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Compile Data Set for Download or QSAR

Found 194 hits of kd data for polymerid = 10444   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047291
PNG
(3-(2-{3-[4-(6-Cyclohexyl-hexanoyl)-oxazol-2-yl]-7-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)CCCCCC1CCCCC1
Show InChI InChI=1S/C31H41NO5/c33-26(14-6-2-5-11-21-9-3-1-4-10-21)25-20-36-31(32-25)30-24(27-16-17-28(30)37-27)19-23-13-8-7-12-22(23)15-18-29(34)35/h7-8,12-13,20-21,24,27-28,30H,1-6,9-11,14-19H2,(H,34,35)
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n/an/an/a 0.0500n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047266
PNG
(3-(2-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C30H40N2O5/c33-27(34)16-13-21-11-4-5-12-22(21)18-23-25-14-15-26(37-25)28(23)30-32-24(19-36-30)29(35)31-17-7-6-10-20-8-2-1-3-9-20/h4-5,11-12,19-20,23,25-26,28H,1-3,6-10,13-18H2,(H,31,35)(H,33,34)
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n/an/an/a 0.100n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for the receptor binding studies with Thromboxane A2 receptor using [3H]-SQ 29548 as radioligand in human platelet membranes.


Bioorg Med Chem Lett 1: 461-464 (1991)


Article DOI: 10.1016/S0960-894X(01)81106-9
BindingDB Entry DOI: 10.7270/Q2319VSZ
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047266
PNG
(3-(2-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C30H40N2O5/c33-27(34)16-13-21-11-4-5-12-22(21)18-23-25-14-15-26(37-25)28(23)30-32-24(19-36-30)29(35)31-17-7-6-10-20-8-2-1-3-9-20/h4-5,11-12,19-20,23,25-26,28H,1-3,6-10,13-18H2,(H,31,35)(H,33,34)
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n/an/an/a 0.100n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Dissociation constant was determined from radioligand binding studies in human platelet membranes using Thromboxane A2 receptor radioligand [3H]-SQ 2...


Bioorg Med Chem Lett 2: 937-940 (1992)


Article DOI: 10.1016/S0960-894X(00)80592-2
BindingDB Entry DOI: 10.7270/Q20R9P9X
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047266
PNG
(3-(2-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C30H40N2O5/c33-27(34)16-13-21-11-4-5-12-22(21)18-23-25-14-15-26(37-25)28(23)30-32-24(19-36-30)29(35)31-17-7-6-10-20-8-2-1-3-9-20/h4-5,11-12,19-20,23,25-26,28H,1-3,6-10,13-18H2,(H,31,35)(H,33,34)
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n/an/an/a 0.100n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047278
PNG
(3-[2-(3-{4-[4-(4-Chloro-phenyl)-butylcarbamoyl]-ox...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCc1ccc(Cl)cc1
Show InChI InChI=1S/C30H33ClN2O5/c31-22-11-8-19(9-12-22)5-3-4-16-32-29(36)24-18-37-30(33-24)28-23(25-13-14-26(28)38-25)17-21-7-2-1-6-20(21)10-15-27(34)35/h1-2,6-9,11-12,18,23,25-26,28H,3-5,10,13-17H2,(H,32,36)(H,34,35)
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n/an/an/a 0.200n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047284
PNG
(3-{2-[3-(4-Heptylcarbamoyl-oxazol-2-yl)-7-oxa-bicy...)
Show SMILES CCCCCCCNC(=O)c1coc(n1)C1C2CCC(O2)C1Cc1ccccc1CCC(O)=O
Show InChI InChI=1S/C27H36N2O5/c1-2-3-4-5-8-15-28-26(32)21-17-33-27(29-21)25-20(22-12-13-23(25)34-22)16-19-10-7-6-9-18(19)11-14-24(30)31/h6-7,9-10,17,20,22-23,25H,2-5,8,11-16H2,1H3,(H,28,32)(H,30,31)
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n/an/an/a 0.200n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047300
PNG
(3-(2-{3-[4-(4-Phenyl-butylcarbamoyl)-oxazol-2-yl]-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C30H34N2O5/c33-27(34)16-13-21-11-4-5-12-22(21)18-23-25-14-15-26(37-25)28(23)30-32-24(19-36-30)29(35)31-17-7-6-10-20-8-2-1-3-9-20/h1-5,8-9,11-12,19,23,25-26,28H,6-7,10,13-18H2,(H,31,35)(H,33,34)
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n/an/an/a 0.300n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047270
PNG
(3-[2-(3-{4-[4-(4-Methoxy-phenyl)-butylcarbamoyl]-o...)
Show SMILES COc1ccc(CCCCNC(=O)c2coc(n2)C2C3CCC(O3)C2Cc2ccccc2CCC(O)=O)cc1
Show InChI InChI=1S/C31H36N2O6/c1-37-23-12-9-20(10-13-23)6-4-5-17-32-30(36)25-19-38-31(33-25)29-24(26-14-15-27(29)39-26)18-22-8-3-2-7-21(22)11-16-28(34)35/h2-3,7-10,12-13,19,24,26-27,29H,4-6,11,14-18H2,1H3,(H,32,36)(H,34,35)
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n/an/an/a 0.300n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50405907
PNG
(CHEMBL2096756)
Show SMILES CC\C=C/CCSCC1C2CCC(O2)C1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C20H32O3S/c1-2-3-4-9-14-24-15-17-16(18-12-13-19(17)23-18)10-7-5-6-8-11-20(21)22/h3-5,7,16-19H,2,6,8-15H2,1H3,(H,21,22)/b4-3-,7-5-
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n/an/an/a 0.400n/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of specific binding of HSQ (5,6-di-3H-SQ 29,548) in washed platelets


