Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Benzodiazepine receptors; peripheral & central (Rattus norvegicus (rat)) | BDBM50122293![]() (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in rat brain | Bioorg Med Chem Lett 13: 201-4 (2002) Article DOI: 10.1016/s0960-894x(02)00886-7 BindingDB Entry DOI: 10.7270/Q2PZ585X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185958![]() (CHEMBL205971 | N-(2-methoxybenzyl)-N-(4-chloro-2-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122294![]() (CHEMBL292092 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122294![]() (CHEMBL292092 | N-(5-fluoro-2-phenoxyphenyl)-N-(2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]DAA1106 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185959![]() (CHEMBL381602 | N-(2-ethoxybenzyl)-N-(4-chloro-2-ph...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122293![]() (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50160807![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122293![]() (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122293![]() (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50122295![]() (CHEMBL63065 | N-(2-Fluoromethoxy-5-methoxy-benzyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Translocator protein (Homo sapiens (Human)) | BDBM50122293![]() (CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro binding affinity for PBR (peripheral benzodiazepine receptor) in monkey brain | Bioorg Med Chem Lett 13: 201-4 (2002) Article DOI: 10.1016/s0960-894x(02)00886-7 BindingDB Entry DOI: 10.7270/Q2PZ585X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185957![]() (CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50056419![]() (4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50266889![]() (CHEMBL513922 | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM22032![]() (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185958![]() (CHEMBL205971 | N-(2-methoxybenzyl)-N-(4-chloro-2-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50016867![]() ((S)-6-Amino-2-((S)-2-{(R)-2-[(S)-2-amino-3-(4-hydr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against mu-opioid receptor by using [3H]-DAGO as radioligand in rat brain | Bioorg Med Chem Lett 4: 2049-2054 (1994) Article DOI: 10.1016/S0960-894X(01)80561-8 BindingDB Entry DOI: 10.7270/Q2MK6CV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185959![]() (CHEMBL381602 | N-(2-ethoxybenzyl)-N-(4-chloro-2-ph...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50266861![]() (CHEMBL515622 | N-benzyl-N-ethyl-2-(7-(2-fluoroethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50449636![]() (BRL-43694 | GRANISETRON | Kytril | LY-278584 | San...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Center Curated by ChEMBL | Assay Description Binding affinity for 5-hydroxytryptamine 3 receptor was determined by measuring displacement of [3H]GR-65630 from rat brain cortices | J Med Chem 41: 3015-21 (1998) Article DOI: 10.1021/jm9801004 BindingDB Entry DOI: 10.7270/Q20P10Q9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50283041![]() ((R)-2-{2-[2-Amino-4-(2-{(S)-guanidino-1-(S)-2-[(R)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against mu-opioid receptor by using [3H]-DAGO as radioligand in rat brain | Bioorg Med Chem Lett 4: 2049-2054 (1994) Article DOI: 10.1016/S0960-894X(01)80561-8 BindingDB Entry DOI: 10.7270/Q2MK6CV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50266863![]() (CHEMBL476811 | N-benzyl-N-(2-fluoroethyl)-2-(7-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM22032![]() (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C](R)-PK1119 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50185957![]() (CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM82519![]() (4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicycl...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50160807![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM22032![]() (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]DAA1106 from Sprague-Dawley rat brain PBR | J Med Chem 49: 2735-42 (2006) Article DOI: 10.1021/jm060006k BindingDB Entry DOI: 10.7270/Q20K29CW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM22032![]() (1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50066000![]() (5-Chloro-7-methyl-2-(4-methyl-[1,4]diazepan-1-yl)-...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Center Curated by ChEMBL | Assay Description Binding affinity for 5-hydroxytryptamine 3 receptor was determined by measuring displacement of [3H]GR-65630 from rat brain cortices | J Med Chem 41: 3015-21 (1998) Article DOI: 10.1021/jm9801004 BindingDB Entry DOI: 10.7270/Q20P10Q9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50283037![]() (CHEMBL291609 | [(S)-5-((S)-2-{(R)-2-[(S)-2-Amino-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against mu-opioid receptor by using [3H]-DAGO as radioligand in rat brain | Bioorg Med Chem Lett 4: 2049-2054 (1994) Article DOI: 10.1016/S0960-894X(01)80561-8 BindingDB Entry DOI: 10.7270/Q2MK6CV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50266862![]() (CHEMBL476607 | N-benzyl-2-(7-(2-fluoroethyl)-8-oxo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description Displacement of [11C]PK11195 from PBR receptor in rat brain membrane | Bioorg Med Chem Lett 19: 1707-10 (2009) Article DOI: 10.1016/j.bmcl.2009.01.093 BindingDB Entry DOI: 10.7270/Q2C82B6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50283039![]() (CHEMBL424228 | [(S)-4-((S)-2-{(R)-2-[(S)-2-Amino-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against mu-opioid receptor by using [3H]-DAGO as radioligand in rat brain | Bioorg Med Chem Lett 4: 2049-2054 (1994) Article DOI: 10.1016/S0960-894X(01)80561-8 BindingDB Entry DOI: 10.7270/Q2MK6CV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50160808![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50144889![]() (CHEMBL72521 | N-(5-Fluoro-2-phenoxy-phenyl)-N-(2-i...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50280258![]() (4-Amino-N-(S)-1-aza-bicyclo[3.3.1]non-4-yl-5-chlor...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50160809![]() ((R)-4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50283036![]() (CHEMBL294785 | [(S)-3-((S)-2-{(S)-2-[(S)-2-Amino-3...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity of the compound against mu-opioid receptor by using [3H]-DAGO as radioligand in rat brain | Bioorg Med Chem Lett 4: 2049-2054 (1994) Article DOI: 10.1016/S0960-894X(01)80561-8 BindingDB Entry DOI: 10.7270/Q2MK6CV3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50160808![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50160810![]() ((S)-4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50132693![]() (4-Amino-N-(1-benzyl-piperidin-4-yl)-5-chloro-2-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 11.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50005836![]() (4-Amino-5-chloro-N-{1-[3-(4-fluoro-phenoxy)-propyl...) | UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50160809![]() ((R)-4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 14.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50160810![]() ((S)-4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peripheral-Type Benzodiazepine Receptor (Rattus norvegicus (rat)) | BDBM50144887![]() (CHEMBL443526 | Toluene-4-sulfonic acid 2-(2-{[acet...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 18.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Radiological Sciences Curated by ChEMBL | Assay Description In vitro inhibition of [11C]2 binding to Peripheral benzodiazepine receptor (PBR) in rat brain | J Med Chem 47: 2228-35 (2004) Article DOI: 10.1021/jm0304919 BindingDB Entry DOI: 10.7270/Q20G3KXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50160806![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity against recombinant human 5-hydroxytryptamine 2A receptor in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50005833![]() ((exo)4-Amino-5-chloro-N-(hexahydro-pyrrolizin-1-yl...) | UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50160806![]() (4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 21.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description In vitro binding affinity of the compound against recombinant human dopamine receptor D2L in human liver microsomes | Bioorg Med Chem Lett 15: 1055-9 (2005) Article DOI: 10.1016/j.bmcl.2004.12.028 BindingDB Entry DOI: 10.7270/Q2Z60NKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50123801![]() (4-Amino-N-[2-(benzyl-methyl-amino)-ethyl]-5-chloro...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 24.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
HTR4 (GUINEA PIG) | BDBM50280258![]() (4-Amino-N-(S)-1-aza-bicyclo[3.3.1]non-4-yl-5-chlor...) | UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 40.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM82519![]() (4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicycl...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | 41.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair |
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