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Compile Data Set for Download or QSAR

Found 3 hits of ec50 for drug = Aldara   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50240849
PNG
(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12
Show InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
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PC cid
PC sid
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Article
PubMed
n/an/an/an/a 2.12E+3n/an/an/an/a



University of Kansas

Curated by ChEMBL


Assay Description
Agonist activity at human TLR7 expressed in NFkappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by rep...


J Med Chem 53: 4450-65 (2010)


Article DOI: 10.1021/jm100358c
BindingDB Entry DOI: 10.7270/Q2Q52PS6
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50240849
PNG
(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12
Show InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
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UniProtKB/SwissProt

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CHEMBL
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PC cid
PC sid
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UniChem

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Article
PubMed
n/an/an/an/a 1.21E+4n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...


ACS Med Chem Lett 3: 501-504 (2012)


Article DOI: 10.1021/ml300079e
BindingDB Entry DOI: 10.7270/Q2FB544F
More data for this
Ligand-Target Pair
Toll-like receptor 8 (TLR8)


(Homo sapiens (Human))
BDBM50240849
PNG
(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Show SMILES CC(C)Cn1cnc2c(N)nc3ccccc3c12
Show InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a>2.70E+5n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene as...


ACS Med Chem Lett 3: 501-504 (2012)


Article DOI: 10.1021/ml300079e
BindingDB Entry DOI: 10.7270/Q2FB544F
More data for this
Ligand-Target Pair