J Med Chem 32: 974-84 (1989)


Article DOI: 10.1021/jm00125a009
BindingDB Entry DOI: 10.7270/Q2TT4PX7
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50281917
PNG
(3-(2-{2-[4-(4-Chloro-benzylcarbamoyl)-oxazol-2-yl]...)
Show SMILES OC(=O)CCc1ccccc1C[C@@H]1CCC[C@H]1c1nc(co1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O4/c27-21-11-8-17(9-12-21)15-28-25(32)23-16-33-26(29-23)22-7-3-6-20(22)14-19-5-2-1-4-18(19)10-13-24(30)31/h1-2,4-5,8-9,11-12,16,20,22H,3,6-7,10,13-15H2,(H,28,32)(H,30,31)/t20-,22+/m0/s1
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n/an/an/a 0.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity was determined for Thromboxane A2 receptor in human platelet membrane using [3H]-SQ-29,548 radioligand


Bioorg Med Chem Lett 3: 1267-1270 (1993)


Article DOI: 10.1016/S0960-894X(00)80329-7
BindingDB Entry DOI: 10.7270/Q2PV6K8B
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047280
PNG
(3-[2-(3-{4-[4-(4-Hydroxy-phenyl)-butylcarbamoyl]-o...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCc1ccc(O)cc1
Show InChI InChI=1S/C30H34N2O6/c33-22-11-8-19(9-12-22)5-3-4-16-31-29(36)24-18-37-30(32-24)28-23(25-13-14-26(28)38-25)17-21-7-2-1-6-20(21)10-15-27(34)35/h1-2,6-9,11-12,18,23,25-26,28,33H,3-5,10,13-17H2,(H,31,36)(H,34,35)
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n/an/an/a 0.5n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047289
PNG
(3-(2-{3-[4-(5,5-Dimethyl-hexylcarbamoyl)-oxazol-2-...)
Show SMILES CC(C)(C)CCCCNC(=O)c1coc(n1)C1C2CCC(O2)C1Cc1ccccc1CCC(O)=O
Show InChI InChI=1S/C28H38N2O5/c1-28(2,3)14-6-7-15-29-26(33)21-17-34-27(30-21)25-20(22-11-12-23(25)35-22)16-19-9-5-4-8-18(19)10-13-24(31)32/h4-5,8-9,17,20,22-23,25H,6-7,10-16H2,1-3H3,(H,29,33)(H,31,32)
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n/an/an/a 0.600n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50008781
PNG
(7-(3-(2-ethyl-N-phenylhydrazinecarboxamide)-7-oxa-...)
Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H]2CCC(O2)[C@H]1CNNC(=O)Nc1ccccc1
Show InChI InChI=1S/C21H29N3O4/c25-20(26)11-7-2-1-6-10-16-17(19-13-12-18(16)28-19)14-22-24-21(27)23-15-8-4-3-5-9-15/h1,3-6,8-9,16-19,22H,2,7,10-14H2,(H,25,26)(H2,23,24,27)/b6-1-/t16-,17+,18+,19?/m1/s1
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n/an/an/a 0.631n/an/an/an/an/a



Squibb Institute for Medical Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Thromboxane A2 receptor in guinea pig trachea in the presence of 11,9-epoxymethano-PGH2


J Med Chem 33: 1741-8 (1990)


Article DOI: 10.1021/jm00168a032
BindingDB Entry DOI: 10.7270/Q2222VZK
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047283
PNG
(3-{2-[3-(4-Phenethylcarbamoyl-oxazol-2-yl)-7-oxa-b...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C28H30N2O5/c31-25(32)13-10-19-8-4-5-9-20(19)16-21-23-11-12-24(35-23)26(21)28-30-22(17-34-28)27(33)29-15-14-18-6-2-1-3-7-18/h1-9,17,21,23-24,26H,10-16H2,(H,29,33)(H,31,32)
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n/an/an/a 0.700n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047288
PNG
(3-(2-{3-[4-(2-Cyclohexyl-ethylcarbamoyl)-oxazol-2-...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCC1CCCCC1
Show InChI InChI=1S/C28H36N2O5/c31-25(32)13-10-19-8-4-5-9-20(19)16-21-23-11-12-24(35-23)26(21)28-30-22(17-34-28)27(33)29-15-14-18-6-2-1-3-7-18/h4-5,8-9,17-18,21,23-24,26H,1-3,6-7,10-16H2,(H,29,33)(H,31,32)
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n/an/an/a 0.700n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047298
PNG
(3-(2-{3-[4-(1,1-Dimethyl-propylcarbamoyl)-oxazol-2...)
Show SMILES CCC(C)(C)NC(=O)c1coc(n1)C1C2CCC(O2)C1Cc1ccccc1CCC(O)=O
Show InChI InChI=1S/C25H32N2O5/c1-4-25(2,3)27-23(30)18-14-31-24(26-18)22-17(19-10-11-20(22)32-19)13-16-8-6-5-7-15(16)9-12-21(28)29/h5-8,14,17,19-20,22H,4,9-13H2,1-3H3,(H,27,30)(H,28,29)
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n/an/an/a 0.800n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047294
PNG
(4-(2-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-...)
Show SMILES OC(=O)CCCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C31H42N2O5/c34-28(35)15-8-14-22-12-4-5-13-23(22)19-24-26-16-17-27(38-26)29(24)31-33-25(20-37-31)30(36)32-18-7-6-11-21-9-2-1-3-10-21/h4-5,12-13,20-21,24,26-27,29H,1-3,6-11,14-19H2,(H,32,36)(H,34,35)
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n/an/an/a 0.850n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047273
PNG
(2-{3-[2-(2-Carboxy-ethyl)-benzyl]-7-oxa-bicyclo[2....)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C30H39NO6/c32-27(33)16-13-21-11-4-5-12-22(21)18-23-25-14-15-26(37-25)28(23)29-31-24(19-36-29)30(34)35-17-7-6-10-20-8-2-1-3-9-20/h4-5,11-12,19-20,23,25-26,28H,1-3,6-10,13-18H2,(H,32,33)
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n/an/an/a 1n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50010073
PNG
(3-(2-{3-[(E)-Phenylcarbamoylmethylimino-amino]-7-o...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1C=NNC(=O)Nc1ccccc1
Show InChI InChI=1S/C24H27N3O4/c28-23(29)13-10-16-6-4-5-7-17(16)14-19-20(22-12-11-21(19)31-22)15-25-27-24(30)26-18-8-2-1-3-9-18/h1-9,15,19-22H,10-14H2,(H,28,29)(H2,26,27,30)
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n/an/an/a 1n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of specific binding of [3H]-SQ 29,548 to thromboxane A2 receptor in human platelet membranes


J Med Chem 34: 2882-91 (1991)


Article DOI: 10.1021/jm00113a030
BindingDB Entry DOI: 10.7270/Q2CJ8CFZ
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391311
PNG
(CHEMBL352040)
Show SMILES CCc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H42N2O4/c1-2-25-17-18-32-22-27(25)26-13-11-24(12-14-26)23-37-29-16-15-28(33-19-7-3-4-8-20-33)31(29)36-21-9-5-6-10-30(34)35/h5,9,11-14,17-18,22,28-29,31H,2-4,6-8,10,15-16,19-21,23H2,1H3,(H,34,35)/b9-5-/t28-,29+,31+/m0/s1
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n/an/an/a 1n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50015853
PNG
(7-(3-{[2-(4-Cyclohexyl-butyrylamino)-acetylamino]-...)
Show SMILES OC(=O)CCC\C=C\CC1C2CCC(O2)C1CNC(=O)CNC(=O)CCCC1CCCCC1
Show InChI InChI=1S/C26H42N2O5/c29-24(13-8-11-19-9-4-3-5-10-19)28-18-25(30)27-17-21-20(22-15-16-23(21)33-22)12-6-1-2-7-14-26(31)32/h1,6,19-23H,2-5,7-18H2,(H,27,30)(H,28,29)(H,31,32)/b6-1+
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n/an/an/a 1.10n/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Binding affinity was determined from the inhibition of [3H]-SQ 29,548 binding to Thromboxane A2 receptor in human platelet membranes.


J Med Chem 33: 2465-76 (1990)


Article DOI: 10.1021/jm00171a021
BindingDB Entry DOI: 10.7270/Q2V123S1
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047303
PNG
((3-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl...)
Show SMILES OC(=O)Cc1cccc(CC2C3CCC(O3)C2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1
Show InChI InChI=1S/C29H38N2O5/c32-26(33)17-21-11-6-10-20(15-21)16-22-24-12-13-25(36-24)27(22)29-31-23(18-35-29)28(34)30-14-5-4-9-19-7-2-1-3-8-19/h6,10-11,15,18-19,22,24-25,27H,1-5,7-9,12-14,16-17H2,(H,30,34)(H,32,33)
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n/an/an/a 1.20n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Thromboxane A2 receptor


(Homo sapiens (Human))
BDBM50047282
PNG
(3-[2-(3-{4-[2-(4-Chloro-phenyl)-ethylcarbamoyl]-ox...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C28H29ClN2O5/c29-20-8-5-17(6-9-20)13-14-30-27(34)22-16-35-28(31-22)26-21(23-10-11-24(26)36-23)15-19-4-2-1-3-18(19)7-12-25(32)33/h1-6,8-9,16,21,23-24,26H,7,10-15H2,(H,30,34)(H,32,33)
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n/an/an/a 1.30n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition against TXA2/PGH2 receptor using [3H]-SQ 29,548 as radioligand in human platelet membrane preparation


Bioorg Med Chem Lett 3: 1271-1276 (1993)


Article DOI: 10.1016/S0960-894X(00)80330-3
BindingDB Entry DOI: 10.7270/Q2K35TJX
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047282
PNG
(3-[2-(3-{4-[2-(4-Chloro-phenyl)-ethylcarbamoyl]-ox...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C28H29ClN2O5/c29-20-8-5-17(6-9-20)13-14-30-27(34)22-16-35-28(31-22)26-21(23-10-11-24(26)36-23)15-19-4-2-1-3-18(19)7-12-25(32)33/h1-6,8-9,16,21,23-24,26H,7,10-15H2,(H,30,34)(H,32,33)
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n/an/an/a 1.30n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391281
PNG
(CHEMBL161108)
Show SMILES OCc1ccccc1-c1ccc(CO[C@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H41NO5/c33-22-26-10-5-6-11-27(26)25-15-13-24(14-16-25)23-37-29-18-17-28(32-19-7-1-2-8-20-32)31(29)36-21-9-3-4-12-30(34)35/h3,5-6,9-11,13-16,28-29,31,33H,1-2,4,7-8,12,17-23H2,(H,34,35)/b9-3-/t28-,29-,31+/m0/s1
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n/an/an/a 1.58n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Thromboxane A2 receptor


(Homo sapiens (Human))
BDBM50405920
PNG
(CHEMBL176714 | CHEMBL3349042)
Show SMILES CCCCCCSC[C@H]1C2CC[C@@H](O2)[C@H]1C\C=C/CCCC(O)=O
Show InChI InChI=1S/C21H36O3S/c1-2-3-4-7-10-15-25-16-18-17(19-13-14-20(18)24-19)11-8-5-6-9-12-21(22)23/h5,8,17-20H,2-4,6-7,9-16H2,1H3,(H,22,23)/b8-5-
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n/an/an/a 1.60n/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of specific binding of HSQ (5,6-di-3H-SQ 29,548) in washed platelets


J Med Chem 32: 974-84 (1989)


Article DOI: 10.1021/jm00125a009
BindingDB Entry DOI: 10.7270/Q2TT4PX7
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047281
PNG
(2-{3-[2-(3-Methanesulfonylamino-3-oxo-propyl)-benz...)
Show SMILES CS(=O)(=O)NC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C31H43N3O6S/c1-41(37,38)34-28(35)17-14-22-12-5-6-13-23(22)19-24-26-15-16-27(40-26)29(24)31-33-25(20-39-31)30(36)32-18-8-7-11-21-9-3-2-4-10-21/h5-6,12-13,20-21,24,26-27,29H,2-4,7-11,14-19H2,1H3,(H,32,36)(H,34,35)
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n/an/an/a 1.60n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391284
PNG
(CHEMBL161252)
Show SMILES OCCc1ccccc1-c1ccc(COC2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C32H43NO5/c34-22-19-26-10-5-6-11-28(26)27-15-13-25(14-16-27)24-38-30-18-17-29(33-20-7-1-2-8-21-33)32(30)37-23-9-3-4-12-31(35)36/h3,5-6,9-11,13-16,29-30,32,34H,1-2,4,7-8,12,17-24H2,(H,35,36)/b9-3-/t29-,30?,32+/m0/s1
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n/an/an/a 2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391298
PNG
(CHEMBL352076)
Show SMILES CC(=O)NCc1ccc(cc1)-c1ccc(COC2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C33H44N2O5/c1-25(36)34-23-26-10-14-28(15-11-26)29-16-12-27(13-17-29)24-40-31-19-18-30(35-20-6-2-3-7-21-35)33(31)39-22-8-4-5-9-32(37)38/h4,8,10-17,30-31,33H,2-3,5-7,9,18-24H2,1H3,(H,34,36)(H,37,38)/b8-4-/t30-,31?,33+/m0/s1
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n/an/an/a 2.51n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391302
PNG
(CHEMBL349625)
Show SMILES Cc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H40N2O4/c1-23-16-17-31-21-26(23)25-12-10-24(11-13-25)22-36-28-15-14-27(32-18-6-2-3-7-19-32)30(28)35-20-8-4-5-9-29(33)34/h4,8,10-13,16-17,21,27-28,30H,2-3,5-7,9,14-15,18-20,22H2,1H3,(H,33,34)/b8-4-/t27-,28+,30+/m0/s1
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n/an/an/a 2.51n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391309
PNG
(CHEMBL159517 | GR-83783)
Show SMILES CCCc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C32H44N2O4/c1-2-10-26-18-19-33-23-28(26)27-14-12-25(13-15-27)24-38-30-17-16-29(34-20-7-3-4-8-21-34)32(30)37-22-9-5-6-11-31(35)36/h5,9,12-15,18-19,23,29-30,32H,2-4,6-8,10-11,16-17,20-22,24H2,1H3,(H,35,36)/b9-5-/t29-,30+,32+/m0/s1
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n/an/an/a 2.51n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50015847
PNG
(7-(3-{[2-(5-Cyclohexyl-pentanoylamino)-acetylamino...)
Show SMILES OC(=O)CCC\C=C\CC1C2CCC(O2)C1CNC(=O)CNC(=O)CCCCC1CCCCC1
Show InChI InChI=1S/C27H44N2O5/c30-25(14-9-8-12-20-10-4-3-5-11-20)29-19-26(31)28-18-22-21(23-16-17-24(22)34-23)13-6-1-2-7-15-27(32)33/h1,6,20-24H,2-5,7-19H2,(H,28,31)(H,29,30)(H,32,33)/b6-1+
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n/an/an/a 2.60n/an/an/an/an/a



Princ

Curated by ChEMBL


Assay Description
Binding affinity was determined from the inhibition of [3H]-SQ 29,548 binding to Thromboxane A2 receptor in human platelet membranes.


J Med Chem 33: 2465-76 (1990)


Article DOI: 10.1021/jm00171a021
BindingDB Entry DOI: 10.7270/Q2V123S1
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047292
PNG
(3-[2-(3-{4-[4-(4-Methylsulfanyl-phenyl)-butylcarba...)
Show SMILES CSc1ccc(CCCCNC(=O)c2coc(n2)C2C3CCC(O3)C2Cc2ccccc2CCC(O)=O)cc1
Show InChI InChI=1S/C31H36N2O5S/c1-39-23-12-9-20(10-13-23)6-4-5-17-32-30(36)25-19-37-31(33-25)29-24(26-14-15-27(29)38-26)18-22-8-3-2-7-21(22)11-16-28(34)35/h2-3,7-10,12-13,19,24,26-27,29H,4-6,11,14-18H2,1H3,(H,32,36)(H,34,35)
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n/an/an/a 2.90n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047296
PNG
(3-(2-{3-[4-(3,3-Dimethyl-butylcarbamoyl)-oxazol-2-...)
Show SMILES CC(C)(C)CCNC(=O)c1coc(n1)C1C2CCC(O2)C1Cc1ccccc1CCC(O)=O
Show InChI InChI=1S/C26H34N2O5/c1-26(2,3)12-13-27-24(31)19-15-32-25(28-19)23-18(20-9-10-21(23)33-20)14-17-7-5-4-6-16(17)8-11-22(29)30/h4-7,15,18,20-21,23H,8-14H2,1-3H3,(H,27,31)(H,29,30)
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n/an/an/a 2.90n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50008805
PNG
(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)
Show SMILES OC(=O)CCC\C=C/C[C@H]1[C@@H]2CCC(C2)C1NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H27NO4S/c22-19(23)11-7-2-1-6-10-18-15-12-13-16(14-15)20(18)21-26(24,25)17-8-4-3-5-9-17/h1,3-6,8-9,15-16,18,20-21H,2,7,10-14H2,(H,22,23)/b6-1-/t15-,16?,18+,20?/m1/s1
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n/an/an/a 2.90n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for binding affinity against platelet TXA2 receptor in washed human platelets using [125I]-BOP as radioligand


Bioorg Med Chem Lett 1: 173-178 (1991)


Article DOI: 10.1016/S0960-894X(01)80794-0
BindingDB Entry DOI: 10.7270/Q2RR1Z4S
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391313
PNG
(CHEMBL159787)
Show SMILES OCc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H40N2O5/c33-21-25-15-16-31-20-26(25)24-11-9-23(10-12-24)22-37-28-14-13-27(32-17-5-1-2-6-18-32)30(28)36-19-7-3-4-8-29(34)35/h3,7,9-12,15-16,20,27-28,30,33H,1-2,4-6,8,13-14,17-19,21-22H2,(H,34,35)/b7-3-/t27-,28+,30+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391312
PNG
(CHEMBL345876)
Show SMILES CC(C)(C)c1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C33H46N2O4/c1-33(2,3)28-18-19-34-23-27(28)26-14-12-25(13-15-26)24-39-30-17-16-29(35-20-8-4-5-9-21-35)32(30)38-22-10-6-7-11-31(36)37/h6,10,12-15,18-19,23,29-30,32H,4-5,7-9,11,16-17,20-22,24H2,1-3H3,(H,36,37)/b10-6-/t29-,30+,32+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391306
PNG
(CHEMBL161532)
Show SMILES OCCc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H42N2O5/c34-20-16-26-15-17-32-22-27(26)25-11-9-24(10-12-25)23-38-29-14-13-28(33-18-5-1-2-6-19-33)31(29)37-21-7-3-4-8-30(35)36/h3,7,9-12,15,17,22,28-29,31,34H,1-2,4-6,8,13-14,16,18-21,23H2,(H,35,36)/b7-3-/t28-,29+,31+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391307
PNG
(CHEMBL162133)
Show SMILES OCc1cnccc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H40N2O5/c33-21-25-20-31-16-15-26(25)24-11-9-23(10-12-24)22-37-28-14-13-27(32-17-5-1-2-6-18-32)30(28)36-19-7-3-4-8-29(34)35/h3,7,9-12,15-16,20,27-28,30,33H,1-2,4-6,8,13-14,17-19,21-22H2,(H,34,35)/b7-3-/t27-,28+,30+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391301
PNG
(CHEMBL162409)
Show SMILES OCc1ncccc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C30H40N2O5/c33-21-26-25(9-8-17-31-26)24-13-11-23(12-14-24)22-37-28-16-15-27(32-18-5-1-2-6-19-32)30(28)36-20-7-3-4-10-29(34)35/h3,7-9,11-14,17,27-28,30,33H,1-2,4-6,10,15-16,18-22H2,(H,34,35)/b7-3-/t27-,28+,30+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391279
PNG
(CHEMBL350418)
Show SMILES OCc1ccc(cc1)-c1ccc(CO[C@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H41NO5/c33-22-24-9-13-26(14-10-24)27-15-11-25(12-16-27)23-37-29-18-17-28(32-19-5-1-2-6-20-32)31(29)36-21-7-3-4-8-30(34)35/h3,7,9-16,28-29,31,33H,1-2,4-6,8,17-23H2,(H,34,35)/b7-3-/t28-,29-,31+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391282
PNG
(CHEMBL159927)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(COC2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H40N2O5/c32-31(36)26-15-13-25(14-16-26)24-11-9-23(10-12-24)22-38-28-18-17-27(33-19-5-1-2-6-20-33)30(28)37-21-7-3-4-8-29(34)35/h3,7,9-16,27-28,30H,1-2,4-6,8,17-22H2,(H2,32,36)(H,34,35)/b7-3-/t27-,28?,30+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391276
PNG
(CHEMBL161360)
Show SMILES CNS(=O)(=O)Cc1ccc(cc1)-c1ccc(COC2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C32H44N2O6S/c1-33-41(37,38)24-26-12-16-28(17-13-26)27-14-10-25(11-15-27)23-40-30-19-18-29(34-20-6-2-3-7-21-34)32(30)39-22-8-4-5-9-31(35)36/h4,8,10-17,29-30,32-33H,2-3,5-7,9,18-24H2,1H3,(H,35,36)/b8-4-/t29-,30?,32+/m0/s1
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n/an/an/a 3.16n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047277
PNG
((2-{3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl...)
Show SMILES OC(=O)COc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCC1CCCCC1
Show InChI InChI=1S/C29H38N2O6/c32-26(33)18-35-23-12-5-4-11-20(23)16-21-24-13-14-25(37-24)27(21)29-31-22(17-36-29)28(34)30-15-7-6-10-19-8-2-1-3-9-19/h4-5,11-12,17,19,21,24-25,27H,1-3,6-10,13-16,18H2,(H,30,34)(H,32,33)
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n/an/an/a 3.20n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391281
PNG
(CHEMBL161108)
Show SMILES OCc1ccccc1-c1ccc(CO[C@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C31H41NO5/c33-22-26-10-5-6-11-27(26)25-15-13-24(14-16-25)23-37-29-18-17-28(32-19-7-1-2-8-20-32)31(29)36-21-9-3-4-12-30(34)35/h3,5-6,9-11,13-16,28-29,31,33H,1-2,4,7-8,12,17-23H2,(H,34,35)/b9-3-/t28-,29-,31+/m0/s1
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n/an/an/a 3.20n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50281915
PNG
(3-(2-{2-[4-(4-Chloro-benzylcarbamoyl)-oxazol-2-yl]...)
Show SMILES OC(=O)CCc1ccccc1C[C@H]1CCC[C@@H]1c1nc(co1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O4/c27-21-11-8-17(9-12-21)15-28-25(32)23-16-33-26(29-23)22-7-3-6-20(22)14-19-5-2-1-4-18(19)10-13-24(30)31/h1-2,4-5,8-9,11-12,16,20,22H,3,6-7,10,13-15H2,(H,28,32)(H,30,31)/t20-,22+/m1/s1
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n/an/an/a 3.30n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity was determined for Thromboxane A2 receptor in human platelet membrane using [3H]-SQ-29,548 radioligand


Bioorg Med Chem Lett 3: 1267-1270 (1993)


Article DOI: 10.1016/S0960-894X(00)80329-7
BindingDB Entry DOI: 10.7270/Q2PV6K8B
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047285
PNG
(3-[2-(3-{4-[4-(4-Fluoro-phenyl)-butylcarbamoyl]-ox...)
Show SMILES OC(=O)CCc1ccccc1CC1C2CCC(O2)C1c1nc(co1)C(=O)NCCCCc1ccc(F)cc1
Show InChI InChI=1S/C30H33FN2O5/c31-22-11-8-19(9-12-22)5-3-4-16-32-29(36)24-18-37-30(33-24)28-23(25-13-14-26(28)38-25)17-21-7-2-1-6-20(21)10-15-27(34)35/h1-2,6-9,11-12,18,23,25-26,28H,3-5,10,13-17H2,(H,32,36)(H,34,35)
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n/an/an/a 3.90n/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand


J Med Chem 36: 1401-17 (1993)


Article DOI: 10.1021/jm00062a013
BindingDB Entry DOI: 10.7270/Q2TX3DF9
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391303
PNG
(CHEMBL158576)
Show SMILES CCCCc1ccncc1-c1ccc(CO[C@@H]2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C33H46N2O4/c1-2-3-11-27-19-20-34-24-29(27)28-15-13-26(14-16-28)25-39-31-18-17-30(35-21-8-4-5-9-22-35)33(31)38-23-10-6-7-12-32(36)37/h6,10,13-16,19-20,24,30-31,33H,2-5,7-9,11-12,17-18,21-23,25H2,1H3,(H,36,37)/b10-6-/t30-,31+,33+/m0/s1
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n/an/an/a 3.98n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood.


Bioorg Med Chem Lett 1: 695-698 (1991)

Checked by Author
Article DOI: 10.1016/S0960-894X(01)81050-7
BindingDB Entry DOI: 10.7270/Q2125TT6
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50391296
PNG
(CHEMBL421831)
Show SMILES NC(=O)Cc1ccc(cc1)-c1ccc(COC2CC[C@@H]([C@H]2OC\C=C/CCC(O)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C32H42N2O5/c33-30(35)22-24-9-13-26(14-10-24)27-15-11-25(12-16-27)23-39-29-18-17-28(34-19-5-1-2-6-20-34)32(29)38-21-7-3-4-8-31(36)37/h3,7,9-16,28-29,32H,1-2,4-6,8,17-23H2,(H2,33,35)(H,36,37)/b7-3-/t28-,29?,32+/m0/s1
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n/an/an/a 3.98n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole blood


Bioorg Med Chem Lett 1: 689-694 (1991)


Article DOI: 10.1016/S0960-894X(01)81049-0
BindingDB Entry DOI: 10.7270/Q24T6KH5
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047274
PNG
(3-{2-[3-(4-Pentylcarbamoyl-oxazol-2-yl)-7-oxa-bicy...)
Show SMILES CCCCCNC(=O)c1coc(n1)C1C2CCC(O2)C1Cc1ccccc1CCC(O)=O
Show InChI InChI=1S/C25H32N2O5/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29)
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n/an/an/a 4n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity was determined for platelet thromboxane receptor in presence of [3H]-SQ 29548


Bioorg Med Chem Lett 3: 1271-1276 (1993)


Article DOI: 10.1016/S0960-894X(00)80330-3
BindingDB Entry DOI: 10.7270/Q2K35TJX
More data for this
Ligand-Target Pair
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