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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Carbonic Anhydrase XV (Mus musculus (mouse)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | KEGG GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 8.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem Lett 19: 1155-8 (2009) Article DOI: 10.1016/j.bmcl.2008.12.082 BindingDB Entry DOI: 10.7270/Q2KD1W79 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA IV | Bioorg Med Chem Lett 14: 5769-73 (2004) Article DOI: 10.1016/j.bmcl.2004.09.063 BindingDB Entry DOI: 10.7270/Q24X58JJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem Lett 19: 1155-8 (2009) Article DOI: 10.1016/j.bmcl.2008.12.082 BindingDB Entry DOI: 10.7270/Q2KD1W79 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 4 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ondokuz Mayis University Curated by ChEMBL | Assay Description Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curves | Bioorg Med Chem 19: 744-8 (2011) Article DOI: 10.1016/j.bmc.2010.12.033 BindingDB Entry DOI: 10.7270/Q2ST7QT4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Astrosclerin-3 (Astrosclera willeyana) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 4.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Slovak Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins ... | Bioorg Med Chem Lett 22: 1314-6 (2012) Article DOI: 10.1016/j.bmcl.2011.12.085 BindingDB Entry DOI: 10.7270/Q2W66M7M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha carbonic anhydrase (Stylophora pistillata) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Scientifique de Monaco Curated by ChEMBL | Assay Description Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | Bioorg Med Chem Lett 21: 710-4 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.124 BindingDB Entry DOI: 10.7270/Q26D5T7K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase (Stylophora pistillata) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 5.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Scientifique de Monaco Curated by ChEMBL | Assay Description Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | Bioorg Med Chem Lett 21: 710-4 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.124 BindingDB Entry DOI: 10.7270/Q26D5T7K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| β-Carbonic anhydrase (βCA) (Helicobacter pylori) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 5.60E+5 | -18.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Università degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy... | J Enzyme Inhib Med Chem 28: 388-91 (2013) Article DOI: 10.3109/14756366.2011.649268 BindingDB Entry DOI: 10.7270/Q2S75F7K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 7.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Scientifique de Monaco Curated by ChEMBL | Assay Description Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | Bioorg Med Chem Lett 21: 710-4 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.124 BindingDB Entry DOI: 10.7270/Q26D5T7K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Carbonic anhydrase 7 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | Article PubMed | 1.84E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Inhibition of human recombinant CA7 | Bioorg Med Chem Lett 16: 3139-43 (2006) Article DOI: 10.1016/j.bmcl.2006.03.078 BindingDB Entry DOI: 10.7270/Q29W0G8R | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-carbonic anhydrase (Helicobacter pylori (strain G27)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 2.70E+6 | -14.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 20 |
Universit£ degli Studi di Firenze | Assay Description Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay | Bioorg Med Chem 24: 3413-7 (2016) Article DOI: 10.1016/j.bmc.2016.05.029 BindingDB Entry DOI: 10.7270/Q2W9583B | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| α-Carbonic anhydrase (αCA) (Helicobacter pylori) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB UniProtKB/TrEMBL GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 2.70E+6 | -14.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Università degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy... | J Enzyme Inhib Med Chem 28: 388-91 (2013) Article DOI: 10.3109/14756366.2011.649268 BindingDB Entry DOI: 10.7270/Q2S75F7K | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 6.00E+6 | -12.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 20 |
Universit£ degli Studi di Firenze | Assay Description Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay | Bioorg Med Chem 24: 3413-7 (2016) Article DOI: 10.1016/j.bmc.2016.05.029 BindingDB Entry DOI: 10.7270/Q2W9583B | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 6.00E+6 | -12.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 20 |
Universita degli Studi di Firenze | Assay Description An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic... | Bioorg Med Chem Lett 19: 1155-8 (2009) Article DOI: 10.1016/j.bmcl.2008.12.082 BindingDB Entry DOI: 10.7270/Q2KD1W79 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM26979 (CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEBI CHEMBL MMDB PC cid PC sid | ||||||||||
