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Compile Data Set for Download or QSAR

Found 341 hits with Last Name = 'sejberg' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK8/Cyclin C


(Homo sapiens)
BDBM50189412
PNG
(CHEMBL3827983)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-21-20(26)18-8-7-15-9-22-11-17(19(15)24-18)14-5-3-13(4-6-14)16-10-23-25(2)12-16/h3-12H,1-2H3,(H,21,26)
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n/an/a 0.200n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189417
PNG
(CHEMBL3828116)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(N)=O
Show InChI InChI=1S/C19H15N5O/c1-24-11-15(9-22-24)12-2-4-13(5-3-12)16-10-21-8-14-6-7-17(19(20)25)23-18(14)16/h2-11H,1H3,(H2,20,25)
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n/an/a 0.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189435
PNG
(CHEMBL3828003)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C21H18N4O/c1-22-21(26)16-7-8-17-10-23-12-20(19(17)9-16)15-5-3-14(4-6-15)18-11-24-25(2)13-18/h3-13H,1-2H3,(H,22,26)
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n/an/a 0.600n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189434
PNG
(CHEMBL3828221)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)-c1nccn1C
Show InChI InChI=1S/C22H18N6/c1-27-10-9-24-22(27)20-8-7-17-11-23-13-19(21(17)26-20)16-5-3-15(4-6-16)18-12-25-28(2)14-18/h3-14H,1-2H3
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n/an/a 0.710n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189415
PNG
(CHEMBL3828637)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C18H16N4O3S/c1-19-18(23)15-5-3-12-8-20-9-14(17(12)21-15)11-4-6-16-13(7-11)10-26(24,25)22(16)2/h3-9H,10H2,1-2H3,(H,19,23)
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n/an/a 0.900n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50189428
PNG
(CHEMBL3828458)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCNC1=O
Show InChI InChI=1S/C21H18N6O/c1-26-13-17(11-24-26)14-2-4-15(5-3-14)18-12-22-10-16-6-7-19(25-20(16)18)27-9-8-23-21(27)28/h2-7,10-13H,8-9H2,1H3,(H,23,28)
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n/an/a 1n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189436
PNG
(CHEMBL3827327)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H20N4O/c1-27-14-19(12-25-27)15-2-4-16(5-3-15)22-13-24-11-18-7-6-17(10-21(18)22)23(28)26-20-8-9-20/h2-7,10-14,20H,8-9H2,1H3,(H,26,28)
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n/an/a 1.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
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n/an/a 1.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189417
PNG
(CHEMBL3828116)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(N)=O
Show InChI InChI=1S/C19H15N5O/c1-24-11-15(9-22-24)12-2-4-13(5-3-12)16-10-21-8-14-6-7-17(19(20)25)23-18(14)16/h2-11H,1H3,(H2,20,25)
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n/an/a 1.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189415
PNG
(CHEMBL3828637)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C18H16N4O3S/c1-19-18(23)15-5-3-12-8-20-9-14(17(12)21-15)11-4-6-16-13(7-11)10-26(24,25)22(16)2/h3-9H,10H2,1-2H3,(H,19,23)
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n/an/a 1.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50189426
PNG
(CHEMBL3827944)
Show SMILES CC(=O)Nc1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-13(26)23-19-8-7-16-9-21-11-18(20(16)24-19)15-5-3-14(4-6-15)17-10-22-25(2)12-17/h3-12H,1-2H3,(H,23,24,26)
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n/an/a 1.80n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189420
PNG
(CHEMBL3827799)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCC1
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-3-5-16(6-4-15)19-13-23-11-17-7-8-20(25-21(17)19)22(28)27-9-2-10-27/h3-8,11-14H,2,9-10H2,1H3
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n/an/a 2n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189436
PNG
(CHEMBL3827327)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H20N4O/c1-27-14-19(12-25-27)15-2-4-16(5-3-15)22-13-24-11-18-7-6-17(10-21(18)22)23(28)26-20-8-9-20/h2-7,10-14,20H,8-9H2,1H3,(H,26,28)
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n/an/a 2.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189427
PNG
(CHEMBL3827470)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCCC1=O
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-4-6-16(7-5-15)19-13-23-11-17-8-9-20(25-22(17)19)27-10-2-3-21(27)28/h4-9,11-14H,2-3,10H2,1H3
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n/an/a 2.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189421
PNG
(CHEMBL3827118)
Show SMILES COC1CN(C1)C(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H21N5O2/c1-27-12-18(10-25-27)15-3-5-16(6-4-15)20-11-24-9-17-7-8-21(26-22(17)20)23(29)28-13-19(14-28)30-2/h3-12,19H,13-14H2,1-2H3
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n/an/a 2.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189413
PNG
(CHEMBL3827774)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-5-3-12-8-20-10-14(17(12)22-15)11-4-6-16-13(7-11)9-21-23(16)2/h3-10H,1-2H3,(H,19,24)
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n/an/a 3.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189423
PNG
(CHEMBL3828523)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H21N5O/c1-27-15-19(13-25-27)16-4-6-17(7-5-16)20-14-24-12-18-8-9-21(26-22(18)20)23(29)28-10-2-3-11-28/h4-9,12-15H,2-3,10-11H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189412
PNG
(CHEMBL3827983)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-21-20(26)18-8-7-15-9-22-11-17(19(15)24-18)14-5-3-13(4-6-14)16-10-23-25(2)12-16/h3-12H,1-2H3,(H,21,26)
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n/an/a 3.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189420
PNG
(CHEMBL3827799)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCC1
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-3-5-16(6-4-15)19-13-23-11-17-7-8-20(25-21(17)19)22(28)27-9-2-10-27/h3-8,11-14H,2,9-10H2,1H3
