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Compile Data Set for Download or QSAR

Found 822 hits with Last Name = 'termin' and Initial = 'ap'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113209
PNG
((1E)-N'-(2-chlorophenyl)-N-(3-ethynylphenyl)-2-oxo...)
Show SMILES CC(=O)C(Nc1cccc(c1)C#C)=NNc1ccccc1Cl
Show InChI InChI=1S/C17H14ClN3O/c1-3-13-7-6-8-14(11-13)19-17(12(2)22)21-20-16-10-5-4-9-15(16)18/h1,4-11,20H,2H3,(H,19,21)
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35n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113201
PNG
((1E)-N-(3-fluorophenyl)-N'-(2-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(F)c1)=NNc1ccccc1C
Show InChI InChI=1S/C16H16FN3O/c1-11-6-3-4-9-15(11)19-20-16(12(2)21)18-14-8-5-7-13(17)10-14/h3-10,19H,1-2H3,(H,18,20)
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43n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113189
PNG
((1E)-N'-(2-chlorophenyl)-N-(3-fluorophenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(F)c1)=NNc1ccccc1Cl
Show InChI InChI=1S/C15H13ClFN3O/c1-10(21)15(18-12-6-4-5-11(17)9-12)20-19-14-8-3-2-7-13(14)16/h2-9,19H,1H3,(H,18,20)
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43n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113184
PNG
((1E)-N-(3-chlorophenyl)-N'-(2-nitrophenyl)-2-oxopr...)
Show SMILES CC(=O)C([N-]c1cccc(Cl)c1)=[NH+]Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C15H12ClN4O3/c1-10(21)15(17-12-6-4-5-11(16)9-12)19-18-13-7-2-3-8-14(13)20(22)23/h2-9H,1H3,(H-,17,18,19,21)/q-1/p+1
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51n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113181
PNG
((1E)-N-(3-ethynylphenyl)-N'-(2-methylphenyl)-2-oxo...)
Show SMILES CC(=O)C(Nc1cccc(c1)C#C)=NNc1ccccc1C
Show InChI InChI=1S/C18H17N3O/c1-4-15-9-7-10-16(12-15)19-18(14(3)22)21-20-17-11-6-5-8-13(17)2/h1,5-12,20H,2-3H3,(H,19,21)
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62n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113188
PNG
((1E)-N-(3-ethynylphenyl)-2-oxo-N'-[2-(trifluoromet...)
Show SMILES CC(=O)C(Nc1cccc(c1)C#C)=NNc1ccccc1C(F)(F)F
Show InChI InChI=1S/C18H14F3N3O/c1-3-13-7-6-8-14(11-13)22-17(12(2)25)24-23-16-10-5-4-9-15(16)18(19,20)21/h1,4-11,23H,2H3,(H,22,24)
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66n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113206
PNG
((1E)-N'-(2-chlorophenyl)-N-(3-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(C)c1)=NNc1ccccc1Cl
Show InChI InChI=1S/C16H16ClN3O/c1-11-6-5-7-13(10-11)18-16(12(2)21)20-19-15-9-4-3-8-14(15)17/h3-10,19H,1-2H3,(H,18,20)
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115n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145742
PNG
((R)-1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-...)
Show SMILES Cc1ccccc1[C@@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-4-2-3-5-18(15)22(26-20-8-7-17(23)14-19(20)24)21(27)9-6-16-10-12-25-13-11-16/h2-5,7-8,10-14,22,26H,6,9H2,1H3/t22-/m1/s1
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154n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113208
PNG
((1E)-N-(3-fluorophenyl)-2-oxo-N'-[2-(trifluorometh...)
Show SMILES CC(=O)C(Nc1cccc(F)c1)=NNc1ccccc1C(F)(F)F
Show InChI InChI=1S/C16H13F4N3O/c1-10(24)15(21-12-6-4-5-11(17)9-12)23-22-14-8-3-2-7-13(14)16(18,19)20/h2-9,22H,1H3,(H,21,23)
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197n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145735
PNG
(1-(2-Bromo-phenyl)-1-(2,4-dichloro-phenylamino)-4-...)
Show SMILES Clc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1
Show InChI InChI=1S/C21H17BrCl2N2O/c22-17-4-2-1-3-16(17)21(26-19-7-6-15(23)13-18(19)24)20(27)8-5-14-9-11-25-12-10-14/h1-4,6-7,9-13,21,26H,5,8H2
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204n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113199
PNG
((1E)-N-(3-chlorophenyl)-N'-(2-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1C
Show InChI InChI=1S/C16H16ClN3O/c1-11-6-3-4-9-15(11)19-20-16(12(2)21)18-14-8-5-7-13(17)10-14/h3-10,19H,1-2H3,(H,18,20)
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216n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145751
PNG
((R)-1-(2-Chloro-4-methyl-phenylamino)-4-pyridin-4-...)
