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Compile Data Set for Download or QSAR

Found 138 hits with Last Name = 'whitney' and Initial = 'ja'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015453
PNG
(CHEMBL3265037)
Show SMILES COc1cc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)ccc1N1CCOCC1
Show InChI InChI=1S/C24H23N7O2/c1-32-22-13-18(4-5-21(22)30-8-10-33-11-9-30)27-23-24-25-6-7-31(24)15-20(28-23)16-2-3-17-14-26-29-19(17)12-16/h2-7,12-15H,8-11H2,1H3,(H,26,29)(H,27,28)
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n/an/a 0.440n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015454
PNG
(CHEMBL3264995)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(O)=O)cc1OC
Show InChI InChI=1S/C28H23N5O5/c1-37-23-11-10-21(15-24(23)38-2)30-25-26-29-12-13-33(26)16-22(32-25)18-4-3-5-19(14-18)27(34)31-20-8-6-17(7-9-20)28(35)36/h3-16H,1-2H3,(H,30,32)(H,31,34)(H,35,36)
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n/an/a 0.840n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015447
PNG
(CHEMBL3265031)
Show SMILES CC1(O)CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C25H25N7O/c1-25(33)8-11-31(12-9-25)20-6-4-19(5-7-20)28-23-24-26-10-13-32(24)16-22(29-23)17-2-3-18-15-27-30-21(18)14-17/h2-7,10,13-16,33H,8-9,11-12H2,1H3,(H,27,30)(H,28,29)
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n/an/a 1.40n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015460
PNG
(CHEMBL3265001)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)-c2nn[nH]n2)cc1OC
Show InChI InChI=1S/C28H23N9O3/c1-39-23-11-10-21(15-24(23)40-2)30-26-27-29-12-13-37(27)16-22(32-26)18-4-3-5-19(14-18)28(38)31-20-8-6-17(7-9-20)25-33-35-36-34-25/h3-16H,1-2H3,(H,30,32)(H,31,38)(H,33,34,35,36)
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n/an/a 1.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM36516
PNG
(4-(tert-Butyl)-N-(2-methyl-3-(4-methyl-6-((4-(morp...)
Show SMILES Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCOCC2)n1
Show InChI InChI=1S/C34H37N5O4/c1-22-27(7-6-8-28(22)37-31(40)23-9-13-25(14-10-23)34(2,3)4)29-21-38(5)33(42)30(36-29)35-26-15-11-24(12-16-26)32(41)39-17-19-43-20-18-39/h6-16,21H,17-20H2,1-5H3,(H,35,36)(H,37,40)
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n/an/a 1.90 1.5n/an/an/a7.523



CGI Pharmaceuticals



Assay Description
Biochemical assay using Lanthascreen (human, full-lenght, C-terminal v5-His6 expressed in Sf9 cell) assay from Invitrogen.


Nat Chem Biol 7: 41-50 (2011)


Article DOI: 10.1038/nchembio.481
BindingDB Entry DOI: 10.7270/Q2B56H2T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015449
PNG
(CHEMBL3265033)
Show SMILES O=S1(=O)CCN(CC1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O2S/c31-33(32)11-9-29(10-12-33)19-5-3-18(4-6-19)26-22-23-24-7-8-30(23)15-21(27-22)16-1-2-17-14-25-28-20(17)13-16/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/a 2.10n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015459
PNG
(CHEMBL3265000)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(=O)NS(C)(=O)=O)cc1OC
Show InChI InChI=1S/C29H26N6O6S/c1-40-24-12-11-22(16-25(24)41-2)31-26-27-30-13-14-35(27)17-23(33-26)19-5-4-6-20(15-19)28(36)32-21-9-7-18(8-10-21)29(37)34-42(3,38)39/h4-17H,1-3H3,(H,31,33)(H,32,36)(H,34,37)
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n/an/a 2.20n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015439
PNG
(CHEMBL3265024)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3OCC(=O)Nc3c2)cc1OC
Show InChI InChI=1S/C22H19N5O4/c1-29-18-6-4-14(10-19(18)30-2)24-21-22-23-7-8-27(22)11-16(26-21)13-3-5-17-15(9-13)25-20(28)12-31-17/h3-11H,12H2,1-2H3,(H,24,26)(H,25,28)
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n/an/a 2.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015457
PNG
(CHEMBL3264998)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(CC(O)=O)cc2)cc1OC
Show InChI InChI=1S/C29H25N5O5/c1-38-24-11-10-22(16-25(24)39-2)31-27-28-30-12-13-34(28)17-23(33-27)19-4-3-5-20(15-19)29(37)32-21-8-6-18(7-9-21)14-26(35)36/h3-13,15-17H,14H2,1-2H3,(H,31,33)(H,32,37)(H,35,36)
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n/an/a 2.60n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015425
PNG
(CHEMBL3265016)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cc[nH]c3c2)cc1OC
Show InChI InChI=1S/C22H19N5O2/c1-28-19-6-5-16(12-20(19)29-2)25-21-22-24-9-10-27(22)13-18(26-21)15-4-3-14-7-8-23-17(14)11-15/h3-13,23H,1-2H3,(H,25,26)
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n/an/a 2.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015450
PNG
(CHEMBL3265034)
Show SMILES C1CC(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C24H22N6O/c1-2-19-14-26-29-21(19)13-18(1)22-15-30-10-9-25-24(30)23(28-22)27-20-5-3-16(4-6-20)17-7-11-31-12-8-17/h1-6,9-10,13-15,17H,7-8,11-12H2,(H,26,29)(H,27,28)
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n/an/a 3.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015427
PNG
(CHEMBL3265017)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1OC
Show InChI InChI=1S/C21H18N6O2/c1-28-18-6-5-15(10-19(18)29-2)24-20-21-22-7-8-27(21)12-17(25-20)13-3-4-14-11-23-26-16(14)9-13/h3-12H,1-2H3,(H,23,26)(H,24,25)
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n/an/a 3.80n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015446
PNG
(CHEMBL3265030)
Show SMILES CC1(O)CN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-23(31)13-30(14-23)18-6-4-17(5-7-18)26-21-22-24-8-9-29(22)12-20(27-21)15-2-3-16-11-25-28-19(16)10-15/h2-12,31H,13-14H2,1H3,(H,25,28)(H,26,27)
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n/an/a 3.90n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015458
PNG
(CHEMBL3264999)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)C(N)=O)cc1OC
Show InChI InChI=1S/C28H24N6O4/c1-37-23-11-10-21(15-24(23)38-2)31-26-27-30-12-13-34(27)16-22(33-26)18-4-3-5-19(14-18)28(36)32-20-8-6-17(7-9-20)25(29)35/h3-16H,1-2H3,(H2,29,35)(H,31,33)(H,32,36)
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n/an/a 4.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015442
PNG
(CHEMBL3265026)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3OCCNc3c2)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-6-4-15(12-20(19)29-2)25-21-22-24-7-9-27(22)13-17(26-21)14-3-5-18-16(11-14)23-8-10-30-18/h3-7,9,11-13,23H,8,10H2,1-2H3,(H,25,26)
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n/an/a 4.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015428
PNG
(CHEMBL3265018)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3nc[nH]c3c2)cc1OC
Show InChI InChI=1S/C21H18N6O2/c1-28-18-6-4-14(10-19(18)29-2)25-20-21-22-7-8-27(21)11-17(26-20)13-3-5-15-16(9-13)24-12-23-15/h3-12H,1-2H3,(H,23,24)(H,25,26)
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n/an/a 6.30n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015445
PNG
(CHEMBL3265029)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C20H16N6O/c1-27-16-6-4-15(5-7-16)23-19-20-21-8-9-26(20)12-18(24-19)13-2-3-14-11-22-25-17(14)10-13/h2-12H,1H3,(H,22,25)(H,23,24)
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n/an/a 7n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015451
PNG
(CHEMBL3265035)
Show SMILES CN(CCO)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C22H21N7O/c1-28(10-11-30)18-6-4-17(5-7-18)25-21-22-23-8-9-29(22)14-20(26-21)15-2-3-16-13-24-27-19(16)12-15/h2-9,12-14,30H,10-11H2,1H3,(H,24,27)(H,25,26)
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n/an/a 7.60n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/a 7.70n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Activin receptor type-1


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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US Patent
n/an/a 8 25n/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...


US Patent US9469613 (2016)


BindingDB Entry DOI: 10.7270/Q2J1024J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015444
PNG
(CHEMBL3265028)
Show SMILES COc1cccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C20H16N6O/c1-27-16-4-2-3-15(10-16)23-19-20-21-7-8-26(20)12-18(24-19)13-5-6-14-11-22-25-17(14)9-13/h2-12H,1H3,(H,22,25)(H,23,24)
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n/an/a 8.5n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015430
PNG
(CHEMBL3265020)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3[nH]ccc3c2)cc1OC
Show InChI InChI=1S/C22H19N5O2/c1-28-19-6-4-16(12-20(19)29-2)25-21-22-24-9-10-27(22)13-18(26-21)14-3-5-17-15(11-14)7-8-23-17/h3-13,23H,1-2H3,(H,25,26)
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n/an/a 8.60n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015456
PNG
(CHEMBL3264997)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2cccc(c2)C(O)=O)cc1OC
Show InChI InChI=1S/C28H23N5O5/c1-37-23-10-9-21(15-24(23)38-2)30-25-26-29-11-12-33(26)16-22(32-25)17-5-3-6-18(13-17)27(34)31-20-8-4-7-19(14-20)28(35)36/h3-16H,1-2H3,(H,30,32)(H,31,34)(H,35,36)
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n/an/a 8.90n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015434
PNG
(CHEMBL3265021)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3[nH]ncc3c2)cc1OC
Show InChI InChI=1S/C21H18N6O2/c1-28-18-6-4-15(10-19(18)29-2)24-20-21-22-7-8-27(21)12-17(25-20)13-3-5-16-14(9-13)11-23-26-16/h3-12H,1-2H3,(H,23,26)(H,24,25)
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n/an/a 10n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015463
PNG
(CHEMBL3265004)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)cc1OC
Show InChI InChI=1S/C30H25N7O3/c1-39-26-11-10-24(15-27(26)40-2)34-28-29-31-12-13-37(29)18-25(36-28)20-4-3-5-21(14-20)30(38)35-23-8-6-19(7-9-23)22-16-32-33-17-22/h3-18H,1-2H3,(H,32,33)(H,34,36)(H,35,38)
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n/an/a 11n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015435
PNG
(CHEMBL3265022)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3cnn(C)c3c2)cc1OC
Show InChI InChI=1S/C22H20N6O2/c1-27-18-10-14(4-5-15(18)12-24-27)17-13-28-9-8-23-22(28)21(26-17)25-16-6-7-19(29-2)20(11-16)30-3/h4-13H,1-3H3,(H,25,26)
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n/an/a 12n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015462
PNG
(CHEMBL3265003)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)-c2cc[nH]n2)cc1OC
Show InChI InChI=1S/C30H25N7O3/c1-39-26-11-10-23(17-27(26)40-2)33-28-29-31-14-15-37(29)18-25(35-28)20-4-3-5-21(16-20)30(38)34-22-8-6-19(7-9-22)24-12-13-32-36-24/h3-18H,1-2H3,(H,32,36)(H,33,35)(H,34,38)
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n/an/a 12n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015429
PNG
(CHEMBL3265019)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3nn[nH]c3c2)cc1OC
Show InChI InChI=1S/C20H17N7O2/c1-28-17-6-4-13(10-18(17)29-2)22-19-20-21-7-8-27(20)11-16(23-19)12-3-5-14-15(9-12)25-26-24-14/h3-11H,1-2H3,(H,22,23)(H,24,25,26)
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n/an/a 13n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015455
PNG
(CHEMBL3264996)
Show SMILES COC(=O)c1ccc(NC(=O)c2cccc(c2)-c2cn3ccnc3c(Nc3ccc(OC)c(OC)c3)n2)cc1
Show InChI InChI=1S/C29H25N5O5/c1-37-24-12-11-22(16-25(24)38-2)31-26-27-30-13-14-34(27)17-23(33-26)19-5-4-6-20(15-19)28(35)32-21-9-7-18(8-10-21)29(36)39-3/h4-17H,1-3H3,(H,31,33)(H,32,35)
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n/an/a 15n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015461
PNG
(CHEMBL3265002)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)Nc2ccc(cc2)-c2ncc[nH]2)cc1OC
Show InChI InChI=1S/C30H25N7O3/c1-39-25-11-10-23(17-26(25)40-2)34-28-29-33-14-15-37(29)18-24(36-28)20-4-3-5-21(16-20)30(38)35-22-8-6-19(7-9-22)27-31-12-13-32-27/h3-18H,1-2H3,(H,31,32)(H,34,36)(H,35,38)
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n/an/a 17n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015465
PNG
(CHEMBL3259820)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(cc2)C(N)=O)cc1OC
Show InChI InChI=1S/C21H19N5O3/c1-28-17-8-7-15(11-18(17)29-2)24-20-21-23-9-10-26(21)12-16(25-20)13-3-5-14(6-4-13)19(22)27/h3-12H,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015487
PNG
(CHEMBL3265012)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(C(N)=O)c(F)c2)cc1OC
Show InChI InChI=1S/C21H18FN5O3/c1-29-17-6-4-13(10-18(17)30-2)25-20-21-24-7-8-27(21)11-16(26-20)12-3-5-14(19(23)28)15(22)9-12/h3-11H,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 19n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015437
PNG
(CHEMBL3265023)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3n(C)ncc3c2)cc1OC
Show InChI InChI=1S/C22H20N6O2/c1-27-18-6-4-14(10-15(18)12-24-27)17-13-28-9-8-23-22(28)21(26-17)25-16-5-7-19(29-2)20(11-16)30-3/h4-13H,1-3H3,(H,25,26)
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n/an/a 21n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015452
PNG
(CHEMBL3265036)
Show SMILES C1COCCN(C1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C24H23N7O/c1-9-30(11-13-32-12-1)20-6-4-19(5-7-20)27-23-24-25-8-10-31(24)16-22(28-23)17-2-3-18-15-26-29-21(18)14-17/h2-8,10,14-16H,1,9,11-13H2,(H,26,29)(H,27,28)
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n/an/a 23n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015423
PNG
(CHEMBL3265014)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(C(N)=O)c(OC)c2)cc1OC
Show InChI InChI=1S/C22H21N5O4/c1-29-17-7-5-14(11-19(17)31-3)25-21-22-24-8-9-27(22)12-16(26-21)13-4-6-15(20(23)28)18(10-13)30-2/h4-12H,1-3H3,(H2,23,28)(H,25,26)
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n/an/a 24n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015464
PNG
(CHEMBL3265005)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(N)=O)cc1OC
Show InChI InChI=1S/C21H19N5O3/c1-28-17-7-6-15(11-18(17)29-2)24-20-21-23-8-9-26(21)12-16(25-20)13-4-3-5-14(10-13)19(22)27/h3-12H,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 27n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015443
PNG
(CHEMBL3265027)
Show SMILES N(c1ccccc1)c1nc(cn2ccnc12)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C19H14N6/c1-2-4-15(5-3-1)22-18-19-20-8-9-25(19)12-17(23-18)13-6-7-14-11-21-24-16(14)10-13/h1-12H,(H,21,24)(H,22,23)
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n/an/a 27n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015485
PNG
(CHEMBL3265009)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(C)c(c2)C(N)=O)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-13-4-5-14(10-16(13)20(23)28)17-12-27-9-8-24-22(27)21(26-17)25-15-6-7-18(29-2)19(11-15)30-3/h4-12H,1-3H3,(H2,23,28)(H,25,26)
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n/an/a 28n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015441
PNG
(CHEMBL3265025)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc3NC(=O)COc3c2)cc1OC
Show InChI InChI=1S/C22H19N5O4/c1-29-17-6-4-14(10-19(17)30-2)24-21-22-23-7-8-27(22)11-16(26-21)13-3-5-15-18(9-13)31-12-20(28)25-15/h3-11H,12H2,1-2H3,(H,24,26)(H,25,28)
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n/an/a 33n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015486
PNG
(CHEMBL3265010)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(OC)c(c2)C(N)=O)cc1OC
Show InChI InChI=1S/C22H21N5O4/c1-29-17-6-4-13(10-15(17)20(23)28)16-12-27-9-8-24-22(27)21(26-16)25-14-5-7-18(30-2)19(11-14)31-3/h4-12H,1-3H3,(H2,23,28)(H,25,26)
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n/an/a 37n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015466
PNG
(CHEMBL3265006)
Show SMILES CNC(=O)c1cccc(c1)-c1cn2ccnc2c(Nc2ccc(OC)c(OC)c2)n1
Show InChI InChI=1S/C22H21N5O3/c1-23-22(28)15-6-4-5-14(11-15)17-13-27-10-9-24-21(27)20(26-17)25-16-7-8-18(29-2)19(12-16)30-3/h4-13H,1-3H3,(H,23,28)(H,25,26)
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n/an/a 50n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015422
PNG
(CHEMBL3265013)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(C(N)=O)c(C)c2)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-13-10-14(4-6-16(13)20(23)28)17-12-27-9-8-24-22(27)21(26-17)25-15-5-7-18(29-2)19(11-15)30-3/h4-12H,1-3H3,(H2,23,28)(H,25,26)
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n/an/a 64n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015488
PNG
(CHEMBL3264994)
Show SMILES CC(C)(C)c1ccc(Nc2nc(cn3ccnc23)-c2cccc(NC(=O)c3ccc(cc3)C(O)=O)c2)cc1
Show InChI InChI=1S/C30H27N5O3/c1-30(2,3)22-11-13-23(14-12-22)32-26-27-31-15-16-35(27)18-25(34-26)21-5-4-6-24(17-21)33-28(36)19-7-9-20(10-8-19)29(37)38/h4-18H,1-3H3,(H,32,34)(H,33,36)(H,37,38)
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n/an/a 65n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015479
PNG
(CHEMBL3265008)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(F)c(c2)C(N)=O)cc1OC
Show InChI InChI=1S/C21H18FN5O3/c1-29-17-6-4-13(10-18(17)30-2)25-20-21-24-7-8-27(21)11-16(26-20)12-3-5-15(22)14(9-12)19(23)28/h3-11H,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 67n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Bone morphogenetic protein receptor type-1B (BMPR1B)


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 107 19n/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...


US Patent US9469613 (2016)


BindingDB Entry DOI: 10.7270/Q2J1024J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015478
PNG
(CHEMBL3265007)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2cccc(c2)C(=O)N(C)C)cc1OC
Show InChI InChI=1S/C23H23N5O3/c1-27(2)23(29)16-7-5-6-15(12-16)18-14-28-11-10-24-22(28)21(26-18)25-17-8-9-19(30-3)20(13-17)31-4/h5-14H,1-4H3,(H,25,26)
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n/an/a 112n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015424
PNG
(CHEMBL3265015)
Show SMILES COc1ccc(Nc2nc(cn3ccnc23)-c2ccc(cc2C)C(N)=O)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-13-10-14(20(23)28)4-6-16(13)17-12-27-9-8-24-22(27)21(26-17)25-15-5-7-18(29-2)19(11-15)30-3/h4-12H,1-3H3,(H2,23,28)(H,25,26)
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n/an/a 113n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of full length Syk (unknown origin) using biotinylated peptide substrate


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50015448
PNG
(CHEMBL3265032)
Show SMILES C1CN(CCO1)c1ccc(Nc2nc(cn3ccnc23)-c2ccc3cn[nH]c3c2)cc1
Show InChI InChI=1S/C23H21N7O/c1-2-17-14-25-28-20(17)13-16(1)21-15-30-8-7-24-23(30)22(27-21)26-18-3-5-19(6-4-18)29-9-11-31-12-10-29/h1-8,13-15H,9-12H2,(H,25,28)(H,26,27)
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n/an/a 147n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Syk in immune complex-stimulated human monocyte assessed as TNFalpha production after 1 hr incubation


J Med Chem 57: 3856-73 (2014)


Article DOI: 10.1021/jm500228a
BindingDB Entry DOI: 10.7270/Q2B27WV1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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US Patent
n/an/a 205 670n/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...


US Patent US9469613 (2016)


BindingDB Entry DOI: 10.7270/Q2J1024J
More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK-3)


(Homo sapiens (Human))
BDBM50311017
PNG
(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Show SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
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n/an/a 405 1.00E+3n/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
Biochemical binding assays (DiscoveRx) and in vitro enzyme inhibition assays (LanthaScreen, Life Technologies) were conducted to determine the bindin...


US Patent US9469613 (2016)


BindingDB Entry DOI: 10.7270/Q2J1024J
More data for this
Ligand-Target Pair
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