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Compile Data Set for Download or QSAR

Found 1625 hits with Last Name = 'zhuo' and Initial = 'j'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98027
PNG
(US8487096, I | US9221824, Formula I)
Show SMILES C[C@@H](O)CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1/C25H21FN6O2/c1-15(33)12-28-24(34)20-6-5-18(11-21(20)26)23-14-30-25-29-13-19(32(25)31-23)10-16-4-7-22-17(9-16)3-2-8-27-22/h2-9,11,13-15,33H,10,12H2,1H3,(H,28,34)/t15-/s2
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n/an/a 0.550n/an/an/an/a7.530



Incyte Corporation

US Patent


Assay Description
The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.


US Patent US8487096 (2013)


BindingDB Entry DOI: 10.7270/Q2319THZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98028
PNG
(US8487096, II | US9221824, Formula II)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17ClN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Corporation

US Patent


Assay Description
The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.


US Patent US8487096 (2013)


BindingDB Entry DOI: 10.7270/Q2319THZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98029
PNG
(US8487096, III | US9221824, Formula III)
Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1
Show InChI InChI=1/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/s2
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n/an/a 0.550n/an/an/an/a7.530



Incyte Corporation

US Patent


Assay Description
The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.


US Patent US8487096 (2013)


BindingDB Entry DOI: 10.7270/Q2319THZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98030
PNG
(US8487096, IV | US9221824, Formula IV)
Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Corporation

US Patent


Assay Description
The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.


US Patent US8487096 (2013)


BindingDB Entry DOI: 10.7270/Q2319THZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98031
PNG
(US8487096, V | US9221824, Formula V)
Show SMILES CNC(=O)c1ccc(cc1C)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-15-10-18(6-7-20(15)23(31)25-2)22-14-28-24-27-13-19(30(24)29-22)12-16-5-8-21-17(11-16)4-3-9-26-21/h3-11,13-14H,12H2,1-2H3,(H,25,31)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...


US Patent US9221824 (2015)


BindingDB Entry DOI: 10.7270/Q2MP524M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98027
PNG
(US8487096, I | US9221824, Formula I)
Show SMILES C[C@@H](O)CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1/C25H21FN6O2/c1-15(33)12-28-24(34)20-6-5-18(11-21(20)26)23-14-30-25-29-13-19(32(25)31-23)10-16-4-7-22-17(9-16)3-2-8-27-22/h2-9,11,13-15,33H,10,12H2,1H3,(H,28,34)/t15-/s2
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n/an/a 0.550n/an/an/an/a7.530



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...


US Patent US9221824 (2015)


BindingDB Entry DOI: 10.7270/Q2MP524M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98028
PNG
(US8487096, II | US9221824, Formula II)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17ClN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...


US Patent US9221824 (2015)


BindingDB Entry DOI: 10.7270/Q2MP524M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98029
PNG
(US8487096, III | US9221824, Formula III)
Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1
Show InChI InChI=1/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/s2
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n/an/a 0.550n/an/an/an/a7.530



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...


US Patent US9221824 (2015)


BindingDB Entry DOI: 10.7270/Q2MP524M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98030
PNG
(US8487096, IV | US9221824, Formula IV)
Show SMILES CNC(=O)c1ccc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H17N7O/c1-23-21(30)19-7-5-16(11-25-19)20-13-27-22-26-12-17(29(22)28-20)10-14-4-6-18-15(9-14)3-2-8-24-18/h2-9,11-13H,10H2,1H3,(H,23,30)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...


US Patent US9221824 (2015)


BindingDB Entry DOI: 10.7270/Q2MP524M
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM98031
PNG
(US8487096, V | US9221824, Formula V)
Show SMILES CNC(=O)c1ccc(cc1C)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C24H20N6O/c1-15-10-18(6-7-20(15)23(31)25-2)22-14-28-24-27-13-19(30(24)29-22)12-16-5-8-21-17(11-16)4-3-9-26-21/h3-11,13-14H,12H2,1-2H3,(H,25,31)
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n/an/a 0.550n/an/an/an/a7.530



Incyte Corporation

US Patent


Assay Description
The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.


US Patent US8487096 (2013)


BindingDB Entry DOI: 10.7270/Q2319THZ
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50228003
PNG
((6S,7S)-6-[4-(4-cyano-3-methyl-phenyl)-piperazine-...)
Show SMILES Cc1cc(ccc1C#N)N1CCN(CC1)C(=O)[C@H]1NCC2(CC2)C[C@@H]1C(=O)NO
Show InChI InChI=1S/C21H27N5O3/c1-14-10-16(3-2-15(14)12-22)25-6-8-26(9-7-25)20(28)18-17(19(27)24-29)11-21(4-5-21)13-23-18/h2-3,10,17-18,23,29H,4-9,11,13H2,1H3,(H,24,27)/t17-,18-/m0/s1
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n/an/a<5n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Binding affinity to MMP2


Bioorg Med Chem Lett 18: 159-63 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.108
BindingDB Entry DOI: 10.7270/Q2GM8720
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50203526
PNG
((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Show SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(=CC1)c1ccccc1
Show InChI InChI=1S/C20H25N3O3/c24-18(22-26)16-12-20(8-9-20)13-21-17(16)19(25)23-10-6-15(7-11-23)14-4-2-1-3-5-14/h1-6,16-17,21,26H,7-13H2,(H,22,24)/t16-,17-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Inhibition of MMP2


J Med Chem 50: 603-6 (2007)


Article DOI: 10.1021/jm061344o
BindingDB Entry DOI: 10.7270/Q2JQ10P5
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50203526
PNG
((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)
Show SMILES ONC(=O)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(=CC1)c1ccccc1
Show InChI InChI=1S/C20H25N3O3/c24-18(22-26)16-12-20(8-9-20)13-21-17(16)19(25)23-10-6-15(7-11-23)14-4-2-1-3-5-14/h1-6,16-17,21,26H,7-13H2,(H,22,24)/t16-,17-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Binding affinity to MMP2


Bioorg Med Chem Lett 18: 159-63 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.108
BindingDB Entry DOI: 10.7270/Q2GM8720
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (Human))
BDBM50268906
PNG
((2S,3S,5RS)-N-hydroxy-5-(2-oxo-2-(pyrrolidin-1-yl)...)
Show SMILES ONC(=O)[C@H]1CC(CC(=O)N2CCCC2)CN[C@@H]1C(=O)N1CCN(CC1)c1ccccc1
Show InChI InChI=1/C23H33N5O4/c29-20(27-8-4-5-9-27)15-17-14-19(22(30)25-32)21(24-16-17)23(31)28-12-10-26(11-13-28)18-6-2-1-3-7-18/h1-3,6-7,17,19,21,24,32H,4-5,8-16H2,(H,25,30)/t17?,19-,21-/s2
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n/an/a 8n/an/an/an/an/an/a



Incyte Corporation

Curated by ChEMBL


Assay Description
Inhibition of human MMP2


Bioorg Med Chem Lett 19: 3525-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.143
BindingDB Entry DOI: 10.7270/Q2ST7PRT
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376816
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC1CCC1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O/c1-16-10-18(12-19(30)11-16)21-8-9-31-15-25(21)33-28(35)22-5-6-24(29)23-13-20(14-32-27(22)23)34(3)26-7-4-17(26)2/h5-6,8-9,13-19,26H,4,7,10-12,30H2,1-3H3,(H,33,35)/t16-,17?,18+,19-,26?/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376817
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccc(cc1)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)24-10-11-33-17-28(24)35-30(37)25-8-9-27(31)26-15-22(16-34-29(25)26)36(2)21-4-6-23(38-3)7-5-21/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376817
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccc(cc1)N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)24-10-11-33-17-28(24)35-30(37)25-8-9-27(31)26-15-22(16-34-29(25)26)36(2)21-4-6-23(38-3)7-5-21/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376818
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C
Show InChI InChI=1/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376818
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1nccnc1C
Show InChI InChI=1/C28H30FN7O/c1-16-10-18(12-19(30)11-16)21-6-7-31-15-25(21)35-28(37)22-4-5-24(29)23-13-20(14-34-26(22)23)36(3)27-17(2)32-8-9-33-27/h4-9,13-16,18-19H,10-12,30H2,1-3H3,(H,35,37)/t16-,18+,19-/s2
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376819
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccncc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H31FN6O2/c1-17-10-18(12-19(31)11-17)21-6-8-32-15-25(21)35-29(37)22-4-5-24(30)23-13-20(14-34-28(22)23)36(2)26-16-33-9-7-27(26)38-3/h4-9,13-19H,10-12,31H2,1-3H3,(H,35,37)/t17-,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376819
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccncc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H31FN6O2/c1-17-10-18(12-19(31)11-17)21-6-8-32-15-25(21)35-29(37)22-4-5-24(30)23-13-20(14-34-28(22)23)36(2)26-16-33-9-7-27(26)38-3/h4-9,13-19H,10-12,31H2,1-3H3,(H,35,37)/t17-,18+,19-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376820
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)C1CCCOC1
Show InChI InChI=1/C28H34FN5O2/c1-17-10-18(12-19(30)11-17)22-7-8-31-15-26(22)33-28(35)23-5-6-25(29)24-13-21(14-32-27(23)24)34(2)20-4-3-9-36-16-20/h5-8,13-15,17-20H,3-4,9-12,16,30H2,1-2H3,(H,33,35)/t17-,18+,19-,20?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376820
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)C1CCCOC1
Show InChI InChI=1/C28H34FN5O2/c1-17-10-18(12-19(30)11-17)22-7-8-31-15-26(22)33-28(35)23-5-6-25(29)24-13-21(14-32-27(23)24)34(2)20-4-3-9-36-16-20/h5-8,13-15,17-20H,3-4,9-12,16,30H2,1-2H3,(H,33,35)/t17-,18+,19-,20?/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376821
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376821
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COc1ccccc1N(C)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H32FN5O2/c1-18-12-19(14-20(32)13-18)22-10-11-33-17-26(22)35-30(37)23-8-9-25(31)24-15-21(16-34-29(23)24)36(2)27-6-4-5-7-28(27)38-3/h4-11,15-20H,12-14,32H2,1-3H3,(H,35,37)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376822
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1ccc2nccn2c1
Show InChI InChI=1/C30H30FN7O/c1-18-11-19(13-20(32)12-18)23-7-8-33-16-27(23)36-30(39)24-4-5-26(31)25-14-22(15-35-29(24)25)37(2)21-3-6-28-34-9-10-38(28)17-21/h3-10,14-20H,11-13,32H2,1-2H3,(H,36,39)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376822
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)c1ccc2nccn2c1
Show InChI InChI=1/C30H30FN7O/c1-18-11-19(13-20(32)12-18)23-7-8-33-16-27(23)36-30(39)24-4-5-26(31)25-14-22(15-35-29(24)25)37(2)21-3-6-28-34-9-10-38(28)17-21/h3-10,14-20H,11-13,32H2,1-2H3,(H,36,39)/t18-,19+,20-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376823
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)[C@@H]1CCOC1
Show InChI InChI=1/C27H32FN5O2/c1-16-9-17(11-18(29)10-16)21-5-7-30-14-25(21)32-27(34)22-3-4-24(28)23-12-20(13-31-26(22)23)33(2)19-6-8-35-15-19/h3-5,7,12-14,16-19H,6,8-11,15,29H2,1-2H3,(H,32,34)/t16-,17+,18-,19+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376823
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N(C)[C@@H]1CCOC1
Show InChI InChI=1/C27H32FN5O2/c1-16-9-17(11-18(29)10-16)21-5-7-30-14-25(21)32-27(34)22-3-4-24(28)23-12-20(13-31-26(22)23)33(2)19-6-8-35-15-19/h3-5,7,12-14,16-19H,6,8-11,15,29H2,1-2H3,(H,32,34)/t16-,17+,18-,19+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376824
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CO[C@@H]1C[C@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17-,18+,19-,21+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376824
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl]pyridi...)
Show SMILES CO[C@@H]1C[C@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17-,18+,19-,21+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376825
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17+,18+,19-,21+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376825
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1C[C@@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17+,18+,19-,21+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376826
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1C[C@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17-,18+,19-,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376826
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1C[C@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17-,18+,19-,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376827
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1C[C@@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17+,18+,19-,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376827
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1C[C@@H](C)N(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H34FN5O2/c1-16-8-18(11-19(30)9-16)22-6-7-31-14-26(22)33-28(35)23-4-5-25(29)24-12-20(13-32-27(23)24)34-15-21(36-3)10-17(34)2/h4-7,12-14,16-19,21H,8-11,15,30H2,1-3H3,(H,33,35)/t16-,17+,18+,19-,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376828
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376828
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/s2
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Incyte Corporation

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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376829
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN([C@@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18-,19+,20-,22+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376829
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN([C@@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18-,19+,20-,22+/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376830
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376830
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22+/s2
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Incyte Corporation

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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376831
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CO[C@@H]1CCN(C[C@H]1F)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C28H33F2N5O2/c1-16-9-17(11-18(31)10-16)20-5-7-32-14-25(20)34-28(36)21-3-4-23(29)22-12-19(13-33-27(21)22)35-8-6-26(37-2)24(30)15-35/h3-5,7,12-14,16-18,24,26H,6,8-11,15,31H2,1-2H3,(H,34,36)/t16-,17+,18-,24+,26+/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376784
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376785
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1
Show InChI InChI=1/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376785
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1
Show InChI InChI=1/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376786
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)CN1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H37FN6O2/c1-18(2)16-37-9-8-36(17-28(37)38)22-13-25-26(31)5-4-24(29(25)34-14-22)30(39)35-27-15-33-7-6-23(27)20-10-19(3)11-21(32)12-20/h4-7,13-15,18-21H,8-12,16-17,32H2,1-3H3,(H,35,39)/t19-,20+,21-/s2
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Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM376786
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES CC(C)CN1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C30H37FN6O2/c1-18(2)16-37-9-8-36(17-28(37)38)22-13-25-26(31)5-4-24(29(25)34-14-22)30(39)35-27-15-33-7-6-23(27)20-10-19(3)11-21(32)12-20/h4-7,13-15,18-21H,8-12,16-17,32H2,1-3H3,(H,35,39)/t19-,20+,21-/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM376787
PNG
(N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...)
Show SMILES COC1(C)CN(C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1
Show InChI InChI=1/C27H32FN5O2/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,15-33)35-3/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assaysó20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9920032 (2018)

More data for this
Ligand-Target Pair
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