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n/an/a 3.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189428
PNG
(CHEMBL3828458)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCNC1=O
Show InChI InChI=1S/C21H18N6O/c1-26-13-17(11-24-26)14-2-4-15(5-3-14)18-12-22-10-16-6-7-19(25-20(16)18)27-9-8-23-21(27)28/h2-7,10-13H,8-9H2,1H3,(H,23,28)
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n/an/a 4.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189435
PNG
(CHEMBL3828003)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C21H18N4O/c1-22-21(26)16-7-8-17-10-23-12-20(19(17)9-16)15-5-3-14(4-6-15)18-11-24-25(2)13-18/h3-13H,1-2H3,(H,22,26)
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n/an/a 4.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189442
PNG
(CHEMBL3828503)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)N1CCOC1=O
Show InChI InChI=1S/C22H18N4O2/c1-25-14-18(12-24-25)15-2-4-16(5-3-15)21-13-23-11-17-6-7-19(10-20(17)21)26-8-9-28-22(26)27/h2-7,10-14H,8-9H2,1H3
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n/an/a 4.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189414
PNG
(CHEMBL3828209)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4cnn(C)c4c3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-6-5-13-8-20-10-14(17(13)22-15)11-3-4-12-9-21-23(2)16(12)7-11/h3-10H,1-2H3,(H,19,24)
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n/an/a 4.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189442
PNG
(CHEMBL3828503)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)N1CCOC1=O
Show InChI InChI=1S/C22H18N4O2/c1-25-14-18(12-24-25)15-2-4-16(5-3-15)21-13-23-11-17-6-7-19(10-20(17)21)26-8-9-28-22(26)27/h2-7,10-14H,8-9H2,1H3
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n/an/a 4.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189434
PNG
(CHEMBL3828221)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)-c1nccn1C
Show InChI InChI=1S/C22H18N6/c1-27-10-9-24-22(27)20-8-7-17-11-23-13-19(21(17)26-20)16-5-3-15(4-6-16)18-12-25-28(2)14-18/h3-14H,1-2H3
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n/an/a 4.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189418
PNG
(CHEMBL3827482)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(O)=O
Show InChI InChI=1S/C19H14N4O2/c1-23-11-15(9-21-23)12-2-4-13(5-3-12)16-10-20-8-14-6-7-17(19(24)25)22-18(14)16/h2-11H,1H3,(H,24,25)
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n/an/a 4.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189439
PNG
(CHEMBL3827699)
Show SMILES CC(=O)Nc1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C21H18N4O/c1-14(26)24-19-8-7-17-10-22-12-21(20(17)9-19)16-5-3-15(4-6-16)18-11-23-25(2)13-18/h3-13H,1-2H3,(H,24,26)
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n/an/a 4.90n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
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n/an/a 5.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) by reporter probe displacement assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189421
PNG
(CHEMBL3827118)
Show SMILES COC1CN(C1)C(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H21N5O2/c1-27-12-18(10-25-27)15-3-5-16(6-4-15)20-11-24-9-17-7-8-21(26-22(17)20)23(29)28-13-19(14-28)30-2/h3-12,19H,13-14H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189416
PNG
(CHEMBL3828575)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4NS(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C17H14N4O3S/c1-18-17(22)15-5-3-11-7-19-8-13(16(11)20-15)10-2-4-14-12(6-10)9-25(23,24)21-14/h2-8,21H,9H2,1H3,(H,18,22)
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n/an/a 5.30n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189413
PNG
(CHEMBL3827774)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-5-3-12-8-20-10-14(17(12)22-15)11-4-6-16-13(7-11)9-21-23(16)2/h3-10H,1-2H3,(H,19,24)
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n/an/a 5.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189441
PNG
(CHEMBL3827678)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)-c1nccn1C
Show InChI InChI=1S/C23H19N5/c1-27-10-9-25-23(27)18-7-8-19-12-24-14-22(21(19)11-18)17-5-3-16(4-6-17)20-13-26-28(2)15-20/h3-15H,1-2H3
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n/an/a 5.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189444
PNG
(CHEMBL3827333)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)S(N)(=O)=O
Show InChI InChI=1S/C19H16N4O2S/c1-23-12-16(10-22-23)13-2-4-14(5-3-13)19-11-21-9-15-6-7-17(8-18(15)19)26(20,24)25/h2-12H,1H3,(H2,20,24,25)
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n/an/a 5.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189450
PNG
(CHEMBL3828071)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(nc12)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C22H18F2N6O/c1-29-10-15(8-27-29)13-2-4-14(5-3-13)17-9-26-20(25)16-6-7-18(28-19(16)17)21(31)30-11-22(23,24)12-30/h2-10H,11-12H2,1H3,(H2,25,26)
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n/an/a 5.80n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189438
PNG
(CHEMBL3828689)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)C(=O)N1CC(F)(F)C1
Show InChI InChI=1S/C23H18F2N4O/c1-28-12-19(10-27-28)15-2-4-16(5-3-15)21-11-26-9-18-7-6-17(8-20(18)21)22(30)29-13-23(24,25)14-29/h2-12H,13-14H2,1H3
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n/an/a 6.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189443
PNG
(CHEMBL3827790)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)N1CCCS1(=O)=O
Show InChI InChI=1S/C22H20N4O2S/c1-25-15-19(13-24-25)16-3-5-17(6-4-16)22-14-23-12-18-7-8-20(11-21(18)22)26-9-2-10-29(26,27)28/h3-8,11-15H,2,9-10H2,1H3
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n/an/a 6.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189414
PNG
(CHEMBL3828209)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4cnn(C)c4c3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-6-5-13-8-20-10-14(17(13)22-15)11-3-4-12-9-21-23(2)16(12)7-11/h3-10H,1-2H3,(H,19,24)
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n/an/a 6.90n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B (KDM5Flag-5B-FL)


(Homo sapiens (Human))
BDBM50153099
PNG
(CHEMBL3775814)
Show SMILES O=c1[nH]cnc2c(nccc12)-n1cc(CCN2CCC(CC2)c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C24H23N7O/c25-13-17-1-3-19(4-2-17)20-7-11-30(12-8-20)10-6-18-14-29-31(15-18)23-22-21(5-9-26-23)24(32)28-16-27-22/h1-5,9,14-16,20H,6-8,10-12H2,(H,27,28,32)
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n/an/a 7n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
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n/an/a 7.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189441
PNG
(CHEMBL3827678)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)-c1nccn1C
Show InChI InChI=1S/C23H19N5/c1-27-10-9-25-23(27)18-7-8-19-12-24-14-22(21(19)11-18)17-5-3-16(4-6-17)20-13-26-28(2)15-20/h3-15H,1-2H3
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n/an/a 7.30n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189449
PNG
(CHEMBL3827023)
Show SMILES COC1(C)CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C24H24N6O2/c1-24(32-3)13-30(14-24)23(31)20-9-8-18-21(28-20)19(11-26-22(18)25)16-6-4-15(5-7-16)17-10-27-29(2)12-17/h4-12H,13-14H2,1-3H3,(H2,25,26)
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n/an/a 8.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189500
PNG
(CHEMBL3827664)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H21N5O/c1-28-13-17(11-26-28)14-2-4-15(5-3-14)21-12-25-22(24)19-9-6-16(10-20(19)21)23(29)27-18-7-8-18/h2-6,9-13,18H,7-8H2,1H3,(H2,24,25)(H,27,29)
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n/an/a 9n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189500
PNG
(CHEMBL3827664)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H21N5O/c1-28-13-17(11-26-28)14-2-4-15(5-3-14)21-12-25-22(24)19-9-6-16(10-20(19)21)23(29)27-18-7-8-18/h2-6,9-13,18H,7-8H2,1H3,(H2,24,25)(H,27,29)
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n/an/a 9.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189451
PNG
(CHEMBL3828286)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(nc12)C(=O)N1CC(C)(F)C1
Show InChI InChI=1S/C23H21FN6O/c1-23(24)12-30(13-23)22(31)19-8-7-17-20(28-19)18(10-26-21(17)25)15-5-3-14(4-6-15)16-9-27-29(2)11-16/h3-11H,12-13H2,1-2H3,(H2,25,26)
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n/an/a 9.80n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189423
PNG
(CHEMBL3828523)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H21N5O/c1-27-15-19(13-25-27)16-4-6-17(7-5-16)20-14-24-12-18-8-9-21(26-22(18)20)23(29)28-10-2-3-11-28/h4-9,12-15H,2-3,10-11H2,1H3
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n/an/a 9.90n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B (KDM5Flag-5B-FL)


(Homo sapiens (Human))
BDBM50153101
PNG
(CHEMBL3774665)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1
Show InChI InChI=1S/C24H26N6O3S/c1-34(32,33)20-4-2-18(3-5-20)19-8-12-29(13-9-19)11-7-17-14-28-30(15-17)23-22-21(6-10-25-23)24(31)27-16-26-22/h2-6,10,14-16,19H,7-9,11-13H2,1H3,(H,26,27,31)
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n/an/a 10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


Citation and Details
More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B (KDM5Flag-5B-FL)


(Homo sapiens (Human))
BDBM50153161
PNG
(CHEMBL3775545)
Show SMILES COc1ccc(cc1)C1CCN(CCc2cnn(c2)-c2nccc3c2nc[nH]c3=O)CC1
Show InChI InChI=1S/C24H26N6O2/c1-32-20-4-2-18(3-5-20)19-8-12-29(13-9-19)11-7-17-14-28-30(15-17)23-22-21(6-10-25-23)24(31)27-16-26-22/h2-6,10,14-16,19H,7-9,11-13H2,1H3,(H,26,27,31)
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n/an/a 10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...


Citation and Details
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50189416
PNG
(CHEMBL3828575)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4NS(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C17H14N4O3S/c1-18-17(22)15-5-3-11-7-19-8-13(16(11)20-15)10-2-4-14-12(6-10)9-25(23,24)21-14/h2-8,21H,9H2,1H3,(H,18,22)
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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem
PubMed
n/an/a 11n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...


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More data for this
Ligand-Target Pair
Lysine-specific demethylase 5B (KDM5Flag-5B-FL)


(Homo sapiens (Human))
BDBM50151919
PNG
(CHEMBL3775121)
Show SMILES Fc1ccc(C2CCN(CCc3cnn(c3)-c3nccc4c3nc[nH]c4=O)CC2)c(F)c1
Show InChI InChI=1S/C23H22F2N6O/c24-17-1-2-18(20(25)11-17)16-5-9-30(10-6-16)8-4-15-12-29-31(13-15)22-21-19(3-7-26-22)23(32)28-14-27-21/h1-3,7,11-14,16H,4-6,8-10H2,(H,27,28,32)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
PubMed
n/an/a 11n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of KDM6B (unknown origin) using biotin-H3K27me3 (21 to 44 residues) as substrate preincubated for 15 mins followed by substrate addition m...


Citation and Details
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189437
PNG
(CHEMBL3828370)
Show SMILES COC1CN(C1)C(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C24H22N4O2/c1-27-13-20(11-26-27)16-3-5-17(6-4-16)23-12-25-10-19-8-7-18(9-22(19)23)24(29)28-14-21(15-28)30-2/h3-13,21H,14-15H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 11n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


Citation and Details
More data for this
Ligand-Target Pair
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