BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 106 hits with Last Name = 'silver' and Initial = 'pj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230226
PNG
(CHEMBL144015)
Show SMILES CCc1nccc2nc(O)ccc12
Show InChI InChI=1S/C10H10N2O/c1-2-8-7-3-4-10(13)12-9(7)5-6-11-8/h3-6H,2H2,1H3,(H,12,13)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230281
PNG
(CHEMBL144682)
Show SMILES CCCc1nccc2nc(O)ccc12
Show InChI InChI=1S/C11H12N2O/c1-2-3-9-8-4-5-11(14)13-10(8)6-7-12-9/h4-7H,2-3H2,1H3,(H,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289368
PNG
(Butane-1-sulfonic acid [3-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-7-26(24,25)21-10-6-4-5-9(8-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-6,8,21H,2-3,7H2,1H3,(H,20,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230227
PNG
(CHEMBL356549)
Show SMILES Oc1ccc2c(nccc2n1)-c1cccs1
Show InChI InChI=1S/C12H8N2OS/c15-11-4-3-8-9(14-11)5-6-13-12(8)10-2-1-7-16-10/h1-7H,(H,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230235
PNG
(CHEMBL144395)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccco1
Show InChI InChI=1S/C12H8N2O2/c15-11-4-3-8-9(14-11)5-6-13-12(8)10-2-1-7-16-10/h1-7H,(H,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230228
PNG
(CHEMBL144154)
Show SMILES Oc1ccc2c(nccc2n1)C(Cl)Cl
Show InChI InChI=1S/C9H6Cl2N2O/c10-9(11)8-5-1-2-7(14)13-6(5)3-4-12-8/h1-4,9H,(H,13,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230229
PNG
(CHEMBL144190)
Show SMILES Oc1ccc2c(Br)nccc2n1
Show InChI InChI=1S/C8H5BrN2O/c9-8-5-1-2-7(12)11-6(5)3-4-10-8/h1-4H,(H,11,12)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230225
PNG
(CHEMBL144713)
Show SMILES Nc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C14H11N3O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,15H2,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1
Show InChI InChI=1/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289368
PNG
(Butane-1-sulfonic acid [3-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-7-26(24,25)21-10-6-4-5-9(8-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-6,8,21H,2-3,7H2,1H3,(H,20,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 290n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE V).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230231
PNG
(CHEMBL556516)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H9ClN2O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 360n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289353
PNG
(2,3-Dibromo-8-(4-methoxy-phenyl)-6H-imidazo[1,2-d]...)
Show SMILES COc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C12H8Br2N4O2/c1-20-7-4-2-6(3-5-7)8-11-15-9(13)10(14)18(11)12(19)17-16-8/h2-5H,1H3,(H,17,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 450n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230222
PNG
(MEDORINONE | Medorinone | WIN-49016)
Show SMILES Cc1nccc2nc(O)ccc12
Show InChI InChI=1S/C9H8N2O/c1-6-7-2-3-9(12)11-8(7)4-5-10-6/h2-5H,1H3,(H,11,12)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP PDE 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230237
PNG
(CHEMBL357234)
Show SMILES CC(C)Cc1nccc2nc(O)ccc12
Show InChI InChI=1S/C12H14N2O/c1-8(2)7-11-9-3-4-12(15)14-10(9)5-6-13-11/h3-6,8H,7H2,1-2H3,(H,14,15)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 570n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230238
PNG
(CHEMBL356805)
Show SMILES Oc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C14H10N2O2/c17-10-3-1-9(2-4-10)14-11-5-6-13(18)16-12(11)7-8-15-14/h1-8,17H,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289357
PNG
(1-Butyl-3-[3-(2,3-dibromo-5-oxo-5,6-dihydro-imidaz...)
Show SMILES CCCCNC(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C16H16Br2N6O2/c1-2-3-7-19-15(25)20-10-6-4-5-9(8-10)11-14-21-12(17)13(18)24(14)16(26)23-22-11/h4-6,8H,2-3,7H2,1H3,(H,23,26)(H2,19,20,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 650n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289360
PNG
(2,3-Dibromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triaz...)
Show SMILES Brc1nc2c(n[nH]c(=O)n2c1Br)-c1ccccc1
Show InChI InChI=1S/C11H6Br2N4O/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h1-5H,(H,16,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289361
PNG
(Butane-1-sulfonic acid [4-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-8-26(24,25)21-10-6-4-9(5-7-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-7,21H,2-3,8H2,1H3,(H,20,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 840n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289367
PNG
(8-(4-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1...)
Show SMILES Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C11H7Br2N5O/c12-8-9(13)18-10(15-8)7(16-17-11(18)19)5-1-3-6(14)4-2-5/h1-4H,14H2,(H,17,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 910n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230223
PNG
(CHEMBL144453)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C14H9FN2O/c15-10-3-1-9(2-4-10)14-11-5-6-13(18)17-12(11)7-8-16-14/h1-8H,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 940n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230279
PNG
(CHEMBL144706)
Show SMILES Cc1nccc2nc(S)ccc12
Show InChI InChI=1S/C9H8N2S/c1-6-7-2-3-9(12)11-8(7)4-5-10-6/h2-5H,1H3,(H,11,12)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 960n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of cAMP Phosphodiesterase 3


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289355
PNG
(8-(2-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1...)
Show SMILES Nc1ccccc1-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C11H7Br2N5O/c12-8-9(13)18-10(15-8)7(16-17-11(18)19)5-3-1-2-4-6(5)14/h1-4H,14H2,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289350
PNG
(1-Butyl-3-[2-(2,3-dibromo-5-oxo-5,6-dihydro-imidaz...)
Show SMILES CCCCNC(=O)Nc1ccccc1-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C16H16Br2N6O2/c1-2-3-8-19-15(25)20-10-7-5-4-6-9(10)11-14-21-12(17)13(18)24(14)16(26)23-22-11/h4-7H,2-3,8H2,1H3,(H,23,26)(H2,19,20,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a>1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289361
PNG
(Butane-1-sulfonic acid [4-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-8-26(24,25)21-10-6-4-9(5-7-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-7,21H,2-3,8H2,1H3,(H,20,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.02E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289353
PNG
(2,3-Dibromo-8-(4-methoxy-phenyl)-6H-imidazo[1,2-d]...)
Show SMILES COc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C12H8Br2N4O2/c1-20-7-4-2-6(3-5-7)8-11-15-9(13)10(14)18(11)12(19)17-16-8/h2-5H,1H3,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289358
PNG
(8-(3-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1...)
Show SMILES Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C11H7Br2N5O/c12-8-9(13)18-10(15-8)7(16-17-11(18)19)5-2-1-3-6(14)4-5/h1-4H,14H2,(H,17,19)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.15E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289357
PNG
(1-Butyl-3-[3-(2,3-dibromo-5-oxo-5,6-dihydro-imidaz...)
Show SMILES CCCCNC(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C16H16Br2N6O2/c1-2-3-7-19-15(25)20-10-6-4-5-9(8-10)11-14-21-12(17)13(18)24(14)16(26)23-22-11/h4-6,8H,2-3,7H2,1H3,(H,23,26)(H2,19,20,25)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289354
PNG
(CHEMBL426946 | N-[3-(2,3-Dibromo-5-oxo-5,6-dihydro...)
Show SMILES CC(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C13H9Br2N5O2/c1-6(21)16-8-4-2-3-7(5-8)9-12-17-10(14)11(15)20(12)13(22)19-18-9/h2-5H,1H3,(H,16,21)(H,19,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.22E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230239
PNG
(CHEMBL343895)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O/c17-13-7-6-11-12(16-13)8-9-15-14(11)10-4-2-1-3-5-10/h1-9H,(H,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230232
PNG
(CHEMBL145429)
Show SMILES CC(=O)c1nccc2nc(O)ccc12
Show InChI InChI=1S/C10H8N2O2/c1-6(13)10-7-2-3-9(14)12-8(7)4-5-11-10/h2-5H,1H3,(H,12,14)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.42E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289367
PNG
(8-(4-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1...)
Show SMILES Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C11H7Br2N5O/c12-8-9(13)18-10(15-8)7(16-17-11(18)19)5-1-3-6(14)4-2-5/h1-4H,14H2,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289362
PNG
(2,3-Dibromo-8-cyclohexyl-6H-imidazo[1,2-d][1,2,4]t...)
Show SMILES Brc1nc2c(n[nH]c(=O)n2c1Br)C1CCCCC1
Show InChI InChI=1S/C11H12Br2N4O/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h6H,1-5H2,(H,16,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50289361
PNG
(Butane-1-sulfonic acid [4-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-8-26(24,25)21-10-6-4-9(5-7-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-7,21H,2-3,8H2,1H3,(H,20,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE V).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289356
PNG
(1-Butyl-3-[4-(2,3-dibromo-5-oxo-5,6-dihydro-imidaz...)
Show SMILES CCCCNC(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C16H16Br2N6O2/c1-2-3-8-19-15(25)20-10-6-4-9(5-7-10)11-14-21-12(17)13(18)24(14)16(26)23-22-11/h4-7H,2-3,8H2,1H3,(H,23,26)(H2,19,20,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289366
PNG
(CHEMBL366491 | N-[4-(2,3-Dibromo-5-oxo-5,6-dihydro...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C13H9Br2N5O2/c1-6(21)16-8-4-2-7(3-5-8)9-12-17-10(14)11(15)20(12)13(22)19-18-9/h2-5H,1H3,(H,16,21)(H,19,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 1.82E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289360
PNG
(2,3-Dibromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triaz...)
