BindingDB PrimarySearch_ki

Found 99 of ic50 for monomerid = 50005480

Tubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 5.70nMAssay Description:Inhibition of beta3 Tubulin (unknown origin) expressed in human HeLa cell line assessed as inhibition of cell proliferation measured after 48 hrs by ...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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3D Structure (crystal)

Tubulin beta-3 chain(Homo sapiens)
Duquesne University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 5.70nMAssay Description:Inhibition of beta3 tubulin overexpressed in human HeLa cells after 48 hrs by SRB assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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3D Structure (crystal)

ATP-dependent translocase ABCB1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 6.60nMAssay Description:Inhibition of p-gp overexpressed in human SKOV3/M6-6 isogenic cells after 48 hrs by sulforhodamine B assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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ATP-dependent translocase ABCB1(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 12nMAssay Description:Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assayMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Tubulin polymerization-promoting protein(Homo sapiens (Human))
University Of Virginia

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 32nMAssay Description:IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B...More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Tubulin beta-1 chain(Homo sapiens (Human))
University Of Salford

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 180nMAssay Description:Concentration required for 50% inhibition of tubulin polymerizationMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 440nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 520nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as decrease in fluorescence intensity measured every 60 sec for 90 mins in presence of GT...More data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Tubulin alpha-1A chain(Sus scrofa (Pig))
University Of North Carolina

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of tubulin polymerization(ITP)More data for this Ligand-Target Pair

PDB MMDB
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3D Structure (crystal)

Tubulin beta-2B chain(Bos taurus)
University Of North Carolina At Chapel Hill

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tubulin beta-2B chain(Bos taurus)
University Of North Carolina At Chapel Hill

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of bovine brain tubulin polymerization (ITP).More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Tested for inhibition against tubulin polymerizationMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 530nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 540nMAssay Description:Inhibition of bovine brain tubulin assembly using GTP as substrate incubated for 20 mins by spectrophotometric methodMore data for this Ligand-Target Pair

PDB
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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of pig brain tubulin polymerizationMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of pig tubulin polymerizationMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 600nMAssay Description:Inhibition of porcine brain tubulin polymerization after 60 minsMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 640nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 640nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition and measured for 20 mins by turbidimetry-based sp...More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 650nMAssay Description:Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysisMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 660nMAssay Description:Concentration inhibiting tubulin polymerization (ITP)More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 680nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric methodMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
Shenyang Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 900nMAssay Description:Inhibition of bovine brain tubulin polymerizationMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 960nMAssay Description:Inhibition of tubulin assembly in bovine brain homogenate assessed as reduction in turbidity increase preincubated for 15 mins followed by GTP additi...More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Tubulin alpha-1A chain(Sus scrofa (Pig))
University Of North Carolina

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of bovine brain tubulin assemblyMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibitory concentration required against MAP-rich tubulin polymerizationMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin assembly preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric analysis in p...More data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrometric methodMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.00E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometric methodMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.06E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.10E+3nMAssay Description:Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.10E+3nMAssay Description:Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.10E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Tubulin beta-2B chain(Bos taurus)
University Of North Carolina At Chapel Hill

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tubulin alpha-1A chain(Sus scrofa (Pig))
University Of North Carolina

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Concentration required to inhibit polymerization of tubulinMore data for this Ligand-Target Pair

PDB MMDB
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3D Structure (crystal)

Tubulin alpha-1A chain(Sus scrofa (Pig))
University Of North Carolina

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Antitubulin activity activity of the compound against tubulin polymerizationMore data for this Ligand-Target Pair

PDB MMDB
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3D Structure (crystal)

Tubulin beta-1 chain(Homo sapiens (Human))
University Of Salford

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree CMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric meth...More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysisMore data for this Ligand-Target Pair

PDB KEGG
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 minsMore data for this Ligand-Target Pair

PDB
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:The compound was tested for the concentration to inhibit 50% of tubulin polymerization.More data for this Ligand-Target Pair

PDB
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization by turbidimetryMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.30E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometeric analysisMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Similar to alpha-tubulin isoform 1(Bos taurus)
University Of Padova

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.30E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 15 mins by spectrophotometryMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
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Tubulin beta chain(Sus scrofa)
Minia University

Curated by ChEMBL

PNG

BDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)

IC50: 1.32E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 30 mins by spectrophotometryMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Displayed 1 to 50 (of 99 total ) | Next | Last >>

Filter my 99 hits

Targets 17▿
- Similar to alpha-tubulin isoform 1 40
- Tubulin beta chain 25
- Tubulin alpha-1A chain 6
- Similar to alpha-tubulin isoform 1/Tubulin beta-2B chain 5
- Tubulin beta-2B chain 4
- Tubulin beta-1 chain 3
- Tubulin beta-3 chain 2
- Tubulin polymerization-promoting protein 2
- Tubulin beta chain [1-43] 2
- DNA topoisomerase 1 2
- ATP-dependent translocase ABCB1 2
- cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D 1
- Tyrosine-protein kinase ABL1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Programmed cell death 1 ligand/protein 1 1
- Fibroblast growth factor receptor 1 1
- Epidermal growth factor receptor 1
- ...
Publications 50▿
- J Med Chem 57: 4598-605 (2014) 4
- J Med Chem 56: 6829-44 (2013) 3
- Chem Biol 12: 1007-14 (2005) 2
- Eur J Med Chem 163: 428-442 (2019) 2
- J Nat Prod 63: 457-60 (2000) 2
- Eur J Med Chem 163: 896-910 (2019) 2
- Eur J Med Chem 183: (2019) 2
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- Eur J Med Chem 84: 476-90 (2014) 2
- J Med Chem 58: 2538-46 (2015) 1
- J Med Chem 48: 457-65 (2005) 1
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- ...
Institutions 30▿
- Universit£ 7
- Nanjing University 6
- University Of Padova 4
- Duquesne University 4
- University Of North Carolina 3
- Southern Medical University 3
- Second Military Medical University 3
- University Of Salford 2
- Csir-Indian Institute Of Chemical Technology 2
- TBA 2
- Virginia Polytechnic Institute And State University 2
- China Pharmaceutical University 2
- Purdue University 2
- Taipei Medical University 2
- University Of Virginia 2
- Minia University 2
- National Cancer Institute-Bethesda 2
- Abbott Laboratories 1
- University Of North Carolina At Chapel Hill 1
- National Health Research Institutes 1
- University Of Antwerp 1
- China Medical College 1
- Australian National University 1
- University Of Milan-Bicocca 1
- The University Of Tokyo 1
- Hokkaido University 1
- Universitá 1
- Arizona State University 1
- Shanghai Institute Of Technology 1
- University Of Oslo 1
- ...
Affinity: 5.7 to 1.0E+5 nM▿
- IC50 99
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1