Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Small conductance calcium-activated potassium channel (Rattus norvegicus-RAT-Rattus norvegicus (Rat)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.0120 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]apamin from rat brain SkCa channel after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.0230 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.0810 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholecystokinin receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]CCK-8s from human recombinant CCK1 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 1 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]AB-MECA from human recombinant adenosine A3 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Galanin receptor 2 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]-endothelin-1 from human recombinant GAL2 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]NDP-alpha -MSH from human recombinant MC4 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]IL-8 from human recombinant CXCR2 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]-prazosin from rat alpha1 adrenoceptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor D2L/neurotensin receptor NTS1 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]Tyr3-neurotensin from human recombinant NTS1 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuropeptide Y receptor type 2 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]peptide YY from human Y2 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50402386![]() (CHEMBL2207747) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development LLC Curated by ChEMBL | Assay Description Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior... | Bioorg Med Chem Lett 22: 7504-11 (2012) Article DOI: 10.1016/j.bmcl.2012.10.036 BindingDB Entry DOI: 10.7270/Q2ZG6TDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Somatostatin receptor (Mus musculus-MOUSE) | BDBM392076![]() (US10301272, Example 7/9) | MMDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]Tyr11-somatostatin-14 from mouse SST receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392066![]() (US10301272, Example 6/64) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
VIPR1 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]-DPCPX from human recombinant adenosine A1 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]ketanserin human recombinant 5-HT2A receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392013![]() (US10301272, Example 6/11) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392136![]() (US10301272, Example 14/6) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 and M3 (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.730 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]4-DAMP from human recombinant M3 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]nociceptin from human recombinant NOP receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50271670![]() (CHEMBL4126317) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50402382![]() (CHEMBL2207751) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development LLC Curated by ChEMBL | Assay Description Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior... | Bioorg Med Chem Lett 22: 7504-11 (2012) Article DOI: 10.1016/j.bmcl.2012.10.036 BindingDB Entry DOI: 10.7270/Q2ZG6TDQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vasopressin V1a receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]AVP from human recombinant V1a receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]U69593 from human kappa receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50044179![]() (CHEMBL3314002 | US10301272, Example 7/4) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from human recombinant mu receptor after 120 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392102![]() (US10301272, Example 8/7) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neurokinin 2 receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50271669![]() (CHEMBL4127932) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392075![]() (US10301272, Example 7/8) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392168![]() (US10301272, Example 20 | trans-3-(4-(Cyclohexylmet...) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392138![]() (US10301272, Example 15 | US10301272, Example 16) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM285736![]() (US10080744, Example 3/4) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f... | US Patent US10080744 (2018) BindingDB Entry DOI: 10.7270/Q21J9CVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392074![]() (US10301272, Example 7/7) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM50425166![]() (CHEMBL2313573) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development LLC Curated by ChEMBL | Assay Description Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after... | Bioorg Med Chem Lett 23: 811-5 (2013) Article DOI: 10.1016/j.bmcl.2012.11.074 BindingDB Entry DOI: 10.7270/Q27H1KW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392012![]() (US10301272, Example 6/10) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]-imipramine from recombinant human 5-HT transporter after 60 mins by scintillation counting relative to control | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50271671![]() (CHEMBL4127282) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM392076![]() (US10301272, Example 7/9) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Displacement of [3H]7-OH-DPAT from human recombinant dopamine D2S receptor after 60 mins by scintillation counting analysis | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50271677![]() (CHEMBL4130294) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM392144![]() (US10301272, Example 15/6) | PDB Reactome pathway UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Phenex Pharmaceuticals AG Curated by ChEMBL | Assay Description Inverse agonist activity at human GAL4 DBD-fused RORgammat LBD (237 to 497 residues) expressed in HEK293T cells assessed as reduction in ROR mediated... | Bioorg Med Chem Lett 28: 1446-1455 (2018) BindingDB Entry DOI: 10.7270/Q27W6FPC | |||||||||||
More data for this Ligand-Target Pair |
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