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Found 1273 of ic50 for UniProtKB: P21396
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of MAO-A in Sprague-Dawley rat brain homogenate using kynuramine as substrate preincubated for 10 mins measured by fluorimetric assayMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  0.700nMAssay Description:In vitro Inhibitory activity of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT (serotonin)More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50381960(CHEMBL2022927)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of mitochondrial MAO-A in rat liver homogenates using [14C]-(5-hydroxy-triptamine) as substrate preincubated for 30 mins by liquid scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50367064(CHEMBL1204338)
Affinity DataIC50: >1nMAssay Description:Compound was tested in vitro for inhibition of rat brain mitochondrial monoamine oxidase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049682(2-Methoxy-6-(5-methyl-[1,3,4]oxadiazol-2-yl)-10,10...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179019(3-benzyl-N-(2-morpholinoethyl)quinoxalin-2-amine |...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50075965(CHEMBL3415613)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179021(3-(4-chlorobenzyl)-N-(2-morpholinoethyl)quinoxalin...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50059304(9,10,10-Trioxo-7-propoxy-9,10-dihydro-10lambda*6*-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Monoamine oxidase A (MAO A) in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50075969(CHEMBL3415617)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049666(5-(10,10-Dioxo-10H-10lambda*6*-phenoxathiin-2-yl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049703(6-(2-Methyl-2H-tetrazol-5-yl)-10,10-dioxo-2-propox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049704(2-(5-Methyl-[1,3,4]oxadiazol-2-yl)-10,11-dioxa-dib...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049686(2-Methoxy-6-(2-methyl-2H-tetrazol-5-yl)-10,10-diox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049671(2-Methyl-6-(5-methyl-[1,3,4]oxadiazol-2-yl)-10,10-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049701(3-(5-Methyl-[1,3,4]oxadiazol-2-yl)-10,10-dioxo-10H...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179017(1-(3-(4-chlorobenzyl)quinoxalin-2-yl)hydrazine | C...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50088564(CHEMBL3577041)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using serotonin as substrate preincubated with enzyme for 60 mins prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using serotonin as substrate preincubated with enzyme for 60 mins prior to substrate additionMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179020(2-(3-benzylquinoxalin-2-ylamino)ethanol | CHEMBL20...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224952(CHEMBL441014)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Monoamine oxidase at rat hyphalamic mitochondrial 5-HT by displacing 2.5 uM of [14C]5-HT.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of MAO-A in rat liver mitochondria using p-tyramine as substrate preincubated for 10 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50288969(4-(7-Bromo-5-methoxy-benzofuran-2-yl)-piperidine |...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225462(CHEMBL554775)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049687(2-Isopropyl-6-(2-methyl-2H-tetrazol-5-yl)-10,10-di...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50282522(4-Chloro-benzenesulfonic acid 3,4-dimethyl-2-oxo-2...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of rat liver mitochondrial MAOA using [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50059303(7-Isopropyl-9,10,10-trioxo-9,10-dihydro-10lambda*6...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Monoamine oxidase A (MAO A) in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50282520(4-Bromo-benzenesulfonic acid 3,4-dimethyl-2-oxo-2H...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50064684(3-Ethyl-phenoxathiine 10,10-dioxide | CHEMBL67629)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against monoamine oxidase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50075994(CHEMBL3415785)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50427725(CHEMBL2324222)
Affinity DataIC50:  7nMAssay Description:Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial suspension using kynuramine as substrate incubated for 5 mins prior to substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A/B(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225466(CHEMBL544509)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against rat brain mitochondrial Monoamine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50049680(6-(4,5-Dihydro-1H-imidazol-2-yl)-2-ethoxy-10,10-di...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat brain mitochondrial monoamine oxidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50064680(2-Ethyl-phenoxathiine 10,10-dioxide | CHEMBL67850)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against monoamine oxidase A.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM10804((3R)-3-[methyl(prop-2-yn-1-yl)amino]-2,3-dihydro-1...)
Affinity DataIC50:  7nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179018(1-(3-benzyl-6,7-dichloroquinoxalin-2-yl)hydrazine ...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM36552(Prochelators, 2)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of rat MAO-AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM36552(Prochelators, 2)
Affinity DataIC50:  7.70nMpH: 7.4 T: 2°CAssay Description:Inhibition of MAO activity in rat brain homogenates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM15581(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Wistar rat brain MAOA using kynuramine as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins ...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50282507(CHEMBL18504 | Esuprone | Ethanesulfonic acid 3,4-d...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM10807(1-[methyl(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-ind...)
Affinity DataIC50:  8nMAssay Description:Inhibition of MAO activity was determined by a radiometric procedure from Tipton and Youdim. Homogenized rat brain was used as the source of enzymes....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50059278(7-Methyl-9,10,10-trioxo-9,10-dihydro-10lambda*6*-t...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Monoamine oxidase A (MAO A) in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50282509(4-Cyano-benzenesulfonic acid 3,4-dimethyl-2-oxo-2H...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50179015(1-(3-benzylquinoxalin-2-yl)hydrazine | CHEMBL37967...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of rat liver mitochondria MAOAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
General Hospital of PLA

Curated by ChEMBL
LigandPNGBDBM50075966(CHEMBL3415614)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat brain MAO-A in nuclei-free homogenates using [14C]hydroxytryptamine substrate after 20 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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