)Nc12
Show InChI InChI=1S/C24H21N5O4S.ClH.H2O/c1-2-32-23(31)22-21-12(9-26-22)19(20-15(27-21)10-25-11-16(20)30)17-7-8-18(33-17)34-24-28-13-5-3-4-6-14(13)29-24;;/h3-9,19,25-27H,2,10-11H2,1H3,(H,28,29);1H;1H2
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50059454
PNG
(CHEMBL3393470)
Show SMILES COC(=O)c1[nH]cc2C(c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1S/C24H20N4O4S/c1-31-23(30)22-21-12(11-25-22)19(20-15(26-21)7-4-8-16(20)29)17-9-10-18(32-17)33-24-27-13-5-2-3-6-14(13)28-24/h2-3,5-6,9-11,19,25-26H,4,7-8H2,1H3,(H,27,28)
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Sanofi

Curated by ChEMBL


Assay Description
Inhibition of poly-histidine tagged full length recombinant aurora B (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...


J Med Chem 58: 362-75 (2015)


Article DOI: 10.1021/jm501326k
BindingDB Entry DOI: 10.7270/Q2T1559D
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50392456
PNG
(CHEMBL2151926)
Show SMILES Fc1ccc(NC(=O)Cc2nc(cc(=O)[nH]2)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C16H16ClFN4O3/c17-11-7-10(1-2-12(11)18)19-15(23)8-13-20-14(9-16(24)21-13)22-3-5-25-6-4-22/h1-2,7,9H,3-6,8H2,(H,19,23)(H,20,21,24)
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n/an/a 2n/an/an/an/an/an/a



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Curated by ChEMBL


Assay Description
Inhibition of PI3Kbeta


Bioorg Med Chem Lett 22: 6381-4 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.072
BindingDB Entry DOI: 10.7270/Q2FN179H
More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263896
PNG
(6-(2,1,3- benzothia- diazol-5-yl)- 5-[4-[(3S)- 1-(...)
Show SMILES Oc1ccc2c(CCCC(c3ccc4nsnc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C30H30FN3O2S/c31-14-2-15-34-16-13-25(19-34)36-24-9-5-20(6-10-24)30-26(22-7-12-28-29(18-22)33-37-32-28)4-1-3-21-17-23(35)8-11-27(21)30/h5-12,17-18,25,35H,1-4,13-16,19H2/t25-/m0/s1
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n/an/a 2n/an/an/an/a7.425



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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263907
PNG
(US9714221, Example 203)
Show SMILES Oc1ccc2c(CCCC(C3CCOCC3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C29H36FNO3/c30-14-2-15-31-16-11-26(20-31)34-25-8-5-22(6-9-25)29-27(21-12-17-33-18-13-21)4-1-3-23-19-24(32)7-10-28(23)29/h5-10,19,21,26,32H,1-4,11-18,20H2/t26-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263917
PNG
(6-(2-chloro-4-fluoro-phenyl)-1-fluoro-5-[4-[(3S)-1...)
Show SMILES OC(=O)c1ccc2c(CCCC(c3ccc(F)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1F
Show InChI InChI=1S/C31H29ClF3NO3/c32-28-17-20(34)7-10-23(28)24-3-1-4-26-25(11-12-27(30(26)35)31(37)38)29(24)19-5-8-21(9-6-19)39-22-13-16-36(18-22)15-2-14-33/h5-12,17,22H,1-4,13-16,18H2,(H,37,38)/t22-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263801
PNG
(6-(2,2- difluoro- 1,3- benzo- dioxol-5-yl)-5- [4-[...)
Show SMILES Oc1ccc2c(CCCC(c3ccc4OC(F)(F)Oc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1
Show InChI InChI=1S/C31H30F3NO4/c32-14-2-15-35-16-13-25(19-35)37-24-9-5-20(6-10-24)30-26(4-1-3-21-17-23(36)8-11-27(21)30)22-7-12-28-29(18-22)39-31(33,34)38-28/h5-12,17-18,25,36H,1-4,13-16,19H2/t25-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263806
PNG
(6-(6- ethoxy-4- methyl-3- pyridyl)-5- [4-[(3S)-1- ...)
Show SMILES CCOc1cc(C)c(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H37FN2O3/c1-3-37-31-18-22(2)30(20-34-31)29-7-4-6-24-19-25(36)10-13-28(24)32(29)23-8-11-26(12-9-23)38-27-14-17-35(21-27)16-5-15-33/h8-13,18-20,27,36H,3-7,14-17,21H2,1-2H3/t27-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263692
PNG
(US9714221, Example 29)
Show SMILES COc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H33F2NO3/c1-36-25-11-13-28(30(33)19-25)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor alpha Y537S


(Homo sapiens (Human))
BDBM263692
PNG
(US9714221, Example 29)
Show SMILES COc1ccc(c(F)c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H33F2NO3/c1-36-25-11-13-28(30(33)19-25)29-5-2-4-22-18-23(35)8-12-27(22)31(29)21-6-9-24(10-7-21)37-26-14-17-34(20-26)16-3-15-32/h6-13,18-19,26,35H,2-5,14-17,20H2,1H3/t26-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263694
PNG
(6-(2,3- dimethyl- phenyl)-5-[4- [(3S)-1-(3- fluoro...)
Show SMILES Cc1cccc(c1C)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C32H36FNO2/c1-22-6-3-8-29(23(22)2)31-9-4-7-25-20-26(35)12-15-30(25)32(31)24-10-13-27(14-11-24)36-28-16-19-34(21-28)18-5-17-33/h3,6,8,10-15,20,28,35H,4-5,7,9,16-19,21H2,1-2H3/t28-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263697
PNG
(6-(6- ethoxy-3- pyridyl)-5- [4-[(3S)-1- (3- fluoro...)
Show SMILES CCOc1ccc(cn1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C31H35FN2O3/c1-2-36-30-14-9-24(20-33-30)28-6-3-5-23-19-25(35)10-13-29(23)31(28)22-7-11-26(12-8-22)37-27-15-18-34(21-27)17-4-16-32/h7-14,19-20,27,35H,2-6,15-18,21H2,1H3/t27-/m0/s1
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n/an/a 2n/an/an/an/a7.425



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US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (Human))
BDBM263669
PNG
(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Show SMILES Oc1cccc(c1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1
Show InChI InChI=1S/C30H32FNO3/c31-15-3-16-32-17-14-27(20-32)35-26-11-8-21(9-12-26)30-28(22-4-1-6-24(33)18-22)7-2-5-23-19-25(34)10-13-29(23)30/h1,4,6,8-13,18-19,27,33-34H,2-3,5,7,14-17,20H2/t27-/m0/s1
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n/an/a 2n/an/an/an/a7.425



SANOFI

US Patent


Assay Description
It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...


US Patent US9714221 (2017)

More data for this
Ligand-Target Pair
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