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Compile Data Set for Download or QSAR

Found 67 hits with Last Name = 'senaiar' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192829
PNG
(CHEMBL3958704 | US10188627, Compound 8a)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,15-16H,9,14,17-18H2,1-2H3,(H,28,29)/b19-15+
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n/an/an/an/a 5.06n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192829
PNG
(CHEMBL3958704 | US10188627, Compound 8a)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,15-16H,9,14,17-18H2,1-2H3,(H,28,29)/b19-15+
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n/an/an/an/a 56n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323590
PNG
(Synthesis of (E)-4-methyl-6-[2-[[methyl-(4-phenylb...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H29NO4/c1-21(12-17-27(30)31)18-19-33-26-11-7-6-10-25(26)20-29(2)28(32)24-15-13-23(14-16-24)22-8-4-3-5-9-22/h3-11,13-16,18H,12,17,19-20H2,1-2H3,(H,30,31)/b21-18+
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n/an/an/an/a 33.6n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323590
PNG
(Synthesis of (E)-4-methyl-6-[2-[[methyl-(4-phenylb...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H29NO4/c1-21(12-17-27(30)31)18-19-33-26-11-7-6-10-25(26)20-29(2)28(32)24-15-13-23(14-16-24)22-8-4-3-5-9-22/h3-11,13-16,18H,12,17,19-20H2,1-2H3,(H,30,31)/b21-18+
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n/an/an/an/a 226n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192832
PNG
(CHEMBL3975891 | US10188627, Compound 8c)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(F)c1
Show InChI InChI=1S/C26H26FNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 1.93n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192832
PNG
(CHEMBL3975891 | US10188627, Compound 8c)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(F)c1
Show InChI InChI=1S/C26H26FNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 15n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192837
PNG
(CHEMBL3964816 | US10188627, Compound 8d)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(Cl)c1
Show InChI InChI=1S/C26H26ClNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 1.59n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192837
PNG
(CHEMBL3964816 | US10188627, Compound 8d)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(Cl)c1
Show InChI InChI=1S/C26H26ClNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 7.40n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323593
PNG
(Synthesis of (E)-4-methyl-6-(2-((N-methyl-4-(5-met...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccc(C)o1
Show InChI InChI=1S/C27H29NO5/c1-19(8-15-26(29)30)16-17-32-24-7-5-4-6-23(24)18-28(3)27(31)22-12-10-21(11-13-22)25-14-9-20(2)33-25/h4-7,9-14,16H,8,15,17-18H2,1-3H3,(H,29,30)/b19-16+
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n/an/an/an/a 11.9n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323594
PNG
(Synthesis of (E)-6-(2-((N,2-dimethylbenzofuran-5-c...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc2oc(C)cc2c1
Show InChI InChI=1S/C25H27NO5/c1-17(8-11-24(27)28)12-13-30-22-7-5-4-6-20(22)16-26(3)25(29)19-9-10-23-21(15-19)14-18(2)31-23/h4-7,9-10,12,14-15H,8,11,13,16H2,1-3H3,(H,27,28)/b17-12+
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n/an/an/an/a 45.1n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192830
PNG
(CHEMBL3983906 | US10188627, Compound 8g)
Show SMILES CN(Cc1cc(F)ccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H26FNO5/c1-18(5-12-25(29)30)13-15-33-24-11-10-22(27)16-21(24)17-28(2)26(31)20-8-6-19(7-9-20)23-4-3-14-32-23/h3-4,6-11,13-14,16H,5,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 5.51n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192830
PNG
(CHEMBL3983906 | US10188627, Compound 8g)
Show SMILES CN(Cc1cc(F)ccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H26FNO5/c1-18(5-12-25(29)30)13-15-33-24-11-10-22(27)16-21(24)17-28(2)26(31)20-8-6-19(7-9-20)23-4-3-14-32-23/h3-4,6-11,13-14,16H,5,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 40n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192831
PNG
(CHEMBL3895104 | US10188627, Compound 8h)
Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 40.2n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192831
PNG
(CHEMBL3895104 | US10188627, Compound 8h)
Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 998n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323597
PNG
(Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCCC\C(C)=C\C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16-17H,5,7,15,18H2,1-2H3,(H,28,29)/b19-17+
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n/an/an/an/a 694n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 64.5n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192833
PNG
(CHEMBL3923083 | US10188627, Compound 8j)
Show SMILES CC(CCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CC(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(17-25(28)29)7-5-15-32-24-9-4-3-8-22(24)18-27(2)26(30)21-13-11-20(12-14-21)23-10-6-16-31-23/h3-4,6,8-14,16,19H,5,7,15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 566n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323599
PNG
(Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCCC\C=C(/C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7-15,17H,5-6,16,18H2,1-2H3,(H,29,30)/b19-8+
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n/an/an/an/a 1.85E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323600
PNG
((E)-7-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl...)
Show SMILES CN(Cc1ccccc1\C=C\CCCCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO4/c1-27(26(30)22-16-14-21(15-17-22)24-12-8-18-31-24)19-23-11-7-6-10-20(23)9-4-2-3-5-13-25(28)29/h4,6-12,14-18H,2-3,5,13,19H2,1H3,(H,28,29)/b9-4+
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n/an/an/an/a 1.27E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192836
PNG
(CHEMBL3911672 | US10188627, Compound 8m)
Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)
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n/an/an/an/a 13.5n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192836
PNG
(CHEMBL3911672 | US10188627, Compound 8m)
Show SMILES CN(Cc1ccccc1OCc1ccc(CC(O)=O)cc1)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-14-12-22(13-15-23)25-7-4-16-33-25)18-24-5-2-3-6-26(24)34-19-21-10-8-20(9-11-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192834
PNG
(CHEMBL3914092 | US10188627, Compound 8n)
Show SMILES CN(Cc1cc(C)ccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C27H29NO5/c1-19(7-13-26(29)30)14-16-33-25-12-6-20(2)17-23(25)18-28(3)27(31)22-10-8-21(9-11-22)24-5-4-15-32-24/h4-6,8-12,14-15,17H,7,13,16,18H2,1-3H3,(H,29,30)/b19-14+
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n/an/an/an/a 22.6n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192834
PNG
(CHEMBL3914092 | US10188627, Compound 8n)
Show SMILES CN(Cc1cc(C)ccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C27H29NO5/c1-19(7-13-26(29)30)14-16-33-25-12-6-20(2)17-23(25)18-28(3)27(31)22-10-8-21(9-11-22)24-5-4-15-32-24/h4-6,8-12,14-15,17H,7,13,16,18H2,1-3H3,(H,29,30)/b19-14+
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n/an/an/an/a 19.8n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323603
PNG
(Synthesis of 6-(2-((4-(furan-2-yl)-N-methylbenzami...)
Show SMILES CC(CCCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)C(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7,9-15,17,19H,5-6,8,16,18H2,1-2H3,(H,29,30)
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n/an/an/an/a 229n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323603
PNG
(Synthesis of 6-(2-((4-(furan-2-yl)-N-methylbenzami...)
Show SMILES CC(CCCCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)C(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(26(29)30)8-5-6-16-31-24-10-4-3-9-22(24)18-27(2)25(28)21-14-12-20(13-15-21)23-11-7-17-32-23/h3-4,7,9-15,17,19H,5-6,8,16,18H2,1-2H3,(H,29,30)
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n/an/an/an/a 1.64E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323604
PNG
(Synthesis of 3-(3-((2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCc1cccc(CCC(O)=O)c1)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C29H27NO5/c1-30(29(33)24-14-12-23(13-15-24)26-10-5-17-34-26)19-25-8-2-3-9-27(25)35-20-22-7-4-6-21(18-22)11-16-28(31)32/h2-10,12-15,17-18H,11,16,19-20H2,1H3,(H,31,32)
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n/an/an/an/a 1.76E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323605
PNG
(Synthesis of 2-(3-((2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCc1cccc(CC(O)=O)c1)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C28H25NO5/c1-29(28(32)23-13-11-22(12-14-23)25-10-5-15-33-25)18-24-8-2-3-9-26(24)34-19-21-7-4-6-20(16-21)17-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)
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n/an/an/an/a 116n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323606
PNG
(Synthesis of 2-(3-((2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCc1cccc(OCC(O)=O)c1)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C28H25NO6/c1-29(28(32)22-13-11-21(12-14-22)25-10-5-15-33-25)17-23-7-2-3-9-26(23)35-18-20-6-4-8-24(16-20)34-19-27(30)31/h2-16H,17-19H2,1H3,(H,30,31)
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n/an/an/an/a 628n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323607
PNG
(Synthesis of 6-(2-((4-(furan-2-yl)-N-methylbenzami...)
Show SMILES CN(Cc1ccccc1OCCCCC(C)(C)C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C27H31NO5/c1-27(2,26(30)31)16-6-7-17-32-24-10-5-4-9-22(24)19-28(3)25(29)21-14-12-20(13-15-21)23-11-8-18-33-23/h4-5,8-15,18H,6-7,16-17,19H2,1-3H3,(H,30,31)
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n/an/an/an/a 511n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323608
PNG
(Synthesis of 2-(3-(2-((4-(furan-2-yl)-N-methylbenz...)
Show SMILES CN(Cc1ccccc1OCCCC1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)
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n/an/an/an/a 52.1n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323608
PNG
(Synthesis of 2-(3-(2-((4-(furan-2-yl)-N-methylbenz...)
Show SMILES CN(Cc1ccccc1OCCCC1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)
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n/an/an/an/a 308n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323609
PNG
((1R*,2S*)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzami...)
Show SMILES CN(Cc1ccccc1OCCC[C@H]1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22?/m0/s1
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n/an/an/an/a 266n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323609
PNG
((1R*,2S*)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzami...)
Show SMILES CN(Cc1ccccc1OCCC[C@H]1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22?/m0/s1
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n/an/an/an/a 320n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323610
PNG
( (1R*,2R*)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzam...)
Show SMILES CN(Cc1ccccc1OCCC[C@@H]1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22?/m1/s1
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n/an/an/an/a 210n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323610
PNG
( (1R*,2R*)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzam...)
Show SMILES CN(Cc1ccccc1OCCC[C@@H]1CC1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22?/m1/s1
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n/an/an/an/a 2.51E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323611
PNG
((1R,2S)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzamido...)
Show SMILES CN(Cc1ccccc1OCCC[C@H]1C[C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22+/m0/s1
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n/an/an/an/a 707n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323611
PNG
((1R,2S)-2-(3-(2-((4-(furan-2-yl)-N-methylbenzamido...)
Show SMILES CN(Cc1ccccc1OCCC[C@H]1C[C@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22+/m0/s1
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n/an/an/an/a 644n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192835
PNG
(CHEMBL3981654 | US10188627, Compound 8x)
Show SMILES CN(Cc1ccccc1OCCC[C@@H]1C[C@@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22+/m1/s1
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n/an/an/an/a 265n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50192835
PNG
(CHEMBL3981654 | US10188627, Compound 8x)
Show SMILES CN(Cc1ccccc1OCCC[C@@H]1C[C@@H]1C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-27(25(28)19-12-10-18(11-13-19)23-9-5-15-31-23)17-21-6-2-3-8-24(21)32-14-4-7-20-16-22(20)26(29)30/h2-3,5-6,8-13,15,20,22H,4,7,14,16-17H2,1H3,(H,29,30)/t20-,22+/m1/s1
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n/an/an/an/a 82.5n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323613
PNG
(Synthesis of 2-((3-(2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCCCSCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C24H25NO5S/c1-25(24(28)19-11-9-18(10-12-19)21-8-4-13-29-21)16-20-6-2-3-7-22(20)30-14-5-15-31-17-23(26)27/h2-4,6-13H,5,14-17H2,1H3,(H,26,27)
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n/an/an/an/a 233n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323614
PNG
(Synthesis of 6-(2-((N,2-dimethylbenzofuran-5-carbo...)
Show SMILES CN(Cc1ccccc1OCCCCC(C)(C)C(O)=O)C(=O)c1ccc2oc(C)cc2c1
Show InChI InChI=1S/C26H31NO5/c1-18-15-21-16-19(11-12-23(21)32-18)24(28)27(4)17-20-9-5-6-10-22(20)31-14-8-7-13-26(2,3)25(29)30/h5-6,9-12,15-16H,7-8,13-14,17H2,1-4H3,(H,29,30)
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n/an/an/an/a 5.54E+3n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323615
PNG
(Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1cc(ccc1OC\C=C(/C)CCC(O)=O)C(F)(F)F)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C27H26F3NO5/c1-18(5-12-25(32)33)13-15-36-24-11-10-22(27(28,29)30)16-21(24)17-31(2)26(34)20-8-6-19(7-9-20)23-4-3-14-35-23/h3-4,6-11,13-14,16H,5,12,15,17H2,1-2H3,(H,32,33)/b18-13+
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n/an/an/an/a 683n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Cell Handling: PathHunter NHR cell lines were expanded from freezer stocks according to standard procedures. Cells were seeded in a total volume of 2...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM323616
PNG
(Synthesis of (E)-6-(2-((4-(furan-2-yl)-N-methylben...)
Show SMILES CN(Cc1ccccc1OCCC\C=C\C(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C25H25NO5/c1-26(25(29)20-14-12-19(13-15-20)22-10-7-17-31-22)18-21-8-4-5-9-23(21)30-16-6-2-3-11-24(27)28/h3-5,7-15,17H,2,6,16,18H2,1H3,(H,27,28)/b11-3+
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n/an/an/an/a 80.4n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM50192829
PNG
(CHEMBL3958704 | US10188627, Compound 8a)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H27NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,15-16H,9,14,17-18H2,1-2H3,(H,28,29)/b19-15+
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n/an/an/an/a 5.06n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM50192832
PNG
(CHEMBL3975891 | US10188627, Compound 8c)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(F)c1
Show InChI InChI=1S/C26H26FNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 1.93n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM50192837
PNG
(CHEMBL3964816 | US10188627, Compound 8d)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(-c2ccco2)c(Cl)c1
Show InChI InChI=1S/C26H26ClNO5/c1-18(9-12-25(29)30)13-15-33-23-7-4-3-6-20(23)17-28(2)26(31)19-10-11-21(22(27)16-19)24-8-5-14-32-24/h3-8,10-11,13-14,16H,9,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 1.59n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM323593
PNG
(Synthesis of (E)-4-methyl-6-(2-((N-methyl-4-(5-met...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccc(C)o1
Show InChI InChI=1S/C27H29NO5/c1-19(8-15-26(29)30)16-17-32-24-7-5-4-6-23(24)18-28(3)27(31)22-12-10-21(11-13-22)25-14-9-20(2)33-25/h4-7,9-14,16H,8,15,17-18H2,1-3H3,(H,29,30)/b19-16+
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n/an/an/an/a 11.9n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM323594
PNG
(Synthesis of (E)-6-(2-((N,2-dimethylbenzofuran-5-c...)
Show SMILES CN(Cc1ccccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc2oc(C)cc2c1
Show InChI InChI=1S/C25H27NO5/c1-17(8-11-24(27)28)12-13-30-22-7-5-4-6-20(22)16-26(3)25(29)19-9-10-23-21(15-19)14-18(2)31-23/h4-7,9-10,12,14-15H,8,11,13,16H2,1-3H3,(H,27,28)/b17-12+
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n/an/an/an/a 45.1n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM50192830
PNG
(CHEMBL3983906 | US10188627, Compound 8g)
Show SMILES CN(Cc1cc(F)ccc1OC\C=C(/C)CCC(O)=O)C(=O)c1ccc(cc1)-c1ccco1
Show InChI InChI=1S/C26H26FNO5/c1-18(5-12-25(29)30)13-15-33-24-11-10-22(27)16-21(24)17-28(2)26(31)20-8-6-19(7-9-20)23-4-3-14-32-23/h3-4,6-11,13-14,16H,5,12,15,17H2,1-2H3,(H,29,30)/b18-13+
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n/an/an/an/a 5.51n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
PPAR delta protein


(Rattus norvegicus (Rat))
BDBM50192831
PNG
(CHEMBL3895104 | US10188627, Compound 8h)
Show SMILES CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O
Show InChI InChI=1S/C26H29NO5/c1-19(9-14-25(28)29)15-17-32-24-7-4-3-6-22(24)18-27(2)26(30)21-12-10-20(11-13-21)23-8-5-16-31-23/h3-8,10-13,16,19H,9,14-15,17-18H2,1-2H3,(H,28,29)
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n/an/an/an/a 40.2n/an/an/an/a



Mitobridge, Inc.; Salk Institute for Biological Studies

US Patent


Assay Description
Medium including test compound was aspirated and washed with PBS. 50 μl PBS including 1 mM Mg++ and Ca++ were then added to each well. The lucif...


US Patent US10188627 (2019)


Article DOI: 10.1016/j.bmcl.2005.03.055
More data for this
Ligand-Target Pair
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