BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 664 hits with Last Name = 'zhou' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264121
PNG
(3-(3-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H27N5O2/c30-19-21-3-8-27-26(18-21)22(20-31-27)2-1-11-32-13-15-33(16-14-32)23-4-6-24(7-5-23)34-12-9-28-25(29(34)35)10-17-36-28/h3-10,12,17-18,20,31H,1-2,11,13-16H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.100n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM4779
PNG
(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
Show InChI InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.110n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysis


J Med Chem 59: 2005-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01633
BindingDB Entry DOI: 10.7270/Q2KS6TDD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264120
PNG
(3-(4-(4-(4-(4-oxofuro[3,2-c]pyridin-5 (4H)-yl)phen...)
Show SMILES O=c1n(ccc2occc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H29N5O2/c31-20-22-4-9-28-27(19-22)23(21-32-28)3-1-2-12-33-14-16-34(17-15-33)24-5-7-25(8-6-24)35-13-10-29-26(30(35)36)11-18-37-29/h4-11,13,18-19,21,32H,1-3,12,14-17H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.140n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264112
PNG
(3-(4-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H27F2N5O/c29-22-16-26(30)28(36)35(19-22)24-7-5-23(6-8-24)34-13-11-33(12-14-34)10-2-1-3-21-18-32-27-9-4-20(17-31)15-25(21)27/h4-9,15-16,18-19,32H,1-3,10-14H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.180n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264097
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C27H29FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h2,4,6-12,14,19-20,29H,1,3,5,13,15-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.190n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301953
PNG
(3-(3-(4-(4,6-Dimethoxypyrimidin-2-yl)piperazin-1-y...)
Show SMILES COc1ccc2[nH]cc(CCCN3CCN(CC3)c3nc(OC)cc(OC)n3)c2c1
Show InChI InChI=1S/C22H29N5O3/c1-28-17-6-7-19-18(13-17)16(15-23-19)5-4-8-26-9-11-27(12-10-26)22-24-20(29-2)14-21(25-22)30-3/h6-7,13-15,23H,4-5,8-12H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.190n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301980
PNG
(3-(3-(4-(4-(Trifluoromethyl)pyrimidin-2-yl)piperaz...)
Show SMILES FC(F)(F)c1ccnc(n1)N1CCN(CCCc2c[nH]c3ccc(cc23)[N+]#[C-])CC1
Show InChI InChI=1S/C21H21F3N6/c1-25-16-4-5-18-17(13-16)15(14-27-18)3-2-8-29-9-11-30(12-10-29)20-26-7-6-19(28-20)21(22,23)24/h4-7,13-14,27H,2-3,8-12H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.200n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264096
PNG
(3-(4-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H29N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h2,4,6-12,14,19,21,30H,1,3,5,13,15-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.230n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301982
PNG
(Ethyl 2-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piper...)
Show SMILES CCOC(=O)c1sc(nc1C)N1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1
Show InChI InChI=1S/C22H27FN4O2S/c1-3-29-21(28)20-15(2)25-22(30-20)27-11-9-26(10-12-27)8-4-5-16-14-24-19-7-6-17(23)13-18(16)19/h6-7,13-14,24H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.270n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301963
PNG
(3-(3-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES COc1ccc2[nH]cc(CCCN3CCN(CC3)c3nc(C)cc(C)n3)c2c1
Show InChI InChI=1S/C22H29N5O/c1-16-13-17(2)25-22(24-16)27-11-9-26(10-12-27)8-4-5-18-15-23-21-7-6-19(28-3)14-20(18)21/h6-7,13-15,23H,4-5,8-12H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.290n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301984
PNG
(Ethyl 2-(4-(3-(5-cyano-1H-indol-3-yl)propyl)pipera...)
Show SMILES CCOC(=O)c1sc(nc1C)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C23H27N5O2S/c1-3-30-22(29)21-16(2)26-23(31-21)28-11-9-27(10-12-28)8-4-5-18-15-25-20-7-6-17(14-24)13-19(18)20/h6-7,13,15,25H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.300n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264113
PNG
(3-(3-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H25F2N5O/c28-21-15-25(29)27(35)34(18-21)23-6-4-22(5-7-23)33-12-10-32(11-13-33)9-1-2-20-17-31-26-8-3-19(16-30)14-24(20)26/h3-8,14-15,17-18,31H,1-2,9-13H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.310n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264104
PNG
(3-(4-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O/c1-22-11-13-34(29(35)18-22)26-8-6-25(7-9-26)33-16-14-32(15-17-33)12-3-2-4-24-21-31-28-10-5-23(20-30)19-27(24)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.480n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264118
PNG
(3-(4-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C31H30N6O/c32-21-23-6-11-29-28(20-23)24(22-34-29)4-1-2-14-35-16-18-36(19-17-35)25-7-9-26(10-8-25)37-15-12-30-27(31(37)38)5-3-13-33-30/h3,5-13,15,20,22,34H,1-2,4,14,16-19H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.5n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264109
PNG
(3-(3-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O2/c1-35-25-10-12-33(28(34)18-25)24-7-5-23(6-8-24)32-15-13-31(14-16-32)11-2-3-22-20-30-27-9-4-21(19-29)17-26(22)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.610n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301967
PNG
(3-(4-(4-(4-Methoxy-6-methylpyrimidin-2-yl)piperazi...)
Show SMILES COc1cc(C)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C23H28N6O/c1-17-13-22(30-2)27-23(26-17)29-11-9-28(10-12-29)8-4-3-5-19-16-25-21-7-6-18(15-24)14-20(19)21/h6-7,13-14,16,25H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.650n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301978
PNG
(3-(4-(4-(4-(Trifluoromethyl)pyrimidin-2-yl)piperaz...)
Show SMILES FC(F)(F)c1ccnc(n1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C22H23F3N6/c23-22(24,25)20-6-7-27-21(29-20)31-11-9-30(10-12-31)8-2-1-3-17-15-28-19-5-4-16(14-26)13-18(17)19/h4-7,13,15,28H,1-3,8-12H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.700n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301964
PNG
(5-Chloro-3-(3-(4-(4,6-dimethylpyrimidin-2-yl)piper...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCc2c[nH]c3ccc(Cl)cc23)CC1
Show InChI InChI=1S/C21H26ClN5/c1-15-12-16(2)25-21(24-15)27-10-8-26(9-11-27)7-3-4-17-14-23-20-6-5-18(22)13-19(17)20/h5-6,12-14,23H,3-4,7-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.710n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301983
PNG
(Ethyl 2-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperaz...)
Show SMILES CCOC(=O)c1sc(nc1C)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C24H29N5O2S/c1-3-31-23(30)22-17(2)27-24(32-22)29-12-10-28(11-13-29)9-5-4-6-19-16-26-21-8-7-18(15-25)14-20(19)21/h7-8,14,16,26H,3-6,9-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.790n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264122
PNG
(3-(4-(4-(4-(2-oxopyrazin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1cnccn1-c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H28N6O/c28-18-21-4-9-26-25(17-21)22(19-30-26)3-1-2-11-31-13-15-32(16-14-31)23-5-7-24(8-6-23)33-12-10-29-20-27(33)34/h4-10,12,17,19-20,30H,1-3,11,13-16H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.800n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264099
PNG
(1-(4-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazi...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3ccc(cc3)-n3ccccc3=O)c2c1
Show InChI InChI=1S/C26H27FN4O/c27-21-6-11-25-24(18-21)20(19-28-25)4-3-12-29-14-16-30(17-15-29)22-7-9-23(10-8-22)31-13-2-1-5-26(31)32/h1-2,5-11,13,18-19,28H,3-4,12,14-17H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.870n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264105
PNG
(3-(3-(4-(4-(4-methyl-2-oxopyridin-1(2H)-yl)phenyl)...)
Show SMILES Cc1ccn(-c2ccc(cc2)N2CCN(CCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C28H29N5O/c1-21-10-12-33(28(34)17-21)25-7-5-24(6-8-25)32-15-13-31(14-16-32)11-2-3-23-20-30-27-9-4-22(19-29)18-26(23)27/h4-10,12,17-18,20,30H,2-3,11,13-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
0.890n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301979
PNG
(5-Fluoro-3-(3-(4-(4-(trifluoromethyl)pyrimidin-2-y...)
Show SMILES Fc1ccc2[nH]cc(CCCN3CCN(CC3)c3nccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C20H21F4N5/c21-15-3-4-17-16(12-15)14(13-26-17)2-1-7-28-8-10-29(11-9-28)19-25-6-5-18(27-19)20(22,23)24/h3-6,12-13,26H,1-2,7-11H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301958
PNG
(3-(4-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES COc1ccc2[nH]cc(CCCCN3CCN(CC3)c3nc(C)cc(C)n3)c2c1
Show InChI InChI=1S/C23H31N5O/c1-17-14-18(2)26-23(25-17)28-12-10-27(11-13-28)9-5-4-6-19-16-24-22-8-7-20(29-3)15-21(19)22/h7-8,14-16,24H,4-6,9-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301957
PNG
(3-(4-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCCc2c[nH]c3ccccc23)CC1
Show InChI InChI=1S/C22H29N5/c1-17-15-18(2)25-22(24-17)27-13-11-26(12-14-27)10-6-5-7-19-16-23-21-9-4-3-8-20(19)21/h3-4,8-9,15-16,23H,5-7,10-14H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301949
PNG
(5-Chloro-3-(4-(4-(4,6-dimethoxypyrimidin-2-yl)pipe...)
Show SMILES COc1cc(OC)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(Cl)cc23)CC1
Show InChI InChI=1S/C22H28ClN5O2/c1-29-20-14-21(30-2)26-22(25-20)28-11-9-27(10-12-28)8-4-3-5-16-15-24-19-7-6-17(23)13-18(16)19/h6-7,13-15,24H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301966
PNG
(3-(3-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C22H26N6/c1-16-12-17(2)26-22(25-16)28-10-8-27(9-11-28)7-3-4-19-15-24-21-6-5-18(14-23)13-20(19)21/h5-6,12-13,15,24H,3-4,7-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.10n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264098
PNG
(3-(3-(4-(4-(2-oxopyridin-1(2H)-yl)phenyl)piperazin...)
Show SMILES O=c1ccccn1-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H27N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h1-2,5-11,13,18,20,29H,3-4,12,14-17H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264108
PNG
(3-(4-(4-(4-(4-methoxy-2-oxopyridin-1(2H)-yl)phenyl...)
Show SMILES COc1ccn(-c2ccc(cc2)N2CCN(CCCCc3c[nH]c4ccc(cc34)C#N)CC2)c(=O)c1
Show InChI InChI=1S/C29H31N5O2/c1-36-26-11-13-34(29(35)19-26)25-8-6-24(7-9-25)33-16-14-32(15-17-33)12-3-2-4-23-21-31-28-10-5-22(20-30)18-27(23)28/h5-11,13,18-19,21,31H,2-4,12,14-17H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264091
PNG
(3-(3-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O/c28-19-21-6-11-26-25(18-21)22(20-29-26)4-3-12-30-14-16-31(17-15-30)23-7-9-24(10-8-23)32-13-2-1-5-27(32)33/h6-11,18,20,29H,1-5,12-17H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.20n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301956
PNG
(3-(3-(4-(4,6-Dimethoxypyrimidin-2-yl)piperazin-1-y...)
Show SMILES COc1cc(OC)nc(n1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C22H26N6O2/c1-29-20-13-21(30-2)26-22(25-20)28-10-8-27(9-11-28)7-3-4-17-15-24-19-6-5-16(14-23)12-18(17)19/h5-6,12-13,15,24H,3-4,7-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.30n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264124
PNG
(3-(4-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H32N6O/c28-19-21-5-10-26-25(18-21)22(20-30-26)4-1-2-12-31-14-16-32(17-15-31)23-6-8-24(9-7-23)33-13-3-11-29-27(33)34/h5-10,18,20,30H,1-4,11-17H2,(H,29,34)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.30n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301965
PNG
(3-(3-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCc2c[nH]c3ccc(F)cc23)CC1
Show InChI InChI=1S/C21H26FN5/c1-15-12-16(2)25-21(24-15)27-10-8-26(9-11-27)7-3-4-17-14-23-20-6-5-18(22)13-19(17)20/h5-6,12-14,23H,3-4,7-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.40n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301948
PNG
(3-(4-(4-(4,6-Dimethoxypyrimidin-2-yl)piperazin-1-y...)
Show SMILES COc1ccc2[nH]cc(CCCCN3CCN(CC3)c3nc(OC)cc(OC)n3)c2c1
Show InChI InChI=1S/C23H31N5O3/c1-29-18-7-8-20-19(14-18)17(16-24-20)6-4-5-9-27-10-12-28(13-11-27)23-25-21(30-2)15-22(26-23)31-3/h7-8,14-16,24H,4-6,9-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.40n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301968
PNG
(3-(3-(4-(4-Methoxy-6-methylpyrimidin-2-yl)piperazi...)
Show SMILES COc1cc(C)nc(n1)N1CCN(CCCc2c[nH]c3ccc(cc23)[N+]#[C-])CC1
Show InChI InChI=1S/C22H26N6O/c1-16-13-21(29-3)26-22(25-16)28-11-9-27(10-12-28)8-4-5-17-15-24-20-7-6-18(23-2)14-19(17)20/h6-7,13-15,24H,4-5,8-12H2,1,3H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.5n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264115
PNG
(3-(5-(4-(4-(3,5-difluoro-2-oxopyridin-1(2H)-yl)phe...)
Show SMILES Fc1cc(F)c(=O)n(c1)-c1ccc(cc1)N1CCN(CCCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C29H29F2N5O/c30-23-17-27(31)29(37)36(20-23)25-8-6-24(7-9-25)35-14-12-34(13-15-35)11-3-1-2-4-22-19-33-28-10-5-21(18-32)16-26(22)28/h5-10,16-17,19-20,33H,1-4,11-15H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.5n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264119
PNG
(3-(3-(4-(4-(5-oxo-1,6-naphthyridin-6(5H)-yl)phenyl...)
Show SMILES O=c1n(ccc2ncccc12)-c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C30H28N6O/c31-20-22-5-10-28-27(19-22)23(21-33-28)3-2-13-34-15-17-35(18-16-34)24-6-8-25(9-7-24)36-14-11-29-26(30(36)37)4-1-12-32-29/h1,4-12,14,19,21,33H,2-3,13,15-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.70n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301960
PNG
(3-(4-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(F)cc23)CC1
Show InChI InChI=1S/C22H28FN5/c1-16-13-17(2)26-22(25-16)28-11-9-27(10-12-28)8-4-3-5-18-15-24-21-7-6-19(23)14-20(18)21/h6-7,13-15,24H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.70n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301959
PNG
(5-Chloro-3-(4-(4-(4,6-dimethylpyrimidin-2-yl)piper...)
Show SMILES Cc1cc(C)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(Cl)cc23)CC1
Show InChI InChI=1S/C22H28ClN5/c1-16-13-17(2)26-22(25-16)28-11-9-27(10-12-28)8-4-3-5-18-15-24-21-7-6-19(23)14-20(18)21/h6-7,13-15,24H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.80n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264011
PNG
(3-(4-(4-(4-(2-oxopiperidin-1-yl)phenyl)piperazin-1...)
Show SMILES O=C1CCCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C28H33N5O/c29-20-22-7-12-27-26(19-22)23(21-30-27)5-1-3-13-31-15-17-32(18-16-31)24-8-10-25(11-9-24)33-14-4-2-6-28(33)34/h7-12,19,21,30H,1-6,13-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.90n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264125
PNG
(3-(3-(4-(4-(2-oxotetrahydropyrimidin-1(2H)-yl)phen...)
Show SMILES O=C1NCCCN1c1ccc(cc1)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C26H30N6O/c27-18-20-4-9-25-24(17-20)21(19-29-25)3-1-11-30-13-15-31(16-14-30)22-5-7-23(8-6-22)32-12-2-10-28-26(32)33/h4-9,17,19,29H,1-3,10-16H2,(H,28,33)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
1.90n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301954
PNG
(5-Chloro-3-(3-(4-(4,6-dimethoxypyrimidin-2-yl)pipe...)
Show SMILES COc1cc(OC)nc(n1)N1CCN(CCCc2c[nH]c3ccc(Cl)cc23)CC1
Show InChI InChI=1S/C21H26ClN5O2/c1-28-19-13-20(29-2)25-21(24-19)27-10-8-26(9-11-27)7-3-4-15-14-23-18-6-5-16(22)12-17(15)18/h5-6,12-14,23H,3-4,7-11H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50159347
PNG
(CHEMBL3787662 | US9586965, Cpd 1)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1
Show InChI InChI=1S/C26H27N7O2/c1-3-23(34)28-19-5-4-6-21(17-19)35-25-22-11-12-27-24(22)30-26(31-25)29-18-7-9-20(10-8-18)33-15-13-32(2)14-16-33/h3-12,17H,1,13-16H2,2H3,(H,28,34)(H2,27,29,30,31)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysis


J Med Chem 59: 2005-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01633
BindingDB Entry DOI: 10.7270/Q2KS6TDD
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50159358
PNG
(CHEMBL3787386)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCC#C)c(NC(=O)C=C)cc23)cc1Cl
Show InChI InChI=1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysis


J Med Chem 59: 2005-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01633
BindingDB Entry DOI: 10.7270/Q2KS6TDD
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301977
PNG
(5-Fluoro-3-(4-(4-(4-(trifluoromethyl)pyrimidin-2-y...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3nccc(n3)C(F)(F)F)c2c1
Show InChI InChI=1S/C21H23F4N5/c22-16-4-5-18-17(13-16)15(14-27-18)3-1-2-8-29-9-11-30(12-10-29)20-26-7-6-19(28-20)21(23,24)25/h4-7,13-14,27H,1-3,8-12H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM264093
PNG
(3-(4-(4-(4-(3-oxomorpholino)phenyl)piperazin-1-yl)...)
Show SMILES O=C1COCCN1c1ccc(cc1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C27H31N5O2/c28-18-21-4-9-26-25(17-21)22(19-29-26)3-1-2-10-30-11-13-31(14-12-30)23-5-7-24(8-6-23)32-15-16-34-20-27(32)33/h4-9,17,19,29H,1-3,10-16,20H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.10n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301951
PNG
(3-(4-(4-(4,6-Dimethoxypyrimidin-2-yl)piperazin-1-y...)
Show SMILES COc1cc(OC)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C23H28N6O2/c1-30-21-14-22(31-2)27-23(26-21)29-11-9-28(10-12-29)8-4-3-5-18-16-25-20-7-6-17(15-24)13-19(18)20/h6-7,13-14,16,25H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.30n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM263988
PNG
(1-(4-(4-(4-(5-fluoro-1H-indol-3-yl)butyl)piperazin...)
Show SMILES Fc1ccc2[nH]cc(CCCCN3CCN(CC3)c3ccc(cc3)N3CCCCC3=O)c2c1
Show InChI InChI=1S/C27H33FN4O/c28-22-7-12-26-25(19-22)21(20-29-26)5-1-3-13-30-15-17-31(18-16-30)23-8-10-24(11-9-23)32-14-4-2-6-27(32)33/h7-12,19-20,29H,1-6,13-18H2
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.5n/an/an/an/an/an/a7.4n/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-0H-DPAT (Perkin-Elmer) in the absence o...


US Patent US9714232 (2017)


Article DOI: 10.1021/jm9508696
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301992
PNG
(2-(4-(3-(5-Cyano-1H-indol-3-yl)propyl)piperazin-1-...)
Show SMILES Cc1nc(sc1C#N)N1CCN(CCCc2c[nH]c3ccc(cc23)C#N)CC1
Show InChI InChI=1S/C21H22N6S/c1-15-20(13-23)28-21(25-15)27-9-7-26(8-10-27)6-2-3-17-14-24-19-5-4-16(12-22)11-18(17)19/h4-5,11,14,24H,2-3,6-10H2,1H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.60n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM301950
PNG
(3-(4-(4-(4,6-Dimethoxypyrimidin-2-yl)piperazin-1-y...)
Show SMILES COc1cc(OC)nc(n1)N1CCN(CCCCc2c[nH]c3ccc(F)cc23)CC1
Show InChI InChI=1S/C22H28FN5O2/c1-29-20-14-21(30-2)26-22(25-20)28-11-9-27(10-12-28)8-4-3-5-16-15-24-19-7-6-17(23)13-18(16)19/h6-7,13-15,24H,3-5,8-12H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
2.80n/an/an/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Human HEK-293 cell homogenates (36 μg protein) were incubated at 22 C. for 60 minutes with 0.3 nM [3H]8-OH-DPAT (Perkin-Elmer) in the absence o...


US Patent US9598401 (2017)


Article DOI: 10.1021/jm034108b
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 664 total )  |  Next  |  Last  >>
Jump to: