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Compile Data Set for Download or QSAR

Found 188 hits with Last Name = 'wadsworth' and Initial = 'hj'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253021
PNG
(US9481685, 4)
Show SMILES CCN(CC)C(=O)C1Sc2c(F)cccc2-c2c1c1ccccc1n2CCF
Show InChI InChI=1/C22H22F2N2OS/c1-3-25(4-2)22(27)21-18-14-8-5-6-11-17(14)26(13-12-23)19(18)15-9-7-10-16(24)20(15)28-21/h5-11,21H,3-4,12-13H2,1-2H3
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US Patent
0.310n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253022
PNG
(US9481685, 5)
Show SMILES CCN(CC)C(=O)C1Sc2cc(F)ccc2-c2c1c1ccccc1n2CCF
Show InChI InChI=1/C22H22F2N2OS/c1-3-25(4-2)22(27)21-19-15-7-5-6-8-17(15)26(12-11-23)20(19)16-10-9-14(24)13-18(16)28-21/h5-10,13,21H,3-4,11-12H2,1-2H3
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US Patent
0.320n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253019
PNG
(US9481685, 1)
Show SMILES CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1cc(OC)ccc1n2CCF
Show InChI InChI=1/C23H25FN2O2S/c1-4-25(5-2)23(27)22-20-17-14-15(28-3)10-11-18(17)26(13-12-24)21(20)16-8-6-7-9-19(16)29-22/h6-11,14,22H,4-5,12-13H2,1-3H3
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US Patent
0.370n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253024
PNG
(US9481685, 2)
Show SMILES CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccc(OC)cc1n2CCF
Show InChI InChI=1/C23H25FN2O2S/c1-4-25(5-2)23(27)22-20-16-11-10-15(28-3)14-18(16)26(13-12-24)21(20)17-8-6-7-9-19(17)29-22/h6-11,14,22H,4-5,12-13H2,1-3H3
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US Patent
0.400n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253023
PNG
(US9481685, 6)
Show SMILES CCOc1ccc2n(CCF)c-3c(C(Sc4ccccc-34)C(=O)N(CC)CC)c2c1
Show InChI InChI=1/C24H27FN2O2S/c1-4-26(5-2)24(28)23-21-18-15-16(29-6-3)11-12-19(18)27(14-13-25)22(21)17-9-7-8-10-20(17)30-23/h7-12,15,23H,4-6,13-14H2,1-3H3
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US Patent
0.520n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50363527
PNG
(CHEMBL1945412 | US9481685, [18F]FE-PBR)
Show SMILES CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1ccccc1n2CCF
Show InChI InChI=1/C22H23FN2OS/c1-3-24(4-2)22(26)21-19-15-9-5-7-11-17(15)25(14-13-23)20(19)16-10-6-8-12-18(16)27-21/h5-12,21H,3-4,13-14H2,1-2H3
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US Patent
0.680n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253020
PNG
(US9481685, 3)
Show SMILES CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1cccc(OC)c1n2CCF
Show InChI InChI=1/C23H25FN2O2S/c1-4-25(5-2)23(27)22-19-16-10-8-11-17(28-3)20(16)26(14-13-24)21(19)15-9-6-7-12-18(15)29-22/h6-12,22H,4-5,13-14H2,1-3H3
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US Patent
0.930n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM253018
PNG
(US9481685, 7)
Show SMILES CCN(CC)C(=O)C1Sc2ccccc2-c2c1c1c(OC)cccc1n2CCF
Show InChI InChI=1/C23H25FN2O2S/c1-4-25(5-2)23(27)22-20-19-16(10-8-11-17(19)28-3)26(14-13-24)21(20)15-9-6-7-12-18(15)29-22/h6-12,22H,4-5,13-14H2,1-3H3
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US Patent
1.09n/an/an/an/an/an/a7.4n/a



GE Healthcare Limited

US Patent


Assay Description
The compounds were screened for their affinity for PBR using a method adapted from Le Fur et al (Life Sci. 1983; USA 33: 449-57).The compounds to be ...


