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Compile Data Set for Download or QSAR

Found 66 hits with Last Name = 'tatsumi' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190686
PNG
((R)-3'-(2,3-dimethylbenzo[b]thiophen-5-yl)spiro[1-...)
Show SMILES Cc1oc2ccc(cc2c1C)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C19H22N2O3/c1-12-13(2)23-17-4-3-15(9-16(12)17)21-11-19(24-18(21)22)10-20-7-5-14(19)6-8-20/h3-4,9,14H,5-8,10-11H2,1-2H3/t19-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164606
PNG
((2R)-3'-(5-bromothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES Brc1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C13H15BrN2O2S/c14-10-1-2-11(19-10)16-8-13(18-12(16)17)7-15-5-3-9(13)4-6-15/h1-2,9H,3-8H2/t13-/m1/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190696
PNG
((2S)-3'-(5-bromothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES Brc1ccc(s1)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C13H15BrN2O2S/c14-10-1-2-11(19-10)16-8-13(18-12(16)17)7-15-5-3-9(13)4-6-15/h1-2,9H,3-8H2/t13-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190677
PNG
((R)-3'-(3-bromobenzo[b]thiophen-5-yl)spiro[1-azabi...)
Show SMILES Brc1coc2ccc(cc12)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C17H17BrN2O3/c18-14-8-22-15-2-1-12(7-13(14)15)20-10-17(23-16(20)21)9-19-5-3-11(17)4-6-19/h1-2,7-8,11H,3-6,9-10H2/t17-/m0/s1
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4n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164618
PNG
((2R)-3'-(5-chlorothien-2-yl)-2'H-spiro[4-azabicycl...)
Show SMILES Clc1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C13H15ClN2O2S/c14-10-1-2-11(19-10)16-8-13(18-12(16)17)7-15-5-3-9(13)4-6-15/h1-2,9H,3-8H2/t13-/m1/s1
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9n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164607
PNG
((2R)-3'-(5-methylthien-2-yl)-2'H-spiro[4-azabicycl...)
Show SMILES Cc1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C14H18N2O2S/c1-10-2-3-12(19-10)16-9-14(18-13(16)17)8-15-6-4-11(14)5-7-15/h2-3,11H,4-9H2,1H3/t14-/m1/s1
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12n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149146
PNG
((S)-3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo...)
Show SMILES C(O[C@@H]1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1S/C16H19NOS/c1-2-4-16-13(3-1)9-14(19-16)11-18-15-10-17-7-5-12(15)6-8-17/h1-4,9,12,15H,5-8,10-11H2/t15-/m1/s1
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13n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164611
PNG
((2R)-3'-(5-ethylthien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES CCc1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C15H20N2O2S/c1-2-12-3-4-13(20-12)17-10-15(19-14(17)18)9-16-7-5-11(15)6-8-16/h3-4,11H,2,5-10H2,1H3/t15-/m1/s1
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21n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164621
PNG
((2R)-3'-(2-naphthyl)-2'H-spiro[4-azabicyclo[2.2.2]...)
Show SMILES O=C1O[C@@]2(CN1c1ccc3ccccc3c1)CN1CCC2CC1
Show InChI InChI=1S/C19H20N2O2/c22-18-21(17-6-5-14-3-1-2-4-15(14)11-17)13-19(23-18)12-20-9-7-16(19)8-10-20/h1-6,11,16H,7-10,12-13H2/t19-/m1/s1
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31n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164627
PNG
((2R)-3'-(5-isopropylthien-2-yl)-2'H-spiro[4-azabic...)
Show SMILES CC(C)c1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C16H22N2O2S/c1-11(2)13-3-4-14(21-13)18-10-16(20-15(18)19)9-17-7-5-12(16)6-8-17/h3-4,11-12H,5-10H2,1-2H3/t16-/m1/s1
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65n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149147
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophe...)
Show SMILES O=C(CC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C17H19NOS/c19-15(9-14-11-18-7-5-12(14)6-8-18)17-10-13-3-1-2-4-16(13)20-17/h1-4,10,12,14H,5-9,11H2
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65n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164622
PNG
((2R)-3'-(1-benzothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES O=C1O[C@@]2(CN1c1cc3ccccc3s1)CN1CCC2CC1
Show InChI InChI=1S/C17H18N2O2S/c20-16-19(15-9-12-3-1-2-4-14(12)22-15)11-17(21-16)10-18-7-5-13(17)6-8-18/h1-4,9,13H,5-8,10-11H2/t17-/m1/s1
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75n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164612
PNG
((2R)-3'-thien-2-yl-2'H-spiro[4-azabicyclo[2.2.2]oc...)
Show SMILES O=C1O[C@@]2(CN1c1cccs1)CN1CCC2CC1
Show InChI InChI=1S/C13H16N2O2S/c16-12-15(11-2-1-7-18-11)9-13(17-12)8-14-5-3-10(13)4-6-14/h1-2,7,10H,3-6,8-9H2/t13-/m1/s1
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80n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164619
PNG
(5-[(2R)-2'-oxo-3'H-spiro[4-azabicyclo[2.2.2]octane...)
Show SMILES O=C1O[C@@]2(CN1c1ccc(s1)C#N)CN1CCC2CC1
Show InChI InChI=1S/C14H15N3O2S/c15-7-11-1-2-12(20-11)17-9-14(19-13(17)18)8-16-5-3-10(14)4-6-16/h1-2,10H,3-6,8-9H2/t14-/m1/s1
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85n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164628
PNG
((2R)-3'-[5-(1-hydroxyethyl)thien-2-yl]-2'H-spiro[4...)
Show SMILES CC(O)c1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C15H20N2O3S/c1-10(18)12-2-3-13(21-12)17-9-15(20-14(17)19)8-16-6-4-11(15)5-7-16/h2-3,10-11,18H,4-9H2,1H3/t10?,15-/m1/s1
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145n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164614
PNG
((2R)-3'-(5-acetylthien-2-yl)-2'H-spiro[4-azabicycl...)
Show SMILES CC(=O)c1ccc(s1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C15H18N2O3S/c1-10(18)12-2-3-13(21-12)17-9-15(20-14(17)19)8-16-6-4-11(15)5-7-16/h2-3,11H,4-9H2,1H3/t15-/m1/s1
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190n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190687
PNG
((R)-3'-(indan-5-yl)spiro[-1-azabicyclo[2.2.2]octan...)
Show SMILES O=C1O[C@]2(CN1c1ccc3CCCc3c1)CN1CCC2CC1
Show InChI InChI=1S/C18H22N2O2/c21-17-20(16-5-4-13-2-1-3-14(13)10-16)12-18(22-17)11-19-8-6-15(18)7-9-19/h4-5,10,15H,1-3,6-9,11-12H2/t18-/m0/s1
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200n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164608
PNG
((2S)-3'-(2-naphthyl)-2'H-spiro[4-azabicyclo[2.2.2]...)
Show SMILES O=C1O[C@]2(CN1c1ccc3ccccc3c1)CN1CCC2CC1
Show InChI InChI=1S/C19H20N2O2/c22-18-21(17-6-5-14-3-1-2-4-15(14)11-17)13-19(23-18)12-20-9-7-16(19)8-10-20/h1-6,11,16H,7-10,12-13H2/t19-/m0/s1
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205n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50061564
PNG
((3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-...)
Show SMILES COc1ccc(\C=C2/CCCN=C2c2cccnc2)c(OC)c1
Show InChI InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
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220n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50093255
PNG
((+)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidi...)
Show SMILES O=C1NCC2(CN3CCC2CC3)O1
Show InChI InChI=1/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)
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340n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164629
PNG
((2R)-3'-(1-benzofuran-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES O=C1O[C@@]2(CN1c1cc3ccccc3o1)CN1CCC2CC1
Show InChI InChI=1S/C17H18N2O3/c20-16-19(15-9-12-3-1-2-4-14(12)21-15)11-17(22-16)10-18-7-5-13(17)6-8-18/h1-4,9,13H,5-8,10-11H2/t17-/m1/s1
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370n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164615
PNG
((2R)-3'-(1,3-benzothiazol-2-yl)-2'H-spiro[4-azabic...)
Show SMILES O=C1O[C@@]2(CN1c1nc3ccccc3s1)CN1CCC2CC1
Show InChI InChI=1S/C16H17N3O2S/c20-15-19(14-17-12-3-1-2-4-13(12)22-14)10-16(21-15)9-18-7-5-11(16)6-8-18/h1-4,11H,5-10H2/t16-/m1/s1
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430n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164624
PNG
((2R)-3'-quinolin-2-yl-2'H-spiro[4-azabicyclo[2.2.2...)
Show SMILES O=C1O[C@@]2(CN1c1ccc3ccccc3n1)CN1CCC2CC1
Show InChI InChI=1S/C18H19N3O2/c22-17-21(16-6-5-13-3-1-2-4-15(13)19-16)12-18(23-17)11-20-9-7-14(18)8-10-20/h1-6,14H,7-12H2/t18-/m1/s1
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450n/an/an/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149143
PNG
(3-(2-Benzo[b]thiophen-2-yl-ethyl)-1-aza-bicyclo[2....)
Show SMILES C(Cc1cc2ccccc2s1)C1CN2CCC1CC2
Show InChI InChI=1/C17H21NS/c1-2-4-17-14(3-1)11-16(19-17)6-5-15-12-18-9-7-13(15)8-10-18/h1-4,11,13,15H,5-10,12H2
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n/an/a 0.0230n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149146
PNG
((S)-3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo...)
Show SMILES C(O[C@@H]1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1S/C16H19NOS/c1-2-4-16-13(3-1)9-14(19-16)11-18-15-10-17-7-5-12(15)6-8-17/h1-4,9,12,15H,5-8,10-11H2/t15-/m1/s1
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n/an/a 0.0260n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149145
PNG
(3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo[2.2...)
Show SMILES C(OC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C16H19NOS/c1-2-4-16-13(3-1)9-14(19-16)11-18-15-10-17-7-5-12(15)6-8-17/h1-4,9,12,15H,5-8,10-11H2
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n/an/a 0.0590n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149143
PNG
(3-(2-Benzo[b]thiophen-2-yl-ethyl)-1-aza-bicyclo[2....)
Show SMILES C(Cc1cc2ccccc2s1)C1CN2CCC1CC2
Show InChI InChI=1/C17H21NS/c1-2-4-17-14(3-1)11-16(19-17)6-5-15-12-18-9-7-13(15)8-10-18/h1-4,11,13,15H,5-10,12H2
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n/an/a 0.0650n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149148
PNG
(3-Benzo[b]thiophen-2-ylmethyl-1-aza-bicyclo[2.2.2]...)
Show SMILES C(C1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C16H19NS/c1-2-4-16-13(3-1)9-15(18-16)10-14-11-17-7-5-12(14)6-8-17/h1-4,9,12,14H,5-8,10-11H2
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n/an/a 0.110n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149147
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophe...)
Show SMILES O=C(CC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C17H19NOS/c19-15(9-14-11-18-7-5-12(14)6-8-18)17-10-13-3-1-2-4-16(13)20-17/h1-4,10,12,14H,5-9,11H2
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n/an/a 0.130n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149140
PNG
(3-(Naphthalen-2-ylmethoxy)-1-aza-bicyclo[2.2.2]oct...)
Show SMILES C(OC1CN2CCC1CC2)c1ccc2ccccc2c1
Show InChI InChI=1/C18H21NO/c1-2-4-17-11-14(5-6-15(17)3-1)13-20-18-12-19-9-7-16(18)8-10-19/h1-6,11,16,18H,7-10,12-13H2
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n/an/a 0.150n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Binding affinities of the compound for the alpha 7 nicotinic acetylcholine receptor was determined in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149147
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophe...)
Show SMILES O=C(CC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C17H19NOS/c19-15(9-14-11-18-7-5-12(14)6-8-18)17-10-13-3-1-2-4-16(13)20-17/h1-4,10,12,14H,5-9,11H2
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n/an/a 0.150n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149147
PNG
(2-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophe...)
Show SMILES O=C(CC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C17H19NOS/c19-15(9-14-11-18-7-5-12(14)6-8-18)17-10-13-3-1-2-4-16(13)20-17/h1-4,10,12,14H,5-9,11H2
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n/an/a 0.170n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149143
PNG
(3-(2-Benzo[b]thiophen-2-yl-ethyl)-1-aza-bicyclo[2....)
Show SMILES C(Cc1cc2ccccc2s1)C1CN2CCC1CC2
Show InChI InChI=1/C17H21NS/c1-2-4-17-14(3-1)11-16(19-17)6-5-15-12-18-9-7-13(15)8-10-18/h1-4,11,13,15H,5-10,12H2
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n/an/a 0.220n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149151
PNG
(3-(3-Benzo[b]thiophen-2-yl-propyl)-1-aza-bicyclo[2...)
Show SMILES C(CC1CN2CCC1CC2)Cc1cc2ccccc2s1
Show InChI InChI=1/C18H23NS/c1-2-7-18-15(4-1)12-17(20-18)6-3-5-16-13-19-10-8-14(16)9-11-19/h1-2,4,7,12,14,16H,3,5-6,8-11,13H2
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n/an/a 0.370n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149138
PNG
((R)-3-(Benzo[b]thiophen-2-ylmethoxy)-1-aza-bicyclo...)
Show SMILES C(O[C@H]1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1S/C16H19NOS/c1-2-4-16-13(3-1)9-14(19-16)11-18-15-10-17-7-5-12(15)6-8-17/h1-4,9,12,15H,5-8,10-11H2/t15-/m0/s1
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n/an/a 0.515n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149149
PNG
(3-(Naphthalen-1-ylmethoxy)-1-aza-bicyclo[2.2.2]oct...)
Show SMILES C(OC1CN2CCC1CC2)c1cccc2ccccc12
Show InChI InChI=1/C18H21NO/c1-2-7-17-14(4-1)5-3-6-16(17)13-20-18-12-19-10-8-15(18)9-11-19/h1-7,15,18H,8-13H2
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n/an/a 0.730n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Binding affinities of the compound for the alpha 7 nicotinic acetylcholine receptor was determined in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149150
PNG
(3-(2,4-Dimethoxy-benzyl)-[2,3']bipyridinyl | CHEMB...)
Show SMILES COc1ccc(Cc2cccnc2-c2cccnc2)c(OC)c1
Show InChI InChI=1S/C19H18N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3-10,12-13H,11H2,1-2H3
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n/an/a 0.760n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149142
PNG
((1-Aza-bicyclo[2.2.2]oct-3-yl)-benzo[b]thiophen-2-...)
Show SMILES O=C(C1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C16H17NOS/c18-16(13-10-17-7-5-11(13)6-8-17)15-9-12-3-1-2-4-14(12)19-15/h1-4,9,11,13H,5-8,10H2
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n/an/a 0.950n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149144
PNG
(3-(1-Aza-bicyclo[2.2.2]oct-3-yl)-1-benzo[b]thiophe...)
Show SMILES O=C(CCC1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C18H21NOS/c20-16(18-11-14-3-1-2-4-17(14)21-18)6-5-15-12-19-9-7-13(15)8-10-19/h1-4,11,13,15H,5-10,12H2
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n/an/a 1.70n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149139
PNG
(Benzoclidine | Benzoic acid 1-aza-bicyclo[2.2.2]oc...)
Show SMILES O=C(OC1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1/C14H17NO2/c16-14(12-4-2-1-3-5-12)17-13-10-15-8-6-11(13)7-9-15/h1-5,11,13H,6-10H2
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n/an/a 2.60n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50149141
PNG
(3-Benzyloxy-1-aza-bicyclo[2.2.2]octane | CHEMBL122...)
Show SMILES C(OC1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1/C14H19NO/c1-2-4-12(5-3-1)11-16-14-10-15-8-6-13(14)7-9-15/h1-5,13-14H,6-11H2
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n/an/a 3.70n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Binding affinities of the compound for the alpha 7 nicotinic acetylcholine receptor was determined in PC12 cells


Bioorg Med Chem Lett 14: 3781-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.04.091
BindingDB Entry DOI: 10.7270/Q2X066G1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164609
PNG
(3'-phenyl-2'H-spiro[4-azabicyclo[2.2.2]octane-2,5'...)
Show SMILES O=C1OC2(CN1c1ccccc1)CN1CCC2CC1
Show InChI InChI=1/C15H18N2O2/c18-14-17(13-4-2-1-3-5-13)11-15(19-14)10-16-8-6-12(15)7-9-16/h1-5,12H,6-11H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164610
PNG
((2S)-3'-(1-benzothien-2-yl)-2'H-spiro[4-azabicyclo...)
Show SMILES O=C1O[C@]2(CN1c1cc3ccccc3s1)CN1CCC2CC1
Show InChI InChI=1S/C17H18N2O2S/c20-16-19(15-9-12-3-1-2-4-14(12)22-15)11-17(21-16)10-18-7-5-13(17)6-8-18/h1-4,9,13H,5-8,10-11H2/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164616
PNG
((2R)-3'-(1,3-benzoxazol-2-yl)-2'H-spiro[4-azabicyc...)
Show SMILES O=C1O[C@@]2(CN1c1nc3ccccc3o1)CN1CCC2CC1
Show InChI InChI=1S/C16H17N3O3/c20-15-19(14-17-12-3-1-2-4-13(12)21-14)10-16(22-15)9-18-7-5-11(16)6-8-18/h1-4,11H,5-10H2/t16-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164617
PNG
((2R)-3'-pyridin-2-yl-2'H-spiro[4-azabicyclo[2.2.2]...)
Show SMILES O=C1O[C@@]2(CN1c1ccccn1)CN1CCC2CC1
Show InChI InChI=1S/C14H17N3O2/c18-13-17(12-3-1-2-6-15-12)10-14(19-13)9-16-7-4-11(14)5-8-16/h1-3,6,11H,4-5,7-10H2/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164620
PNG
((2R)-3'-(4-methylthien-2-yl)-2'H-spiro[4-azabicycl...)
Show SMILES Cc1csc(c1)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C14H18N2O2S/c1-10-6-12(19-7-10)16-9-14(18-13(16)17)8-15-4-2-11(14)3-5-15/h6-7,11H,2-5,8-9H2,1H3/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164623
PNG
((2R)-3'-(3-methylthien-2-yl)-2'H-spiro[4-azabicycl...)
Show SMILES Cc1ccsc1N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C14H18N2O2S/c1-10-4-7-19-12(10)16-9-14(18-13(16)17)8-15-5-2-11(14)3-6-15/h4,7,11H,2-3,5-6,8-9H2,1H3/t14-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164625
PNG
((2R)-3'-(4,5-dimethylthien-2-yl)-2'H-spiro[4-azabi...)
Show SMILES Cc1cc(sc1C)N1C[C@@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C15H20N2O2S/c1-10-7-13(20-11(10)2)17-9-15(19-14(17)18)8-16-5-3-12(15)4-6-16/h7,12H,3-6,8-9H2,1-2H3/t15-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50164626
PNG
((2R)-3'-thien-3-yl-2'H-spiro[4-azabicyclo[2.2.2]oc...)
Show SMILES O=C1O[C@@]2(CN1c1ccsc1)CN1CCC2CC1
Show InChI InChI=1S/C13H16N2O2S/c16-12-15(11-3-6-18-7-11)9-13(17-12)8-14-4-1-10(13)2-5-14/h3,6-7,10H,1-2,4-5,8-9H2/t13-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7


J Med Chem 48: 2678-86 (2005)


Article DOI: 10.1021/jm049188d
BindingDB Entry DOI: 10.7270/Q2M0466W
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM50190684
PNG
((R)-3'-(3-methyl-2-oxo-2,3-dihydro-1,3-benzothiazo...)
Show SMILES Cn1c2ccc(cc2sc1=O)N1C[C@]2(CN3CCC2CC3)OC1=O
Show InChI InChI=1S/C17H19N3O3S/c1-18-13-3-2-12(8-14(13)24-16(18)22)20-10-17(23-15(20)21)9-19-6-4-11(17)5-7-19/h2-3,8,11H,4-7,9-10H2,1H3/t17-/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mitsubishi Pharma Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]alpha-BTX from alpha-7 nAChR in rat hippocampus membrane


J Med Chem 49: 4374-83 (2006)


Article DOI: 10.1021/jm060249c
BindingDB Entry DOI: 10.7270/Q2BR8T08
More data for this
Ligand-Target Pair
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