Found 61 of ec50 for monomerid = 50018958 
Affinity DataEC50: 9.70nMAssay Description:Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human D3 receptor stably expressed in HEK293T cells co-expressing ElucN-betaarr2 hD3R-ElucC by beta-arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 680nMAssay Description:Agonist activity at D2 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMAssay Description:Intrinsic activity at human dopamine D2S receptor expressed in HEK293 cells co-transfected with Galpha0i assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+3nMAssay Description:Intrinsic activity at human dopamine D2S receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.70E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galpha0i assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.80E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:Agonist activity at ARMS2-PK2-tagged human dopamine D2S receptor expressed in HEK293 cells co-expressing (EA)-tagged beta arrestin fusion protein ass...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation count...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation countin...More data for this Ligand-Target Pair
Affinity DataEC50: 617nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...More data for this Ligand-Target Pair
Affinity DataEC50: 1.62E+3nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...More data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Activity at pro-link-tagged D2S-ARMS2PK2 (unknown origin) expressed in HEK293 cells by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293 cells cotransfected with Gqi5 protein assessed as [3H]IP3 accumulation after 120 mins by s...More data for this Ligand-Target Pair
Affinity DataEC50: 86nMAssay Description:Agonist activity at ARMS2-PK-tagged D2S receptor (unknown origin) transfected in HEK293 cells after 5 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
Affinity DataEC50: 186nMAssay Description:Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 148nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
Affinity DataEC50: 353nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 270nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
Affinity DataEC50: 360nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor/Metabotropic glutamate receptor 5(Homo sapiens (Human))
Ghent University
Curated by ChEMBL
Ghent University
Curated by ChEMBL
Affinity DataEC50: 1.90nMAssay Description:Agonist activity at human dopamine D2 receptor /mGluR5a (unknown origin) expressed in HEK293T cells assessed as reduction in forskolin-induced cAMP a...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293T cells assessed as reduction in forskolin-induced cAMP accumulation preincubated f...More data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Displacement of [3H]spiperone from human D2SR expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
Affinity DataEC50: 115nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells co-expressing N-terminal venus-tagged beta-arrestin2 assessed as beta-arres...More data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Partial agonist activity at D2L receptor (unknown origin) expressed in human HTLA cells assessed as beta-arrestin2 recruitment after 20 to 22 hrs by ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Partial agonist activity at human D2L receptor expressed in HEK293T cells co-expressing Galpahi1/Gbeta1/GFP2-Ggamma2 assessed as Galphai1 dissociatio...More data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Partial agonist activity at human Gi/o-coupled D2R expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Agonist activity at human D2S receptor expressed in CHOK1 cells assessed as inhibition of forskolin induced cAMP production preincubated for 10 mins ...More data for this Ligand-Target Pair
Affinity DataEC50: 151nMAssay Description:Agonist activity at human D2S receptor expressed in CHOK1 cells assessed as inhibition of forskolin induced cAMP production preincubated for 10 mins ...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataEC50: 83nMAssay Description:Agonist activity at PKA-tagged D4 receptor (unknown origin) expressed in HEK293 cells co-expressing beta-arrestin2 assessed as induction of beta-arre...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataEC50: 2.20nMAssay Description:Agonist activity at human D4 receptor expressed in HEK293T cells co-expressing G-alphaqi assessed as accumulation of inositol monophosphate using d2-...More data for this Ligand-Target Pair
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataEC50: 2.70nMAssay Description:Agonist activity at D4R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at D2R (unknown origin) expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gi-cAMP Glosensor...More data for this Ligand-Target Pair
Affinity DataEC50: 0.420nMAssay Description:Agonist activity at human Gi/o-coupled D3 receptor expressed in HEK293T cells assessed as inhibition of isoproterenol-induced cAMP accumulation prein...More data for this Ligand-Target Pair
Affinity DataEC50: 35nMAssay Description:Agonist activity at D3 receptor (unknown origin) expressed in human HTLA cells assessed as induction of beta-arrestin2 recruitment measured after 16 ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at human D2R isoform 2 stably expressed in HEK293 cells assessed as inhibition of forskolin-induced increase of cAMP accumulation pr...More data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at human histamine D2L receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80nMAssay Description:Agonist activity at human histamine D3 receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Partial agonist activity at D2 receptor (unknown origin) expressed in HEK293T cells co-expressing Rluc8-tagged Galpahi1 assessed as Galphai1 dissocia...More data for this Ligand-Target Pair