US Patent US9481685 (2016)


BindingDB Entry DOI: 10.7270/Q25M64NT
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229676
PNG
(CHEMBL78697)
Show SMILES Nc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H12N6/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2,(H2,8,10)/t5-,6-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229669
PNG
(CHEMBL309432)
Show SMILES OC(c1nnn(n1)C1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23N5O/c27-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-22-24-26(23-20)19-15-25-13-11-16(19)12-14-25/h1-10,16,19,27H,11-15H2
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n/an/a 2.80n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229528
PNG
(CHEMBL93406)
Show SMILES Cc1noc(n1)[C@@H]1C[N@]2CC[C@@H]1C2
Show InChI InChI=1S/C9H13N3O/c1-6-10-9(13-11-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3/t7-,8-/m1/s1
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n/an/a 2.80n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229684
PNG
(CHEMBL78615)
Show SMILES Clc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C8H12ClN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 3.5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229669
PNG
(CHEMBL309432)
Show SMILES OC(c1nnn(n1)C1CN2CCC1CC2)(c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H23N5O/c27-21(17-7-3-1-4-8-17,18-9-5-2-6-10-18)20-22-24-26(23-20)19-15-25-13-11-16(19)12-14-25/h1-10,16,19,27H,11-15H2
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n/an/a 3.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229617
PNG
(CHEMBL311799)
Show SMILES Cc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-6-9-11-13(10-6)8-5-12-3-2-7(8)4-12/h7-8H,2-5H2,1H3/t7-,8-/m0/s1
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n/an/a 4.20n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229681
PNG
(CHEMBL79040)
Show SMILES Cn1ncc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229685
PNG
(CHEMBL311212)
Show SMILES Brc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C8H12BrN5/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2
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n/an/a 5.5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229678
PNG
(CHEMBL80723)
Show SMILES Nc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C8H14N6/c9-7-10-12-14(11-7)8-2-1-4-13(6-8)5-3-8/h1-6H2,(H2,9,11)
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n/an/a 5.90n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229696
PNG
(CHEMBL419659)
Show SMILES Brc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10BrN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229694
PNG
(CHEMBL81481)
Show SMILES Clc1nnn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C7H10ClN5/c8-7-9-11-13(10-7)6-4-12-2-1-5(6)3-12/h5-6H,1-4H2/t5-,6-/m0/s1
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n/an/a 7.60n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229623
PNG
(CHEMBL81281)
Show SMILES Cn1nnc(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c1-12-10-8(9-11-12)7-5-13-3-2-6(7)4-13/h6-7H,2-5H2,1H3/t6-,7-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229675
PNG
(CHEMBL309638)
Show SMILES C1CC2(CN1CCC2)n1cncn1
Show InChI InChI=1/C9H14N4/c1-2-9(13-8-10-7-11-13)3-5-12(4-1)6-9/h7-8H,1-6H2
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM10759
PNG
(2-acetoxyethyl(trimethyl)ammonium;bromide | 2-acet...)
Show SMILES CC(=O)OCC[N+](C)(C)C
Show InChI InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
BindingDB Entry DOI: 10.7270/Q2G1632Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229692
PNG
(CHEMBL311562)
Show SMILES Cc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C10H16N4/c1-9-11-8-14(12-9)10-3-2-5-13(7-10)6-4-10/h8H,2-7H2,1H3
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n/an/a 12n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229672
PNG
(CHEMBL309729)
Show SMILES Nc1ncn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C9H15N5/c10-8-11-7-14(12-8)9-2-1-4-13(6-9)5-3-9/h7H,1-6H2,(H2,10,12)
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50005677
PNG
(CHEMBL23957 | OXO-M | Trimethyl-[4-(2-oxo-pyrrolid...)
Show SMILES C[N+](C)(C)CC#CCN1CCCC1=O
Show InChI InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
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n/an/a 13n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
BindingDB Entry DOI: 10.7270/Q2G1632Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229526
PNG
(CHEMBL279356)
Show SMILES Cc1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1/C10H15N3O/c1-7-11-10(14-12-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
BindingDB Entry DOI: 10.7270/Q2G1632Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229693
PNG
(CHEMBL312434)
Show SMILES Clc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11ClN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229673
PNG
(CHEMBL311703)
Show SMILES Cc1nnn(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C9H15N5/c1-8-10-12-14(11-8)9-3-2-5-13(7-9)6-4-9/h2-7H2,1H3
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SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229526
PNG
(CHEMBL279356)
Show SMILES Cc1noc(n1)C1CN2CCC1CC2
Show InChI InChI=1/C10H15N3O/c1-7-11-10(14-12-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229621
PNG
(CHEMBL311036)
Show SMILES Cn1ncc(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C10H16N4/c1-13-11-7-9(12-13)10-3-2-5-14(8-10)6-4-10/h7H,2-6,8H2,1H3
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n/an/a 14n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229524
PNG
(CHEMBL329351)
Show SMILES Cc1noc(n1)C12CCN(C1)CCC2
Show InChI InChI=1/C10H15N3O/c1-8-11-9(14-12-8)10-3-2-5-13(7-10)6-4-10/h2-7H2,1H3
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n/an/a 15n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central Muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229683
PNG
(CHEMBL79020)
Show SMILES Cn1ncc(n1)[C@@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-12-10-4-9(11-12)8-6-13-3-2-7(8)5-13/h4,7-8H,2-3,5-6H2,1H3/t7-,8+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229698
PNG
(CHEMBL81492)
Show SMILES Cc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C9H14N4/c1-7-10-6-13(11-7)9-5-12-3-2-8(9)4-12/h6,8-9H,2-5H2,1H3/t8-,9-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
BindingDB Entry DOI: 10.7270/Q2G1632Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50004665
PNG
((oxotremorine)1-(4-Pyrrolidin-1-yl-but-2-ynyl)-pyr...)
Show SMILES O=C1CCCN1CC#CCN1CCCC1
Show InChI InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
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n/an/a 17n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229686
PNG
(CHEMBL311989)
Show SMILES Nc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H13N5/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2,(H2,9,11)/t6-,7-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229530
PNG
(CHEMBL329434)
Show SMILES COC(=O)C12CCN(C1)CCC2
Show InChI InChI=1/C9H15NO2/c1-12-8(11)9-3-2-5-10(7-9)6-4-9/h2-7H2,1H3
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n/an/a 19n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229619
PNG
(CHEMBL442975)
Show SMILES C1CC2(CN1CCC2)n1ncnn1
Show InChI InChI=1/C8H13N5/c1-2-8(13-10-7-9-11-13)3-5-12(4-1)6-8/h7H,1-6H2
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n/an/a 19n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229680
PNG
(CHEMBL312656)
Show SMILES Brc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1/C8H12BrN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 20n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229614
PNG
(CHEMBL78964)
Show SMILES Clc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1/C8H12ClN5/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 27n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229520
PNG
(CHEMBL93430)
Show SMILES Cc1noc(n1)[C@@H]1C[C@H]2CC[N@@](C2)C1
Show InChI InChI=1S/C10H15N3O/c1-7-11-10(14-12-7)9-4-8-2-3-13(5-8)6-9/h8-9H,2-6H2,1H3/t8-,9-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Valu...


J Med Chem 34: 2726-35 (1991)


Article DOI: 10.1021/jm00113a009
BindingDB Entry DOI: 10.7270/Q2BG2R7J
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 30n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioliga...


J Med Chem 35: 1280-90 (1992)


Article DOI: 10.1021/jm00085a016
BindingDB Entry DOI: 10.7270/Q2G1632Q
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229615
PNG
(CHEMBL81314)
Show SMILES C1C[N@@]2C[C@H]1[C@H](C2)n1ncnn1
Show InChI InChI=1S/C7H11N5/c1-2-11-3-6(1)7(4-11)12-9-5-8-10-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229687
PNG
(CHEMBL308343)
Show SMILES Brc1ncn(n1)[C@H]1C[N@@]2CC[C@H]1C2
Show InChI InChI=1S/C8H11BrN4/c9-8-10-5-13(11-8)7-4-12-2-1-6(7)3-12/h5-7H,1-4H2/t6-,7-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229691
PNG
(CHEMBL23118)
Show SMILES Cc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1/C9H15N5/c1-7-10-12-14(11-7)9-6-13-4-2-8(9)3-5-13/h8-9H,2-6H2,1H3
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n/an/a 31n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229682
PNG
(CHEMBL79374)
Show SMILES Cn1ncc(n1)[C@@]12CC[N@@](CC1)C2
Show InChI InChI=1/C9H14N4/c1-12-10-6-8(11-12)9-2-4-13(7-9)5-3-9/h6H,2-5,7H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 35n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor


(RAT)
BDBM50229690
PNG
(CHEMBL311297)
Show SMILES Nc1nnn(n1)C1CN2CCC1CC2
Show InChI InChI=1/C8H14N6/c9-8-10-12-14(11-8)7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2,(H2,9,11)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor.


J Med Chem 35: 2392-406 (1992)


Article DOI: 10.1021/jm00091a007
BindingDB Entry DOI: 10.7270/Q2TF00K5
More data for this
Ligand-Target Pair
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