Show SMILES Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1
Show InChI InChI=1S/C23H23ClN2O/c1-16-7-9-21(20(24)15-16)26-23(19-6-4-3-5-17(19)2)22(27)10-8-18-11-13-25-14-12-18/h3-7,9,11-15,23,26H,8,10H2,1-2H3/t23-/m1/s1
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244n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113154
PNG
((1E)-N'-(2-methylphenyl)-2-oxo-N-[3-(trifluorometh...)
Show SMILES CC(=O)C(Nc1cccc(c1)C(F)(F)F)=NNc1ccccc1C
Show InChI InChI=1S/C17H16F3N3O/c1-11-6-3-4-9-15(11)22-23-16(12(2)24)21-14-8-5-7-13(10-14)17(18,19)20/h3-10,22H,1-2H3,(H,21,23)
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291n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113190
PNG
((1E)-N'-(2-chlorophenyl)-2-oxo-N-phenylpropanehydr...)
Show SMILES CC(=O)C(Nc1ccccc1)=NNc1ccccc1Cl
Show InChI InChI=1S/C15H14ClN3O/c1-11(20)15(17-12-7-3-2-4-8-12)19-18-14-10-6-5-9-13(14)16/h2-10,18H,1H3,(H,17,19)
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299n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145754
PNG
(1-(2,4-Dichloro-phenylamino)-1-(2-ethyl-phenyl)-4-...)
Show SMILES CCc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C23H22Cl2N2O/c1-2-17-5-3-4-6-19(17)23(27-21-9-8-18(24)15-20(21)25)22(28)10-7-16-11-13-26-14-12-16/h3-6,8-9,11-15,23,27H,2,7,10H2,1H3
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330n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145731
PNG
(1-(2,4-Dichloro-phenylamino)-1-(2,6-dimethyl-pheny...)
Show SMILES Cc1cccc(C)c1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C23H22Cl2N2O/c1-15-4-3-5-16(2)22(15)23(27-20-8-7-18(24)14-19(20)25)21(28)9-6-17-10-12-26-13-11-17/h3-5,7-8,10-14,23,27H,6,9H2,1-2H3
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338n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145749
PNG
(1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-o-to...)
Show SMILES Cc1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-4-2-3-5-18(15)22(26-20-8-7-17(23)14-19(20)24)21(27)9-6-16-10-12-25-13-11-16/h2-5,7-8,10-14,22,26H,6,9H2,1H3
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370n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145732
PNG
(2-(2,4-Dichloro-phenylamino)-1-(3-hydroxy-4-methox...)
Show SMILES COc1ccc(cc1O)C(=O)C(Nc1ccc(Cl)cc1Cl)c1ccccc1C
Show InChI InChI=1S/C22H19Cl2NO3/c1-13-5-3-4-6-16(13)21(25-18-9-8-15(23)12-17(18)24)22(27)14-7-10-20(28-2)19(26)11-14/h3-12,21,25-26H,1-2H3
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387n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113162
PNG
((1E)-N-(3-chlorophenyl)-N'-(2-cyanophenyl)-2-oxopr...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1C#N
Show InChI InChI=1S/C16H13ClN4O/c1-11(22)16(19-14-7-4-6-13(17)9-14)21-20-15-8-3-2-5-12(15)10-18/h2-9,20H,1H3,(H,19,21)
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415n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113159
PNG
((1E)-N'-(2-chlorophenyl)-N-(3-chlorophenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1Cl
Show InChI InChI=1S/C15H13Cl2N3O/c1-10(21)15(18-12-6-4-5-11(16)9-12)20-19-14-8-3-2-7-13(14)17/h2-9,19H,1H3,(H,18,20)
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417n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145745
PNG
(1-(2-Fluoro-4-methyl-phenylamino)-4-pyridin-4-yl-1...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(F)c1
Show InChI InChI=1S/C23H23FN2O/c1-16-7-9-21(20(24)15-16)26-23(19-6-4-3-5-17(19)2)22(27)10-8-18-11-13-25-14-12-18/h3-7,9,11-15,23,26H,8,10H2,1-2H3
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439n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145758
PNG
(1-(4-Chloro-2-trifluoromethyl-phenylamino)-4-pyrid...)
Show SMILES Cc1ccccc1C(Nc1ccc(Cl)cc1C(F)(F)F)C(=O)CCc1ccncc1
Show InChI InChI=1S/C23H20ClF3N2O/c1-15-4-2-3-5-18(15)22(21(30)9-6-16-10-12-28-13-11-16)29-20-8-7-17(24)14-19(20)23(25,26)27/h2-5,7-8,10-14,22,29H,6,9H2,1H3
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469n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145733
PNG
(1-(2,4-Dichloro-phenylamino)-1-(4-fluoro-2-methyl-...)
Show SMILES Cc1cc(F)ccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C22H19Cl2FN2O/c1-14-12-17(25)4-5-18(14)22(27-20-6-3-16(23)13-19(20)24)21(28)7-2-15-8-10-26-11-9-15/h3-6,8-13,22,27H,2,7H2,1H3
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512n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145739
PNG
(CHEMBL81912 | N-{3-[2-(2-Bromo-phenyl)-2-(2,4-dich...)
Show SMILES CC(=O)Nc1cccc(c1)C(=O)C(Nc1ccc(Cl)cc1Cl)c1ccccc1Br
Show InChI InChI=1S/C22H17BrCl2N2O2/c1-13(28)26-16-6-4-5-14(11-16)22(29)21(17-7-2-3-8-18(17)23)27-20-10-9-15(24)12-19(20)25/h2-12,21,27H,1H3,(H,26,28)
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514n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113153
PNG
((1E)-N'-(2-methylphenyl)-N-(3-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(C)c1)=NNc1ccccc1C
Show InChI InChI=1S/C17H19N3O/c1-12-7-6-9-15(11-12)18-17(14(3)21)20-19-16-10-5-4-8-13(16)2/h4-11,19H,1-3H3,(H,18,20)
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526n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113155
PNG
((1E)-N'-(2-methylphenyl)-2-oxo-N-phenylpropanehydr...)
Show SMILES CC(=O)C(Nc1ccccc1)=NNc1ccccc1C
Show InChI InChI=1S/C16H17N3O/c1-12-8-6-7-11-15(12)18-19-16(13(2)20)17-14-9-4-3-5-10-14/h3-11,18H,1-2H3,(H,17,19)
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526n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113203
PNG
((1E)-N-(3-chlorophenyl)-2-oxo-N'-[2-(trifluorometh...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1C(F)(F)F
Show InChI InChI=1S/C16H13ClF3N3O/c1-10(24)15(21-12-6-4-5-11(17)9-12)23-22-14-8-3-2-7-13(14)16(18,19)20/h2-9,22H,1H3,(H,21,23)
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538n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145741
PNG
((R)-1-(2-Bromo-phenyl)-1-(2-chloro-4-methyl-phenyl...)
Show SMILES Cc1ccc(N[C@@H](C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1
Show InChI InChI=1S/C22H20BrClN2O/c1-15-6-8-20(19(24)14-15)26-22(17-4-2-3-5-18(17)23)21(27)9-7-16-10-12-25-13-11-16/h2-6,8,10-14,22,26H,7,9H2,1H3/t22-/m1/s1
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546n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of compound towards human corticotropin releasing factor (h-CRF1) receptor showed a 2-fold activity in racemic mixture


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145755
PNG
(1-(4-Methyl-2-trifluoromethyl-phenylamino)-4-pyrid...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2O/c1-16-7-9-21(20(15-16)24(25,26)27)29-23(19-6-4-3-5-17(19)2)22(30)10-8-18-11-13-28-14-12-18/h3-7,9,11-15,23,29H,8,10H2,1-2H3
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641n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113205
PNG
(3-methylphenyl (1E)-N-(2-cyanophenyl)-2-oxopropane...)
Show SMILES CC(=O)C(Oc1cccc(C)c1)=NNc1ccccc1C#N
Show InChI InChI=1S/C17H15N3O2/c1-12-6-5-8-15(10-12)22-17(13(2)21)20-19-16-9-4-3-7-14(16)11-18/h3-10,19H,1-2H3
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650n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113210
PNG
((1E)-N'-(2-chlorophenyl)-N-(3-methoxyphenyl)-2-oxo...)
Show SMILES COc1cccc(NC(=NNc2ccccc2Cl)C(C)=O)c1
Show InChI InChI=1S/C16H16ClN3O2/c1-11(21)16(18-12-6-5-7-13(10-12)22-2)20-19-15-9-4-3-8-14(15)17/h3-10,19H,1-2H3,(H,18,20)
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652n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145740
PNG
(1-(2-Chloro-4-methyl-phenylamino)-4-pyridin-4-yl-1...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C=C)c(Cl)c1
Show InChI InChI=1S/C24H23ClN2O/c1-3-19-6-4-5-7-20(19)24(27-22-10-8-17(2)16-21(22)25)23(28)11-9-18-12-14-26-15-13-18/h3-8,10,12-16,24,27H,1,9,11H2,2H3
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752n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145729
PNG
(1-(2-Chloro-4-methyl-phenylamino)-4-pyridin-4-yl-1...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2C)c(Cl)c1
Show InChI InChI=1S/C23H23ClN2O/c1-16-7-9-21(20(24)15-16)26-23(19-6-4-3-5-17(19)2)22(27)10-8-18-11-13-25-14-12-18/h3-7,9,11-15,23,26H,8,10H2,1-2H3
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922n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145759
PNG
(1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-(2-t...)
Show SMILES FC(F)(F)c1ccccc1C(Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C22H17Cl2F3N2O/c23-15-6-7-19(18(24)13-15)29-21(16-3-1-2-4-17(16)22(25,26)27)20(30)8-5-14-9-11-28-12-10-14/h1-4,6-7,9-13,21,29H,5,8H2
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1.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145730
PNG
(1-(2-Bromo-phenyl)-1-(2-chloro-4-methyl-phenylamin...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Br)c(Cl)c1
Show InChI InChI=1S/C22H20BrClN2O/c1-15-6-8-20(19(24)14-15)26-22(17-4-2-3-5-18(17)23)21(27)9-7-16-10-12-25-13-11-16/h2-6,8,10-14,22,26H,7,9H2,1H3
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1.04E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of compound towards human Corticotropin releasing factor receptor 1


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145737
PNG
(2-(2-Bromo-phenyl)-2-(2-chloro-4-methyl-phenylamin...)
Show SMILES COc1ccc(cc1O)C(=O)C(Nc1ccc(C)cc1Cl)c1ccccc1Br
Show InChI InChI=1S/C22H19BrClNO3/c1-13-7-9-18(17(24)11-13)25-21(15-5-3-4-6-16(15)23)22(27)14-8-10-20(28-2)19(26)12-14/h3-12,21,25-26H,1-2H3
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1.07E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145764
PNG
(3-[2-(2-Bromo-phenyl)-2-(2-chloro-4-methyl-phenyla...)
Show SMILES CNC(=O)c1cccc(c1)C(=O)C(Nc1ccc(C)cc1Cl)c1ccccc1Br
Show InChI InChI=1S/C23H20BrClN2O2/c1-14-10-11-20(19(25)12-14)27-21(17-8-3-4-9-18(17)24)22(28)15-6-5-7-16(13-15)23(29)26-2/h3-13,21,27H,1-2H3,(H,26,29)
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1.08E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113168
PNG
((1E)-N'-(2-cyanophenyl)-2-oxo-N-phenylpropanehydra...)
Show SMILES CC(=O)C(Nc1ccccc1)=NNc1ccccc1C#N
Show InChI InChI=1S/C16H14N4O/c1-12(21)16(18-14-8-3-2-4-9-14)20-19-15-10-6-5-7-13(15)11-17/h2-10,19H,1H3,(H,18,20)
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1.08E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113200
PNG
((1E)-N-(3-methoxyphenyl)-N'-(2-methylphenyl)-2-oxo...)
Show SMILES COc1cccc(NC(=NNc2ccccc2C)C(C)=O)c1
Show InChI InChI=1S/C17H19N3O2/c1-12-7-4-5-10-16(12)19-20-17(13(2)21)18-14-8-6-9-15(11-14)22-3/h4-11,19H,1-3H3,(H,18,20)
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1.40E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113180
PNG
((1E)-N-(3-methylphenyl)-2-oxo-N'-[2-(trifluorometh...)
Show SMILES CC(=O)C(Nc1cccc(C)c1)=NNc1ccccc1C(F)(F)F
Show InChI InChI=1S/C17H16F3N3O/c1-11-6-5-7-13(10-11)21-16(12(2)24)23-22-15-9-4-3-8-14(15)17(18,19)20/h3-10,22H,1-2H3,(H,21,23)
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1.42E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113150
PNG
((1E)-N'-(4-bromophenyl)-N-(3-chlorophenyl)-2-oxopr...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccc(Br)cc1
Show InChI InChI=1S/C15H13BrClN3O/c1-10(21)15(18-14-4-2-3-12(17)9-14)20-19-13-7-5-11(16)6-8-13/h2-9,19H,1H3,(H,18,20)
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1.46E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113152
PNG
((1E)-N-(4-chlorophenyl)-N'-(2-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1ccc(Cl)cc1)=NNc1ccccc1C
Show InChI InChI=1S/C16H16ClN3O/c1-11-5-3-4-6-15(11)19-20-16(12(2)21)18-14-9-7-13(17)8-10-14/h3-10,19H,1-2H3,(H,18,20)
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1.83E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113166
PNG
(4-chlorophenyl (1E)-N-(2-cyanophenyl)-2-oxopropane...)
Show SMILES CC(=O)C(Oc1ccc(Cl)cc1)=NNc1ccccc1C#N
Show InChI InChI=1S/C16H12ClN3O2/c1-11(21)16(22-14-8-6-13(17)7-9-14)20-19-15-5-3-2-4-12(15)10-18/h2-9,19H,1H3
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2.21E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113174
PNG
((1E)-2-oxo-N-phenyl-N'-[2-(trifluoromethyl)phenyl]...)
Show SMILES CC(=O)C(Nc1ccccc1)=NNc1ccccc1C(F)(F)F
Show InChI InChI=1S/C16H14F3N3O/c1-11(23)15(20-12-7-3-2-4-8-12)22-21-14-10-6-5-9-13(14)16(17,18)19/h2-10,21H,1H3,(H,20,22)
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2.26E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113172
PNG
((1E)-N-(3-chlorophenyl)-N'-(4-methylphenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccc(C)cc1
Show InChI InChI=1S/C16H16ClN3O/c1-11-6-8-14(9-7-11)19-20-16(12(2)21)18-15-5-3-4-13(17)10-15/h3-10,19H,1-2H3,(H,18,20)
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2.29E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113163
PNG
((1E)-N-(3-chlorophenyl)-2-oxo-N'-phenylpropanehydr...)
Show SMILES CC(=O)C(Nc1cccc(Cl)c1)=NNc1ccccc1
Show InChI InChI=1S/C15H14ClN3O/c1-11(20)15(17-14-9-5-6-12(16)10-14)19-18-13-7-3-2-4-8-13/h2-10,18H,1H3,(H,17,19)
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2.72E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145761
PNG
((S)-1-(2,4-Dichloro-phenylamino)-4-pyridin-4-yl-1-...)
Show SMILES Cc1ccccc1[C@H](Nc1ccc(Cl)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-4-2-3-5-18(15)22(26-20-8-7-17(23)14-19(20)24)21(27)9-6-16-10-12-25-13-11-16/h2-5,7-8,10-14,22,26H,6,9H2,1H3/t22-/m0/s1
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3.18E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145728
PNG
(1-(2-Chloro-4-methyl-phenylamino)-1-(2-isopropyl-p...)
Show SMILES CC(C)c1ccccc1C(Nc1ccc(C)cc1Cl)C(=O)CCc1ccncc1
Show InChI InChI=1S/C25H27ClN2O/c1-17(2)20-6-4-5-7-21(20)25(28-23-10-8-18(3)16-22(23)26)24(29)11-9-19-12-14-27-15-13-19/h4-8,10,12-17,25,28H,9,11H2,1-3H3
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3.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards human corticotropin releasing factor (h-CRF1) receptor


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50145752
PNG
(1-(2-Chloro-4-methyl-phenylamino)-1-(2-chloro-phen...)
Show SMILES Cc1ccc(NC(C(=O)CCc2ccncc2)c2ccccc2Cl)c(Cl)c1
Show InChI InChI=1S/C22H20Cl2N2O/c1-15-6-8-20(19(24)14-15)26-22(17-4-2-3-5-18(17)23)21(27)9-7-16-10-12-25-13-11-16/h2-6,8,10-14,22,26H,7,9H2,1H3
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3.35E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Pharma Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of compound towards human Corticotropin releasing factor receptor 1


J Med Chem 47: 2426-9 (2004)


Article DOI: 10.1021/jm049974i
BindingDB Entry DOI: 10.7270/Q2PZ5888
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50113171
PNG
((1E)-N'-(2-chlorophenyl)-N-(4-chlorophenyl)-2-oxop...)
Show SMILES CC(=O)C(Nc1ccc(Cl)cc1)=NNc1ccccc1Cl
Show InChI InChI=1S/C15H13Cl2N3O/c1-10(21)15(18-12-8-6-11(16)7-9-12)20-19-14-5-3-2-4-13(14)17/h2-9,19H,1H3,(H,18,20)
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3.87E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity against human Corticotropin releasing factor receptor 1


J Med Chem 45: 2123-6 (2002)


Article DOI: 10.1021/jm025512y
BindingDB Entry DOI: 10.7270/Q2ZS2VT3
More data for this
Ligand-Target Pair
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