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Compile Data Set for Download or QSAR

Found 10 hits of ec50 for UniProtKB: A0A024R0L5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219340
PNG
(CHEMBL65944)
Show SMILES N(\N=C\c1ccncc1)c1ncnc2n(ncc12)-c1cccc2[nH]cnc12
Show InChI InChI=1S/C18H13N9/c1-2-14-16(21-10-20-14)15(3-1)27-18-13(9-25-27)17(22-11-23-18)26-24-8-12-4-6-19-7-5-12/h1-11H,(H,20,21)(H,22,23,26)/b24-8+
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n/an/an/an/a 110n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219339
PNG
(GW784752X)
Show SMILES COc1cccc(c1)-n1ncc2c(N\N=C\c3ccncc3)ncnc12
Show InChI InChI=1S/C18H15N7O/c1-26-15-4-2-3-14(9-15)25-18-16(11-23-25)17(20-12-21-18)24-22-10-13-5-7-19-8-6-13/h2-12H,1H3,(H,20,21,24)/b22-10+
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n/an/an/an/a 220n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219003
PNG
(CHEMBL66860)
Show SMILES Fc1ccc(\C=N\Nc2ncnc3n(ncc23)-c2cccc3[nH]cnc23)cc1
Show InChI InChI=1S/C19H13FN8/c20-13-6-4-12(5-7-13)8-25-27-18-14-9-26-28(19(14)24-11-23-18)16-3-1-2-15-17(16)22-10-21-15/h1-11H,(H,21,22)(H,23,24,27)/b25-8+
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n/an/an/an/a 230n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219001
PNG
(CHEMBL69687)
Show SMILES CS(=O)(=O)c1ccc(\C=N\Nc2ncnc3n(ncc23)-c2cccc3[nH]cnc23)cc1
Show InChI InChI=1S/C20H16N8O2S/c1-31(29,30)14-7-5-13(6-8-14)9-25-27-19-15-10-26-28(20(15)24-12-23-19)17-4-2-3-16-18(17)22-11-21-16/h2-12H,1H3,(H,21,22)(H,23,24,27)/b25-9+
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n/an/an/an/a 240n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219327
PNG
(GW811168X | PYRAZOLOPYRIMIDINE 2)
Show SMILES COc1cccc(c1)-n1ncc2c(N\N=C\c3ccc(cc3)S(C)(=O)=O)ncnc12
Show InChI InChI=1S/C20H18N6O3S/c1-29-16-5-3-4-15(10-16)26-20-18(12-24-26)19(21-13-22-20)25-23-11-14-6-8-17(9-7-14)30(2,27)28/h3-13H,1-2H3,(H,21,22,25)/b23-11+
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n/an/an/an/a 310n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219006
PNG
(CHEMBL63727)
Show SMILES N(\N=C\c1ccncc1)c1ncnc2n(ncc12)-c1ccccc1
Show InChI InChI=1S/C17H13N7/c1-2-4-14(5-3-1)24-17-15(11-22-24)16(19-12-20-17)23-21-10-13-6-8-18-9-7-13/h1-12H,(H,19,20,23)/b21-10+
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n/an/an/an/a 1.22E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219338
PNG
(CHEMBL65988)
Show SMILES COc1cccc(c1)-n1ncc2c(N\N=C\c3ccc(cc3)C(O)=O)ncnc12
Show InChI InChI=1S/C20H16N6O3/c1-29-16-4-2-3-15(9-16)26-19-17(11-24-26)18(21-12-22-19)25-23-10-13-5-7-14(8-6-13)20(27)28/h2-12H,1H3,(H,27,28)(H,21,22,25)/b23-10+
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n/an/an/an/a 1.88E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219326
PNG
(PYRAZOLOPYRIMIDINE 1)
Show SMILES CN(C)CCNC(=O)c1ccc(\C=N\Nc2ncnc3n(ncc23)-c2cccc3[nH]cnc23)cc1
Show InChI InChI=1S/C24H24N10O/c1-33(2)11-10-25-24(35)17-8-6-16(7-9-17)12-30-32-22-18-13-31-34(23(18)29-15-28-22)20-5-3-4-19-21(20)27-14-26-19/h3-9,12-15H,10-11H2,1-2H3,(H,25,35)(H,26,27)(H,28,29,32)/b30-12+
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n/an/an/an/a 2.33E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219004
PNG
(CHEMBL66072)
Show SMILES OC(=O)c1ccc(\C=N\Nc2ncnc3n(ncc23)-c2cccc3[nH]cnc23)cc1
Show InChI InChI=1S/C20H14N8O2/c29-20(30)13-6-4-12(5-7-13)8-25-27-18-14-9-26-28(19(14)24-11-23-18)16-3-1-2-15-17(16)22-10-21-15/h1-11H,(H,21,22)(H,29,30)(H,23,24,27)/b25-8+
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n/an/an/an/a 2.73E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM50219005
PNG
(CHEMBL67374)
Show SMILES COc1cccc(c1)-n1ncc2c(N\N=C\c3ccc(cc3)C(=O)NCCN(C)C)ncnc12
Show InChI InChI=1S/C24H26N8O2/c1-31(2)12-11-25-24(33)18-9-7-17(8-10-18)14-28-30-22-21-15-29-32(23(21)27-16-26-22)19-5-4-6-20(13-19)34-3/h4-10,13-16H,11-12H2,1-3H3,(H,25,33)(H,26,27,30)/b28-14+
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n/an/an/an/a 4.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of glycogen synthesis in rat skeletal muscle L6 cells


Bioorg Med Chem Lett 14: 2127-30 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.037
BindingDB Entry DOI: 10.7270/Q2Q242DJ
More data for this
Ligand-Target Pair