Show SMILES Brc1nc2c(n[nH]c(=O)n2c1Br)-c1ccccc1
Show InChI InChI=1S/C11H6Br2N4O/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h1-5H,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289364
PNG
(2,3-Dimethyl-8-phenyl-6H-imidazo[1,2-d][1,2,4]tria...)
Show SMILES Cc1nc2c(n[nH]c(=O)n2c1C)-c1ccccc1
Show InChI InChI=1S/C13H12N4O/c1-8-9(2)17-12(14-8)11(15-16-13(17)18)10-6-4-3-5-7-10/h3-7H,1-2H3,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230224
PNG
(CHEMBL147736)
Show SMILES Oc1ccc2c(nccc2n1)-c1ccncc1
Show InChI InChI=1S/C13H9N3O/c17-12-2-1-10-11(16-12)5-8-15-13(10)9-3-6-14-7-4-9/h1-8H,(H,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289366
PNG
(CHEMBL366491 | N-[4-(2,3-Dibromo-5-oxo-5,6-dihydro...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C13H9Br2N5O2/c1-6(21)16-8-4-2-7(3-5-8)9-12-17-10(14)11(15)20(12)13(22)19-18-9/h2-5H,1H3,(H,16,21)(H,19,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289358
PNG
(8-(3-Amino-phenyl)-2,3-dibromo-6H-imidazo[1,2-d][1...)
Show SMILES Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C11H7Br2N5O/c12-8-9(13)18-10(15-8)7(16-17-11(18)19)5-2-1-3-6(14)4-5/h1-4H,14H2,(H,17,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289351
PNG
(2,3-Dibromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triaz...)
Show SMILES Brc1nc2c(n[nH]c(=S)n2c1Br)-c1ccccc1
Show InChI InChI=1S/C11H6Br2N4S/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h1-5H,(H,16,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 2.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230280
PNG
(CHEMBL142834)
Show SMILES Cc1cn(cn1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C12H10N4O/c1-8-6-16(7-14-8)12-9-2-3-11(17)15-10(9)4-5-13-12/h2-7H,1H3,(H,15,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50289360
PNG
(2,3-Dibromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triaz...)
Show SMILES Brc1nc2c(n[nH]c(=O)n2c1Br)-c1ccccc1
Show InChI InChI=1S/C11H6Br2N4O/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h1-5H,(H,16,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 2.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE V).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50289368
PNG
(Butane-1-sulfonic acid [3-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-7-26(24,25)21-10-6-4-5-9(8-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-6,8,21H,2-3,7H2,1H3,(H,20,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE V).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human))
BDBM50289369
PNG
(3-Bromo-8-phenyl-6H-imidazo[1,2-d][1,2,4]triazin-5...)
Show SMILES Brc1cnc2c(n[nH]c(=O)n12)-c1ccccc1
Show InChI InChI=1S/C11H7BrN4O/c12-8-6-13-10-9(7-4-2-1-3-5-7)14-15-11(17)16(8)10/h1-6H,(H,15,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 3.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE I).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230236
PNG
(CHEMBL2112000)
Show SMILES Cc1[n+]([O-])ccc2[nH]c(=O)ccc12
Show InChI InChI=1S/C9H8N2O2/c1-6-7-2-3-9(12)10-8(7)4-5-11(6)13/h2-5H,1H3,(H,10,12)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50230234
PNG
(CHEMBL356143)
Show SMILES COc1ccc(cc1)-c1nccc2nc(O)ccc12
Show InChI InChI=1S/C15H12N2O2/c1-19-11-4-2-10(3-5-11)15-12-6-7-14(18)17-13(12)8-9-16-15/h2-9H,1H3,(H,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20E+3n/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cAMP PDE III.


J Med Chem 35: 4858-65 (1992)


Article DOI: 10.1021/jm00104a012
BindingDB Entry DOI: 10.7270/Q2H13480
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (Human))
BDBM50289362
PNG
(2,3-Dibromo-8-cyclohexyl-6H-imidazo[1,2-d][1,2,4]t...)
Show SMILES Brc1nc2c(n[nH]c(=O)n2c1Br)C1CCCCC1
Show InChI InChI=1S/C11H12Br2N4O/c12-8-9(13)17-10(14-8)7(15-16-11(17)18)6-4-2-1-3-5-6/h6H,1-5H2,(H,16,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 106 total )  |  Next  |  Last  >>
Jump to: