Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230326![]() (CHEMBL4060950) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230326![]() (CHEMBL4060950) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human coagulation factor 11a using pyroGlu-Pro-Arg-pNA as substrate after 10 to 120 mins at 37 degC by spectrophotometric method | J Med Chem 60: 1060-1075 (2017) Article DOI: 10.1021/acs.jmedchem.6b01460 BindingDB Entry DOI: 10.7270/Q25D8V31 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269207![]() (CHEMBL4097522) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269199![]() (CHEMBL4083769) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12659![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0900 | -56.8 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50344100![]() (2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piper...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Antagonist activity at human B1 receptor | J Med Chem 54: 7232-46 (2011) Article DOI: 10.1021/jm200808v BindingDB Entry DOI: 10.7270/Q28C9WP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12661![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.100 | -56.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269209![]() (CHEMBL4063677) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269190![]() (CHEMBL4103982) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12657![]() (1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsul...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.150 | -55.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230322![]() (CHEMBL4071545) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230322![]() (CHEMBL4071545) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human coagulation factor 11a using pyroGlu-Pro-Arg-pNA as substrate after 10 to 120 mins at 37 degC by spectrophotometric method | J Med Chem 60: 1060-1075 (2017) Article DOI: 10.1021/acs.jmedchem.6b01460 BindingDB Entry DOI: 10.7270/Q25D8V31 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12660![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.160 | -55.3 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12675![]() (1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.170 | -55.2 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269186![]() (CHEMBL4089185) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid PDB UniChem Similars | PDB PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12676![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 0.190 | -54.9 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50219966![]() (CHEMBL23959) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity to the CRF receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50203205![]() ((R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Displacement of [3H]DAK from human bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells | Bioorg Med Chem Lett 18: 4764-9 (2008) Article DOI: 10.1016/j.bmcl.2008.07.108 BindingDB Entry DOI: 10.7270/Q29C6X87 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 3 (IAP1 BIR3) (Homo sapiens (Human)) | BDBM50255183![]() ((1S,3S,6S,10aS)-1-benzyl-6-((S)-2-(methylamino)pro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Displacement of fluorescent SM5F peptide from His-tagged human cIAP2 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polari... | J Med Chem 52: 593-6 (2009) Article DOI: 10.1021/jm801101z BindingDB Entry DOI: 10.7270/Q2Z03816 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM21397![]() (8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Displacement of [3H]Spiprone from human dopamine D2 receptor expressed in HEK293 cells | Bioorg Med Chem 20: 4862-71 (2012) Article DOI: 10.1016/j.bmc.2012.05.057 BindingDB Entry DOI: 10.7270/Q28P61K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50355063![]() (CHEMBL1834619) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Antagonist activity at human B1 receptor | J Med Chem 54: 7232-46 (2011) Article DOI: 10.1021/jm200808v BindingDB Entry DOI: 10.7270/Q28C9WP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269191![]() (CHEMBL4063746) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | 0.330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50136575![]() (CHEMBL3752610) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human coagulation factor 11a assessed as substrate hydrolysis to p-nitroaniline incubated for 10 to 120 mins by spectrophotometry analy... | Bioorg Med Chem Lett 26: 472-8 (2016) Article DOI: 10.1016/j.bmcl.2015.11.089 BindingDB Entry DOI: 10.7270/Q27H1MFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12677![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.370 | -53.3 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human)) | BDBM50255183![]() ((1S,3S,6S,10aS)-1-benzyl-6-((S)-2-(methylamino)pro...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polari... | J Med Chem 52: 593-6 (2009) Article DOI: 10.1021/jm801101z BindingDB Entry DOI: 10.7270/Q2Z03816 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269195![]() (CHEMBL4101766) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | PubMed | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50219965![]() (CHEMBL430913) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity to the CRF receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50463297![]() (CHEMBL4246433) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysis | Bioorg Med Chem 26: 4254-4263 (2018) BindingDB Entry DOI: 10.7270/Q28W3GZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50463294![]() (CHEMBL4249256) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University Curated by ChEMBL | Assay Description Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysis | Bioorg Med Chem 26: 4254-4263 (2018) BindingDB Entry DOI: 10.7270/Q28W3GZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human)) | BDBM50393632![]() (CHEMBL2158601) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay | J Med Chem 55: 106-14 (2012) Article DOI: 10.1021/jm201072x BindingDB Entry DOI: 10.7270/Q2BG2Q3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50209744![]() ((R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmet...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells | J Med Chem 50: 2200-12 (2007) Article DOI: 10.1021/jm070055c BindingDB Entry DOI: 10.7270/Q2MS3SG2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM22867![]() (1,1-diethyl-3-[(8beta)-6-methyl-9,10-didehydroergo...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Canterbury Curated by PDSP Ki Database | Biochem Pharmacol 45: 1003-9 (1993) Article DOI: 10.1016/0006-2952(93)90243-p BindingDB Entry DOI: 10.7270/Q2JH3JPG | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230325![]() (CHEMBL4062923) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50230325![]() (CHEMBL4062923) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human coagulation factor 11a using pyroGlu-Pro-Arg-pNA as substrate after 10 to 120 mins at 37 degC by spectrophotometric method | J Med Chem 60: 1060-1075 (2017) Article DOI: 10.1021/acs.jmedchem.6b01460 BindingDB Entry DOI: 10.7270/Q25D8V31 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM21397![]() (8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 0.5 | -54.0 | 2.56 | n/a | n/a | n/a | n/a | n/a | 30 |
Shanghai Institute of Materia Medica, Chinese Academy of Sciences US Patent | Assay Description Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as recepto... | US Patent US9359372 (2016) BindingDB Entry DOI: 10.7270/Q2736PSP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human)) | BDBM50343522![]() ((S,3S,3'S,6S,6'S,10aS,10a'S)-N,N'-((1S,1'S)-(1,1'-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Binding affinity to BIR3 domain of cIAP1 by fluorescence polarization assay | J Med Chem 55: 106-14 (2012) Article DOI: 10.1021/jm201072x BindingDB Entry DOI: 10.7270/Q2BG2Q3B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50220479![]() (CHEMBL23342) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity to the CRF receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12662![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.510 | -52.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12666![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.520 | -52.5 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM50018688![]() (CHEMBL3291301) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamasa Corporation Curated by ChEMBL | Assay Description Displacement of [3H]-CGS-21680 from human adenosine A2A receptor expressed in HEK293 cells after 90 mins | Bioorg Med Chem 22: 3072-82 (2014) Article DOI: 10.1016/j.bmc.2014.04.041 BindingDB Entry DOI: 10.7270/Q2348MXH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50355062![]() (CHEMBL1834752) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Antagonist activity at human B1 receptor | J Med Chem 54: 7232-46 (2011) Article DOI: 10.1021/jm200808v BindingDB Entry DOI: 10.7270/Q28C9WP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bradykinin B1 receptor (Homo sapiens (Human)) | BDBM50355057![]() (CHEMBL1834751) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Antagonist activity at human B1 receptor | J Med Chem 54: 7232-46 (2011) Article DOI: 10.1021/jm200808v BindingDB Entry DOI: 10.7270/Q28C9WP1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50463297![]() (CHEMBL4246433) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University Curated by ChEMBL | Assay Description Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysis | Bioorg Med Chem 26: 4254-4263 (2018) BindingDB Entry DOI: 10.7270/Q28W3GZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM12667![]() (1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | 0.600 | -52.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter... | J Med Chem 48: 1729-44 (2005) Article DOI: 10.1021/jm0497949 BindingDB Entry DOI: 10.7270/Q2BK19K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50220478![]() (CHEMBL22622) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity to the CRF receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50219957![]() (CHEMBL3085294) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity to the CRF receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM10755![]() (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 cells | Bioorg Med Chem 20: 4862-71 (2012) Article DOI: 10.1016/j.bmc.2012.05.057 BindingDB Entry DOI: 10.7270/Q28P61K9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Baculoviral IAP repeat-containing protein 2 (Homo sapiens (Human)) | BDBM26223![]() ((3S,6S,10aS)-6-[(2S)-2-(methylamino)propanamido]-5...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Displacement of fluorescent SM5F peptide from His-tagged human cIAP1 BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polari... | J Med Chem 52: 593-6 (2009) Article DOI: 10.1021/jm801101z BindingDB Entry DOI: 10.7270/Q2Z03816 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor XI (Homo sapiens (Human)) | BDBM50269206![]() (CHEMBL4070961) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid PDB UniChem | PDB PubMed | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description Inhibition of human Factor XIa using S-2366 as chromogenic substrate after 60 mins by Lineweaver-Burk plot analysis | Bioorg Med Chem Lett 27: 3833-3839 (2017) BindingDB Entry DOI: 10.7270/Q2GT5QPS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Corticotropin releasing factor receptor (Rattus norvegicus (rat)-RAT) | BDBM50219954![]() (CHEMBL283993) | PDB MMDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Co. Curated by ChEMBL | Assay Description In vitro binding affinity against Corticotropin releasing factor receptor in rat cortical homogenates | Bioorg Med Chem Lett 13: 125-8 (2003) Article DOI: 10.1016/s0960-894x(02)00833-8 BindingDB Entry DOI: 10.7270/Q2JM2CV9 | |||||||||||
More data for this Ligand-Target Pair |
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