Found 1129 hits of ki for drug = Acetazolamide Sodium Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Carbonic anhydrase 2
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 0.343 | n/a | 0.485 | n/a | n/a | n/a | n/a | n/a | n/a |
Cumhuriyet University
| Assay Description Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr... |
Bioorg Chem 70: 118-125 (2017)
Article DOI: 10.1016/j.bioorg.2016.12.001 BindingDB Entry DOI: 10.7270/Q2CF9NZB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 0.747 | n/a | 0.996 | n/a | n/a | n/a | n/a | n/a | n/a |
Cumhuriyet University
| Assay Description Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr... |
Bioorg Chem 70: 118-125 (2017)
Article DOI: 10.1016/j.bioorg.2016.12.001 BindingDB Entry DOI: 10.7270/Q2CF9NZB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase
(Homo sapiens (human)-Homo sapiens (Human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
KEGG
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| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of Carbonic anhydrase (Non competitive) |
J Med Chem 29: 1488-94 (1986)
Article DOI: 10.1021/jm00158a028 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
CA VII + BH
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA7 by stopped flow CO2 hydrase assay |
J Med Chem 53: 850-4 (2010)
Article DOI: 10.1021/jm901524f BindingDB Entry DOI: 10.7270/Q2PV6M96 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 19: 1371-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.038 BindingDB Entry DOI: 10.7270/Q2JW8FS8 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human CA7 by stopped-flow CO2 hydration assay |
Bioorg Med Chem 18: 2159-64 (2010)
Article DOI: 10.1016/j.bmc.2010.01.076 BindingDB Entry DOI: 10.7270/Q2GQ6ZP1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 18: 2669-74 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.023 BindingDB Entry DOI: 10.7270/Q23R0TRX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 by CO2 hydration assay |
Eur J Med Chem 43: 2853-60 (2008)
Article DOI: 10.1016/j.ejmech.2008.02.018 BindingDB Entry DOI: 10.7270/Q2Z03922 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dumlupinar University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli assessed as reduction in CO2 hydration preincubated for 15 mins pr... |
Bioorg Med Chem Lett 27: 86-89 (2017)
Article DOI: 10.1016/j.bmcl.2016.11.028 BindingDB Entry DOI: 10.7270/Q25D8TT1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 12
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration method |
Bioorg Med Chem 18: 4873-8 (2010)
Article DOI: 10.1016/j.bmc.2010.06.028 BindingDB Entry DOI: 10.7270/Q2D21ZKM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description Inhibition of human recombinant full length CA7-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay |
J Med Chem 55: 3891-9 (2012)
Article DOI: 10.1021/jm300112w BindingDB Entry DOI: 10.7270/Q20G3M6Q |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem Lett 20: 4376-81 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.082 BindingDB Entry DOI: 10.7270/Q2C24XCB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay |
Bioorg Med Chem Lett 20: 3601-5 (2010)
Article DOI: 10.1016/j.bmcl.2010.04.114 BindingDB Entry DOI: 10.7270/Q2NV9K7Q |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Ki value against human carbonic anhydrase VII |
Bioorg Med Chem Lett 15: 971-6 (2005)
Article DOI: 10.1016/j.bmcl.2004.12.052 BindingDB Entry DOI: 10.7270/Q25H7H1N |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA7 after 15 mins by CO2 hydration stopped flow assay |
Bioorg Med Chem Lett 17: 2685-91 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.008 BindingDB Entry DOI: 10.7270/Q2VM4D3D |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 |
Bioorg Med Chem 15: 4336-50 (2007)
Article DOI: 10.1016/j.bmc.2007.04.020 BindingDB Entry DOI: 10.7270/Q28916QG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 12
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of tumor-associated transmembrane human carbonic anhydrase-12 after 15 mins by Stopped-flow CO2 hydrase assay |
Bioorg Med Chem 21: 2314-8 (2013)
Article DOI: 10.1016/j.bmc.2013.02.022 BindingDB Entry DOI: 10.7270/Q2Q241MT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CAH7 |
J Med Chem 54: 2522-6 (2011)
Article DOI: 10.1021/jm2000213 BindingDB Entry DOI: 10.7270/Q22F7NSJ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assay |
J Med Chem 54: 3977-81 (2011)
Article DOI: 10.1021/jm200209n BindingDB Entry DOI: 10.7270/Q2736R8S |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 19: 3732-8 (2011)
Article DOI: 10.1016/j.bmc.2011.05.006 BindingDB Entry DOI: 10.7270/Q2BG2PCH |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istanbul University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method |
Bioorg Med Chem Lett 19: 3170-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.123 BindingDB Entry DOI: 10.7270/Q2TQ61V6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration method |
Bioorg Med Chem 19: 3105-19 (2011)
Article DOI: 10.1016/j.bmc.2011.04.005 BindingDB Entry DOI: 10.7270/Q2FF3SQ6 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ecole Nationale Sup£rieure de Chimie de Montpellier
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 preincubated for 15 mins at pH 7.5 by stopped flow CO2 hydration method |
Bioorg Med Chem Lett 21: 5210-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.045 BindingDB Entry DOI: 10.7270/Q2XP75B3 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffith University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 expressed in Escherichia coli BL21 (DE3) by stopped-flow CO2 hydration assay |
J Med Chem 59: 5462-70 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00443 BindingDB Entry DOI: 10.7270/Q2TF0084 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dumlupinar University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant membrane bound CA7 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 24: 3548-55 (2016)
Article DOI: 10.1016/j.bmc.2016.05.064 BindingDB Entry DOI: 10.7270/Q2N29ZVD |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 19: 4102-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.002 BindingDB Entry DOI: 10.7270/Q23778S7 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration method |
J Med Chem 53: 5511-22 (2010)
Article DOI: 10.1021/jm1003667 BindingDB Entry DOI: 10.7270/Q22N52FB |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Griffith University
Curated by ChEMBL
| Assay Description Inhibition of carbonic anhydrase-7 (unknown origin) |
J Med Chem 58: 7580-90 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01228 BindingDB Entry DOI: 10.7270/Q2QC0591 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aristotle University of Thessaloniki
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assa... |
Bioorg Med Chem 23: 7219-25 (2015)
Article DOI: 10.1016/j.bmc.2015.10.018 BindingDB Entry DOI: 10.7270/Q2862J84 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 pre-incubated for 15 mins by stopped-flow CO2 hydration assay |
Bioorg Med Chem 22: 6768-75 (2015)
Article DOI: 10.1016/j.bmc.2014.10.041 BindingDB Entry DOI: 10.7270/Q2697560 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human recombinant CA-7 after 15 mins by stopped-flow CO2 hydrase assay |
Bioorg Med Chem 23: 1828-40 (2015)
Article DOI: 10.1016/j.bmc.2015.02.027 BindingDB Entry DOI: 10.7270/Q2KS6T6Q |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite Montpellier II
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
J Med Chem 49: 7024-31 (2006)
Article DOI: 10.1021/jm060807n BindingDB Entry DOI: 10.7270/Q24T6GKT |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
Bioorg Med Chem Lett 18: 4282-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.105 BindingDB Entry DOI: 10.7270/Q27D2SF1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNR
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... |
J Med Chem 52: 5990-8 (2009)
Article DOI: 10.1021/jm900641r BindingDB Entry DOI: 10.7270/Q2GF0RVR |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | -49.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Universita degli Studi di Firenze
| Assay Description Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8. |
Chem Biol Drug Des 74: 196-202 (2009)
Article DOI: 10.1111/j.1747-0285.2009.00842.x BindingDB Entry DOI: 10.7270/Q2G44NS1 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ecole Nationale Supérieure de Chimie de Montpellier
| Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity. Phenol red (at a concentration of... |
J Enzyme Inhib Med Chem 28: 397-401 (2013)
Article DOI: 10.3109/14756366.2011.650692 BindingDB Entry DOI: 10.7270/Q20Z726F |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abant Izzet Baysal University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human carbonic anhydrase 7 assessed as reduction in CO2 hydration preincubated for 15 mins by stopped flow assay |
Bioorg Med Chem 25: 1456-1464 (2017)
Article DOI: 10.1016/j.bmc.2017.01.008 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase-7 using CO2 as substrate preincubated for 10 mins by stopped-flow CO2 hydrase assay |
Bioorg Med Chem 25: 539-544 (2017)
Article DOI: 10.1016/j.bmc.2016.11.027 BindingDB Entry DOI: 10.7270/Q2G73GQQ |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
CA VII + BH
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tampere and Tampere University Hospital
| Assay Description Reactions were measured using 0.2 mM phenol red (Absmax at 557 nm) as the indicator, in 10 mM HEPES, 0.1 M Na2SO4, pH 7.5, for a period of 10-100 s. ... |
J Enzyme Inhib Med Chem 26: 862-70 (2011)
Article DOI: 10.3109/14756366.2011.588227 BindingDB Entry DOI: 10.7270/Q2S181DX |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of S-glutathionylated form of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to s... |
Bioorg Med Chem Lett 22: 1560-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.134 BindingDB Entry DOI: 10.7270/Q2NK3FHM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 7
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto di Biostrutture e Bioimmagini-CNR
Curated by ChEMBL
| Assay Description Inhibition of human recombinant carbonic anhydrase 7 using carbon-dioxide as substrate preincubated for 10 mins prior to substrate addition by stoppe... |
Bioorg Med Chem Lett 22: 1560-4 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.134 BindingDB Entry DOI: 10.7270/Q2NK3FHM |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 9
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
| Assay Description Inhibition assay using carbonic anhydrases. |
Biochemistry 48: 1322-31 (2009)
Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic Anhydrase III
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank Article PubMed
| 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of human carbonic anhydrase 3 |
Bioorg Med Chem 15: 4336-50 (2007)
Article DOI: 10.1016/j.bmc.2007.04.020 BindingDB Entry DOI: 10.7270/Q28916QG |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet 
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
| Assay Description Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay |
J Med Chem 48: 1941-7 (2005)
Article DOI: 10.1021/jm040124c BindingDB Entry DOI: 10.7270/Q2SQ9152 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase, alpha family
(Thiomicrospira crunogena (strain XCL-2)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
GoogleScholar AffyNet 
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 26: 401-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.104 BindingDB Entry DOI: 10.7270/Q2DB83QG |
More data for this Ligand-Target Pair | |
Carbonate dehydratase
(Sulfurihydrogenibium sp. (strain YO3AOP1)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB
GoogleScholar AffyNet 
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CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay |
Bioorg Med Chem Lett 26: 401-5 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.104 BindingDB Entry DOI: 10.7270/Q2DB83QG |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Carbonic anhydrase 2
(Homo sapiens (human)) | BDBM10880
 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet 
| Purchase
CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
| Assay Description Inhibition assay using carbonic anhydrases. |
Biochemistry 48: 1322-31 (2009)
Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |