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Compile Data Set for Download or QSAR

Found 35 hits of ec50 data for polymerid = 10879,6944,7406   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50442649
PNG
(CHEMBL2441929)
Show SMILES COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1
Show InChI InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1
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n/an/an/an/a 40n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay


Bioorg Med Chem Lett 23: 6118-22 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50241426
PNG
(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
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n/an/an/an/a 60n/an/an/an/a



Ferrara University

Curated by ChEMBL


Assay Description
Activation of TRPM8 channel


J Med Chem 53: 5085-107 (2010)


Article DOI: 10.1021/jm100062h
BindingDB Entry DOI: 10.7270/Q2416Z02
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50241426
PNG
(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
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n/an/an/an/a 110n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50082781
PNG
(CHEMBL3422796)
Show SMILES COc1cccc(c1)N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4/c1-24-15-7-3-5-13(11-15)19-9-8-16(18-17(19)21)12-4-2-6-14(10-12)20(22)23/h2-8,10-11H,9H2,1H3,(H,18,21)
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n/an/an/an/a 130n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083005
PNG
(CHEMBL3422799)
Show SMILES Cc1ccc(O)c(c1)N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4/c1-11-5-6-16(21)15(9-11)19-8-7-14(18-17(19)22)12-3-2-4-13(10-12)20(23)24/h2-7,9-10,21H,8H2,1H3,(H,18,22)
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n/an/an/an/a 140n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50241426
PNG
(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
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n/an/an/an/a 190n/an/an/an/a



Università di Milano

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant TRPM8 receptor expressed in HEK293 cells assessed as increase in intracellular calcium concentration by fluorimet...


Bioorg Med Chem 17: 1636-9 (2009)


Article DOI: 10.1016/j.bmc.2008.12.057
BindingDB Entry DOI: 10.7270/Q28915RH
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420677
PNG
(CHEMBL2087057)
Show SMILES CC(C)c1ccc(C)cc1C(=O)NCCc1ccccc1
Show InChI InChI=1S/C19H23NO/c1-14(2)17-10-9-15(3)13-18(17)19(21)20-12-11-16-7-5-4-6-8-16/h4-10,13-14H,11-12H2,1-3H3,(H,20,21)
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n/an/an/an/a 270n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083017
PNG
(CHEMBL3422811)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1cccc(I)c1
Show InChI InChI=1S/C16H12IN3O3/c17-12-4-2-5-13(10-12)19-8-7-15(18-16(19)21)11-3-1-6-14(9-11)20(22)23/h1-7,9-10H,8H2,(H,18,21)
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n/an/an/an/a 300n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50241426
PNG
(3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...)
Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
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n/an/an/an/a 300n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay


Bioorg Med Chem Lett 23: 6118-22 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420675
PNG
(CHEMBL2087059)
Show SMILES CC(C)c1ccc(C)cc1NC(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H27NO/c1-14(2)18-12-7-15(3)13-19(18)22-20(23)16-8-10-17(11-9-16)21(4,5)6/h7-14H,1-6H3,(H,22,23)
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n/an/an/an/a 440n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083016
PNG
(CHEMBL3422810)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1cccc(Br)c1
Show InChI InChI=1S/C16H12BrN3O3/c17-12-4-2-5-13(10-12)19-8-7-15(18-16(19)21)11-3-1-6-14(9-11)20(22)23/h1-7,9-10H,8H2,(H,18,21)
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n/an/an/an/a 600n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420681
PNG
(CHEMBL2087052)
Show SMILES CC(C)c1ccc(C)cc1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H27NO/c1-14(2)18-12-7-15(3)13-19(18)20(23)22-17-10-8-16(9-11-17)21(4,5)6/h7-14H,1-6H3,(H,22,23)
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n/an/an/an/a 600n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083013
PNG
(CHEMBL3422807)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1ccccc1Br
Show InChI InChI=1S/C16H12BrN3O3/c17-13-6-1-2-7-15(13)19-9-8-14(18-16(19)21)11-4-3-5-12(10-11)20(22)23/h1-8,10H,9H2,(H,18,21)
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n/an/an/an/a 620n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420679
PNG
(CHEMBL2087055)
Show SMILES CC(C)c1ccc(C)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C17H18ClNO/c1-11(2)15-9-4-12(3)10-16(15)17(20)19-14-7-5-13(18)6-8-14/h4-11H,1-3H3,(H,19,20)
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n/an/an/an/a 850n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083012
PNG
(CHEMBL3422806)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1ccccc1Cl
Show InChI InChI=1S/C16H12ClN3O3/c17-13-6-1-2-7-15(13)19-9-8-14(18-16(19)21)11-4-3-5-12(10-11)20(22)23/h1-8,10H,9H2,(H,18,21)
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n/an/an/an/a 890n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50082780
PNG
(CHEMBL1451030)
Show SMILES COc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4/c1-24-16-8-3-2-7-15(16)19-10-9-14(18-17(19)21)12-5-4-6-13(11-12)20(22)23/h2-9,11H,10H2,1H3,(H,18,21)
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n/an/an/an/a 1.10E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083014
PNG
(CHEMBL3422808)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1ccccc1I
Show InChI InChI=1S/C16H12IN3O3/c17-13-6-1-2-7-15(13)19-9-8-14(18-16(19)21)11-4-3-5-12(10-11)20(22)23/h1-8,10H,9H2,(H,18,21)
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n/an/an/an/a 1.20E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50082783
PNG
(CHEMBL3422798)
Show SMILES Cc1ccc(N2CC=C(NC2=O)c2cccc(c2)[N+]([O-])=O)c(O)c1
Show InChI InChI=1S/C17H15N3O4/c1-11-5-6-15(16(21)9-11)19-8-7-14(18-17(19)22)12-3-2-4-13(10-12)20(23)24/h2-7,9-10,21H,8H2,1H3,(H,18,22)
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n/an/an/an/a 1.20E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083015
PNG
(CHEMBL3422809)
Show SMILES [O-][N+](=O)c1cccc(c1)C1=CCN(C(=O)N1)c1cccc(Cl)c1
Show InChI InChI=1S/C16H12ClN3O3/c17-12-4-2-5-13(10-12)19-8-7-15(18-16(19)21)11-3-1-6-14(9-11)20(22)23/h1-7,9-10H,8H2,(H,18,21)
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n/an/an/an/a 1.50E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50082778
PNG
(CHEMBL3422794)
Show SMILES Oc1cccc(c1)N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13N3O4/c20-14-6-2-4-12(10-14)18-8-7-15(17-16(18)21)11-3-1-5-13(9-11)19(22)23/h1-7,9-10,20H,8H2,(H,17,21)
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n/an/an/an/a 1.70E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420678
PNG
(CHEMBL2087056)
Show SMILES COc1ccc(NC(=O)c2cc(C)ccc2C(C)C)cc1
Show InChI InChI=1S/C18H21NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h5-12H,1-4H3,(H,19,20)
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n/an/an/an/a 1.70E+3n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50441018
PNG
(CHEMBL67100)
Show SMILES COc1ccc(\C=C2/OC(=O)c3ccccc23)cc1
Show InChI InChI=1S/C16H12O3/c1-18-12-8-6-11(7-9-12)10-15-13-4-2-3-5-14(13)16(17)19-15/h2-10H,1H3/b15-10-
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n/an/an/an/a 1.80E+3n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Agonist activity at rat recombinant TRPM8 overexpressed in HEK293 cells assessed as induction of intracellular calcium influx by Fluo-4-AM dye-based ...


Bioorg Med Chem Lett 23: 5614-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.08.039
BindingDB Entry DOI: 10.7270/Q2GQ706J
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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n/an/an/an/a 3.00E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay


Bioorg Med Chem Lett 23: 6118-22 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.016
BindingDB Entry DOI: 10.7270/Q2125V4N
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420691
PNG
(CHEMBL2087061)
Show SMILES COc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(C)C
Show InChI InChI=1S/C18H21NO2/c1-12(2)16-10-5-13(3)11-17(16)19-18(20)14-6-8-15(21-4)9-7-14/h5-12H,1-4H3,(H,19,20)
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n/an/an/an/a 4.80E+3n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083006
PNG
(CHEMBL3422800)
Show SMILES OCc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4/c21-11-13-4-1-2-7-16(13)19-9-8-15(18-17(19)22)12-5-3-6-14(10-12)20(23)24/h1-8,10,21H,9,11H2,(H,18,22)
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n/an/an/an/a 5.00E+3n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420662
PNG
(CHEMBL1385022)
Show SMILES COc1ccc(NC(=O)Oc2cc(C)ccc2C(C)C)cc1
Show InChI InChI=1S/C18H21NO3/c1-12(2)16-10-5-13(3)11-17(16)22-18(20)19-14-6-8-15(21-4)9-7-14/h5-12H,1-4H3,(H,19,20)
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n/an/an/an/a 5.10E+3n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083018
PNG
(CHEMBL3422812)
Show SMILES CC1=C(NC(=O)N(C1)c1ccccc1O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H15N3O4/c1-11-10-19(14-7-2-3-8-15(14)21)17(22)18-16(11)12-5-4-6-13(9-12)20(23)24/h2-9,21H,10H2,1H3,(H,18,22)
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n/an/an/an/a>1.00E+4n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50083008
PNG
(CHEMBL3422802)
Show SMILES NC(=O)c1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H14N4O4/c18-16(22)13-6-1-2-7-15(13)20-9-8-14(19-17(20)23)11-4-3-5-12(10-11)21(24)25/h1-8,10H,9H2,(H2,18,22)(H,19,23)
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n/an/an/an/a 1.54E+4n/an/an/an/a



National Research Council

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as induction of intracellular Ca2+ level by Fluo-4-AM dye based spectrofluorimetry


Bioorg Med Chem Lett 25: 2285-90 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.032
BindingDB Entry DOI: 10.7270/Q2QZ2CP2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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n/an/an/an/a 2.90E+4n/an/an/an/a



KU Leuven

Curated by ChEMBL


Assay Description
Activity at human TRPM8 expressed in HEK293 cells assessed as compound concentration causing leftward shift of voltage for half maximal activation


Nat Chem Biol 3: 174-82 (2007)


Article DOI: 10.1038/nchembio862
BindingDB Entry DOI: 10.7270/Q2057G4K
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50159506
PNG
(CHEMBL3787319)
Show SMILES C(Cc1c[nH]c2ccccc12)NCc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H22N2O/c1-2-6-20(7-3-1)26-21-12-10-18(11-13-21)16-24-15-14-19-17-25-23-9-5-4-8-22(19)23/h1-13,17,24-25H,14-16H2
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n/an/an/an/a 4.00E+4n/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...


J Med Chem 59: 2179-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01914
BindingDB Entry DOI: 10.7270/Q2B85B1Z
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420659
PNG
(CHEMBL2087075)
Show SMILES CC(C)c1ccc(C)cc1N
Show InChI InChI=1S/C10H15N/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7H,11H2,1-3H3
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n/an/an/an/a 4.34E+4n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50420658
PNG
(CHEMBL2087053)
Show SMILES CC(C)c1ccc(C)cc1C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H18F3NO/c1-11(2)15-9-4-12(3)10-16(15)17(23)22-14-7-5-13(6-8-14)18(19,20)21/h4-11H,1-3H3,(H,22,23)
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n/an/an/an/a 4.58E+4n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50240432
PNG
(1-hydroxy-5-methyl-2-isopropylbenzene | 2-isopropy...)
Show SMILES CC(C)c1ccc(C)cc1O
Show InChI InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3
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n/an/an/an/a 5.22E+4n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Activation of rat TRPM8 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels


Bioorg Med Chem Lett 22: 3535-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.055
BindingDB Entry DOI: 10.7270/Q2M61MJ8
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Rattus norvegicus (Rat))
BDBM50318482
PNG
((-)-menthol | CHEMBL470670 | MENTHOL | l-menthol)
Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Show InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
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n/an/an/an/a 7.50E+4n/an/an/an/a



University of Salerno

Curated by ChEMBL


Assay Description
Agonist activity at rat TRPM8 expressed in HEK293 cells assessed as increase in current amplitude at +80 mV holding potential by whole cell patch-cla...


J Med Chem 59: 2179-91 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01914
BindingDB Entry DOI: 10.7270/Q2B85B1Z
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))
BDBM50037023
PNG
(CHEBI:17447 | GERANIOL | Geraniol)
Show SMILES CC(C)=CCC\C(C)=C\CO
Show InChI InChI=1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,7,11H,4,6,8H2,1-3H3/b10-7+
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n/an/an/an/a 5.90E+6n/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Agonist activity at TRPM8 (unknown origin)


Bioorg Med Chem Lett 24: 5507-11 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.012
BindingDB Entry DOI: 10.7270/Q2SB47B3
More data for this
Ligand-Target Pair