Compile Data Set for Download or QSAR
maximum 50k data
Found 47 of ic50 for UniProtKB: P00734
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585342(5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperidin-1...)
Affinity DataIC50:  0.891nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044989((O10eq)-beta-guanidinopropionylryanodine | CHEMBL2...)
Affinity DataIC50:  1.10nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  1.29nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044982(CHEMBL283836 | GLYCYLRYANODINE)
Affinity DataIC50:  1.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044986((O10eq)-guanidino acetylryanodine | CHEMBL435362)
Affinity DataIC50:  1.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 2 hr by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531785(CHEMBL4543226 | US11530198, Example 69)
Affinity DataIC50:  2nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531784(Fanotaprim | TRC-2533 | TRC-2533-NX | US11530198, ...)
Affinity DataIC50:  2.09nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585326(5-(4-(3-(2-chloropyrimidin-5- yl)phenyl)piperazin-...)
Affinity DataIC50:  2.51nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531797(CHEMBL4550110 | US11530198, Example 86)
Affinity DataIC50:  2.51nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044995((O10eq)-beta-alanylryanodine | CHEMBL282089)
Affinity DataIC50:  2.60nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 1 hr by com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585317(5-(4-(3-(2-ethylpyrimidin-5- yl)phenyl)piperazin-1...)
Affinity DataIC50:  3.80nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044993(Benzyloxycarbonyl-glycylryanodine | CHEMBL28383)
Affinity DataIC50:  4.80nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531786(CHEMBL4573445 | US11530198, Example 74)
Affinity DataIC50:  5.62nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044990((O10eq)-Benzyloxycarbonyl-beta-alanylryanodine | C...)
Affinity DataIC50:  5.90nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  6.20nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531783(CHEMBL4591892 | US11530198, Example 87)
Affinity DataIC50:  7.41nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044991(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50:  8.90nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044994(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016403(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM50531779(CHEMBL4553229 | US11530198, Example 4)
Affinity DataIC50:  31.6nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016410(2,6,9,11,13,14-hexahydroxy-11-(2-hydroxy-1-methyle...)
Affinity DataIC50:  41nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044987((O10eq)-beta-N,N'-Bis-Benzyloxycarbonyl-guanidinop...)
Affinity DataIC50:  44nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044988(CHEMBL432278 | N-methyl ryanodine-succinamidate)
Affinity DataIC50:  49nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016413(18-HYDROXYRYANODINE | 2,6,9,11,13,14-hexahydroxy-1...)
Affinity DataIC50:  88nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016418(10-KETORYANODINE | 6,9,11,13,14-pentahydroxy-11-is...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044984(CHEMBL416926 | Di-Benzyloxycarbonyl-guanidino acet...)
Affinity DataIC50:  136nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016416(10-ACETYLRYANODINE | 6,9,11,13,14-pentahydroxy-11-...)
Affinity DataIC50:  140nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016411(2',6',9',11',13',14'-hexahydroxy-11'-isopropyl-7',...)
Affinity DataIC50:  140nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044992((O10eq)-beta-alanyl-anhydro-ryanodine | CHEMBL2826...)
Affinity DataIC50:  149nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016406(2,6,11,13,14-pentahydroxy-11-isopropyl-9-methoxy-3...)
Affinity DataIC50:  280nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016417(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  310nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma brucei brucei)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  407nMAssay Description:TBDMore data for this Ligand-Target Pair
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016405(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50:  860nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044991(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044991(2,6,9,11,13,14-hexahydroxy-11-isopropyl-7,10-dimet...)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50044985(ryanodine-hemi-succinate)
Affinity DataIC50: >1.00E+3nMAssay Description:Affinity for sarcoplasmic reticular calcium release channel (SR CRC) of rabbit skeletal membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016412(2,11,13,14-tetrahydroxy-11-isopropyl-6,9-dimethoxy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016409(2,6,11,14-tetrahydroxy-11-isopropyl-9,13-dimethoxy...)
Affinity DataIC50:  4.50E+3nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016404(2,3,6,9,11,13,14-heptahydroxy-3-hydroxymethyl-11-i...)
Affinity DataIC50:  4.90E+3nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016414(6,9,11,13,14-pentahydroxy-11-isopropyl-3,7,10-trim...)
Affinity DataIC50:  7.30E+3nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016420(2,6,9,11,13,14-hexahydroxy-11-isopropyl-3,7,10-tri...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016407(6,11,14-trihydroxy-11-isopropyl-2,9,13-trimethoxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016408(2,6,8,12-tetrahydroxy-10-isopropyl-3,7,11-trimethy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016402(11-isopropyl-7,10-dimethyl-3-methylene-(1R,2R,6S,7...)
Affinity DataIC50:  1.00E+4nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRyanodine receptor 1(Oryctolagus cuniculus)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50016415(11-isopropyl-3,7,10-trimethyl-(1R,2R,3S,6S,7S,9S,1...)
Affinity DataIC50:  3.50E+4nMAssay Description:Displacement of [3H]ryanodine from Ca2+-ryanodine receptor in Oryctolagus cuniculus (rabbit) skeletal muscle sarcoplasmic reticulum after 80 min by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed