Compile Data Set for Download or QSAR
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Found 249 of ic50 for UniProtKB: Q13510
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  0.800nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367209(2-oxo-4-phenyl-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238556(CHEMBL4093029)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238557(CHEMBL4103207)
Affinity DataIC50:  1nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367226(4-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  1nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238562(CHEMBL4084295)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238574(CHEMBL4092051)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238573(CHEMBL4062592)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238569(CHEMBL4075447)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238572(CHEMBL4065362)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238568(CHEMBL4100744)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50511300(CHEMBL4580541)
Affinity DataIC50:  3nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367195(6-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367194(5-nitro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  3nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238578(CHEMBL4071239)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238558(CHEMBL4075028)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50556798(CHEMBL4742096)
Affinity DataIC50:  5nMAssay Description:Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50511282(CHEMBL4592427)
Affinity DataIC50:  6nMAssay Description:Inhibition of human acid ceramidase expressed in HEK293 cells using Rbm14-12 as substrate preincubated for 10 mins followed by substrate addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238563(Benzoimidazole-1-Carboxylic Acid Hexylamide | CHEM...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238570(CHEMBL4089655)
Affinity DataIC50:  7nMAssay Description:Inhibition of dopamine uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238577(CHEMBL4096883)
Affinity DataIC50:  7nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50431253(CHEMBL2333055)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238576(CHEMBL4076230)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238561(CHEMBL4101140)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367187(5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  9nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238565(CHEMBL4095461)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367186(6-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  10nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367198(5-cyano-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367196(2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...)
Affinity DataIC50:  11nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367185(5-fluoro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50556790(CHEMBL4777626)
Affinity DataIC50:  13nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50556791(CHEMBL4754069)
Affinity DataIC50:  14nMAssay Description:Inhibition of human acid ceramidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM241946(US9428465, 24)
Affinity DataIC50:  14nMpH: 4.5Assay Description:A hAC protein preparation (10 μg) was preincubated with inhibitors (final DMSO concentration 1%) in assay buffer (100 mM sodium phosphate, 0.1% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238554(CHEMBL4094489)
Affinity DataIC50:  14nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367214(6-(4-chlorobenzoyl)-2-oxo-N- (4-phenylbutyl)-1,3- ...)
Affinity DataIC50:  14nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50238566(CHEMBL4075846)
Affinity DataIC50:  15nMAssay Description:Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367187(5-chloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367212(2-oxo-N-(4-phenylbutyl)-6- propanoyl-1,3-benzoxazo...)
Affinity DataIC50:  16nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367199(5,6-dichloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxa...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367201(7-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367201(7-bromo-2-oxo-N-(4- phenylbutyl)-1,3- benzoxazole-...)
Affinity DataIC50:  18nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM50556813(CHEMBL4777275)
Affinity DataIC50:  18nMAssay Description:Inhibition of human acid ceramidase using N-lauroyl ceramide incubated for 1 hr by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367199(5,6-dichloro-2-oxo-N-(4- phenylbutyl)-1,3- benzoxa...)
Affinity DataIC50:  18nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367196(2-oxo-N-(4-phenylbutyl)-5- (trifluoromethyl)-1,3- ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367217(2-oxo-N-[(4- propylphenyl)methyl]-1,3- benzoxazole...)
Affinity DataIC50:  19nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367217(2-oxo-N-[(4- propylphenyl)methyl]-1,3- benzoxazole...)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human acid ceramidase expressed in HEK293 cells using N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-4-(2-oxochromen-7-yl)-oxybutyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcid ceramidase(Homo sapiens (Human))
University Of California

US Patent
LigandPNGBDBM367197(2-oxo-N-(4-phenylbutyl)-6- (trifluoromethyl)-1,3- ...)
Affinity DataIC50:  20nMAssay Description:The assay was performed in Optiplate 96-wells black plates, with each reaction well containing a mixture of 25 mM sodium acetate buffer pH 4.5 and a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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